| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W A Wolf, A Bobi. alpha-Methyldopa metabolism in central serotonergic nerve terminals: effects on serotonin levels, synthesis and release. European journal of pharmacology. vol 163. issue 1. 1989-08-21. PMID:2472968. |
alpha-methyldopa metabolism in central serotonergic nerve terminals: effects on serotonin levels, synthesis and release. |
1989-08-21 |
2023-08-11 |
rat |
| H M Pappiu. Involvement of indoleamines in functional disturbances after brain injury. Progress in neuro-psychopharmacology & biological psychiatry. vol 13. issue 3-4. 1989-08-21. PMID:2473486. |
to find if these changes in the serotonergic system are of functional importance and mediate the observed changes in lcgu, the effects of inhibition of 5-ht synthesis with p-chlorophenylalanine (pcpa) on cerebral metabolism and indoleamine content in injured brain were studied (pappius et al. |
1989-08-21 |
2023-08-11 |
rat |
| Y Kayama, S Shimada, Y Hishikawa, T Ogaw. Effects of stimulating the dorsal raphe nucleus of the rat on neuronal activity in the dorsal lateral geniculate nucleus. Brain research. vol 489. issue 1. 1989-08-21. PMID:2787190. |
the suppression was mimicked by ionophoresis of serotonin, and antagonized by a serotonergic antagonist, methysergide. |
1989-08-21 |
2023-08-11 |
rat |
| V Aslanian, B Renau. Changes in serotonin metabolism in the rat raphe magnus and cardiovascular modifications following systemic administration of clonidine and other central alpha 2-agonists: an in vivo voltammetry study. Neuropharmacology. vol 28. issue 4. 1989-08-17. PMID:2568594. |
by using the in vivo voltammetry, it was demonstrated that an injection of clonidine induced both cardiovascular modifications (hypotension and bradycardia) and a decrease in the level of 5-hydroxyindolacetic acid (5-hiaa) in the ventromedial b3 serotonergic (5-ht) cell bodies of the medulla oblongata of the rat. |
1989-08-17 |
2023-08-11 |
rat |
| M Fava, P M Copeland, U Schweiger, D B Herzo. Neurochemical abnormalities of anorexia nervosa and bulimia nervosa. The American journal of psychiatry. vol 146. issue 8. 1989-08-17. PMID:2568763. |
anorexia nervosa is associated with changes in the noradrenergic, serotonergic, and opioid systems; bulimia nervosa is accompanied by marked alterations in serotonin and norepinephrine activity. |
1989-08-17 |
2023-08-11 |
Not clear |
| M R Pranzatelli, B En. Chronic ACTH treatment: influence on 5-HT2 receptors and behavioral supersensitivity induced by 5,7-dihydroxytryptamine lesions. Peptides. vol 10. issue 1. 1989-08-14. PMID:2546129. |
the capacity of the serotonin (5-ht) precursor 5-hip to induce the acth-responsive myoclonic-convulsive disorder infantile spasms in patients with down's syndrome has been cited as evidence for altered serotonergic neurotransmission in infantile spasms. |
1989-08-14 |
2023-08-11 |
rat |
| Y Ohno, J E Warnic. Presynaptic activation of the spinal serotonergic system in the rat by phencyclidine in vitro. The Journal of pharmacology and experimental therapeutics. vol 250. issue 1. 1989-08-11. PMID:2746496. |
these results suggest that pcp acts at sites located on presynaptic terminals of spinal serotonergic neurons, enhancing 5-ht release and thereby depressing the monosynaptic reflex. |
1989-08-11 |
2023-08-11 |
rat |
| G J Marek, A A Li, L S Seide. Evidence for involvement of 5-hydroxytryptamine1 receptors in antidepressant-like drug effects on differential-reinforcement-of-low-rate 72-second behavior. The Journal of pharmacology and experimental therapeutics. vol 250. issue 1. 1989-08-11. PMID:2746511. |
serotonergic mediation of antidepressant drug effects on drl 72-s behavior was assessed with a series of 5-ht agonists, and blockade of the effects of the antidepressant drugs clorgyline and fluoxetine (which presumably indirectly stimulate 5-ht1 receptors) was attempted in separate experiments with the 5-ht1 and 5-ht2 antagonist methysergide and the 5-ht neurotoxin 5,7-dihydroxytryptamine. |
1989-08-11 |
2023-08-11 |
rat |
| D Becquet, M Faudon, F Her. In vivo evidence for acetylcholine control of serotonin release in the cat caudate nucleus: influence of halothane anaesthesia. Neuroscience. vol 27. issue 3. 1989-08-01. PMID:3252174. |
the superfusion of serotonergic nerve terminals of the caudate nucleus with tetrodotoxin prevented the inhibitory acetylcholine-induced effect on serotonin release. |
1989-08-01 |
2023-08-11 |
cat |
| K T Borer, R Bonna, M Kiel. Hippocampal serotonin mediates hypoactivity in dietarily obese hamsters: a possible manifestation of aging? Pharmacology, biochemistry, and behavior. vol 31. issue 4. 1989-08-01. PMID:3252281. |
since serotonin mediates some other manifestations of aging, and slow weight increases characterize mid-portion of hamster life span, we hypothesize that serotonergic mediation of hypoactivity is another manifestation of aging. |
1989-08-01 |
2023-08-11 |
Not clear |
| E F Coccaro, L J Siever, H M Klar, G Maurer, K Cochrane, T B Cooper, R C Mohs, K L Davi. Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior. Archives of general psychiatry. vol 46. issue 7. 1989-07-27. PMID:2735812. |
to evaluate central serotonergic function in relation to these variables, prolactin responses to a single-dose challenge with fenfluramine hydrochloride (60 mg orally), a serotonin releasing/uptake-inhibiting agent, were examined in 45 male patients with clearly defined major affective (n = 25) and/or personality disorder (n = 20) and in 18 normal male control patients. |
