| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Kushiro, H Kurumatani, T Ishii, H Yokoyama, J Koike, Y Hatayama, Y Kobayashi, N Kajiwar. Role of central serotonergic (5-HT2) receptor in blood pressure regulation in rats. Clinical and experimental hypertension. Part A, Theory and practice. vol 10 Suppl 1. 1989-05-30. PMID:3243000. |
to investigate the role of the serotonergic nervous system in blood pressure regulation, 5 micrograms of 5-hydroxytryptamine (5-ht) was given i.c.v. |
1989-05-30 |
2023-08-11 |
rat |
| W A Radwan, N A Granger, J M Laude. Development and distribution of serotonin in the central nervous system of Manduca sexta during embryogenesis. I. The brain and frontal ganglion. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 7. issue 1. 1989-05-26. PMID:2711867. |
development of the serotonergic system in the brain and frontal ganglion of the manduca embryo between 35 and 100% of development was studied immunocytochemically with an antiserum to serotonin (5-ht). |
1989-05-26 |
2023-08-11 |
Not clear |
| S de St Hilaire-Kafi, J M Gaillar. Hypnotic action of flunitrazepam in the rat: does 5-HT mechanism play a role? Neuropharmacology. vol 27. issue 12. 1989-05-26. PMID:2977426. |
this study examined whether pharmacological manipulation of serotonergic (5-ht) systems would affect the hypnotic action of flunitrazepam in rats. |
1989-05-26 |
2023-08-11 |
rat |
| H Tamir, K P Liu, R F Payette, S C Hsiung, M Adlersberg, E A Nunez, M D Gersho. Human medullary thyroid carcinoma: characterization of the serotonergic and neuronal properties of a neurectodermally derived cell line. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 9. issue 4. 1989-05-24. PMID:2539440. |
mtc cells also were observed to store endogenous 5-ht, to be able to synthesize 3h-5-ht from 3h-l-tryptophan, and to take up 3h-5-ht from the ambient medium by a carrier-mediated mechanism very similar to that of serotonergic neurons. |
1989-05-24 |
2023-08-11 |
human |
| H Tamir, K P Liu, R F Payette, S C Hsiung, M Adlersberg, E A Nunez, M D Gersho. Human medullary thyroid carcinoma: characterization of the serotonergic and neuronal properties of a neurectodermally derived cell line. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 9. issue 4. 1989-05-24. PMID:2539440. |
in addition, the longterm accumulation of 3h-5-ht in mtc cells was antagonized by reserpine, suggesting that the cells contain 5-ht storage vesicles that, like the synaptic vesicles of serotonergic neurons, are characterized by a reserpine-sensitive transporter of biogenic amines. |
1989-05-24 |
2023-08-11 |
human |
| G A Marks, S G Speciale, H P Roffwar. Sleep state-specific neuronal activity in rat dorsal lateral geniculate nucleus is not altered by local serotonin and norepinephrine depletion. Experimental brain research. vol 74. issue 2. 1989-05-05. PMID:2494051. |
both noradrenergic (ne) and serotonergic (5-ht) systems innervate dlgn and are implicated in sleep-wake control mechanisms. |
1989-05-05 |
2023-08-11 |
rat |
| J Butler, B E Leonar. The platelet serotonergic system in depression and following sertraline treatment. International clinical psychopharmacology. vol 3. issue 4. 1989-05-02. PMID:3235819. |
this preliminary study examined the effect of 8 weeks' treatment with the serotonin (5ht) uptake inhibitor, sertraline, on the platelet serotonergic system in depression. |
1989-05-02 |
2023-08-11 |
Not clear |
| C W Hennig, W C Steinhoff, S A Braughle. Tonic immobility and the serotonergic system in chickens: differential blockade of receptors by cyproheptadine and cinanserin. Physiology & behavior. vol 44. issue 1. 1989-04-28. PMID:3237811. |
cyproheptadine, a serotonergic antagonist, eliminated increases generated by low doses of serotonin and reduced durations in control subjects, but had no effect on the attenuation produced by high doses of the drug. |
1989-04-28 |
2023-08-11 |
human |
| C W Hennig, W C Steinhoff, S A Braughle. Tonic immobility and the serotonergic system in chickens: differential blockade of receptors by cyproheptadine and cinanserin. Physiology & behavior. vol 44. issue 1. 1989-04-28. PMID:3237811. |
cinanserin, another serotonergic blocker, also eliminated the potentiation generated by low doses of serotonin and partially reduced the attenuation caused by high doses, but had no effect on immobility durations in control animals. |
1989-04-28 |
2023-08-11 |
human |
| G Richter-Levin, M Sega. Raphe cells grafted into the hippocampus can ameliorate spatial memory deficits in rats with combined serotonergic/cholinergic deficiencies. Brain research. vol 478. issue 1. 1989-04-27. PMID:2924115. |
the presence of an active serotonergic graft was examined in the intact rat hippocampus using the serotonin releasing drug fenfluramine (ffa). |
1989-04-27 |
2023-08-11 |
rat |
| A de Lorenzo, M Ceccanti, G Assogna, M Romeo, G Cavaleri, M L Attili. Ketanserin, hypertension, and chronic alcoholism: double-blind study in forty patients. International journal of clinical pharmacology research. vol 8. issue 5. 1989-04-19. PMID:3068159. |
