| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M E Blue, K A Yagaloff, L A Mamounas, P R Hartig, M E Mollive. Correspondence between 5-HT2 receptors and serotonergic axons in rat neocortex. Brain research. vol 453. issue 1-2. 1988-09-15. PMID:3401769. |
the anatomic relationship between serotonergic (5-ht) axons and 5-ht2 receptors in the rat forebrain was determined by a combined analysis of transmitter immunocytochemistry and receptor autoradiography. |
1988-09-15 |
2023-08-11 |
rat |
| M Vergnes, A Depaulis, A Boehrer, E Kemp. Selective increase of offensive behavior in the rat following intrahypothalamic 5,7-DHT-induced serotonin depletion. Behavioural brain research. vol 29. issue 1-2. 1988-09-12. PMID:3401325. |
in order to localize the brain structures involved in this effect, 5,7-dihydroxytryptamine (5,7-dht), a neurotoxin of 5-ht neurons, was injected into the ascending serotonergic pathway within the lateral hypothalamus, thus depleting 5-ht only in the forebrain structures. |
1988-09-12 |
2023-08-11 |
rat |
| S Uma, M Tuncer, S O Kayaal. Influence of temperature on the responses to serotonin (5-HT) in perfused rat lung. Archives internationales de pharmacodynamie et de therapie. vol 292. 1988-08-25. PMID:3395171. |
the order of potencies of the 4 serotonergic antagonists was compared with their affinity for central 5-ht receptors. |
1988-08-25 |
2023-08-11 |
rat |
| A L Frankhuijzen, G Wardeh, F Hogenboom, A H Mulde. Alpha 2-adrenoceptor mediated inhibition of the release of radiolabelled 5-hydroxytryptamine and noradrenaline from slices of the dorsal region of the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 337. issue 3. 1988-08-22. PMID:2839776. |
possible local interactions between noradrenergic and serotonergic systems in the dorsal raphe region of the rat were investigated by studying the effects of various drugs on depolarization (20 mmol/l k+)-induced release of [3h]5-hydroxytryptamine (5-ht) and [3h]noradrenaline (na) in vitro using a superfusion method. |
1988-08-22 |
2023-08-11 |
human |
| R A Glenno. Site-selective serotonin agonists as discriminative stimuli. Psychopharmacology series. vol 4. 1988-08-19. PMID:3293039. |
however, with the recent discovery of multiple populations of central 5-ht binding sites, the concept of site-selective serotonergic agents needs to be addressed. |
1988-08-19 |
2023-08-11 |
rat |
| K Elekes, R Huster. The efferent innervation of the genital chamber by an identified serotonergic neuron in the female cricket Acheta domestica. Cell and tissue research. vol 252. issue 2. 1988-08-11. PMID:3383221. |
the serotonergic innervation of the genital chamber of the female cricket, acheta domestica, has been investigated applying anti-serotonin (5-ht) immunocytochemistry at both light- and electron-microscopic levels as well as using conventional electron microscopy. |
1988-08-11 |
2023-08-11 |
cricket |
| B Arneklo-Nobin, O Elmér, A Akesso. Effect of long-term ketanserin treatment on 5-HT levels, platelet aggregation and peripheral circulation in patients with Raynaud's phenomenon. A double-blind, placebo-controlled cross-over study. International angiology : a journal of the International Union of Angiology. vol 7. issue 1. 1988-08-08. PMID:3290356. |
the long-term effects of the serotonergic (5-hydroxy-tryptamine, 5-ht) receptor antagonist, ketanserin, on 5-ht levels in whole blood, platelet aggregation and peripheral circulation were investigated in a double-blind placebo-controlled cross-over study. |
1988-08-08 |
2023-08-11 |
Not clear |
| R E Solomon, G F Gebhar. Mechanisms of effects of intrathecal serotonin on nociception and blood pressure in rats. The Journal of pharmacology and experimental therapeutics. vol 245. issue 3. 1988-07-29. PMID:2455040. |
serotonin (5-ht) and a number of serotonergic receptor agonists on nociception and blood pressure were examined in rats. |
1988-07-29 |
2023-08-11 |
rat |
| P I Korner, G A Head, E Badoer, A Bobik, J A Angu. Role of brain amine transmitters and some neuromodulators in blood pressure, heart rate, and baroreflex control. Journal of cardiovascular pharmacology. vol 10 Suppl 12. 1988-07-29. PMID:2455190. |
6-hydroxydopamine (6-ohda) from mainly noradrenergic (na) neurons and by 5,6-dihydroxytryptamine (5,6-dht) from serotonergic (5ht) neurons. |
1988-07-29 |
2023-08-11 |
Not clear |
| F Gilbert, C Brazell, M D Tricklebank, S M Stah. Activation of the 5-HT1A receptor subtype increases rat plasma ACTH concentration. European journal of pharmacology. vol 147. issue 3. 1988-07-25. PMID:2897920. |
serotonergic (5-ht) neuronal pathways regulate the release of adrenocorticotropin hormone (acth) from the pituitary gland probably through the action of hypothalamic corticotropin-releasing hormone (crh). |
