| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P J Fletcher, I A Paterso. A comparison of the effects of tryptamine and 5-hydroxytryptamine on feeding following injection into the paraventricular nucleus of the hypothalamus. Pharmacology, biochemistry, and behavior. vol 32. issue 4. 1989-11-07. PMID:2529575. |
overall, the results suggest that tryptamine may act via the serotonergic system in the pvn to affect food intake, but it is a weaker compound than 5-ht in this respect. |
1989-11-07 |
2023-08-11 |
rat |
| M P Johnson, D E Nichol. Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration. Pharmacology, biochemistry, and behavior. vol 33. issue 1. 1989-10-26. PMID:2476831. |
a behaviorally equipotent dose of mbdb (25 mg/kg, ip) also produced a significant decrease in the serotonergic markers; 5-ht, 5-hiaa and [3h]-paroxetine binding sites. |
1989-10-26 |
2023-08-11 |
rat |
| P A Broderic. Characterizing stearate probes in vitro for the electrochemical detection of dopamine and serotonin. Brain research. vol 495. issue 1. 1989-10-19. PMID:2776030. |
the methodology is relevant to the interpretation of electrochemical signals for dopamine and serotonin in vivo in neuroanatomical substrates, richly innervated by dopaminergic and serotonergic neuronal circuitry. |
1989-10-19 |
2023-08-11 |
Not clear |
| R J Secrest, D D Schoepp, M L Cohe. Comparison of contractions to serotonin, carbamylcholine and prostaglandin F2 alpha in rat stomach fundus. The Journal of pharmacology and experimental therapeutics. vol 250. issue 3. 1989-10-17. PMID:2550624. |
contractile effects of serotonin were compared to those of carbamylcholine and prostaglandin (pg) f2 alpha in an effort to characterize serotonergic receptor activation in rat stomach fundus. |
1989-10-17 |
2023-08-11 |
rat |
| A L Ask, I Fagervall, R B Huang, S B Ros. Release of 3H-5-hydroxytryptamine by amiflamine and related phenylalkylamines from rat occipital cortex slices. Naunyn-Schmiedeberg's archives of pharmacology. vol 339. issue 6. 1989-10-12. PMID:2770890. |
amiflamine, some related compounds and alpha-ethyltryptamine which in vivo after transport by the 5-ht uptake mechanism preferentially inhibit mao within the serotonergic neurons caused a ca2+-independent release of 3h-5-ht. |
1989-10-12 |
2023-08-11 |
rat |
| A L Ask, I Fagervall, R B Huang, S B Ros. Release of 3H-5-hydroxytryptamine by amiflamine and related phenylalkylamines from rat occipital cortex slices. Naunyn-Schmiedeberg's archives of pharmacology. vol 339. issue 6. 1989-10-12. PMID:2770890. |
it is concluded that compounds which were effective releasers of 5-ht in vitro were those that are transported into the serotonergic neurons by the 5-ht carrier in vivo and has in addition an ability to mobilise vesicular 5-ht. |
1989-10-12 |
2023-08-11 |
rat |
| M Lamacz, M C Tonon, F Leboulenger, F Héry, S Idres, A J Verhofstad, G Pelletier, H Vaudr. Effect of serotonin on alpha-melanocyte-stimulating hormone secretion from perifused frog neurointermediate lobe: evidence for the presence of serotonin-containing cells in the frog pars intermedia. The Journal of endocrinology. vol 122. issue 1. 1989-10-03. PMID:2549146. |
the inhibitory effect of 5-ht was partially blocked by the serotonergic antagonists methysergide and ics-205-930 (10 mumol/l each). |
1989-10-03 |
2023-08-11 |
Not clear |
| P Herregodts, M Bruyland, J De Keyser, C Solheid, Y Michotte, G Ebinge. Monoaminergic neurotransmitters in Alzheimer's disease. An HPLC study comparing presenile familial and sporadic senile cases. Journal of the neurological sciences. vol 92. issue 1. 1989-09-27. PMID:2570132. |
the serotonergic system was dramatically affected in the familial cases with very low or undetectable serotonin concentrations in most cortical and subcortical areas studied and an important cell loss in the nucleus raphe dorsalis, origin of the main ascending serotonergic system. |
1989-09-27 |
2023-08-11 |
Not clear |
| B A Lawlor, T Sunderland, J L Hill, A M Mellow, S E Molchan, E A Mueller, F M Jacobsen, D L Murph. Evidence for a decline with age in behavioral responsivity to the serotonin agonist, m-chlorophenylpiperazine, in healthy human subjects. Psychiatry research. vol 29. issue 1. 1989-09-27. PMID:2772095. |
using the effects of the 5ht agonist, m-chlorophenylpiperazine (m-cpp), as a measure of central serotonergic responsivity, we compared the behavioral and neuroendocrine responses of older normal volunteers (mean age +/- sd = 62.4 +/- 4.12) to those of younger normal volunteers (mean age +/- sd = 31.6 +/- 5.52). |
1989-09-27 |
2023-08-11 |
human |
| B A Lawlor, T Sunderland, J L Hill, A M Mellow, S E Molchan, E A Mueller, F M Jacobsen, D L Murph. Evidence for a decline with age in behavioral responsivity to the serotonin agonist, m-chlorophenylpiperazine, in healthy human subjects. Psychiatry research. vol 29. issue 1. 1989-09-27. PMID:2772095. |
