| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| U Scheffel, G A Ricaurt. Paroxetine as an in vivo indicator of 3,4-methylenedioxymethamphetamine neurotoxicity: a presynaptic serotonergic positron emission tomography ligand? Brain research. vol 527. issue 1. 1991-03-19. PMID:1980843. |
the present study sought to determine whether [3h]paroxetine, a potent and selective inhibitor of serotonin uptake in vitro, could be used to label the serotonin transporter in the rat brain in vivo such that it might be employed to develop a presynaptic serotonergic positron emission tomography ligand. |
1991-03-19 |
2023-08-11 |
human |
| U Scheffel, G A Ricaurt. Paroxetine as an in vivo indicator of 3,4-methylenedioxymethamphetamine neurotoxicity: a presynaptic serotonergic positron emission tomography ligand? Brain research. vol 527. issue 1. 1991-03-19. PMID:1980843. |
these results demonstrate that [3h]paroxetine can be used to label serotonin uptake sites in the rat brain in vivo, and that the damage induced by serotonergic neurotoxins can be detected using in vivo [3h]paroxetine binding as an indicator. |
1991-03-19 |
2023-08-11 |
human |
| J C Holstege, F Calkoe. The distribution of GABA in lumbar motoneuronal cell groups. A quantitative ultrastructural study in rat. Brain research. vol 530. issue 1. 1991-02-28. PMID:2271943. |
a few of the gaba-labeled terminal profiles (1.7%) were g-type (containing many granular vesicles and presumed serotonergic), possibly indicating co-existence of gaba and serotonin. |
1991-02-28 |
2023-08-11 |
rat |
| G Bonvento, P Lacombe, E T MacKenzie, D Fage, J Benavides, L Rouquier, B Scatto. Evidence for differing origins of the serotonergic innervation of major cerebral arteries and small pial vessels in the rat. Journal of neurochemistry. vol 56. issue 2. 1991-02-26. PMID:1703222. |
to this end, the levels of serotonin [5-hydroxytryptamine (5-ht)] and 5-hydroxyindoleacetic acid (5-hiaa) were measured by hplc in both cerebrovascular compartments after either bilateral sympathectomy or destruction of the ascending serotonergic pathways, which originate from the raphe nuclei. |
1991-02-26 |
2023-08-11 |
rat |
| G Bonvento, P Lacombe, E T MacKenzie, D Fage, J Benavides, L Rouquier, B Scatto. Evidence for differing origins of the serotonergic innervation of major cerebral arteries and small pial vessels in the rat. Journal of neurochemistry. vol 56. issue 2. 1991-02-26. PMID:1703222. |
destruction of the ascending serotonergic pathways (via local administration of 5,7-dihydroxytryptamine into the ventral tegmental area) produced a dramatic fall in 5-ht and 5-hiaa concentrations in both vascular compartments. |
1991-02-26 |
2023-08-11 |
rat |
| G Bonvento, P Lacombe, E T MacKenzie, D Fage, J Benavides, L Rouquier, B Scatto. Evidence for differing origins of the serotonergic innervation of major cerebral arteries and small pial vessels in the rat. Journal of neurochemistry. vol 56. issue 2. 1991-02-26. PMID:1703222. |
to establish the authenticity of the serotonergic innervation, the synthesis of 5-ht [as assessed by measuring the accumulation of 5-hydroxytryptophan (5-htp) after decarboxylase inhibition] was measured in the two vascular beds under control conditions and after destruction of the ascending serotonergic pathways. |
1991-02-26 |
2023-08-11 |
rat |
| N Takishita, H Kubo, A Mitani, Y Nakamura, S Masuda, K Iwahashi, K Kataok. Differential effects of fasciculus retroflexus lesions on serotonin, glutamate and gamma-aminobutyrate content and choline acetyltransferase activity in the interpeduncular nucleus. Brain research bulletin. vol 25. issue 4. 1991-02-26. PMID:2271960. |
in such cases, the following changes were observed; 1) the serotonin level increased consistently and roughly doubled at the 120th survival day, suggesting heterotypic sprouting of serotonergic fibers and/or enhanced serotonin synthesis in the serotonergic neurons in the ipn, 2) the glutamate level decreased by approximately one-half, while the activity of high affinity uptake of glutamate remained unaltered, at the 7th survival day, suggesting a lowered glutamate formation coupled with lowered glucose utilization in the ipn, and 3) the gaba level decreased at a slower rate and reached one-third of the control at the 120th survival day, for which either transsynaptic degeneration of gaba neurons in the ipn or a suppressed metabolic rate in the gaba shunt following the lowered glutamate formation is a possible explanation. |
1991-02-26 |
2023-08-11 |
rat |
| C J Schmidt, V L Taylor, G M Abbate, T R Nieduza. 5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa. The Journal of pharmacology and experimental therapeutics. vol 256. issue 1. 1991-02-22. PMID:1899117. |
the active and inactive stereoisomers of the serotonin (5-ht2) antagonist, mdl 11,939, were used to examine the relationship between the acute effects of 3,4-methylenedioxymethamphetamine (mdma) on the dopaminergic system and its long-term effects on the serotonergic system. |
1991-02-22 |
2023-08-11 |
Not clear |
