| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Lappalainen, J Hietala, M Koulu, T Seppälä, B Sjöholm, E Syvälaht. Chronic treatment with SCH 23390 and haloperidol: effects on dopaminergic and serotonergic mechanisms in rat brain. The Journal of pharmacology and experimental therapeutics. vol 252. issue 2. 1990-04-16. PMID:2179533. |
sch 23390 and haloperidol had no significant effects on serotonin synthesis and metabolism in serotonergic and dopaminergic areas. |
1990-04-16 |
2023-08-11 |
rat |
| K A Miczek, J Mos, B Olivie. Brain 5-HT and inhibition of aggressive behavior in animals: 5-HIAA and receptor subtypes. Psychopharmacology bulletin. vol 25. issue 3. 1990-04-04. PMID:2483273. |
evolutionary constant serotonin (5-ht) neuronal systems evolved along medial brain structures; yet, wide variations in functionality characterize serotonergic systems in mediating aggressive responses in species ranging from lobsters, ants, electric fish, and rodents to primates. |
1990-04-04 |
2023-08-11 |
Not clear |
| S A Eaton, T E Sal. Modulatory effects of serotonin on excitatory amino acid responses and sensory synaptic transmission in the ventrobasal thalamus. Neuroscience. vol 33. issue 2. 1990-03-28. PMID:2560148. |
it is concluded that serotonin can modulate responses to excitatory amino acids relatively selectively and that synaptic transmission of somatosensory information through the ventrobasal thalamus may be susceptible to brainstem serotonergic modulation. |
1990-03-28 |
2023-08-11 |
rat |
| C Konradi, J Kornhuber, L Froelich, J Fritze, H Heinsen, H Beckmann, E Schulz, P Riedere. Demonstration of monoamine oxidase-A and -B in the human brainstem by a histochemical technique. Neuroscience. vol 33. issue 2. 1990-03-28. PMID:2622533. |
while dopaminergic neurons of the substantia nigra revealed no staining for monoamine oxidase, noradrenergic neurons of the locus coeruleus stained positively with the monoamine oxidase-a substrate serotonin, and serotonergic neurons of the raphe nuclei were stained by the monoamine oxidase-b substrate beta-phenylethylamine. |
1990-03-28 |
2023-08-11 |
human |
| C L Kirstein, J Traber, W H Gispen, L P Spea. ACTH-induced behaviors and their modulation by serotonergic agonists differ in neonatal and weanling rat pups. Psychopharmacology. vol 100. issue 2. 1990-03-27. PMID:2154832. |
four-day-old (p4) and 21-22-day-old (p21-22) rat pups received an intracisternal injection of either acth1-16nh2 or saline followed by a subcutaneous (sc) injection of saline, the serotonergic (5ht)1a agonists 8-oh-dpat or ipsapirone, the 5ht1b agonist tfmpp or the 5ht2 agonist doi. |
1990-03-27 |
2023-08-11 |
rat |
| B M de Jong, J M Ruijter, T P Van der Woude, M Mirmiran, E A van Roye. Serotonergic denervation does not reduce brain uptake of n-isopropyl-p-[123I]iodoamphetamine in vivo. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. vol 16. issue 8. 1990-03-27. PMID:2621111. |
the relation between brain uptake of radiolabeled n-isopropyl-p-iodoamphetamine [( 123i]imp) and serotonin re-uptake sites was studied in vivo by lesioning serotonergic nerve endings. |
1990-03-27 |
2023-08-11 |
rat |
| L C Reis, M J Ramalho, J Antunes-Rodrigue. Participation of the serotonergic system in the regulation of water and electrolyte balance. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 22. issue 6. 1990-03-26. PMID:2620188. |
to determine the possible participation of the serotonergic (5-ht) system in the regulation of water and electrolyte balance, rats were submitted to two sessions of water overloading and the 5-ht agonist mk 212 was administered intracerebroventricularly (icv) in 1.0 microliters 20 min after the second session. |
1990-03-26 |
2023-08-11 |
rat |
| K P Liu, H Tamir, M Adlersber. Photoaffinity labeling of the two forms of serotonin binding protein: peptide mapping of the binding sites. Journal of neurochemistry. vol 54. issue 3. 1990-03-22. PMID:2303822. |
serotonin binding protein (sbp) is a vesicular protein found in neurectoderm-derived cells that store 5-hydroxytryptamine (5-ht, serotonin), such as central and peripheral serotonergic neurons and paraneurons (parafollicular cells of the thyroid). |
1990-03-22 |
2023-08-11 |
Not clear |
| G M Anderson, I N Mefford, T J Tolliver, M A Riddle, D M Ocame, J F Leckman, D J Cohe. Serotonin in human lumbar cerebrospinal fluid: a reassessment. Life sciences. vol 46. issue 4. 1990-03-21. PMID:2304369. |
the extremely low concentrations of 5-ht present in csf make it unlikely that csf 5-ht will be of clinical utility in assessing central serotonergic function. |
1990-03-21 |
2023-08-11 |
human |
