| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Rammsayer, P Nette. Personality related differences in response to 5-HT uptake inhibition. The International journal of neuroscience. vol 55. issue 2-4. 1991-05-14. PMID:2128079. |
conflicting results on clinical effects of serotonergic drugs gave rise to this investigation on the relationship between depression-related personality factors and effects of the 5-ht uptake inhibitor fluoxetine on psychomotor functions and emotional states. |
1991-05-14 |
2023-08-11 |
human |
| P A van Zwieten, G J Blauw, P van Brummele. The role of serotonin in cardiovascular diseases and their treatment. Cardiovascular drugs and therapy. vol 4. issue 6. 1991-05-08. PMID:2081137. |
certain symptoms of the carcinoid syndrome, thromboembolic processes at the level of the microcirculation, and possibly also coronary spasm and peripheral vascular disease are likely to be associated, at least in part, with endogenous 5ht and serotonergic mechanisms. |
1991-05-08 |
2023-08-11 |
human |
| D L Murph. Neuropsychiatric disorders and the multiple human brain serotonin receptor subtypes and subsystems. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 5-6. 1991-04-29. PMID:2078279. |
most evaluations of the contributions of possible alterations in serotonergic neurotransmission to the etiology and treatment of neuropsychiatric disorders preceded the recent explosion of information regarding multiple serotonin (5-ht) receptors and brain 5-ht subsystems. |
1991-04-29 |
2023-08-11 |
human |
| B L Jacobs, L O Wilkinson, C A Forna. The role of brain serotonin. A neurophysiologic perspective. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 5-6. 1991-04-29. PMID:2078280. |
continuing this line of investigation, we have utilized in vivo brain microdialysis in order to determine whether there could be a dissociation between level of serotonergic neuronal activity and release of serotonin at the nerve terminal. |
1991-04-29 |
2023-08-11 |
Not clear |
| A Lista, P Blier, C de Montign. Benzodiazepine receptors modulating serotonergic neurotransmission in rat hippocampus do not desensitize after long-term diazepam treatment. Brain research. vol 526. issue 1. 1991-04-26. PMID:1964107. |
previous studies have shown in the rat that long-term diazepam treatment induces a desensitization of gamma-aminobutyric acid (gaba) benzodiazepine receptors which modulate serotonergic (5-ht) neuron firing activity in the dorsal raphe. |
1991-04-26 |
2023-08-11 |
rat |
| L Zhang, D C Dye. Receptor mechanisms for 5-hydroxytryptamine (5-HT) in isolated ovine umbilical vein. European journal of pharmacology. vol 184. issue 2-3. 1991-04-26. PMID:1981873. |
the order of potency of serotonergic agonists in this tissue was: dom greater than 5-ht greater than alpha-methyl-5-ht greater than 1(3-chlorophenyl) piperazine (mcpp) greater than m-trifluoromethyl-phenylpiperazine (tfmpp) greater than 8-hydroxy-dipropylaminotetralin (8-oh-dpat) = 2-methyl-5-ht. |
1991-04-26 |
2023-08-11 |
Not clear |
| D P Lotshaw, P E Lloy. Peptidergic and serotonergic facilitation of a neuromuscular synapse in Aplysia. Brain research. vol 526. issue 1. 1991-04-26. PMID:2078821. |
(4) stimulation of the identified serotonergic metacerebral neuron or perfusion of exogenous serotonin (5-ht) over the 13 muscle also potentiated b38-induced muscle contractions and ejp amplitude. |
1991-04-26 |
2023-08-11 |
aplysia |
| D P Lotshaw, P E Lloy. Peptidergic and serotonergic facilitation of a neuromuscular synapse in Aplysia. Brain research. vol 526. issue 1. 1991-04-26. PMID:2078821. |
serotonergic effects on muscle fiber hyperpolarization and increase in muscle fiber membrane conductance were similar in magnitude to those of scpb but 5-ht induced a much larger increase in the ejp amplitude which was additive with that of scpb. |
1991-04-26 |
2023-08-11 |
aplysia |
| S T Bateman, A H Lichtman, C P Crame. Peripheral serotonergic inhibition of suckling. Pharmacology, biochemistry, and behavior. vol 37. issue 2. 1991-04-26. PMID:2080185. |
thus, serotonin receptors in the periphery may play an important role in the serotonergic inhibitory mechanism that has been hypothesized as the developing system leading to weaning. |
1991-04-26 |
2023-08-11 |
rat |
| P J Fletcher, M Davie. Dorsal raphe microinjection of 5-HT and indirect 5-HT agonists induces feeding in rats. European journal of pharmacology. vol 184. issue 2-3. 1991-04-26. PMID:2150377. |
the effects of 8-oh-dpat appear to be mediated in part in the dorsal raphe nucleus by serotonergic somatodendritic autoreceptors which normally regulate impulse flow in 5-ht dorsal raphe neurons. |
1991-04-26 |
2023-08-11 |
rat |
| P J Fletcher, M Davie. Dorsal raphe microinjection of 5-HT and indirect 5-HT agonists induces feeding in rats. European journal of pharmacology. vol 184. issue 2-3. 1991-04-26. PMID:2150377. |
the present experiments sought to examine whether suppression of dorsal raphe serotonergic neural activity induced by exogenously applied, or endogenously released 5-ht would increase feeding. |
1991-04-26 |
2023-08-11 |
rat |
