| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Glennon, N A Darmani, B R Marti. Multiple populations of serotonin receptors may modulate the behavioral effects of serotonergic agents. Life sciences. vol 48. issue 26. 1991-07-18. PMID:2046474. |
in order to establish a functional role for the various populations of serotonin (5-ht) receptors, behavioral studies have been conducted over the past decade with serotonergic agonists and antagonists. |
1991-07-18 |
2023-08-11 |
Not clear |
| R A Glennon, N A Darmani, B R Marti. Multiple populations of serotonin receptors may modulate the behavioral effects of serotonergic agents. Life sciences. vol 48. issue 26. 1991-07-18. PMID:2046474. |
and, although there is reason to believe that certain behavioral effects may be mediated via particular populations of 5-ht receptors, evidence now suggests that some serotonin-mediated behaviors may be modulated by the interaction of serotonergic agents at multiple subtypes of 5-ht receptors. |
1991-07-18 |
2023-08-11 |
Not clear |
| T Alexi, E C Azmiti. Ethanol stimulates [3H]5-HT high-affinity uptake by rat forebrain synaptosomes: role of 5-HT receptors and voltage channel blockers. Brain research. vol 544. issue 2. 1991-07-11. PMID:1645610. |
the serotonergic transport mechanism was chosen because ethanol consumption patterns can be manipulated by serotonin receptors and uptake blockers. |
1991-07-11 |
2023-08-11 |
rat |
| R Nagata, K Izumi, S Iwata, T Shimizu, T Fukud. Mechanisms of veratramine-induced 5-HT syndrome in mice. Japanese journal of pharmacology. vol 55. issue 1. 1991-07-10. PMID:1710298. |
these results suggest that veratramine is both a releaser and uptake inhibitor of 5-ht and that the veratramine-induced involuntary movements may be mediated by serotonergic hyperfunction. |
1991-07-10 |
2023-08-11 |
mouse |
| K P Lesch, A Hoh, J Disselkamp-Tietze, M Wiesmann, M Osterheider, H M Schult. 5-Hydroxytryptamine1A receptor responsivity in obsessive-compulsive disorder. Comparison of patients and controls. Archives of general psychiatry. vol 48. issue 6. 1991-07-01. PMID:1674853. |
these results provide no direct support for the hypothesis that a serotonergic dysfunction related to 5-hydroxytryptamine1a receptors may be linked to the pathophysiologic characteristics of obsessive-compulsive disorder and point to the need for the evaluation of other 5-hydroxytryptamine receptor subtypes. |
1991-07-01 |
2023-08-11 |
Not clear |
| R W Fulle. Role of serotonin in therapy of depression and related disorders. The Journal of clinical psychiatry. vol 52 Suppl. 1991-06-20. PMID:1674251. |
selective inhibitors of serotonin uptake, which enhance serotonergic function by preventing the removal of serotonin from the synaptic cleft via the membrane transporter, have been introduced for the treatment of depression and may be effective in other disorders. |
1991-06-20 |
2023-08-11 |
Not clear |
| P M Thompson, G Zebrowski, R S Neuma. Alteration of neocortical activity in response to noxious stimulation: participation of the dorsal raphe. Neuropharmacology. vol 30. issue 2. 1991-06-20. PMID:1827661. |
agents known to inhibit serotonergic unit activity including serotonin, (+/-)-8-hydroxy-dipropylaminotetralin, fluoxetine and baclofen, when pressure ejected in the vicinity of the dorsal raphe, prevented cortical desynchronization as well as the suppression of focal epileptiform activity in response to noxious stimulation. |
1991-06-20 |
2023-08-11 |
Not clear |
| H Y Meltze. Beyond serotonin. The Journal of clinical psychiatry. vol 52 Suppl. 1991-06-20. PMID:2030105. |
available therapies for treating depression, even the specific serotonin reuptake blockers, may not act via a serotonergic mechanism. |
1991-06-20 |
2023-08-11 |
Not clear |
| M P Johnson, X M Huang, R Oberlender, J F Nash, D E Nichol. Behavioral, biochemical and neurotoxicological actions of the alpha-ethyl homologue of p-chloroamphetamine. European journal of pharmacology. vol 191. issue 1. 1991-06-17. PMID:1982656. |
a 10 mg/kg dose of pca caused an 80% decrease in cortical and hippocampal serotonergic markers, while an equimolar dose of cab decreased only hippocampal 5-ht and 5-hydroxyindoleacetic acid (5-hiaa) levels. |
1991-06-17 |
2023-08-11 |
Not clear |
| F R Georg. Cocaine produces low dose locomotor depressant effects in NBR and F344 rats. Pharmacology, biochemistry, and behavior. vol 37. issue 4. 1991-06-17. PMID:2093183. |
it was postulated that these low doses of cocaine which depress locomotor activity do so via inhibition of serotonin uptake, resulting in potentiation of serotonergic activity. |
1991-06-17 |
2023-08-11 |
mouse |
| R A Glennon, J De Vry, D G Spencer, T Glase. Stimulus properties of tiflucarbine: a novel antidepressant agent. Pharmacology, biochemistry, and behavior. vol 37. issue 4. 1991-06-17. PMID:2151199. |
