| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D S Robinson, D R Alms, R C Shrotriya, M Messina, P Wickramaratn. Serotonergic anxiolytics and treatment of depression. Psychopathology. vol 22 Suppl 1. 1989-07-03. PMID:2657837. |
in addition, gepirone induces a full-blown serotonin syndrome in rodents and is active in the behavioral despair test mediated by an action on serotonergic neurons. |
1989-07-03 |
2023-08-11 |
Not clear |
| L Svensson, J Engel, E Hår. Effects of the 5-HT receptor agonist, 8-OH-DPAT, on ethanol preference in the rat. Alcohol (Fayetteville, N.Y.). vol 6. issue 1. 1989-06-27. PMID:2524201. |
clinical and animal studies have suggested that consumption of ethanol is influenced by the central serotonergic (5-ht) transmission system. |
1989-06-27 |
2023-08-11 |
rat |
| T J Murphy, D B Bylun. Characterization of serotonin-1B receptors negatively coupled to adenylate cyclase in OK cells, a renal epithelial cell line from the opossum. The Journal of pharmacology and experimental therapeutics. vol 249. issue 2. 1989-06-26. PMID:2542534. |
many serotonergic drugs, including 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyrindinyl)1h-indol, 5-ht and methysergide, but not (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide or buspirone, were full agonists at this receptor as defined by the inhibition of bovine parathyroid hormone peptide fragment 1-34-stimulated cyclic amp production in an intact cell assay. |
1989-06-26 |
2023-08-11 |
cattle |
| T R Norman, G D Burrows, F K Judd, I M McIntyr. Serotonin and panic disorders: a review of clinical studies. International journal of clinical pharmacology research. vol 9. issue 2. 1989-06-22. PMID:2654037. |
the evidence for serotonergic hyperactivity in panic disorders is supported by the efficacy of specific serotonin reuptake blockers and 5ht2 receptor antagonists in the treatment of the condition. |
1989-06-22 |
2023-08-11 |
Not clear |
| T R Norman, G D Burrows, F K Judd, I M McIntyr. Serotonin and panic disorders: a review of clinical studies. International journal of clinical pharmacology research. vol 9. issue 2. 1989-06-22. PMID:2654037. |
clinical evidence of serotonin dysfunction has been sought using the blood platelet, a putative model of central serotonergic neurons. |
1989-06-22 |
2023-08-11 |
Not clear |
| S Hunskaar, J H Rosland, K Hol. Mechanisms of orphenadrine-induced antinociception in mice: a role for serotonergic pathways. European journal of pharmacology. vol 160. issue 1. 1989-06-20. PMID:2469592. |
a general depletion of serotonin by means of p-chlorophenylalanine significantly reduced the effect of orphenadrine in both tests, while lesion of the ascending serotonergic systems by means of p-chloroamphetamine did not affect the analgesia. |
1989-06-20 |
2023-08-11 |
mouse |
| S K Bhattacharya, S S Parma. Prostaglandin D2 inhibits pentylenetetrazole-induced convulsions in rats by a serotonin-mediated mechanism. Pharmaceutical research. vol 4. issue 5. 1989-06-20. PMID:2977646. |
the anticonvulsant action of pgd2 (20 micrograms, icv) was significantly attenuated following pretreatment of the rats with pharmacologic agents known to reduce central serotonergic activity, including 5,6-dihydroxytryptamine, a selective neurotoxin for serotonergic neurons, p-chlorophenylalanine, a specific inhibitor of serotonin biosynthesis, metergoline, a serotonin postsynaptic receptor antagonist, and quipazine, which is known to inhibit neuronal release of serotonin. |
1989-06-20 |
2023-08-11 |
rat |
| J G Yu, T J Le. 5-Hydroxytryptamine-containing fibers in cerebral arteries of the cat, rat and guinea pig. Blood vessels. vol 26. issue 1. 1989-06-19. PMID:2653470. |
these results indicate that the presence of 5-ht-containing nerves in pial vessels in various species examined is due to the uptake of 5-ht into sympathetic nerves, and further support our hypothesis that cerebral pial vessels do not receive authentic serotonergic innervation. |
1989-06-19 |
2023-08-11 |
rat |
| L A Koriakina, L I Serov. [Central serotonin administration and post-stress damage of the gastric mucosa in inbred mice during various seasons]. Patologicheskaia fiziologiia i eksperimental'naia terapiia. issue 1. 1989-06-19. PMID:2717227. |
the intensifying effect of exogenous serotonin on post-stress gm damage was mainly manifested in the spring, which is associated with es induced activation of the brain serotonergic system. |
1989-06-19 |
2023-08-11 |
mouse |
| L A Koriakina, L I Serov. [Central serotonin administration and post-stress damage of the gastric mucosa in inbred mice during various seasons]. Patologicheskaia fiziologiia i eksperimental'naia terapiia. issue 1. 1989-06-19. PMID:2717227. |
the effect of exogenous serotonin on the degree of the neurogenous damage to the gm caused by es is determined to a great measure by the genotype differences in the sensitivity of the central serotonergic mechanisms to the stimulating effect. |
1989-06-19 |
2023-08-11 |
mouse |
| N A Sharif, A C Towle, D R Burt, R A Mueller, G R Brees. Cotransmitters: differential effects of serotonin (5-HT)-depleting drugs on levels of 5-HT and TRH and their receptors in rat brain and spinal cord. Brain research. vol 480. issue 1-2. 1989-06-16. PMID:2540880. |