1988-07-25 |
2023-08-11 |
rat |
| M J Kadan, P R Harti. Autoradiographic localization and characterization of [125I]lysergic acid diethylamide binding to serotonin receptors in Aplysia. Neuroscience. vol 24. issue 3. 1988-07-18. PMID:3380298. |
the sensitive serotonergic radioligand 2-[125i]lysergic acid diethylamide was used to study the distribution and pharmacological binding properties of serotonin receptors in aplysia californica. |
1988-07-18 |
2023-08-11 |
aplysia |
| P Wang, C S Aulakh, J L Hill, D L Murph. Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists. Psychopharmacology. vol 94. issue 4. 1988-07-14. PMID:2967518. |
these findings support some other data that fawn hooded rats, a strain with a peripheral platelet serotonin storage disorder, also possess altered central nervous system serotonergic function. |
1988-07-14 |
2023-08-11 |
rat |
| J P Rivot, D Pointis, J M Besso. Morphine increases 5-HT metabolism in the nucleus raphe magnus: an in vivo study in freely moving rats using 5-hydroxyindole electrochemical detection. Brain research. vol 446. issue 2. 1988-06-30. PMID:3370493. |
thus the question remains as to the relationship between the activation of 5-ht metabolism in the nrm and previous neurochemical evidence for morphine-induced augmentation of 5-ht metabolism within the terminal area of serotonergic raphe-spinal pathways. |
1988-06-30 |
2023-08-11 |
rat |
| I R Cohen, P M Wis. Age-related changes in the diurnal rhythm of serotonin turnover in microdissected brain areas of estradiol-treated ovariectomized rats. Endocrinology. vol 122. issue 6. 1988-06-28. PMID:2453346. |
the loss in the circadian component of 5ht activity is not due to a loss in serotonergic function, since overall turnover rates were not reduced compared to young animals. |
1988-06-28 |
2023-08-11 |
rat |
| P D Hrdin. Sodium-dependent [3H]imipramine binding in rat hippocampus and its relationship to serotonin uptake. Canadian journal of physiology and pharmacology. vol 65. issue 12. 1988-06-20. PMID:2452679. |
the relationship of [3h]imipramine recognition sites and serotonergic function was investigated by simultaneously determining the desipramine-defined and sodium-dependent components of [3h]imipramine binding and the serotonin levels and uptake in hippocampus of rats without and with selective lesion of serotonergic neurons with 5,7-dihydroxytryptamine. |
1988-06-20 |
2023-08-11 |
rat |
| H M Pappius, R Dadoun, M McHug. The effect of p-chlorophenylalanine on cerebral metabolism and biogenic amine content of traumatized brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 8. issue 3. 1988-06-20. PMID:2452825. |
to find out if the changes in the serotonergic system are of functional importance and mediate the observed changes in lcgu, the effects of the inhibition of 5-ht synthesis with p-chlorophenylalanine (pcpa) on cerebral metabolism and biogenic amine content in injured brain were studied. |
1988-06-20 |
2023-08-11 |
rat |
| G Battaglia, S Y Yeh, E B De Souz. MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons. Pharmacology, biochemistry, and behavior. vol 29. issue 2. 1988-06-09. PMID:2452449. |
in addition, the neurodegenerative effects of mdma on 5-ht neurons exhibited some species specificity as comparable decreases in cerebral cortical 5-ht, 5-hiaa and 5-ht uptake sites were observed in rat and guinea pig while no significant changes in any of these serotonergic parameters were seen in mouse brain. |
1988-06-09 |
2023-08-11 |
mouse |
| L H Gold, G F Koo. Methysergide potentiates the hyperactivity produced by MDMA in rats. Pharmacology, biochemistry, and behavior. vol 29. issue 3. 1988-06-09. PMID:2896363. |
mdma binds to serotonergic receptors and has been shown to potently deplete brain serotonin concentrations. |
1988-06-09 |
2023-08-11 |
rat |
| N S Lee, G C Wagner, J R Trout, H Fishe. Fenfluramine-induced behavior changes in rats prefed serotonin-altering amounts of tryptophan and pyridoxine. Pharmacology, biochemistry, and behavior. vol 29. issue 3. 1988-06-09. PMID:3362951. |
it has been well established that elevated dietary tryptophan (trp) levels can increase brain serotonin concentrations, thereby influencing serotonergic transmission. |
1988-06-09 |
2023-08-11 |
rat |
| M Carlsson, A Carlsso. A regional study of sex differences in rat brain serotonin. Progress in neuro-psychopharmacology & biological psychiatry. vol 12. issue 1. 1988-06-02. PMID:2452455. |
in contrast, the serotonergic system was more expressed in females: 5-ht levels were significantly higher in females than in males in the brainstem and limbic forebrain and tended to be so in the cortex. |
1988-06-02 |
2023-08-11 |
rat |