this report is the first in vivo study in humans to demonstrate decreased behavioral responsivity with age following serotonergic stimulation, and may indicate a functionally less responsive 5ht subsystem in older subjects. |
1989-09-27 |
2023-08-11 |
human |
| G A Ricaurte, L E DeLanney, I Irwin, J M Witkin, J L Katz, J W Langsto. Evaluation of the neurotoxic potential of N,N-dimethylamphetamine: an illicit analog of methamphetamine. Brain research. vol 490. issue 2. 1989-09-25. PMID:2765865. |
assessment of n,n-dma's effects on serotonergic neurons showed that it did not produce a long-lasting depletion of serotonin in either the mouse or rat brain. |
1989-09-25 |
2023-08-11 |
mouse |
| R E Halpern, E W Black, J M Lakosk. Aging but not estrogen alters regional [3H]5-HT binding in the CNS of female Fischer 344 rats. Neuroscience letters. vol 101. issue 3. 1989-09-25. PMID:2771173. |
age-related changes in serotonergic regulation of neuroendocrine function were investigated in female fischer 344 rats; serotonin ([3h]5-ht) binding sites were characterized in several brain regions. |
1989-09-25 |
2023-08-11 |
rat |
| A B Tobin, N N Osborn. Evidence for the presence of serotonin receptors negatively coupled to adenylate cyclase in the rabbit iris-ciliary body. Journal of neurochemistry. vol 53. issue 3. 1989-09-18. PMID:2547897. |
serotonergic, cholinergic, muscarinic, alpha-adrenergic, and dopaminergic antagonists have no effect on the serotonin response. |
1989-09-18 |
2023-08-11 |
rabbit |
| A B Tobin, N N Osborn. Evidence for the presence of serotonin receptors negatively coupled to adenylate cyclase in the rabbit iris-ciliary body. Journal of neurochemistry. vol 53. issue 3. 1989-09-18. PMID:2547897. |
topical application of a serotonin/pargyline solution to the living eye causes desensitisation of the serotonin response in the iris-ciliary body, an observation confirming the presence of specific serotonergic receptors linked to adenylate cyclase. |
1989-09-18 |
2023-08-11 |
rabbit |
| J S Takahashi, D E Nelson, A Eski. Immunocytochemical localization of serotonergic fibers innervating the ocular circadian system of Aplysia. Neuroscience. vol 28. issue 1. 1989-09-18. PMID:2761688. |
although the effects of serotonin on various physiological processes in the aplysia eye have been studied, very little is known about the anatomy of the serotonergic innervation. |
1989-09-18 |
2023-08-11 |
aplysia |
| N Yamazaki, M Nomura, A Nagaoka, Y Nagaw. Idebenone improves learning and memory impairment induced by cholinergic or serotonergic dysfunction in rats. Archives of gerontology and geriatrics. vol 8. issue 3. 1989-09-14. PMID:2764640. |
the central serotonergic dysfunction model was produced by giving rats a diet deficient in tryptophan, a precursor of serotonin. |
1989-09-14 |
2023-08-11 |
rat |
| B Y Ho, A E Takemor. Serotonergic involvement in the antinociceptive action of and the development of tolerance to the kappa-opioid receptor agonist, U-50, 488H. The Journal of pharmacology and experimental therapeutics. vol 250. issue 2. 1989-09-12. PMID:2547935. |
the antinociceptive action of u-50,488h [( trans-(+/-)-3,4-dichloro-n-methyl-n-[2-(1-pyrrolidinyl)- cyclohexyl]benzeneacetamide]), a selective kappa-opioid receptor agonist, was antagonized by serotonergic (5-ht) but not by noradrenergic receptor antagonists. |
1989-09-12 |
2023-08-11 |
mouse |
| W Dimpfel, M Spüler, B Nicke. Dose- and time-dependent action of morphine, tramadol and flupirtine as studied by radioelectroencephalography in the freely behaving rat. Neuropsychobiology. vol 20. issue 3. 1989-09-08. PMID:2548117. |
the frequency pattern produced by the opiates closely resembles that of centrally acting serotonin uptake inhibitors and thus is consistent with the view of a serotonergic prevalence of neurochemical interactions within the recorded brain areas. |
1989-09-08 |
2023-08-11 |
rat |
| P H Vlasses, H H Rotmensch, B N Swanson, R A Clementi, R K Ferguso. Effect of repeated doses of L-5-hydroxytryptophan and carbidopa on prolactin and aldosterone secretion in man. Journal of endocrinological investigation. vol 12. issue 2. 1989-09-07. PMID:2474017. |
to evaluate changes in serum prolactin and plasma and urine aldosterone after a serotonergic challenge, 8 healthy men (19 to 42 yr), taking dexamethasone (0.75 mg qid), received the serotonin precursor l-5-hydroxytryptophan (l5htp; 100 mg qid) with the peripheral decarboxylase inhibitor carbidopa (c; 50 mq qid) or matching placebos in a randomized, crossover manner. |
1989-09-07 |
2023-08-11 |
human |
| R A Glennon, N A Naiman, M E Pierson, J D Smith, A M Ismaiel, M Titeler, R A Lyo. N-(phthalimidoalkyl) derivatives of serotonergic agents: a common interaction at 5-HT1A serotonin binding sites? Journal of medicinal chemistry. vol 32. issue 8. 1989-09-07. PMID:2754715. |
n-(phthalimidoalkyl) derivatives of serotonergic agents: a common interaction at 5-ht1a serotonin binding sites? |
1989-09-07 |
2023-08-11 |
Not clear |