| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| U Traversa, P Puppini, C Florio, R Vertu. Effects of an atypical barbiturate (valofan) on spontaneous and stimulated locomotor activity and on brain serotonin metabolism in mice. Il Farmaco; edizione scientifica. vol 42. issue 10. 1988-03-25. PMID:2449358. |
no correlation seems to exist between the effects of valofan, on its own or combined with serotonergic agents, on motor activity and its effects on the accumulation of 5-ht and 5-hiaa. |
1988-03-25 |
2023-08-11 |
mouse |
| J Quintan. Platelet MAO deamination of serotonin in depressed patients. Changes after imipramine treatment and clinical correlations. Biological psychiatry. vol 23. issue 1. 1988-03-18. PMID:3337854. |
to correlate changes in platelet mao activity with the enzyme activity in central serotonergic systems, the platelet mao activity of depressed patients (first unmedicated and then after 3 weeks and 2 months of imipramine treatment) and normal controls was measured using 5-ht as substrate. |
1988-03-18 |
2023-08-11 |
Not clear |
| G L Ricchieri, T T Soncrant, H W Holloway, S I Rapopor. Methiothepin reduces glucose utilization in forebrain regions of awake rats. Psychopharmacology. vol 93. issue 4. 1988-03-07. PMID:3124178. |
most of the regions affected by methiothepin possess a substantial number of serotonin receptors, although lcgu was also reduced in a few regions not primarily involved in serotonergic neurotransmission. |
1988-03-07 |
2023-08-11 |
rat |
| K Krootila, H Uusitalo, A Palkam. Effect of alpha-adrenergic and serotonergic blockers on the acute irritative response in the rabbit eye. Experimental eye research. vol 45. issue 5. 1988-03-03. PMID:2892693. |
the effect of alpha-adrenergic and serotonergic (5-ht) blockers on the acute irritative response in the rabbit eye elicited by topical, neutral formaldehyde (1%), was studied. |
1988-03-03 |
2023-08-11 |
rabbit |
| A D Ramirez, V D Ramirez, D C Meye. The nature and magnitude of in vivo 5-hydroxyindoleacetic acid output from 5-hydroxytryptamine terminals is related to specific regions of the suprachiasmatic nucleus. Neuroendocrinology. vol 46. issue 5. 1988-02-26. PMID:2448699. |
these results suggest that the in vivo measurement of 5-hiaa from 5-hydroxytryptamine (5-ht) terminals in the region of the scn could reflect discrete functional activity of serotonergic terminals within specific regions of the scn in a freely behaving rat. |
1988-02-26 |
2023-08-11 |
rat |
| J Zohar, T R Insel, R C Zohar-Kadouch, J L Hill, D L Murph. Serotonergic responsivity in obsessive-compulsive disorder. Effects of chronic clomipramine treatment. Archives of general psychiatry. vol 45. issue 2. 1988-02-24. PMID:3276283. |
to investigate whether clomipramine treatment in ocd affects brain serotonergic responsiveness, metachlorophenylpiperazine (mcpp), a selective serotonin agonist, and placebo were given under double-blind conditions to nine patients with ocd before and after treatment with clomipramine. |
1988-02-24 |
2023-08-11 |
Not clear |
| R R Mize, M P Payn. The innervation density of serotonergic (5-HT) fibers varies in different subdivisions of the cat lateral geniculate nucleus complex. Neuroscience letters. vol 82. issue 2. 1988-02-16. PMID:3696488. |
the innervation density of serotonergic (5-ht) fibers varies in different subdivisions of the cat lateral geniculate nucleus complex. |
1988-02-16 |
2023-08-11 |
cat |
| H K Lehman, M J Greenber. The actions of FMRFamide-like peptides on visceral and somatic muscles of the snail Helix aspersa. The Journal of experimental biology. vol 131. 1988-02-12. PMID:3694118. |
the effects of fmrfamide and pqdpflrfamide on all of the preparations could be distinguished from those produced by ach and 5-hydroxytryptamine (5-ht); thus the actions of the neuropeptides were not mediated by cholinergic or serotonergic neurones. |
1988-02-12 |
2023-08-11 |
Not clear |
| K A Mulligan, I Tör. Serotonergic axons form basket-like terminals in cerebral cortex. Neuroscience letters. vol 81. issue 1-2. 1988-02-08. PMID:3696477. |
serotonergic axons in the posterior cerebral cortex of the cat were demonstrated immunohistochemically using a monoclonal antibody to serotonin (5-ht). |
1988-02-08 |
2023-08-11 |
cat |
| C Haslam, R Stevens, T P Donoho. The influence of cyproheptadine on immobilization and oestradiol benzoate induced anorexia in ovariectomized rats. Psychopharmacology. vol 93. issue 2. 1988-02-03. PMID:3122252. |
to determine whether serotonergic mechanisms are involved in the stress- and oestrogen-induced anorexia, the 5-ht antagonist cyproheptadine was given to ovariectomized rats that were immobilized and treated with oestradiol benzoate. |
1988-02-03 |
2023-08-11 |
rat |
