| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Moret, M Brile. Platelet 3H-paroxetine binding to the serotonin transporter is insensitive to changes in central serotonergic innervation in the rat. Psychiatry research. vol 38. issue 2. 1992-01-28. PMID:1836639. |
thus, following a major serotonergic lesion in the brain, changes in the platelet serotonin transporter do not parallel serotonergic changes in the brain. |
1992-01-28 |
2023-08-11 |
rat |
| C Moret, M Brile. Platelet 3H-paroxetine binding to the serotonin transporter is insensitive to changes in central serotonergic innervation in the rat. Psychiatry research. vol 38. issue 2. 1992-01-28. PMID:1836639. |
the hypothesis that binding to the platelet serotonin transporter is a state-dependent marker of brain serotonergic activity therefore appears to be unlikely. |
1992-01-28 |
2023-08-11 |
rat |
| M A Wilson, M E Mollive. The organization of serotonergic projections to cerebral cortex in primates: regional distribution of axon terminals. Neuroscience. vol 44. issue 3. 1992-01-24. PMID:1754051. |
moreover, the discrete laminar distribution of serotonin axons suggests that serotonergic projections selectively innervate particular neuronal elements in cerebral cortex. |
1992-01-24 |
2023-08-11 |
Not clear |
| F Takemoto, T Satoh, H T Cohen, A I Kat. Localization of dopamine-1 receptors along the microdissected rat nephron. Pflugers Archiv : European journal of physiology. vol 419. issue 3-4. 1992-01-14. PMID:1660593. |
in cortical collecting tubules competition studies with unlabeled dopamine and probes for da1 (sch 23390, fenoldopam), da2 (domperidone, s-sulpiride), serotonergic (serotonin, ketanserin, mianserin), and alpha-(phentolamine) and beta-(propranolol) adrenergic receptors indicated a rank-order potency for displacement of 125i-sch 23982 binding, consistent with labeling of da1 receptors. |
1992-01-14 |
2023-08-11 |
rat |
| F Nevens, M P Pizcueta, M Fernández, J Bosch, J Rodé. Effects of ritanserin, a selective and specific S2-serotonergic antagonist, on portal pressure and splanchnic hemodynamics in portal hypertensive rats. Hepatology (Baltimore, Md.). vol 14. issue 6. 1992-01-07. PMID:1959867. |
serotonergic mechanisms have recently been implicated in the pathogenesis of portal hypertension; this suggests that blockade of serotonin s2 receptors may be a new approach for the pharmacological therapy of portal hypertension. |
1992-01-07 |
2023-08-11 |
rat |
| P A van Zwieten, G J Blauw, P van Brummele. Pathophysiological and pharmacotherapeutic aspects of serotonin and serotonergic drugs. Clinical physiology and biochemistry. vol 8 Suppl 3. 1992-01-06. PMID:2132170. |
pathophysiological and pharmacotherapeutic aspects of serotonin and serotonergic drugs. |
1992-01-06 |
2023-08-11 |
Not clear |
| P A van Zwieten, G J Blauw, P van Brummele. Pathophysiological and pharmacotherapeutic aspects of serotonin and serotonergic drugs. Clinical physiology and biochemistry. vol 8 Suppl 3. 1992-01-06. PMID:2132170. |
a major breakthrough in the pharmacology of the serotonergic system was achieved by the discovery of several subtypes of 5ht receptors, with a corresponding collection of selective agonists and antagonists towards these receptor subtypes. |
1992-01-06 |
2023-08-11 |
Not clear |
| R J Kat. Neurobiology of obsessive compulsive disorder--a serotonergic basis of Freudian repression. Neuroscience and biobehavioral reviews. vol 15. issue 3. 1991-12-31. PMID:1956605. |
ocd patients frequently also often have reductions in normal serotonergic (5-ht) function. |
1991-12-31 |
2023-08-11 |
Not clear |
| F D Yocca, A S Eison, D K Hyslop, E Ryan, D P Taylor, G Gianutso. Unique modulation of central 5-HT2 receptor binding sites and 5-HT2 receptor-mediated behavior by continuous gepirone treatment. Life sciences. vol 49. issue 24. 1991-12-26. PMID:1682780. |
these results suggest that the curious dissociation of behavioral and biochemical indices of 5-ht2 receptor function produced by continuous gepirone treatment may be the result of a dual yet separate action of the drug on central presynaptic noradrenergic and serotonergic mechanisms and postsynaptic 5-ht receptors. |
1991-12-26 |
2023-08-11 |
rat |
| H S Orer, N Merahi, A Nosjean, C M Fattaccini, R Laguzz. Cardiovascular effects of the local injection of 5,7-dihydroxytryptamine into the nodose ganglia and nucleus tractus solitarius in awake freely moving rats. Brain research. vol 553. issue 1. 1991-12-24. PMID:1718538. |
the local degeneration of serotonergic elements was associated with a significant decrease in the 5-ht and 5-hydroxyindole acetic acid levels within the ng and nts in 5,7-dht treated rats. |
