| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Humble, B Wisted. Serotonin, panic disorder and agoraphobia: short-term and long-term efficacy of citalopram in panic disorders. International clinical psychopharmacology. vol 6 Suppl 5. 1992-12-23. PMID:1431019. |
the documented antipanic potential of selective serotonin reuptake inhibitors (ssris), are reviewed, lending support for a serotonergic deficit contributing to the pathophysiology of pd. |
1992-12-23 |
2023-08-11 |
Not clear |
| M Humble, B Wisted. Serotonin, panic disorder and agoraphobia: short-term and long-term efficacy of citalopram in panic disorders. International clinical psychopharmacology. vol 6 Suppl 5. 1992-12-23. PMID:1431019. |
thus, an initial deterioration, possibly due to transient decrease of serotonin transmission, turns to improvement when serotonergic potentiation has occurred. |
1992-12-23 |
2023-08-11 |
Not clear |
| C López-Rubalcava, A Saldívar, A Fernández-Guast. Interaction of GABA and serotonin in the anxiolytic action of diazepam and serotonergic anxiolytics. Pharmacology, biochemistry, and behavior. vol 43. issue 2. 1992-12-22. PMID:1359576. |
interaction of gaba and serotonin in the anxiolytic action of diazepam and serotonergic anxiolytics. |
1992-12-22 |
2023-08-11 |
mouse |
| C López-Rubalcava, A Saldívar, A Fernández-Guast. Interaction of GABA and serotonin in the anxiolytic action of diazepam and serotonergic anxiolytics. Pharmacology, biochemistry, and behavior. vol 43. issue 2. 1992-12-22. PMID:1359576. |
the general purpose of the present study was to analyze the possible interactions between the gaba-benzodiazepine and the serotonergic (5-ht) systems in the anxiolytic action of diazepam and the 5-ht1a agonists, ipsapirone, indorenate, and 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat). |
1992-12-22 |
2023-08-11 |
mouse |
| P Preziosi, M D'Amato, R Del Carmine, M Martire, G Pozzoli, P Navarr. The effects of 5-HT3 receptor antagonists on cisplatin-induced emesis in the pigeon. European journal of pharmacology. vol 221. issue 2-3. 1992-12-22. PMID:1426010. |
a serotonergic mechanism appears to be involved in both cisplatin- and 5-ht3 receptor antagonist-induced emesis, since pretreatment with an inhibitor of 5-ht synthesis, para-chlorophenylalanine (pcpa), prevented vomiting induced by either cisplatin or 5-ht3 receptor antagonists. |
1992-12-22 |
2023-08-11 |
pigeon |
| S J Kish, Y Robitaille, L Schut, M el-Awar, M J Ball, K Shanna. Normal serotonin but elevated 5-hydroxyindoleacetic acid concentration in cerebellar cortex of patients with dominantly-inherited olivopontocerebellar atrophy. Neuroscience letters. vol 144. issue 1-2. 1992-12-18. PMID:1279488. |
however, the markedly elevated serotonin turnover ratio suggests the possibility of increased serotonergic neuronal activity, which might alter, and perhaps improve, the functioning of the preserved cerebellar cortical neurones in opca. |
1992-12-18 |
2023-08-11 |
human |
| D Pawlak, D Krygicz, E Chabielska, W Buczk. Influence of acetaldehyde on the vasopressor effect of serotonin in pithed rats. Alcohol and alcoholism (Oxford, Oxfordshire). vol 27. issue 4. 1992-12-18. PMID:1418111. |
our data suggested that the action of acetaldehyde on the effects of serotonin in pithed rats was non-specific and independent of its interaction with serotonergic 5-ht1 and 5-ht2 receptors in blood vessels. |
1992-12-18 |
2023-08-11 |
rat |
| S Puig, J P Rivot, J M Besso. Effect of subcutaneous administration of the chemical algogen formalin, on 5-HT metabolism in the nucleus raphe magnus and the medullary dorsal horn: a voltammetric study in freely moving rats. Brain research. vol 590. issue 1-2. 1992-12-15. PMID:1422833. |
these findings suggest that, depending on the anatomical level (nrm or mdh) and/or the period of observation, one can measure differences in the time-course of the increase in 5-ht metabolism in the nrm-dorsal horn serotonergic system by tonic noxious stimuli, such as the formalin test. |
1992-12-15 |
2023-08-11 |
rat |
| S C Risch, C B Nemerof. Neurochemical alterations of serotonergic neuronal systems in depression. The Journal of clinical psychiatry. vol 53 Suppl. 1992-12-11. PMID:1331029. |
specifically, studies have revealed (1) decreases in brain concentrations of serotonin and decreases in cerebrospinal fluid (csf) concentrations of 5-hydroxyindoleacetic acid (5-hiaa) in a sizeable subgroup of depressed patients; (2) alterations in both presynaptic and postsynaptic cns serotonergic receptors in depressed patients; (3) alterations in putative peripheral markers of cns serotonergic function such as platelet serotonin uptake, platelet [3h]imipramine or [3h]paroxetine binding, platelet 5-ht2 receptor density, and whole blood serotonin content in depressed patients; (4) that virtually all known antidepressant agents, regardless of their receptor-specific properties, have been shown to increase the efficacy of cns serotonergic neurotransmission; (5) that in patients treated with antidepressants who exhibit a remission, rapid depletion of serotonin results in a prompt clinical relapse; and (6) that all known serotonin re-uptake blockers thus far studied have been demonstrated to be clinically effective antidepressant medications. |