| B Malinowska, D Pawlak, E Chabielska, W Buczk. Influence of acute and chronic ethanol administration on the vasopressor effect of serotonin in pithed rats. Pharmacology. vol 41. issue 2. 1991-02-04. PMID:2263674. |
these data suggest that the action of ethanol on the vasopressor effect of serotonin in pithed rats does not depend on its influence on serotonergic receptors in blood vessels. |
1991-02-04 |
2023-08-11 |
rat |
| B K Ko. Preclinical pharmacology of sertraline: a potent and specific inhibitor of serotonin reuptake. The Journal of clinical psychiatry. vol 51 Suppl B. 1991-01-30. PMID:2175308. |
specific serotonin reuptake inhibitors constitute a new class of psychotherapeutic agents that promote enhanced central serotonergic neurotransmission in animal studies. |
1991-01-30 |
2023-08-11 |
Not clear |
| C de Montigny, Y Chaput, P Blie. Modification of serotonergic neuron properties by long-term treatment with serotonin reuptake blockers. The Journal of clinical psychiatry. vol 51 Suppl B. 1991-01-30. PMID:2175309. |
the response of serotonergic neurons to intravenously administered lysergic acid diethylamide (lsd), a somatodendritic 5-ht autoreceptor agonist, was reduced in rats treated with citalopram for 14 days, suggesting that such a treatment reduces the sensitivity of the somatodendritic autoreceptor. |
1991-01-30 |
2023-08-11 |
rat |
| C de Montigny, Y Chaput, P Blie. Modification of serotonergic neuron properties by long-term treatment with serotonin reuptake blockers. The Journal of clinical psychiatry. vol 51 Suppl B. 1991-01-30. PMID:2175309. |
this enhanced efficacy of serotonergic synaptic transmission was not the result of an increased sensitivity of postsynaptic neurons to serotonin, as the effect of the direct microiontophoretic application of serotonin onto these same neurons was not modified. |
1991-01-30 |
2023-08-11 |
rat |
| O Spigse. [The role of serotonin in normal appetite regulation and in the pathogenesis of anorexia/bulimia]. Nordisk medicin. vol 105. issue 11. 1991-01-17. PMID:2251105. |
this article discusses the role of serotonin in appetite regulation and presents new evidence that a dysfunction in hypothalamic serotonergic pathways can be an important part of the pathogenesis of anorexia and bulimia nervosa. |
1991-01-17 |
2023-08-11 |
Not clear |
| J M Laude. Ontogeny of the serotonergic system in the rat: serotonin as a developmental signal. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252317. |
ontogeny of the serotonergic system in the rat: serotonin as a developmental signal. |
1991-01-14 |
2023-08-11 |
rat |
| J M Laude. Ontogeny of the serotonergic system in the rat: serotonin as a developmental signal. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252317. |
the apparent function of 5-ht as a differentiation signal in the developing nervous system raises important issues regarding the use of psychoactive serotonergic drugs by pregnant women, since these drugs may act as neural teratogens in the unborn child. |
1991-01-14 |
2023-08-11 |
rat |
| H W Steinbusch, M G Van Luijtelaar, H Dijkstra, A Nijssen, J A Tonnae. Aging and regenerative capacity of the rat serotonergic system. A morphological, neurochemical and behavioral analysis after transplantation of fetal raphe cells. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252322. |
there was a striking resemblance between the immunohistochemical and neurochemical data with respect to the increase in the amount of newly formed serotonergic fibers, the increase in uptake of [3h]-5-ht and in 5-ht and 5-hiaa levels. |
1991-01-14 |
2023-08-11 |
rat |
| H Tamir, M D Gersho. Serotonin-storing secretory vesicles. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252332. |
like the synaptic vesicles of central and peripheral serotonergic neurons parafollicular vesicles contain a specific 5-ht binding protein, sbp. |
1991-01-14 |
2023-08-11 |
Not clear |
| R W Fuller, D T Won. Serotonin uptake and serotonin uptake inhibition. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252338. |
selective inhibitors of serotonin uptake enhance neurotransmission via serotonergic neurons and have been useful pharmacologic tools for studying physiologic roles of serotonin neurons. |
1991-01-14 |
2023-08-11 |
Not clear |
| G C Kwiat, A I Basbau. Organization of tyrosine hydroxylase- and serotonin-immunoreactive brainstem neurons with axon collaterals to the periaqueductal gray and the spinal cord in the rat. Brain research. vol 528. issue 1. 1991-01-09. PMID:1978796. |
in contrast, the 5-ht contribution to the spinal antinociceptive effects produced by pag electrical stimulation is more likely to derive, as previously proposed, from orthodromic activation of raphe-spinal serotonergic axons. |
1991-01-09 |
2023-08-11 |
rat |
| A Chédotal, E Hame. Serotonin-synthesizing nerve fibers in rat and cat cerebral arteries and arterioles: immunohistochemistry of tryptophan-5-hydroxylase. Neuroscience letters. vol 116. issue 3. 1990-12-31. PMID:2243604. |
these results provide the evidence that, at least in these species, the cerebrovascular bed is innervated by authentic serotonergic fibers which can synthesize their own 5-ht. |
1990-12-31 |
2023-08-11 |
rat |