| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E S Arzt, S Fernández-Castelo, L M Finocchiaro, M E Criscuolo, A Díaz, S Finkielman, V E Nahmo. Immunomodulation by indoleamines: serotonin and melatonin action on DNA and interferon-gamma synthesis by human peripheral blood mononuclear cells. Journal of clinical immunology. vol 8. issue 6. 1989-03-16. PMID:3146586. |
the serotonin effect was reversed by the serotonergic s1-s2 receptor antagonist methysergide but not by the s2 antagonist ketanserin. |
1989-03-16 |
2023-08-11 |
human |
| K Gill, Z Amit, B K Ko. Treatment with sertraline, a new serotonin uptake inhibitor, reduces voluntary ethanol consumption in rats. Alcohol (Fayetteville, N.Y.). vol 5. issue 5. 1989-03-16. PMID:3219181. |
it is uncertain whether serotonin uptake blockers exert their effects directly through serotonergic mechanisms or whether an interaction between the serotonin and noradrenergic systems is involved. |
1989-03-16 |
2023-08-11 |
rat |
| Y Yoshid. [Characteristics of 3H-paroxetine-labeled serotonin uptake sites in rat brain]. Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology. vol 8. issue 2. 1989-03-09. PMID:2975437. |
the finding that depletion of brain serotonin content with p-chlorophenylalanine did not induce any alteration in the number and the affinity of the 3h-par-binding sites suggests the lack of serotonergic modulation on these sites. |
1989-03-09 |
2023-08-11 |
rat |
| R W Fuller, H D Snoddy, D W Robertso. Mechanisms of effects of d-fenfluramine on brain serotonin metabolism in rats: uptake inhibition versus release. Pharmacology, biochemistry, and behavior. vol 30. issue 3. 1989-02-23. PMID:2463643. |
d-fenfluramine (or the racemate) releases serotonin through a carrier-dependent mechanism, and serotonin release is the mechanism usually thought to produce its serotonergic effects. |
1989-02-23 |
2023-08-11 |
rat |
| K B Thor, K M Hill, C Harrod, C J Helk. Immunohistochemical and biochemical analysis of serotonin and substance P colocalization in the nucleus tractus solitarii and associated afferent ganglia of the rat. Synapse (New York, N.Y.). vol 2. issue 3. 1989-02-23. PMID:2463690. |
the objectives of the present study were to 1) directly determine if varicosities in the nts, the area postrema (ap), and the dorsal motor nucleus of the vagus nerve (dmn) do contain both transmitters, 2) determine if primary afferent neurons in the nodose and pretrosal ganglia might also colocalize serotonin and substance p, and 3) quantify the amount of substance p that is contained in serotonergic varicosities in the nts. |
1989-02-23 |
2023-08-11 |
rat |
| K B Thor, K M Hill, C Harrod, C J Helk. Immunohistochemical and biochemical analysis of serotonin and substance P colocalization in the nucleus tractus solitarii and associated afferent ganglia of the rat. Synapse (New York, N.Y.). vol 2. issue 3. 1989-02-23. PMID:2463690. |
distributions and colocalization of substance p and serotonin in the nts were studied using dual-color immunohistochemistry, while the quantity of substance p in serotonergic varicosities was assessed by radioimmunoassay (ria) using micropunches from the nts of 5,7-dihydroxytryptamine-(5,7 dht-) and vehicle-treated rats. |
1989-02-23 |
2023-08-11 |
rat |
| C S Aulakh, R M Cohen, M M Dauphin, C A McLellan, D L Murph. Role of serotonergic input in the down-regulation of beta-adrenoceptors following long-term clorgyline treatment. European journal of pharmacology. vol 156. issue 1. 1989-02-21. PMID:2463178. |