in a randomized double-blind trial involving 40 alcoholic hypertensive patients, the antihypertensive activity of ketanserin, a serotonin antagonist with high affinity for s2 serotonergic receptors, was compared with a placebo. |
1989-04-19 |
2023-08-11 |
Not clear |
| C S Brown, T A Kent, S G Bryant, R M Gevedon, J L Campbell, A R Felthous, E S Barratt, R M Ros. Blood platelet uptake of serotonin in episodic aggression. Psychiatry research. vol 27. issue 1. 1989-04-14. PMID:2922444. |
blood platelet uptake of 3h-serotonin (5ht uptake), a potential marker of serotonergic function, was determined in male outpatients with episodic aggression (n = 15) and in age- and sex-matched nonaggressive controls (n = 15). |
1989-04-14 |
2023-08-11 |
Not clear |
| P K Eide, K Hol. Increased behavioural response to intrathecal serotonin after lesion of serotonergic pathways with 5,7-dihydroxytryptamine seems not to be due to depletion of serotonin. Acta physiologica Scandinavica. vol 134. issue 2. 1989-04-06. PMID:2976239. |
increased behavioural response to intrathecal serotonin after lesion of serotonergic pathways with 5,7-dihydroxytryptamine seems not to be due to depletion of serotonin. |
1989-04-06 |
2023-08-11 |
mouse |
| M G van Luijtelaar, H W Steinbusch, J A Tonnae. Aberrant morphology of serotonergic fibers in the forebrain of the aged rat. Neuroscience letters. vol 95. issue 1-3. 1989-03-29. PMID:3226627. |
the morphological aspects and density of the serotonergic innervation in the forebrain of young (2 months) and aged (28-32 months) rats was studied employing immunocytochemistry with an antibody to serotonin. |
1989-03-29 |
2023-08-11 |
rat |
| P K Eide, K Hole, O J Broc. Increased behavioural response to intrathecal substance P after intracerebroventricular 5,7-dihydroxytryptamine but not after p-chlorophenylalanine administration. Acta physiologica Scandinavica. vol 132. issue 3. 1989-03-27. PMID:2465667. |
the behavioural response to intrathecally injected substance p (sp, 1.25 ng) was investigated in mice after lesioning of serotonergic (5-ht) pathways by intracerebroventricular 5,7-dihydroxytryptamine (5,7-dht, 80 micrograms base/mouse) and after 5-ht synthesis inhibition by p-chlorophenylalanine (pcpa, 400 mg kg-1 for 6 consecutive days). |
1989-03-27 |
2023-08-11 |
mouse |
| F Chaouloff, D Laude, D Merino, B Serrurier, J L Elghoz. Peripheral and central consequences of immobilization stress in genetically obese Zucker rats. The American journal of physiology. vol 256. issue 2 Pt 2. 1989-03-23. PMID:2464947. |
thus hypothalamic serotonergic metabolism was analyzed by measuring the concentrations of serotonin (5-hydroxytryptamine, 5-ht), tryptophan (trp; the precursor of 5-ht), and 5-hydroxyindoleacetic acid (5-hiaa; 5-ht metabolite). |
1989-03-23 |
2023-08-11 |
rat |
| K Ohi, S Hayashi, K Takahash. Development of circadian rhythms in rats with lesions of serotonergic system. Physiology & behavior. vol 44. issue 3. 1989-03-23. PMID:3222362. |
in order to assess the role of the serotonergic system in the development of overt circadian rhythms in the rat, serotonin neurons in the brain were destroyed either by thermocoagulation of the median raphe (mrl) or by an intracerebroventricular injection of the neurotoxin, 5,7-dihydroxytryptamine (dht). |
1989-03-23 |
2023-08-11 |
rat |
| D Jackson, J P Bruno, M K Stachowiak, M J Zigmon. Inhibition of striatal acetylcholine release by serotonin and dopamine after the intracerebral administration of 6-hydroxydopamine to neonatal rats. Brain research. vol 457. issue 2. 1989-03-22. PMID:3146404. |
in the accompanying report we observed that endogenous 5-ht, like da, exerts an inhibitory influence on the release of acetylcholine (ach) from striatal slices prepared from control animals and that the extent of this inhibition is related to the degree of serotonergic innervation of the region being examined. |
1989-03-22 |
2023-08-11 |
rat |
| D Jackson, J P Bruno, M K Stachowiak, M J Zigmon. Inhibition of striatal acetylcholine release by serotonin and dopamine after the intracerebral administration of 6-hydroxydopamine to neonatal rats. Brain research. vol 457. issue 2. 1989-03-22. PMID:3146404. |
these results suggest that the serotonergic hyperinnervation of striatum produced by neonatal 6-ohda is accompanied by a loss of the inhibitory influence of endogenous 5-ht and da on striatal ach release and, thus, provide no evidence for a role for either transmitter in the behavioral sparing associated with such lesions. |
1989-03-22 |
2023-08-11 |
rat |
| D Jackson, M K Stachowiak, J P Bruno, M J Zigmon. Inhibition of striatal acetylcholine release by endogenous serotonin. Brain research. vol 457. issue 2. 1989-03-22. PMID:3219554. |
these results suggest that endogenous 5-ht normally is capable of inhibiting striatal ach release, and that the extent of the modulation is related to the degree of serotonergic innervation. |
1989-03-22 |
2023-08-11 |
rat |