| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J P Liu, J M Laude. Serotonin and nialamide differentially regulate survival and growth of cultured serotonin and catecholamine neurons. Brain research. Developmental brain research. vol 62. issue 2. 1992-02-26. PMID:1685108. |
the decreased sensitivity of e15 5-ht neurons to these treatments, despite similar viability and growth of these neurons in control cultures, suggests the existence of a critical period for this regulation during the initial period of serotonergic neurogenesis when these neurons are forming the bilateral b4-9 raphe complex. |
1992-02-26 |
2023-08-11 |
Not clear |
| W G Tatton, C E Greenwood, M C Verrier, D P Holland, M M Kwan, F E Biddl. Different rates of age-related loss for four murine monoaminergic neuronal populations. Neurobiology of aging. vol 12. issue 5. 1992-02-21. PMID:1722872. |
the age-related loss of locus coeruleus (lc) noradrenergic neurons, substantia nigra compacta (snc) dopaminergic neurons, dopaminergic retinal amacrine (ram) neurons and raphe serotonergic neurons, identified using antibodies against tyrosine hydroxylase (th) and serotonin (5ht) was investigated in c57b1 mice aged 8 to 104 weeks. |
1992-02-21 |
2023-08-11 |
mouse |
| K J Axt, M E Mollive. Immunocytochemical evidence for methamphetamine-induced serotonergic axon loss in the rat brain. Synapse (New York, N.Y.). vol 9. issue 4. 1992-02-18. PMID:1722593. |
two morphologically distinct subtypes of 5-ht axons (fine and beaded) were differentially affected by d-methamphetamine (d-ma); the density of fine serotonergic axons was selectively decreased both 4 hours and 2 weeks after administration of d-ma. |
1992-02-18 |
2023-08-11 |
rat |
| K J Axt, M E Mollive. Immunocytochemical evidence for methamphetamine-induced serotonergic axon loss in the rat brain. Synapse (New York, N.Y.). vol 9. issue 4. 1992-02-18. PMID:1722593. |
these data provide morphologic evidence of 5-ht axon loss following methamphetamine administration and further confirm the differential vulnerability of a particular morphological subtype of serotonergic axons to the neurotoxic effects of substituted amphetamines. |
1992-02-18 |
2023-08-11 |
rat |
| D R McPherson, J E Blankenshi. Neural control of swimming in Aplysia brasiliana. III. Serotonergic modulatory neurons. Journal of neurophysiology. vol 66. issue 4. 1992-02-13. PMID:1662263. |
5,7-dihydroxytryptamine (5,7-dht) staining, immunocytochemistry using serotonin (5-ht) antibodies, and direct biochemical measurements revealed that pop cells are serotonergic. |
1992-02-13 |
2023-08-11 |
aplysia |
| M Maes, P D'Hondt, E Suy, B Minner, C Vandervorst, J Rau. HPA-axis hormones and prolactin responses to dextro-fenfluramine in depressed patients and healthy controls. Progress in neuro-psychopharmacology & biological psychiatry. vol 15. issue 6. 1992-02-13. PMID:1662403. |
like other authors we have established disturbances in central serotonergic neurotransmission in severely depressed patients by implementing hypothalamic pituitary adrenal (hpa)-axis hormones and prolactin responses to serotonin agonists or precursors. |
1992-02-13 |
2023-08-11 |
human |
| J Lappalainen, J Hietala, M Koulu, B Sjöholm, E Syvälaht. Effects of acute administration of SCH 23390 on dopamine and serotonin turnover in major dopaminergic areas and mesencephalic raphe nuclei--comparison with ritanserin. Progress in neuro-psychopharmacology & biological psychiatry. vol 15. issue 6. 1992-02-13. PMID:1722342. |