selective lesioning of central serotonergic axons by 5,7-dihydroxytryptamine (5,7-dht; confirmed by the presence of the serotonin syndrome in response to a 40 mg/kg dose of 5-hydroxytryptophan (5-htp) or inhibition of 5-ht synthesis by parachlorophenylalanine (pcpa) caused significant 5-ht and 5-hiaa depletions in the cortex without much effect on ne and da concentrations, but did not have any significant effect on beta-adrenoceptor density, and furthermore failed to attenuate clorgyline-induced decreases in beta-adrenoceptor density. |
1989-02-21 |
2023-08-11 |
rat |
| R D Staton, J D Enderle, J W Gers. The electroencephalographic pattern during electroconvulsive therapy: V. Observations on the origins of phase III delta energy and the mechanism of action of ECT. Clinical EEG (electroencephalography). vol 19. issue 4. 1989-02-09. PMID:3060288. |
a specific anatomical and functional model of the mechanism of action of ect is proposed, in which: (1) adrenergic and cholinergic pathways in the forebrain are assumed to be massively stimulated during ect seizures, whereas serotonergic pathways are assumed to be inhibited during these seizures; (2) the beneficial effects of ect are considered to be more dependent upon ect-induced changes in 5-ht neurotransmission than upon alteration of noradrenergic function; (3) these beneficial effects involve up-regulation of 5-ht2 and down-regulation of m1- and m2-muscarinic receptor densities by both agonist-independent and agonist-dependent mechanisms, coupled with functional augmentation of noradrenergic neurotransmission; and (4) these effects may be brought about by phase iii inhibitory current flow- and/or spike burst-induced alteration of the function of second-messenger generator systems. |
1989-02-09 |
2023-08-11 |
Not clear |
| S G Britt, S L Gonias, J M Sanders, S R Vandenber. Agonist and antagonist activities of arylpiperazines at human platelet serotonin2 receptors. The Journal of pharmacology and experimental therapeutics. vol 247. issue 3. 1989-01-31. PMID:3204525. |
the platelet serotonergic agonists 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi), 5-ht and 5-methoxytryptamine (5-meot) and the antagonist ketanserin were used for comparison of potency and amplitude of response. |
1989-01-31 |
2023-08-11 |
human |
| L S Seiden, D L Commins, G Vosmer, K Axt, G Mare. Neurotoxicity in dopamine and 5-hydroxytryptamine terminal fields: a regional analysis in nigrostriatal and mesolimbic projections. Annals of the New York Academy of Sciences. vol 537. 1989-01-23. PMID:3059922. |
the reasons for this differential sensitivity of the 5-ht and da systems to the toxic effect of ma is speculative, but may be related to the differential formation of toxins due to the differing availability of oxygen and superoxides at serotonergic and dopaminergic synapses. |
1989-01-23 |
2023-08-11 |
Not clear |
| J Yamada, Y Sugimoto, H Wakita, K Horisak. The involvement of serotonergic and dopaminergic systems in hypothermia induced in mice by intracerebroventricular injection of serotonin. Japanese journal of pharmacology. vol 48. issue 1. 1989-01-18. PMID:3199603. |
the involvement of serotonergic and dopaminergic systems in hypothermia induced in mice by intracerebroventricular injection of serotonin. |
1989-01-18 |
2023-08-11 |
mouse |
| R Magoul, A Oblin, A Calas, S Araned. Serotonergic projections to the spinal cord but not those to the olfactory bulb also contain substance P. A combined immunocytochemical and autoradiographic study following retrograde axonal transport of [3H]serotonin labeled products. Neuroscience. vol 26. issue 3. 1989-01-17. PMID:2462186. |
serotonergic projections to the spinal cord but not those to the olfactory bulb also contain substance p. a combined immunocytochemical and autoradiographic study following retrograde axonal transport of [3h]serotonin labeled products. |
1989-01-17 |
2023-08-11 |
rat |