1991-12-24 |
2023-08-11 |
rat |
| R A Le Feuvre, L Aisenthal, N J Rothwel. Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds. Brain research. vol 555. issue 2. 1991-12-23. PMID:1933336. |
10 min prior to serotonergic compounds, significantly reduced (77-106%) the increases in vo2 observed in response to central injections of 5-htp (20 micrograms), 5-ht (50 micrograms) or peripheral injections of fenfluramine, but not those observed in response to either 30 micrograms fenfluramine (i.c.v.) |
1991-12-23 |
2023-08-11 |
rat |
| B Robertson, G B Baker, C H Vanderwol. The effects of serotonergic stimulation on hippocampal and neocortical slow waves and behavior. Brain research. vol 555. issue 2. 1991-12-23. PMID:1933339. |
metergoline (and methysergide to a lesser extent) suppressed the stereotypic behaviors of the serotonin syndrome, resulting in a striking increase in the locomotion caused by central serotonergic stimulation. |
1991-12-23 |
2023-08-11 |
rat |
| B Robertson, G B Baker, C H Vanderwol. The effects of serotonergic stimulation on hippocampal and neocortical slow waves and behavior. Brain research. vol 555. issue 2. 1991-12-23. PMID:1933339. |
it was concluded that increased serotonergic activity in the cns causes an increase in motor activity and a correlated increase in scopolamine-resistant hippocampal rsa and scopolamine-resistant neocortical lvfa and suggested that metergoline blocks serotonin receptors mediating stereotyped behaviors, thereby permitting the expression of serotonin-mediated locomotion. |
1991-12-23 |
2023-08-11 |
rat |
| L Kiedrowsk. The distribution of serotonergic 5-HT1A and non-5-HT1A recognition sites along the dorso-ventral axis of the rat hippocampus. Polish journal of pharmacology and pharmacy. vol 43. issue 2. 1991-12-23. PMID:1946036. |
the distribution of serotonergic 5-ht1 binding sites along the hippocampal dorso-ventral axis was compared with [3h]5-ht uptake considered as a marker of the quantity of serotonergic nerve terminals. |
1991-12-23 |
2023-08-11 |
rat |
| R A Glenno. Serotonin receptors and site-selective agents. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 42. issue 1. 1991-12-20. PMID:1932772. |
few site-selective serotonergic agents are currently available; in fact, most of these agents might more appropriately be termed semi-selective in that they typically bind to at least two different populations of serotonin receptors. |
1991-12-20 |
2023-08-11 |
Not clear |
| S W Kim, M W Dysken, G N Pandey, J M Davi. Platelet 3H-imipramine binding sites in obsessive-compulsive behavior. Biological psychiatry. vol 30. issue 5. 1991-12-17. PMID:1657222. |
however, the possibility that there may be an abnormal platelet serotonin uptake or other serotonergic function in ocd cannot be ruled out. |
1991-12-17 |
2023-08-11 |
human |
| A Fernández-Guasti, A Escalant. Role of presynaptic serotonergic receptors on the mechanism of action of 5-HT1A and 5-HT1B agonists on masculine sexual behaviour: physiological and pharmacological implications. Journal of neural transmission. General section. vol 85. issue 2. 1991-12-17. PMID:1834089. |
the icv or the intraraphé administration of the serotonergic neurotoxin, 5,7-dihydroxytryptamine (5,7-dht), slightly stimulated masculine sexual behaviour and produced a decrease in serotonin and its metabolite levels. |
1991-12-17 |
2023-08-11 |
rat |
| I Mintz, H Kor. Serotonergic facilitation of quantal release at central inhibitory synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 11. issue 11. 1991-12-12. PMID:1941086. |
the effects of 5-ht on this inhibition were studied in current- and voltage-clamp experiments because the m-cell and its afferents have a profuse serotonergic innervation, including axoaxonal contacts with terminals of the inhibitory interneurons. |
1991-12-12 |
2023-08-11 |
Not clear |
| S R Kay, R Sandy. Experimental models of schizophrenia. The International journal of neuroscience. vol 58. issue 1-2. 1991-12-04. PMID:1938175. |
this may in part underlie the negative syndrome and its response to antipsychotic compounds with serotonergic (5-ht) antagonism. |
1991-12-04 |
2023-08-11 |
Not clear |
| T Yamaguchi, A Yamagat. Serotonergic ligand binding in aging brain of experimental animals. Neurochemical research. vol 16. issue 4. 1991-11-21. PMID:1833658. |
we examined the changes in binding to the membrane fraction of aging brain cortex of the experimental animals suncus and fischer rat of the serotonergic ligands, 5-ht, imipramine, and 8-oh-dpat. |
1991-11-21 |
2023-08-11 |
rat |