| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L H Price, D S Charney, P L Delgado, W K Goodman, J H Krystal, S W Woods, G R Heninge. Clinical studies of 5-HT function using i.v. L-tryptophan. Progress in neuro-psychopharmacology & biological psychiatry. vol 14. issue 4. 1990-12-07. PMID:2236580. |
preclinical studies reveal that long-term treatment with antidepressant drugs induces significant changes in serotonergic (5-ht) receptor sensitivity. |
1990-12-07 |
2023-08-11 |
Not clear |
| C A Connelly, H H Ellenberger, J L Feldma. Are there serotonergic projections from raphe and retrotrapezoid nuclei to the ventral respiratory group in the rat? Neuroscience letters. vol 105. issue 1-2. 1990-12-06. PMID:2485883. |
retrotrapezoid neurons, which exhibited exclusively ipsilateral projections to the ventral respiratory group, were located lateral to clusters of serotonergic cells near the ventral surface, but were not serotonin immunoreactive. |
1990-12-06 |
2023-08-11 |
rat |
| N H Raski. Pharmacology of migraine. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. vol 34. 1990-12-05. PMID:2173018. |
by serotonin receptor agonism, by prolonging the biologic half-life of serotonin in the synaptic cleft (through blockade of its re-uptake or metabolic degradation), by an increase in its synthesis, by inhibiting the release of serotonin, or by activation of cyclic amp (fig), a unitary expression for the action of these drugs can be formulated which is corroborated, for many of the drugs, by direct measurement of serotonergic neuronal firing rates. |
1990-12-05 |
2023-08-11 |
Not clear |
| J A Severson, L S Schneider, E R Fredrickso. Methodological issues in the preparation and assay of platelet 3H-imipramine binding. Psychiatry research. vol 33. issue 1. 1990-11-20. PMID:1699244. |
overall, these data suggest that not all 3h-imi binding that is displaced by desipramine is related to serotonergic mechanisms, and suggest that 5ht is a better choice than desipramine for the determination of the nonspecific binding of 3h-imi. |
1990-11-20 |
2023-08-11 |
Not clear |
| T R Inse. New pharmacologic approaches to obsessive compulsive disorder. The Journal of clinical psychiatry. vol 51 Suppl. 1990-11-20. PMID:2120204. |
the few drugs that have been demonstrated to be antiobsessional share a high potency for the blockade of serotonin reuptake, suggesting a serotonergic mechanism for antiobsessional drug action. |
1990-11-20 |
2023-08-11 |
Not clear |
| L W Rogers, J Giordan. Effects of systemically administered monoamine reuptake blocking agents on patterns of buspirone-induced analgesia in rats. Life sciences. vol 47. issue 11. 1990-11-13. PMID:2145489. |
as a 5-ht1a agonist, buspirone may change serotonergic (5-ht) tone to alter the balance of central monoaminergic (ma) systems that function in analgesia. |
1990-11-13 |
2023-08-11 |
rat |
| B H Westerink, P De Boer, W Timmerman, J B De Vrie. In vivo evidence for the existence of autoreceptors on dopaminergic, serotonergic, and cholinergic neurons in the brain. Annals of the New York Academy of Sciences. vol 604. 1990-10-31. PMID:1977359. |
in order to evaluate the properties of synthesis-modulating autoreceptors on dopaminergic and serotonergic neurons we have estimated the synthesis rate of serotonin (5-ht) or da by monitoring the 5-htp or dopa formation in the dialysates during infusion of a decarboxylase inhibitor. |
1990-10-31 |
2023-08-11 |
Not clear |
| G N Gurguis, E Klein, I N Mefford, T W Uhd. Biogenic amines distribution in the brain of nervous and normal pointer dogs. A genetic animal model of anxiety. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 4. 1990-10-26. PMID:1698064. |
the nervous dogs had higher [ne] in the reticular formation and lower serotonin, and its metabolite 5-hydroxyindoleacetic acid, in the septal nuclei, indicating possible important differences in noradrenergic and serotonergic functions in the nervous dogs. |
1990-10-26 |
2023-08-11 |
Not clear |
| P Bałuk, G Gabell. Some parasympathetic neurons in the guinea-pig heart express aspects of the catecholaminergic phenotype in vivo. Cell and tissue research. vol 261. issue 2. 1990-10-22. PMID:1976043. |
the cardiac neurons do not show any immunohistochemically detectable serotonergic characteristics; there is no evidence for uptake of the precursors l-tryptophan and 5-hydroxytryptophan or 5-ht itself, whereas the extrinsic noradrenergic nerve fibres within the ganglia can take up 5-ht when it is applied in high concentrations. |
1990-10-22 |
2023-08-11 |
Not clear |
| J V Martin, E Edwards, J O Johnson, F A Hen. Monoamine receptors in an animal model of affective disorder. Journal of neurochemistry. vol 55. issue 4. 1990-10-17. PMID:1697887. |