1989-07-27 |
2023-08-11 |
Not clear |
| P E Potter, C E Tedford, G Kindel, I Hani. Inhibition of high affinity choline transport attenuates both cholinergic and non-cholinergic effects of ethylcholine aziridinium (AF64A). Brain research. vol 487. issue 2. 1989-07-18. PMID:2525061. |
these results indicate that changes in noradrenergic and serotonergic neurons following af64a administration are not due to non-specific toxicity of af64a, but may be the result of adaptation of these neurons to withdrawal of cholinergic input, which would normally inhibit the release of na and 5-ht. |
1989-07-18 |
2023-08-11 |
rat |
| W Fischer, H J Lüth, H Pette. [Morphological and immunohistochemical investigation of serotonergic neurons in the dorsal raphe nucleus of Wistar rats]. Journal fur Hirnforschung. vol 30. issue 2. 1989-07-18. PMID:2732465. |
the serotonergic neurons of the nucleus raphe dorsalis (nrd) of the adult male wistar rat were characterized morphologically using nissl and golgi-kopsch techniques, fluorescence histochemistry as well as a peroxidase-antiperoxidase (pap) immunocytochemical method employing specific antibodies to serotonin. |
1989-07-18 |
2023-08-11 |
rat |
| R Kuczenski, D Sega. Concomitant characterization of behavioral and striatal neurotransmitter response to amphetamine using in vivo microdialysis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 9. issue 6. 1989-07-13. PMID:2566664. |
comparisons of concentrations of da and 5-ht for individual animals revealed significant correlations both during baseline and drug response, suggesting a possible functional interdependence between dopaminergic and serotonergic activity in striatum. |
1989-07-13 |
2023-08-11 |
rat |
| A Jackowski, A Crockard, G Burnstoc. 5-Hydroxytryptamine demonstrated immunohistochemically in rat cerebrovascular nerves largely represents 5-hydroxytryptamine uptake into sympathetic nerve fibres. Neuroscience. vol 29. issue 2. 1989-07-07. PMID:2725865. |
prior treatment with a predominantly noradrenergic uptake inhibitor desmethylimipramine but not the serotonergic uptake inhibitor fluoxetine produced a major diminution in the 5-hydroxytryptamine immunoreactive plexus visualized in these immersion-fixed vessels. |
1989-07-07 |
2023-08-11 |
rat |
| A Jackowski, A Crockard, G Burnstoc. 5-Hydroxytryptamine demonstrated immunohistochemically in rat cerebrovascular nerves largely represents 5-hydroxytryptamine uptake into sympathetic nerve fibres. Neuroscience. vol 29. issue 2. 1989-07-07. PMID:2725865. |
it would appear therefore that 5-hydroxytryptamine is rarely present under normal circumstances in the perivascular nerves of major cerebral vessels, and that previous descriptions of a dense serotonergic nerve plexus represent 5-hydroxytryptamine in blood released during vessel dissection being taken up via the noradrenaline-uptake system into perivascular sympathetic nerves. |
1989-07-07 |
2023-08-11 |
rat |
| M R Pranzatell. In vivo and in vitro effects of adrenocorticotrophic hormone on serotonin receptors in neonatal rat brain. Developmental pharmacology and therapeutics. vol 12. issue 1. 1989-07-03. PMID:2470562. |
abnormalities of serotonergic neurotransmission have been suggested in the acth-responsive disorder infantile spasms based on elevated blood or platelet serotonin (5-ht) levels and induction of infantile spasms in down's syndrome by the 5-ht precursor 5-hydroxytryptophan. |
1989-07-03 |
2023-08-11 |
rat |
| L D Van de Kar, S A Lorens, J H Urban, C L Bethe. Effect of selective serotonin (5-HT) agonists and 5-HT2 antagonist on prolactin secretion. Neuropharmacology. vol 28. issue 3. 1989-07-03. PMID:2524677. |
by deduction, these data suggest that 5-ht1b receptors, or as yet undefined 5-ht receptor subtypes may be involved in the stimulation of the secretion of prolactin by endogenously released 5-ht, and that 5-ht2 receptors may play a minor role in the serotonergic regulation of the secretion of prolactin. |
1989-07-03 |
2023-08-11 |
rat |
| C L Broekkamp, H H Berendsen, F Jenck, A M Van Delf. Animal models for anxiety and response to serotonergic drugs. Psychopathology. vol 22 Suppl 1. 1989-07-03. PMID:2567038. |
in examining anxiety and the response of animal models to serotonergic drugs, four aspects should be taken into account: (1) the serotonin receptor is subdivided into at least six receptor subtypes; (2) benzodiazepines have acute anxiety-relieving effects, whereas antidepressants, serotonin-uptake inhibitors, buspirone, and serotonin antagonists have antianxiety effects only after prolonged administration; (3) diagnostic criteria differentiate several distinguishable anxiety disorders that have different responsiveness to serotonin-related drugs, and (4) various types of animal models exist, each responding differently to serotonin-related drugs. |
1989-07-03 |
2023-08-11 |
Not clear |
| D S Robinson, D R Alms, R C Shrotriya, M Messina, P Wickramaratn. Serotonergic anxiolytics and treatment of depression. Psychopathology. vol 22 Suppl 1. 1989-07-03. PMID:2657837. |
the serotonin 5-hydroxytryptamine-1a (5-ht1a) receptor agonists buspirone and gepirone have effects on serotonergic systems, including presynaptic and postsynaptic receptors, that predict both anxiolytic and antidepressant activity. |
1989-07-03 |
2023-08-11 |
Not clear |