the effects of acute administration of sch 23390 (0.05 and 0.25 mg/kg s.c.), a dopamine d-1 receptor antagonist having also a moderate serotonin-s2 (5-ht-2) receptor blocking activity, and ritanserin (0.5 mg/kg), a specific 5-ht-2 antagonist, on dopamine (da) and serotonin (5-ht) turnover were investigated in dopaminergic (nucleus caudatus, nucleus accumbens, substantia nigra, a10 area) and serotonergic (nucleus raphe dorsalis and nucleus raphe medialis) rat brain nuclei. |
1992-02-13 |
2023-08-11 |
rat |
| A R Mercer, N J Emptage, T J Care. Pharmacological dissociation of modulatory effects of serotonin in Aplysia sensory neurons. Science (New York, N.Y.). vol 254. issue 5039. 1992-02-12. PMID:1662413. |
the classical 5ht antagonist cyproheptadine (cyp) permits dissociation of three forms of serotonergic modulation in these sns: (i) cyp reversibly blocks spike-broadening induced either by exogenous application of 5ht or by sensitizing stimulation of a tail nerve. |
1992-02-12 |
2023-08-11 |
aplysia |
| V J DeNoble, L M Schrack, A L Reigel, K F DeNobl. Visual recognition memory in squirrel monkeys: effects of serotonin antagonists on baseline and hypoxia-induced performance deficits. Pharmacology, biochemistry, and behavior. vol 39. issue 4. 1992-02-10. PMID:1763118. |
while the majority of preclinical studies have focused on the effects of acetylcholine (ach), it has been shown that activation of the serotonergic (5-ht) pathways in the central nervous system interferes with passive avoidance retention in rats. |
1992-02-10 |
2023-08-11 |
rat |
| M I Sweeney, T D White, J Sawyno. Intracerebroventricular morphine releases adenosine and adenosine 3',5'-cyclic monophosphate from the spinal cord via a serotonergic mechanism. The Journal of pharmacology and experimental therapeutics. vol 259. issue 3. 1992-02-07. PMID:1662270. |
morphine activates descending serotonergic pathways to release purines from the spinal cord, and that such release is secondary to release of 5-hydroxytryptamine. |
1992-02-07 |
2023-08-11 |
rat |
| J Franck, E Brodin, K Fried, A Rosén, Y Yamamoto, G Frie. The effect of selective serotonergic neurotoxin treatment on tachykinin levels in the rat ventral spinal cord. Neuroscience. vol 45. issue 2. 1992-02-07. PMID:1722290. |
the levels of 5-hydroxytryptamine and tachykinin neuropeptides substance p, neurokinin a, neurokinin b and neuropeptide k were measured in the spinal cord of rats treated by intraventricular injection of the selective serotonergic neurotoxin 5,7-dihydroxytryptamine. |
1992-02-07 |
2023-08-11 |
rat |
| P A Broderick, M F Pierce. 5-HT1A agonists uncouple noradrenergic somatodendritic impulse flow and terminal release. Brain research bulletin. vol 27. issue 5. 1992-02-06. PMID:1684526. |
both noradrenergic (ne) and serotonergic (5-ht) systems have been implicated in anxiety and depression, as well as in the therapeutic actions of drugs treating these conditions. |
1992-02-06 |
2023-08-11 |
Not clear |
| M A Lee, H Y Meltze. Neuroendocrine responses to serotonergic agents in alcoholics. Biological psychiatry. vol 30. issue 10. 1992-02-06. PMID:1756196. |
in order to further assess the serotonergic system in alcoholism, the plasma cortisol and prolactin (prl) responses following 6-chloro-2-[1-piperazinyl]pyrazine (mk-212), a direct-acting serotonin2 (5-ht2)/5-ht1c receptor agonist, l-5-hydroxytryptophan (l-5-htp), a precursor of 5-ht, and placebo were compared in male alcoholics and normal controls. |
1992-02-06 |
2023-08-11 |
human |