| P J Fletcher, M Davie. Dorsal raphe microinjection of 5-HT and indirect 5-HT agonists induces feeding in rats. European journal of pharmacology. vol 184. issue 2-3. 1991-04-26. PMID:2150377. |
thus, increased serotonergic activity within the dorsal raphe increases feeding, presumably by inhibiting the activity of dorsal raphe 5-ht neurons. |
1991-04-26 |
2023-08-11 |
rat |
| M Watanabe, M Kinuya, G Mamiya, T Tatsunuma, M Nagayoshi, T Matsutani, Y Tsukad. Increased uptake sites for serotonin and dopamine with decreased S2 serotonin receptors in microencephalic rat brain. Neurochemical research. vol 15. issue 10. 1991-04-25. PMID:2077427. |
methylazoxymethanol (mam)-induced cerebral hypoplasia resulted in a significant increase in densities of both serotonin uptake sites in frontal cortex and dopamine uptake sites in striatum, suggesting serotonergic and dopaminergic axons terminals were compressed in the smaller brain volumes. |
1991-04-25 |
2023-08-11 |
rat |
| D J Nutt, P Glue, C Lawso. The neurochemistry of anxiety: an update. Progress in neuro-psychopharmacology & biological psychiatry. vol 14. issue 5. 1991-04-08. PMID:1963497. |
there is evidence of serotonergic involvement in anxiety, in that serotonin agonists may increase anxiety, whilst drugs that reduce serotonin function are anxiolytic. |
1991-04-08 |
2023-08-11 |
Not clear |
| D H Schwartz, L Hernandez, B G Hoebe. Serotonin release in lateral and medial hypothalamus during feeding and its anticipation. Brain research bulletin. vol 25. issue 6. 1991-04-01. PMID:2289169. |
we have now verified brain serotonin peaks in four different ways: 1) a serotonergic reuptake blocker (fluoxetine 1 or 10 microm) in the perfusion medium raised basal levels of serotonin, 2) every sample was oxidized at two potentials using a dual potentiostat to confirm the voltage characteristics of each peak, 3) serotonin peaks were reduced by the selective serotonin cell body agonist, 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat), thus helping confirm that most of the serotonin observed in these experiments was neuronal in origin, and 4) lateral and medial hypothalamic microdialysis probes were used simultaneously to monitor the degree of diffusion from one to the other. |
1991-04-01 |
2023-08-11 |
Not clear |
| G F Weiss, N Rogacki, A Fueg, D Buchen, S F Leibowit. Impact of hypothalamic d-norfenfluramine and peripheral d-fenfluramine injection on macronutrient intake in the rat. Brain research bulletin. vol 25. issue 6. 1991-04-01. PMID:2289171. |
to explore further the action of 5-ht in the brain, the present studies tested the serotonergic stimulants, d-norfenfluramine (dnf) and d-fenfluramine (df), in freely feeding, brain-cannulated animals maintained on pure macronutrient diets (protein, carbohydrate and fat) and tested at different times of the diurnal cycle. |
1991-04-01 |
2023-08-11 |
rat |
| R W Fulle. Drugs affecting serotonin neurons. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. vol 35. 1991-03-29. PMID:2149771. |
advances in serotonin pharmacology, the development of drugs that intervene at specific sites to modify serotonergic function, have accompanied advances in the understanding of physiologic roles of serotonin present in neurons and elsewhere and of serotonin receptors that are widely distributed in brain and many peripheral tissues. |
1991-03-29 |
2023-08-11 |
Not clear |
| R W Fulle. Drugs affecting serotonin neurons. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. vol 35. 1991-03-29. PMID:2149771. |
having drugs that act with high specificity or selectivity on particular enzymes in serotonin biosynthesis, on particular serotonin receptors, or at other sites such as uptake carriers for serotonin not only offers the hope of improved clinical therapy in diseases caused by abnormal serotonergic function or in which alteration of serotonergic function can alleviate symptoms, but also provides valuable pharmacologic tools for learning more about serotonin physiology and probing the functional status of serotonergic systems. |
1991-03-29 |
2023-08-11 |
Not clear |
| V M Piñeiro-Carrero, M H Clench, R H Davis, J M Andres, D A Franzini, J R Mathia. Intestinal motility changes in rats after enteric serotonergic neuron destruction. The American journal of physiology. vol 260. issue 2 Pt 1. 1991-03-27. PMID:1996644. |
these studies support the cellular concepts that serotonergic neurons function as interneurons in the myenteric plexus, modulating and processing the neural stimuli, and that serotonin is an important neurotransmitter in the small intestine. |
1991-03-27 |
2023-08-11 |
rat |
| M Matsumoto, H Togashi, M Yoshioka, K Morii, M Hirokami, M Tochihara, T Ikeda, Y Saito, H Sait. Significant correlation between cerebrospinal fluid and brain levels of norepinephrine, serotonin and acetylcholine in anesthetized rats. Life sciences. vol 48. issue 8. 1991-03-20. PMID:1994188. |
these findings suggest that ne, 5-ht and ach concentrations in the csf are direct indications of central noradrenergic, serotonergic and cholinergic nerve activity, respectively. |
1991-03-20 |
2023-08-11 |
rat |