| N Chinmayee, D P Joshi, A A Mehta, R K Goya. Autoinhibition and desensitization of serotonergic responses in guinea pig ileum. Indian journal of physiology and pharmacology. vol 32. issue 3. 1989-01-17. PMID:3198243. |
our data suggest that 5-ht and mk-212 produce desensitization which is specific for serotonergic receptors and possibly involves ca++ ions. |
1989-01-17 |
2023-08-11 |
Not clear |
| A B Tobin, W Unger, N N Osborn. Evidence for the presence of serotonergic nerves and receptors in the iris-ciliary body complex of the rabbit. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 10. 1989-01-03. PMID:3193177. |
it is concluded that 5-ht is taken up by both serotonergic and adrenergic fibers of the iris-ciliary body. |
1989-01-03 |
2023-08-11 |
rabbit |
| E V Shabunina, I A Petrunin, L Kh Vinograd, E B Manukhina, F Z Meerso. [Prevention of arrhythmia in acute ischemia in conscious animals using a serotonin analog]. Biulleten' eksperimental'noi biologii i meditsiny. vol 106. issue 10. 1988-12-30. PMID:2461232. |
the state of the serotonergic system was studied in adaptation of rats to short-term non-damaging stress actions along with the possibility of protecting the heart of conscious animals against arrhythmias in acute ischemia with the serotonin analogue 4-nitro-5-methoxytryptamine. |
1988-12-30 |
2023-08-11 |
rat |
| N Brunello, M Riva, A C Rovescalli, R Galimberti, G Racagn. Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment. Pharmacology & toxicology. vol 63. issue 3. 1988-12-22. PMID:2460847. |
noradrenergic (na) and serotonergic (5-ht) receptor profiles were compared in the cerebral cortex of young adult (3 months old) and aged (24 months old) male sprague dawley rats. |
1988-12-22 |
2023-08-11 |
rat |
| I Fagervall, D Kelder, S B Ros. Selective inhibition by 4,alpha-dimethyl-m-tyramine (H77/77) and 4-methyl-alpha-ethyl-m-tyramine (H75/12) of the monoamine oxidase within serotonergic and noradrenergic neurons in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 338. issue 2. 1988-12-21. PMID:2460774. |
it was shown that the protection by h75/12 within the serotonergic neurons was somewhat reduced in 5-ht depleted reserpinized rats and that the protection outside these neurons was abolished. |
1988-12-21 |
2023-08-11 |
rat |
| L A Mamounas, M E Mollive. Evidence for dual serotonergic projections to neocortex: axons from the dorsal and median raphe nuclei are differentially vulnerable to the neurotoxin p-chloroamphetamine (PCA). Experimental neurology. vol 102. issue 1. 1988-12-07. PMID:2846339. |
previous studies have shown that there are morphologically dissimilar serotonergic (5-ht) axon types in rat cerebral cortex which are differentially sensitive to the neurotoxic effects of certain psychotropic drugs: methylenedioxyamphetamines (mda and mdma) and p-chloroamphetamine (pca) cause degeneration of fine 5-ht axon terminals in cortex, while sparing beaded axons. |
1988-12-07 |
2023-08-11 |
rat |
| M Schütte, R Weile. Mesencephalic innervation of the turtle retina by a single serotonin-containing neuron. Neuroscience letters. vol 91. issue 3. 1988-11-30. PMID:3185966. |
co-localization of retrograde transported nuclear yellow and serotonin immunoreactivity revealed the existence of a central serotonergic projection to the retina in the turtle pseudemys scripta elegans. |
1988-11-30 |
2023-08-11 |
Not clear |
| P T Männistö, R K Tuomine. Further studies of serotonergic activity in the regulation of the cold stimulated thyrotropin secretion in male rats. Pharmacology & toxicology. vol 63. issue 2. 1988-11-30. PMID:3186622. |
serotonergic agonists and antagonists were used to study the role of 5-ht in the regulation of thyrotropin (tsh) secretion in male rats. |
1988-11-30 |
2023-08-11 |
rat |