| J S Kelly, P Larkman, N J Penington, D G Rainnie, H McAllister-Williams, J Hodgkis. Serotonin receptor heterogeneity and the role of potassium channels in neuronal excitability. Advances in experimental medicine and biology. vol 287. 1992-02-06. PMID:1759607. |
our studies have confirmed the 5-ht evoked depolarisation of rat facial motorneurones (fm's) and the hyperpolarisation seen in presumed serotonergic neurones of the dorsal raphe nucleus (drn) to be the result of opposite effects on k+ ion permeability. |
1992-02-06 |
2023-08-11 |
rat |
| J M Zgombick, R L Weinshank, M Macchi, L E Schechter, T A Branchek, P R Harti. Expression and pharmacological characterization of a canine 5-hydroxytryptamine1D receptor subtype. Molecular pharmacology. vol 40. issue 6. 1992-02-05. PMID:1758439. |
serotonergic ligands displaced specific [3h]5-ht binding with a rank order of potency expected of a 5-ht1d receptor subtype, 5-carboxyamidotryptamine greater than 5-ht greater than yohimbine greater than 8-hydroxy-2-(di-n-propylamino)tetralin greater than ketanserin = spiperone greater than zacopride. |
1992-02-05 |
2023-08-11 |
Not clear |
| T T Yen, R W Fulle. Preclinical pharmacology of fluoxetine, a serotonergic drug for weight loss. The American journal of clinical nutrition. vol 55. issue 1 Suppl. 1992-02-03. PMID:1728830. |
fluoxetine selectively inhibits serotonin uptake in vitro and in vivo and thus enhances serotonergic function, leading to a decrease in food intake beginning with the first dose and a decrease in body weight or in weight gain after multiple doses of fluoxetine. |
1992-02-03 |
2023-08-11 |
mouse |
| E Hollander, C M DeCaria, A Nitescu, R Gully, R F Suckow, T B Cooper, J M Gorman, D F Klein, M R Liebowit. Serotonergic function in obsessive-compulsive disorder. Behavioral and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers. Archives of general psychiatry. vol 49. issue 1. 1992-01-30. PMID:1728249. |
to evaluate serotonergic (5-hydroxytryptamine) function in obsessive-compulsive disorder, behavioral and neuroendocrine responses to m-chlorophenylpiperazine (m-cpp; 0.5 mg/kg orally) and fenfluramine hydrochloride (60 mg orally) were examined in 20 patients and 10 healthy controls under double-blind, placebo-controlled conditions. |
1992-01-30 |
2023-08-11 |
human |
| C Moret, M Brile. Platelet 3H-paroxetine binding to the serotonin transporter is insensitive to changes in central serotonergic innervation in the rat. Psychiatry research. vol 38. issue 2. 1992-01-28. PMID:1836639. |
platelet 3h-paroxetine binding to the serotonin transporter is insensitive to changes in central serotonergic innervation in the rat. |
1992-01-28 |
2023-08-11 |
rat |
| C Moret, M Brile. Platelet 3H-paroxetine binding to the serotonin transporter is insensitive to changes in central serotonergic innervation in the rat. Psychiatry research. vol 38. issue 2. 1992-01-28. PMID:1836639. |
the present study was designed to determine whether major changes in central serotonergic innervation modify the platelet serotonin transporter as labeled by 3h-paroxetine binding. |
1992-01-28 |
2023-08-11 |
rat |
| C Moret, M Brile. Platelet 3H-paroxetine binding to the serotonin transporter is insensitive to changes in central serotonergic innervation in the rat. Psychiatry research. vol 38. issue 2. 1992-01-28. PMID:1836639. |
fifteen days after the intracerebroventricular administration of 5,7-dihydroxytryptamine (250 micrograms/animal) to rats to lesion central serotonergic neurons, serotonergic innervation was reduced by 82% in the cortex and 98% in the hippocampus as determined by endogenous serotonin levels. |
1992-01-28 |
2023-08-11 |
rat |