| J M Witkin, R S Mansbach, J E Barrett, G T Bolger, P Skolnick, B Weissma. Behavioral studies with anxiolytic drugs. IV. Serotonergic involvement in the effects of buspirone on punished behavior of pigeons. The Journal of pharmacology and experimental therapeutics. vol 243. issue 3. 1988-02-02. PMID:2891840. |
hill coefficients significantly less than unity for all drugs except 5-ht suggested multiple serotonergic binding sites for buspirone and analogs. |
1988-02-02 |
2023-08-11 |
rat |
| J J Man. Psychobiologic predictors of suicide. The Journal of clinical psychiatry. vol 48 Suppl. 1988-02-02. PMID:3320036. |
biologic markers such as low cerebrospinal fluid levels of the serotonin metabolite 5-hydroxyindoleacetic acid and related indices of serotonergic function appear to correlate with violent and impulsive suicidal behavior. |
1988-02-02 |
2023-08-11 |
Not clear |
| J M Barasch, H Tamir, E A Nunez, M D Gersho. Serotonin-storing secretory granules from thyroid parafollicular cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 7. issue 12. 1988-01-28. PMID:3694261. |
it is concluded that parafollicular cell granules are different from other amine-storing vesicles that do contain atp; nevertheless, since parafollicular cell granules store 5-ht and have the same 45 kda sbp as is found in serotonergic axon terminals, parafollicular cell granules may be analogous to the synaptic vesicles of serotonergic neurons. |
1988-01-28 |
2023-08-11 |
Not clear |
| M L Cohen, K D Kurz, R W Fulle. Effect of meta-chlorophenylpiperazine (mCPP), a central serotonin agonist and vascular serotonin receptor antagonist, on blood pressure in SHR. Clinical and experimental hypertension. Part A, Theory and practice. vol 9. issue 10. 1988-01-21. PMID:3677442. |
1 hr after administration) increased serotonin and decreased 5-hydroxy-indolacetic acid (5-hiaa) brain concentrations and elevated serum corticosterone and prolactin, indications of central serotonergic agonist activities. |
1988-01-21 |
2023-08-11 |
rat |
| D Piomelli, E Shapiro, S J Feinmark, J H Schwart. Metabolites of arachidonic acid in the nervous system of Aplysia: possible mediators of synaptic modulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 7. issue 11. 1988-01-19. PMID:3119791. |
application of serotonin or stimulation of the giant serotonergic cell (gcn) in the cerebral ganglion did not cause detectable amounts of the labeled eicosanoids to be released. |
1988-01-19 |
2023-08-11 |
aplysia |
| D L Commins, K J Axt, G Vosmer, L S Seide. Endogenously produced 5,6-dihydroxytryptamine may mediate the neurotoxic effects of para-chloroamphetamine. Brain research. vol 419. issue 1-2. 1988-01-11. PMID:2445423. |
para-chloroamphetamine (pca) has been used to deplete brain serotonin (5-ht) in numerous studies of serotonergic involvement in various behaviors and physiological functions. |
1988-01-11 |
2023-08-11 |
rat |
| D L Commins, K J Axt, G Vosmer, L S Seide. Endogenously produced 5,6-dihydroxytryptamine may mediate the neurotoxic effects of para-chloroamphetamine. Brain research. vol 419. issue 1-2. 1988-01-11. PMID:2445423. |
pca is believed to cause long-lasting depletions of 5-ht by causing the selective degeneration of serotonergic nerve terminals, but the mechanism by which it exerts this neurotoxic effect is not understood. |
1988-01-11 |
2023-08-11 |
rat |
| D L Commins, K J Axt, G Vosmer, L S Seide. Endogenously produced 5,6-dihydroxytryptamine may mediate the neurotoxic effects of para-chloroamphetamine. Brain research. vol 419. issue 1-2. 1988-01-11. PMID:2445423. |
we hypothesize that the formation of 5,6-dht, perhaps from endogenous 5-ht, may mediate the toxic effects of pca, ma and other amphetamine-related drugs on serotonergic neurons and on a subpopulation of cortical neurons. |
1988-01-11 |
2023-08-11 |
rat |
| N Toda, K Bian, S Inou. Age-related changes in the response to vasoconstrictor and dilator agents in isolated beagle coronary arteries. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 3. 1988-01-11. PMID:3317070. |
it may be concluded that greater responsiveness to serotonin of senescent beagle coronary arteries is due preferentially to increased function of serotonergic receptors rather than impaired function of the arterial endothelium responsible for the release of relaxing factor(s), although some impairment of the function is supposed, on the basis of interferences with acetylcholine-induced relaxation in the aged beagle arteries. |
1988-01-11 |
2023-08-11 |
Not clear |
| J Zohar, T R Inse. Drug treatment of obsessive-compulsive disorder. Journal of affective disorders. vol 13. issue 2. 1988-01-06. PMID:2960711. |
the apparent specificity of clomipramine, and, to some extent, newer serotonin selective antidepressants, suggests a serotonergic role in the psychobiology of ocd. |
1988-01-06 |
2023-08-11 |
Not clear |