| C W Murray, A Cowa. Formalin nociception in the mouse does not lead to increased spinal serotonin turnover. Neuroscience letters. vol 108. issue 1-2. 1990-03-19. PMID:1689471. |
to test the hypothesis that bulbospinal serotonergic pathways modulate such nociception, whole spinal cords from mice pretreated with probenecid and sacrificed at 15, 30, 45 and 60 min after injection of 5% formalin or 0.9% saline in the hindpaw were assayed by high performance liquid chromatography with electrochemical detection for the serotonin metabolite, 5-hydroxyindoleacetic acid, as an index of turnover. |
1990-03-19 |
2023-08-11 |
mouse |
| A Lista, P Blier, C De Montign. In vivo presynaptic modulation of serotonergic neurotransmission in the rat hippocampus by diazepam. European journal of pharmacology. vol 171. issue 2-3. 1990-03-19. PMID:2559857. |
the effect of the benzodiazepine agonist, diazepam, on serotonergic (5-ht) neurotransmission was assessed in in vivo electrophysiological experiments. |
1990-03-19 |
2023-08-11 |
rat |
| R Gaggi, R De Iasio, A M Giann. Relationships between the effects of peripherally administered salmon calcitonin on calcaemia and brain biogenic amines. Japanese journal of pharmacology. vol 51. issue 3. 1990-03-19. PMID:2576081. |
it was speculated that the activation of the brain serotonergic system could result from two indirect and separate mechanisms: the first, which would involve enhanced serotonin synthesis, seemed to be facilitated by calcium availability. |
1990-03-19 |
2023-08-11 |
rat |
| K Sawaki, M Kawaguch. Some correlations between procaine-induced convulsions and monoamines in the spinal cord of rats. Japanese journal of pharmacology. vol 51. issue 3. 1990-03-19. PMID:2622091. |
these results suggest that procaine causes significant elevations of rat spinal da and 5-ht in the convulsive process and suggest that dopaminergic and serotonergic neurons may be associated with procaine-induced convulsions. |
1990-03-19 |
2023-08-11 |
rat |
| J Marin, M C Ibañez, S Arriba. Therapeutic management of nausea and vomiting. General pharmacology. vol 21. issue 1. 1990-03-15. PMID:2404830. |
recently, antagonists of serotonergic (5-ht) receptors of the subtype 5-ht3 appear to possess interesting antiemetic properties and they have a promising future in this field. |
1990-03-15 |
2023-08-11 |
Not clear |
| D L Murphy, J Zohar, C Benkelfat, M T Pato, T A Pigott, T R Inse. Obsessive-compulsive disorder as a 5-HT subsystem-related behavioural disorder. The British journal of psychiatry. Supplement. issue 8. 1990-03-15. PMID:2692636. |
clomipramine's antiobsessional effect has been augmented with the serotonin precursor, l-tryptophan, or with lithium, which has prominent serotonergic effects. |
1990-03-15 |
2023-08-11 |
Not clear |
| H Meltze. Serotonergic dysfunction in depression. The British journal of psychiatry. Supplement. issue 8. 1990-03-15. PMID:2692637. |
blood platelets, which have been suggested as models for serotonergic nerve terminals, have a significantly decreased number of 5-ht uptake sites and 3h-imipramine binding sites in depressed patients. |
1990-03-15 |
2023-08-11 |
Not clear |
| H Meltze. Serotonergic dysfunction in depression. The British journal of psychiatry. Supplement. issue 8. 1990-03-15. PMID:2692637. |
the serotonergic deficit may occur at any of several levels: diminished availability of precursor, impaired activity of tryptophan hydroxylase, abnormalities in 5-ht release or uptake, 5-ht receptor abnormalities or interactions with other neurotransmitters. |
1990-03-15 |
2023-08-11 |
Not clear |
| S Garattini, T Mennini, R Samani. Reduction of food intake by manipulation of central serotonin. Current experimental results. The British journal of psychiatry. Supplement. issue 8. 1990-03-15. PMID:2692639. |
serotonergic anorectics are correctly defined only if they enhance 5-ht transmission and have their anorectic effects inhibited by drugs that block 5-ht receptors. |
1990-03-15 |
2023-08-11 |
human |
| S Garattini, T Mennini, R Samani. Reduction of food intake by manipulation of central serotonin. Current experimental results. The British journal of psychiatry. Supplement. issue 8. 1990-03-15. PMID:2692639. |
the effect of serotonergic anorectics on 5-ht release has been poorly investigated. |
1990-03-15 |
2023-08-11 |
human |
| E F Coccar. Central serotonin and impulsive aggression. The British journal of psychiatry. Supplement. issue 8. 1990-03-15. PMID:2692640. |
the role of central serotonergic (5-ht) system dysfunction in the regulation of aggression in both animals and man has been investigated for more than the past two decades. |
1990-03-15 |
2023-08-11 |
Not clear |