1992-12-11 |
2023-08-11 |
Not clear |
| S C Risch, C B Nemerof. Neurochemical alterations of serotonergic neuronal systems in depression. The Journal of clinical psychiatry. vol 53 Suppl. 1992-12-11. PMID:1331029. |
the recent identification and cloning of multiple serotonergic receptor subtypes and the identification and cloning of the serotonin transporter offer further promise for elucidating the role of cns serotonergic neurons in the pathogenesis of depression and, moreover, for the development of innovative treatment strategies for this disorder. |
1992-12-11 |
2023-08-11 |
Not clear |
| R W Fulle. Basic advances in serotonin pharmacology. The Journal of clinical psychiatry. vol 53 Suppl. 1992-12-11. PMID:1429483. |
the introduction of selective inhibitors of serotonin uptake into clinical use has established more firmly the relevance of brain serotonin neurons to depressive illness and is permitting an exploration of other therapeutic consequences of amplifying serotonergic function. |
1992-12-11 |
2023-08-11 |
Not clear |
| R S Kahn, L J Siever, S Gabriel, F Amin, R G Stern, K DuMont, S Apter, M Davidso. Serotonin function in schizophrenia: effects of meta-chlorophenylpiperazine in schizophrenic patients and healthy subjects. Psychiatry research. vol 43. issue 1. 1992-12-09. PMID:1332094. |
the 5ht agonist meta-chlorophenylpiperazine (mcpp) was used as a probe of serotonergic function. |
1992-12-09 |
2023-08-11 |
human |
| M B Emerit, M Riad, M Hamo. Trophic effects of neurotransmitters during brain maturation. Biology of the neonate. vol 62. issue 4. 1992-12-09. PMID:1358226. |
5-ht can also indirectly influence the differentiation of serotonergic neurons by the intermediate of astrocytes, and it was shown in our laboratory that 5-ht1a agonists can stimulate the cholinergic parameters of primary cultures of rat fetal septal neurons. |
1992-12-09 |
2023-08-11 |
rat |
| M E Olds, A Yuwile. Effects of acute and chronic fenfluramine on self-stimulation and its facilitation by amphetamine. European journal of pharmacology. vol 216. issue 3. 1992-12-09. PMID:1425928. |
these findings support a serotonin-dopamine interaction in self-stimulation behavior and suggest that repeated fenfluramine treatment results in chronic low level serotonergic stimulation and diminished serotonin storage capacity. |
1992-12-09 |
2023-08-11 |
rat |
| M E Alburges, M E Hunt, R D McQuade, J K Wamsle. D1-receptor antagonists: comparison of [3H]SCH39166 to [3H]SCH23390. Journal of chemical neuroanatomy. vol 5. issue 5. 1992-12-04. PMID:1358117. |
inhibition of [3h]sch39166 binding by dopaminergic and serotonergic agents supports the hypothesis that this is indeed a d1-specific compound with little overlap onto serotonin (5-ht) receptors. |
1992-12-04 |
2023-08-11 |
Not clear |
| M Medanic, M U Gillett. Serotonin regulates the phase of the rat suprachiasmatic circadian pacemaker in vitro only during the subjective day. The Journal of physiology. vol 450. 1992-12-02. PMID:1432721. |
while serotonin is not endogenous to the scn, a major midbrain hypothalamic afferent pathway is serotonergic. |
1992-12-02 |
2023-08-11 |
rat |
| C Crouzel, M Guillaume, L Barre, C Lemaire, V W Pik. Ligands and tracers for PET studies of the 5-HT system--current status. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. vol 19. issue 8. 1992-11-27. PMID:1428914. |
though, it has not proved possible to recommend tracers or radioligands for the study of other aspects of serotonergic system, prospects for future radiochemical development are indicated, especially for developing radioligands for the 5-ht re-uptake site, and for the 5-ht1 and 5-ht3 receptors. |
1992-11-27 |
2023-08-11 |
Not clear |
| K Aoyagi, Y Oomura, N Shimiz. Concurrent measurement of serotonin metabolism and single neuron activity changes in the lateral hypothalamus of freely behaving rat. Behavioural brain research. vol 49. issue 2. 1992-11-25. PMID:1382449. |
to further investigate the activity of serotonin neurons in relation to feeding behavior, the metabolic activity of the serotonergic system and single neuron activity changes in the lateral hypothalamic area (lha) were investigated concurrently in freely behaving rats. |
1992-11-25 |
2023-08-11 |
rat |
| D L Shuey, T W Sadler, J M Laude. Serotonin as a regulator of craniofacial morphogenesis: site specific malformations following exposure to serotonin uptake inhibitors. Teratology. vol 46. issue 4. 1992-11-23. PMID:1412065. |
from these results it appears that inhibition of 5-ht uptake into craniofacial epithelia may produce developmental defects by interference with serotonergic regulation of epithelial-mesenchymal interactions important for normal craniofacial morphogenesis. |
1992-11-23 |
2023-08-11 |
mouse |
| E S Levine, B L Jacob. Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 10. 1992-11-18. PMID:1357117. |
serotonergic (5-ht) neurons of the brainstem dorsal raphe nucleus (drn) have been implicated in a diversity of physiological and behavioral processes in vertebrates. |
1992-11-18 |
2023-08-11 |
cat |