| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Kawase, A K Sinhababu, E M McGhee, T Milby, R T Borchard. Synthesis and biological evaluation of 4-fluoro-, 7-fluoro-, and 4,7-difluoro-5,6-dihydroxytryptamines. Journal of medicinal chemistry. vol 33. issue 8. 1990-08-30. PMID:2100997. |
surprisingly, 26a-c exhibited 32-, 23-, and 13-fold higher affinities, respectively, compared to 5,6-dht for the serotonergic uptake system of n-2a cells as measured by the ability of 26a-c and 5,6-dht to antagonize the uptake of [3h]5-ht into the n-2a cells. |
1990-08-30 |
2023-08-11 |
Not clear |
| Y P Dragan, E F Elli. 5-Hydroxytryptamine and the metabolism of arachidonic acid by the lipoxygenase and cyclooxygenase of washed human platelets. Biochemical pharmacology. vol 40. issue 2. 1990-08-30. PMID:2142882. |
we conclude that 5-ht depresses co product formation while increasing 12-hete formation through interaction with a platelet serotonergic binding site other than the 5-ht2 receptor. |
1990-08-30 |
2023-08-11 |
human |
| S F Leibowit. The role of serotonin in eating disorders. Drugs. vol 39 Suppl 3. 1990-08-27. PMID:2197074. |
serotonergic stimulation of these 3 nuclei with exogenous serotonin or drugs that release endogenous serotonin, preferentially reduces carbohydrate intake in naturally feeding animals through satiety mechanisms involved in the termination of feeding. |
1990-08-27 |
2023-08-11 |
Not clear |
| S F Leibowit. The role of serotonin in eating disorders. Drugs. vol 39 Suppl 3. 1990-08-27. PMID:2197074. |
the clinical response to several psychotropic agents known to potentiate serotonergic transmission further substantiates a serotonin dysregulation hypothesis of bulimia nervosa. |
1990-08-27 |
2023-08-11 |
Not clear |
| S Ueda, T Tanabe, N Ihara, Y San. Rearrangement of serotonin-immunoreactive fibers in the denervated rat suprachiasmatic nucleus after transplantation of fetal raphe tissue. Cell and tissue research. vol 260. issue 3. 1990-08-27. PMID:2372815. |
at both survival periods, there was no abundant arborization of serotonin fibers in the scn, while the preoptic and periventricular areas of the host rats displayed a pattern of serotonergic innervation resembling that in normal (untreated) rats. |
1990-08-27 |
2023-08-11 |
rat |
| M Baez, L Yu, M L Cohe. Pharmacological and molecular evidence that the contractile response to serotonin in rat stomach fundus is not mediated by activation of the 5-hydroxytryptamine1C receptor. Molecular pharmacology. vol 38. issue 1. 1990-08-21. PMID:2196436. |
the receptor mediating contraction in response to serotonin in the rat stomach fundus has not been characterized in light of the currently acceptable serotonergic receptor classification scheme. |
1990-08-21 |
2023-08-11 |
rat |
| A Lista, P Blier, C de Montign. Benzodiazepine receptors modulate 5-hydroxytryptamine neurotransmission in the rat hippocampus: in vivo electrophysiological evidence. The Journal of pharmacology and experimental therapeutics. vol 254. issue 1. 1990-08-13. PMID:2164098. |
in the present electrophysiological studies the effects of the activation of putative presynaptic benzodiazepine receptors (bzr) in modulating serotonergic (5-ht) transmission in dorsal hippocampus were investigated in chloral hydrate-anesthetized rats. |
1990-08-13 |
2023-08-11 |
rat |
| E C Azmitia, K Dolan, P M Whitaker-Azmiti. S-100B but not NGF, EGF, insulin or calmodulin is a CNS serotonergic growth factor. Brain research. vol 516. issue 2. 1990-08-13. PMID:2194631. |
only chronic s-100b showed enhancement (maximal at 3.2 ng/ml is 171%) after 3 days of incubation of the [3h]5-ht uptake capacity by serotonergic neurons. |
1990-08-13 |
2023-08-11 |
Not clear |
| E C Azmitia, K Dolan, P M Whitaker-Azmiti. S-100B but not NGF, EGF, insulin or calmodulin is a CNS serotonergic growth factor. Brain research. vol 516. issue 2. 1990-08-13. PMID:2194631. |
a single application at initial plating of s-100b (maximal at 5 ng/ml is 185%), but not calmodulin, increased the development of the [3h]5-ht uptake capacity by the cultured serotonergic neurons. |
1990-08-13 |
2023-08-11 |
Not clear |
| K B Thor, T Hisamitsu, W C de Groa. Unmasking of a neonatal somatovesical reflex in adult cats by the serotonin autoreceptor agonist 5-methoxy-N,N-dimethyltryptamine. Brain research. Developmental brain research. vol 54. issue 1. 1990-08-13. PMID:2364543. |
the serotonergic system was suppressed by the intravenous administration of 5-methoxy-n,n-dimethyltryptamine (5-meodmt), a serotonin agonist that inhibits the firing of serotonergic neurons via activation of inhibitory somatodendritic autoreceptors. |
1990-08-13 |
2023-08-11 |
cat |
| C Moret, M Brile. Serotonin autoreceptor subsensitivity and antidepressant activity. European journal of pharmacology. vol 180. issue 2-3. 1990-08-13. PMID:2365009. |