to further characterize the serotonergic actions of this agent, tiflucarbine was evaluated in groups of rats trained to discriminate the 5-ht1a agonist 8-oh dpat, the 5-ht2 agonist dom, and the nonselective 5-ht agonist 5-ome dmt from saline. |
1991-06-17 |
2023-08-11 |
rat |
| J G Hensler, G B Kovachich, A Fraze. A quantitative autoradiographic study of serotonin1A receptor regulation. Effect of 5,7-dihydroxytryptamine and antidepressant treatments. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 4. issue 2. 1991-06-13. PMID:2025379. |
consequently, the binding of 3h-8-hydroxy-2-(di-n-propylamino)-tetralin (dpat) to 5-ht1a receptors in serotonergic cell body and terminal field areas of rat brain was measured by quantitative autoradiography following either the lesioning of serotonergic neurons with 5,7-dihydroxytryptamine (5,7-dht), or after chronic administration of monoamine oxidase inhibitors (maois) (clorgyline, phenelzine, or tranylcypromine) or inhibitors of 5-ht uptake (citalopram or sertraline). |
1991-06-13 |
2023-08-11 |
rat |
| J Vriend, M S Sheppard, K T Bore. Melatonin increases serum growth hormone and insulin-like growth factor I (IGF-I) levels in male Syrian hamsters via hypothalamic neurotransmitters. Growth, development, and aging : GDA. vol 54. issue 4. 1991-06-12. PMID:1709150. |
highly significant increases in 5-hydroxyindole acetic acid (5hiaa) concentrations and in ratios of 5hiaa to serotonin (5ht) were noted in extracts of hypothalamus and in extracts of brain stem, suggesting a serotonergic component to melatonin-induced increase in gh-induced igf secretion and subsequent growth. |
1991-06-12 |
2023-08-11 |
Not clear |
| D R McPherson, J E Blankenshi. Retrograde labelling of serotonergic projections onto the neuroendocrine bag cells of Aplysia. Neuroscience letters. vol 123. issue 2. 1991-06-12. PMID:1851265. |
subsequent staining for serotonin immunoreactivity demonstrated consistent double-labelling in specific cerebral and abdominal ganglion serotonergic cells. |
1991-06-12 |
2023-08-11 |
aplysia |
| P Celada, M J Sarrias, F Artiga. Serotonin and 5-hydroxyindoleacetic acid in plasma. Potential use as peripheral measures of MAO-A activity. Journal of neural transmission. Supplementum. vol 32. 1991-05-29. PMID:1708403. |
these results support the use of plasma 5-ht and 5-hiaa in humans to evaluate the action of maoi on the serotonergic system. |
1991-05-29 |
2023-08-11 |
rat |
| W J Burke, D H Park, H D Chung, G L Marshall, J H Haring, T H Jo. Evidence for decreased transport of tryptophan hydroxylase in Alzheimer's disease. Brain research. vol 537. issue 1-2. 1991-05-23. PMID:1707735. |
tryptophan hydroxylase (tph) is the rate-limiting enzyme in the synthesis of serotonin and a specific marker for serotonergic neurons. |
1991-05-23 |
2023-08-11 |
Not clear |
| W J Burke, D H Park, H D Chung, G L Marshall, J H Haring, T H Jo. Evidence for decreased transport of tryptophan hydroxylase in Alzheimer's disease. Brain research. vol 537. issue 1-2. 1991-05-23. PMID:1707735. |
the accumulation of oxidative metabolites of serotonin may contribute to the degeneration of serotonergic neurons in ad. |
1991-05-23 |
2023-08-11 |
Not clear |
| E Hollander, C DeCaria, R Gully, A Nitescu, R F Suckow, J M Gorman, D F Klein, M R Liebowit. Effects of chronic fluoxetine treatment on behavioral and neuroendocrine responses to meta-chlorophenylpiperazine in obsessive-compulsive disorder. Psychiatry research. vol 36. issue 1. 1991-05-23. PMID:2017519. |
to investigate the effect of fluoxetine on serotonergic sensitivity in obsessive-compulsive disorder (ocd), the partial serotonin agonist metachlorophenylpiperazine (mcpp) was compared to placebo under double-blind conditions in six patients with ocd before and during treatment with fluoxetine. |
1991-05-23 |
2023-08-11 |
Not clear |
| V Coiro, M Passeri, L Capretti, G Speroni, C Davoli, C Marchesi, G Rossi, L Camellini, R Volpi, E Rot. Serotonergic control of TSH and PRL secretion in obese men. Psychoneuroendocrinology. vol 15. issue 4. 1991-05-23. PMID:2128415. |
to evaluate whether the inhibitory control of tsh and the stimulatory control of prolactin (prl) secretion exerted by endogenous serotonin was altered in obesity, 22 obese men and 10 normal controls were tested with trh (200 micrograms iv bolus) in the presence (experimental test) and absence (control test) of the serotonergic agonist fenfluramine (60 mg po 90 min before trh). |
1991-05-23 |
2023-08-11 |
human |
| J Lip. Possible mechanisms of morphine analgesia. Clinical neuropharmacology. vol 14. issue 2. 1991-05-17. PMID:1849794. |
these include the opioid system associated with the release of the endorphins, the adrenergic system associated with the release of norepinephrine, and the serotonergic system associated with the release of serotonin. |
1991-05-17 |
2023-08-11 |
Not clear |