a statistically significant increase in levels of 5-hydroxytryptamine was noted in the hippocampus and hypothalamus of rd rats as compared to levels in nd rats, but no significant differences were measured between groups of rats in terms of s1 or s2 serotonergic receptor binding. |
1990-10-17 |
2023-08-11 |
rat |
| E K Perry, E Marshall, J Kerwin, C J Smith, S Jabeen, A V Cheng, R H Perr. Evidence of a monoaminergic-cholinergic imbalance related to visual hallucinations in Lewy body dementia. Journal of neurochemistry. vol 55. issue 4. 1990-10-17. PMID:1697897. |
in contrast with the cholinergic enzyme choline acetyltransferase, which was more extensively reduced in hallucinating individuals, serotonergic s2 receptor binding and both dopamine and serotonin metabolites were significantly decreased in nonhallucinating cases. |
1990-10-17 |
2023-08-11 |
human |
| D Becquet, M Faudon, F Her. In vivo evidence for an inhibitory glutamatergic control of serotonin release in the cat caudate nucleus: involvement of GABA neurons. Brain research. vol 519. issue 1-2. 1990-10-16. PMID:1975768. |
l-glutamic acid (5 x 10(-5) m) decreased [3h]serotonin release from nerve terminals of the dorsalis raphe-striatal serotonergic neurons. |
1990-10-16 |
2023-08-11 |
cat |
| D Becquet, M Faudon, F Her. In vivo evidence for an inhibitory glutamatergic control of serotonin release in the cat caudate nucleus: involvement of GABA neurons. Brain research. vol 519. issue 1-2. 1990-10-16. PMID:1975768. |
the superfusion of serotonergic nerve terminals in the caudate nucleus with tetrodotoxin prevented the inhibitory l-glutamic acid-induced effect on serotonin release. |
1990-10-16 |
2023-08-11 |
cat |
| H B Moss, J K Yao, G L Panza. Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse. Biological psychiatry. vol 28. issue 4. 1990-10-12. PMID:2397249. |
in order to assess the possibility of altered serotonergic responsivity in antisocial personality disorder with substance abuse (asp), 15 men with asp and 12 controls were challenged with the serotonin agonist, m-chlorophenylpiperazine (m-cpp), and prolactin and cortisol responses were evaluated. |
1990-10-12 |
2023-08-11 |
human |
| K P Liu, P Y Yu, S H Hsiung, A L Kirchgessner, M D Gershon, H Tami. Preparation and characterization of monoclonal antibodies to serotonin binding protein. Journal of neurochemistry. vol 55. issue 3. 1990-09-17. PMID:1696614. |
serotonin binding protein (sbp) is a constituent of the synaptic vesicles of serotonergic neurons. |
1990-09-17 |
2023-08-11 |
mouse |
| P F VonVoigtlander, M A Burian, J S Althaus, L R William. Effects of chronic haloperidol on vitamin E levels and monoamine metabolism in rats fed normal and vitamin E deficient diets. Research communications in chemical pathology and pharmacology. vol 68. issue 3. 1990-09-17. PMID:2385757. |
in addition, serotonergic activity was reduced, as indicated by lowered 5-hydroxytryptophan (5-htp), 5-hydroxyindoleacetic acid (5-hiaa), and 5-hydroxytryptamine (5-ht) levels. |
1990-09-17 |
2023-08-11 |
rat |
| D L Murphy, M T Pato, T A Pigot. Obsessive-compulsive disorder: treatment with serotonin-selective uptake inhibitors, azapirones, and other agents. Journal of clinical psychopharmacology. vol 10. issue 3 Suppl. 1990-09-05. PMID:1973944. |
these studies are reviewed briefly and evaluated in the context of investigations that used other drugs with serotonergic actions either alone or in combination with selective 5-ht uptake inhibitors in ocd patients. |
1990-09-05 |
2023-08-11 |
Not clear |
| M S Eiso. Serotonin: a common neurobiologic substrate in anxiety and depression. Journal of clinical psychopharmacology. vol 10. issue 3 Suppl. 1990-09-05. PMID:2198299. |
it is proposed that imbalances in serotonergic neurotransmission may contribute significantly to both pathologies and that agents that act as serotonin partial agonists may normalize neurotransmission in both serotonin deficit (depression) and excess (anxiety) diseases. |
1990-09-05 |
2023-08-11 |
Not clear |
| M S Eiso. Serotonin: a common neurobiologic substrate in anxiety and depression. Journal of clinical psychopharmacology. vol 10. issue 3 Suppl. 1990-09-05. PMID:2198299. |
the azapirones, a new class of drugs that includes buspirone, ipsapirone, and gepirone, act as serotonin partial agonists at the serotonergic type1a receptor, and may prove useful in treating multiple psychopathologies characterized by aberrant serotonin neurotransmission. |
1990-09-05 |
2023-08-11 |
Not clear |
| R Miledi, I Parke. Latencies of membrane currents evoked in Xenopus oocytes by receptor activation, inositol trisphosphate and calcium. The Journal of physiology. vol 415. 1990-09-04. PMID:2484206. |
currents evoked by acetylcholine and serotonin, in oocytes induced to acquire muscarinic and serotonergic receptors following injection of brain messenger rna, began following latencies similar to that of the serum response. |
1990-09-04 |
2023-08-11 |
xenopus_laevis |