thus a chronic treatment with citalopram provokes a down-regulation of the serotonergic autoreceptor, allowing an increase of serotonin neurotransmission. |
1990-08-13 |
2023-08-11 |
rat |
| P Drapea. Loss of channel modulation by transmitter and protein kinase C during innervation of an identified leech neuron. Neuron. vol 4. issue 6. 1990-08-06. PMID:1694445. |
when serotonergic retzius (r) neurons of the leech contact pressure-sensitive (p) neurons in culture, p cells selectively lose a protein kinase c-dependent cationic response to serotonin and the r cell reforms the inhibitory, chloride-dependent synapse seen in vivo. |
1990-08-06 |
2023-08-11 |
Not clear |
| E Lieth, D R McClay, J M Laude. Neuronal-glial interactions: complexity of neurite outgrowth correlates with substrate adhesivity of serotonergic neurons. Glia. vol 3. issue 3. 1990-07-31. PMID:2141593. |
to study the interactions between neurons of known transmitter phenotype and non-neuronal cells of glial or fibroblastic origin, serotonergic (5-ht) neurons were tested for their strength of adhesion and neurite outgrowth patterns on substrates of astrocytes or fibroblasts using a cell adhesion assay for transmitter-identified neurons, and morphometry of immunocytochemically stained neurons in dissociated cell cultures. |
1990-07-31 |
2023-08-11 |
Not clear |
| K Rasmussen, G K Aghajania. Serotonin excitation of facial motoneurons: receptor subtype characterization. Synapse (New York, N.Y.). vol 5. issue 4. 1990-07-31. PMID:2360199. |
taken together, these results indicate a role for 5-ht2 and/or 5-ht1c but not 5-ht1a receptors in serotonergic enhancement of facial motoneuron excitability since 5-ht's effect was 1) at least partially mimicked by the selective 5-ht2/5-ht1c agonist dom, 2) mimicked by the broad-spectrum 5-ht1 agonist 5-ct but not the selective 5-ht1a agonist 8-oh-dpat, and 3) blocked by the 5-ht2/5-ht1c antagonists ritanserin and ly 53857. |
1990-07-31 |
2023-08-11 |
rat |
| A Inoue, R D Buña. Sympathetic inhibition and vasopressin mediation during centrally induced responses to serotonin in rats. Journal of cardiovascular pharmacology. vol 13. issue 6. 1990-07-26. PMID:2484085. |
pressor and bradycardic responses must have been caused by activation of specific serotonergic receptors in the brain because both responses were inhibited following serotonin blockade produced by i.c.v. |
1990-07-26 |
2023-08-11 |
rat |
| A Inoue, R D Buña. Sympathetic inhibition and vasopressin mediation during centrally induced responses to serotonin in rats. Journal of cardiovascular pharmacology. vol 13. issue 6. 1990-07-26. PMID:2484085. |
collectively, our results are compatible with the interpretation that i.c.v.-injected serotonin acts on serotonergic brain receptors to elevate blood pressure by releasing endogenous vasopressin, and slow the heart through sympathetic inhibition. |
1990-07-26 |
2023-08-11 |
rat |
| G R Cuadra, V A Molin. Behavioral reactivity following 5-MeODMT administration in 5,7-DHT-pretreated killer rats. Pharmacology, biochemistry, and behavior. vol 36. issue 2. 1990-07-20. PMID:2356202. |
this evidence suggests an altered capacity to promote adaptive changes on 5-ht sites in killer rats following the destruction of central serotonergic fibers. |
1990-07-20 |
2023-08-11 |
rat |
| D Singer, R Boton, O Moran, N Dasca. Short- and long-term desensitization of serotonergic response in Xenopus oocytes injected with brain RNA: roles for inositol 1,4,5-trisphosphate and protein kinase C. Pflugers Archiv : European journal of physiology. vol 416. issue 1-2. 1990-07-17. PMID:1693768. |
short- and long-term desensitization of serotonergic response in xenopus oocytes injected with brain rna: roles for inositol 1,4,5-trisphosphate and protein kinase c. in xenopus oocytes injected with rat brain rna, serotonin (5ht) and acetylcholine (ach) evoke membrane responses through a common biochemical cascade that includes activation of phospholipase c, production of inositol 1,4,5-trisphosphate (ins1,4,5-p3), release of ca2+ from intracellular stores, and opening of ca-dependent cl- channels. |
1990-07-17 |
2023-08-11 |
human |
| M Briley, P Chopin, C More. Effect of serotonergic lesion on "anxious" behaviour measured in the elevated plus-maze test in the rat. Psychopharmacology. vol 101. issue 2. 1990-07-12. PMID:2140904. |
the lesion destroyed 81% of the serotonergic innervation in the cortex and 99% in the hippocampus as determined by endogenous serotonin levels. |
1990-07-12 |
2023-08-11 |
rat |
| M Briley, P Chopin, C More. Effect of serotonergic lesion on "anxious" behaviour measured in the elevated plus-maze test in the rat. Psychopharmacology. vol 101. issue 2. 1990-07-12. PMID:2140904. |
these results are compatible with the implication of serotonin in the control of anxiety and suggest that an anxiolytic effect may be induced by lowering the level of serotonergic activation. |
1990-07-12 |
2023-08-11 |
rat |