following codepletion of endogenous serotonin (5-ht, greater than 90%) and thyrotropin-releasing hormone (trh, 66%) by neonatal treatment with the serotonergic neurotoxin, 5,7-dihydroxytryptamine (dht), a 33% (n = 12, p less than 0.01) increase in specific trh receptor binding was observed in adult rat spinal cord (sc) homogenates. |
1989-06-16 |
2023-08-11 |
rat |
| E Demeter, K Tekes, K Majorossy, M Palkovits, M Soós, K Magyar, E Somogy. The asymmetry of 3H-imipramine binding may predict psychiatric illness. Life sciences. vol 44. issue 19. 1989-06-16. PMID:2541295. |
it was postulated that the inhibiting effect of central serotonin (5-ht) has weakened in psychiatric cases, therefore the change of presynaptic serotonergic activity might be associated with psychiatric illness in the left hemisphere of human brain. |
1989-06-16 |
2023-08-11 |
human |
| A S Eison, M S Eison, F D Yocca, G Gianutso. Effects of imipramine and serotonin-2 agonists and antagonists on serotonin-2 and beta-adrenergic receptors following noradrenergic or serotonergic denervation. Life sciences. vol 44. issue 19. 1989-06-16. PMID:2785627. |
the effects of chronic (14 day) administration of the tricyclic antidepressant imipramine, the serotonin-2 (5-ht2) antagonist ketanserin, and the serotonin agonist quipazine on 5-ht2 receptor binding parameters and 5-ht2-mediated behavior were examined in rats with or without prior serotonergic denervation [via 5,7-dihydroxytryptamine (5,7-dht)] or noradrenergic denervation [via n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine (dsp4)]. |
1989-06-16 |
2023-08-11 |
rat |
| N Tajuddin, M J Drus. Chronic maternal ethanol consumption results in decreased serotonergic 5-HT1 sites in cerebral cortical regions from offspring. Alcohol (Fayetteville, N.Y.). vol 5. issue 6. 1989-06-16. PMID:3245890. |
serotonergic 5-ht1 sites were assessed by measuring the binding of [3h]-5-ht to synaptosomal membranes in the presence and absence of nonradioactive 5-ht. |
1989-06-16 |
2023-08-11 |
rat |
| L M Grover, J Farley, S B Auerbac. Serotonin involvement during in vitro conditioning of Hermissenda. Brain research bulletin. vol 22. issue 2. 1989-06-08. PMID:2706543. |
to determine if serotonin may be involved in associative conditioning-produced changes in the excitability and photoresponses of type b photoreceptors, isolated nervous systems were exposed to an in vitro conditioning procedure in the presence or absence of drugs that alter normal serotonergic neurotransmission. |
1989-06-08 |
2023-08-11 |
Not clear |
| S L Cohen, R M Kriebe. Terminal processes of serotonin neurons in the caudal spinal cord of the molly, Poecilia latipinna, project to the leptomeninges and urophysis. Cell and tissue research. vol 255. issue 3. 1989-06-08. PMID:2706662. |
serotonin may be secreted into the submeningeal cerebrospinal fluid, the urophysis, and the caudal vein by type-a and type-b fibers, whereas, type-c fibers may be processes of serotonergic interneurons in the neuroendocrine nucleus. |
1989-06-08 |
2023-08-11 |
Not clear |
| R R Mize, L H Horne. Origin, distribution, and morphology of serotonergic afferents to the cat superior colliculus: a light and electron microscope immunocytochemistry study. Experimental brain research. vol 75. issue 1. 1989-06-06. PMID:2468516. |
we have studied the serotonergic (5-ht) projection to the cat superior colliculus (sc) using serotonin antibody immunocytochemistry and retrograde transport of peroxidase-conjugated wheatgerm agglutinin (wga-hrp). |
1989-06-06 |
2023-08-11 |
cat |
| D Schwartz, L Hernandez, B G Hoebe. Fenfluramine administered systemically or locally increases extracellular serotonin in the lateral hypothalamus as measured by microdialysis. Brain research. vol 482. issue 2. 1989-06-01. PMID:2468397. |
these results provide direct evidence that the anorectic drug d-fen can increase extracellular serotonin in the hypothalamus in vivo and suggest a serotonergic action in the perifornical region. |
1989-06-01 |
2023-08-11 |
rat |
| P Preziosi, M Martire, P Navarra, G Pistritto, M Vacc. Prolactin-lowering ability of (+/-)-idazoxan may be linked to a central noradrenergic-serotonergic interplay. The Journal of pharmacology and experimental therapeutics. vol 249. issue 1. 1989-06-01. PMID:2565391. |
on the contrary, in the rat idazoxan counteracts hyperprolactinemias due to central presynaptic serotonergic neurotransmission increase (5-hydroxytryptophan, d-fenfluramine and fluoxetine) but not those related to direct agonists at 5-hydroxytryptamine (5-ht) receptor (6-chloro-2-[1-piperazinyl] pyrazine, mk 212; 1-(2,5-dimethoxy-4-iodophenyl)2-aminopropane, doi). |
1989-06-01 |
2023-08-11 |
rat |
| P Preziosi, M Martire, P Navarra, G Pistritto, M Vacc. Prolactin-lowering ability of (+/-)-idazoxan may be linked to a central noradrenergic-serotonergic interplay. The Journal of pharmacology and experimental therapeutics. vol 249. issue 1. 1989-06-01. PMID:2565391. |
the noradrenergic outflow selectively induced by idazoxan in the brain may negatively modulate the 5-ht release from the relevant nerve endings, thus preventing prolactin release due to an activation of presynaptic serotonergic axons induced both physiologically (lactation) and pharmacologically (5-hydroxytryptophan, d-fenfluramine and fluoxetine) without influencing hyperprolactinemias related to a direct activation of serotonergic receptors (mk 212 and doi). |
1989-06-01 |
2023-08-11 |
rat |