| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Chen, W Paredes, H M van Praag, E L Gardne. Serotonin denervation enhances responsiveness of presynaptic dopamine efflux to acute clozapine in nucleus accumbens but not in caudate-putamen. Brain research. vol 582. issue 1. 1992-09-14. PMID:1379872. |
since (i) up-regulation of 5ht receptors on da neurons may result from 5ht denervation, (ii) clozapine has potent anti-5ht action, and (iii) 5ht receptors are more dense in acb than cpu, these data appear to add additional weight to previous suggestions that a serotonergic mechanism may partly underlie clozapine's mesolimbic selectivity. |
1992-09-14 |
2023-08-11 |
rat |
| M Rinaldi-Carmona, C Congy, V Santucci, J Simiand, B Gautret, G Neliat, B Labeeuw, G Le Fur, P Soubrie, J C Brelier. Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist. The Journal of pharmacology and experimental therapeutics. vol 262. issue 2. 1992-09-11. PMID:1501121. |
active serotonergic [5-hydroxytryptamine (5-ht2)] receptor antagonist, sr 46349b [trans, 4-([3z)3-(2-dimethylaminoethyl)oxyimino-3(2-flurophenyl++ +)propen-1-yl]phenol hemifumarate) has been characterized by a series of "in vitro" and "in vivo" methods. |
1992-09-11 |
2023-08-11 |
mouse |
| J W Lanc. The pathophysiology of migraine: a tentative synthesis. Pathologie-biologie. vol 40. issue 4. 1992-09-08. PMID:1379708. |
whether the place of 5-ht lies in central pain-control pathways, in the serotonergic project to the cerebral cortex, in a direct action on the cranial blood vessels or in its action at all three sites remains uncertain. |
1992-09-08 |
2023-08-11 |
human |
| W L Woolverto. Determinants of cocaine self-administration by laboratory animals. Ciba Foundation symposium. vol 166. 1992-09-03. PMID:1638910. |
both indirect and direct dopamine agonists can function as positive reinforcers in animals, whereas noradrenergic and serotonergic (5-ht, 5-hydroxytryptamine) agonists have not been found to do so. |
1992-09-03 |
2023-08-11 |
human |
| Q P Ma, J S Ha. Neurochemical and morphological evidence of an antinociceptive neural pathway from nucleus raphe dorsalis to nucleus accumbens in the rabbit. Brain research bulletin. vol 28. issue 6. 1992-08-28. PMID:1638420. |
horseradish peroxidase (hrp) retrograde tracing in combination with 5-hydroxytryptamine (5-ht) immunocytochemistry revealed a serotonergic projection from the nrd and ventral pag to the nucleus accumbens in the rabbit. |
1992-08-28 |
2023-08-11 |
rabbit |
| P Broqua, V Baudrie, F Chaoulof. Differential effects of the novel antidepressant tianeptine on L-5-hydroxytryptophan (5-HTP)-elicited corticosterone release and body weight loss. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 2. issue 2. 1992-08-25. PMID:1633432. |
these results suggest that tianeptine preferentially activates 5-ht reuptake in central serotonergic neurones. |
1992-08-25 |
2023-08-11 |
rat |
| B Söderpalm, J A Enge. Serotonergic involvement in conflict behaviour. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 1. issue 1. 1992-08-25. PMID:2136217. |
the effects of different manipulations of brain serotonergic (5-ht) systems were investigated in montgomery's conflict test, an animal anxiety model based on the animal's inborn urge to explore a new environment and its simultaneous fear of elevated, open spaces. |
1992-08-25 |
2023-08-11 |
Not clear |
| D C Merz, P Drapea. Cell-specific contact selects transmitter responses in an identified leech neuron. Proceedings. Biological sciences. vol 248. issue 1322. 1992-08-19. PMID:1352889. |
non-synaptic sensory cells, non-serotonergic pre- and postsynaptic partners and serotonergic neurons that do not form chemical synapses with the p cell failed to alter its responses to 5-ht. |
1992-08-19 |
2023-08-11 |
Not clear |
| D C Merz, P Drapea. Cell-specific contact selects transmitter responses in an identified leech neuron. Proceedings. Biological sciences. vol 248. issue 1322. 1992-08-19. PMID:1352889. |
the selective reduction of the extrasynaptic response to 5-ht in the p cell therefore appears to be induced specifically by contact with its only known serotonergic partner during neuronal recognition leading to synapse formation. |
1992-08-19 |
2023-08-11 |
Not clear |
| S J Peroutka, A J Sleight, B G McCarthy, P A Pierce, A W Schmidt, C R Hekmatpana. The clinical utility of pharmacological agents that act at serotonin receptors. The Journal of neuropsychiatry and clinical neurosciences. vol 1. issue 3. 1992-08-18. PMID:2562495. |
the increasing ability to modulate serotonergic neurotransmission through distinct 5-ht receptor subtypes should greatly facilitate the analysis of 5-ht in both normal and abnormal human brain function. |
1992-08-18 |
2023-08-11 |
human |
| G Bonvento, B Scatton, Y Claustre, L Rouquie. Effect of local injection of 8-OH-DPAT into the dorsal or median raphe nuclei on extracellular levels of serotonin in serotonergic projection areas in the rat brain. Neuroscience letters. vol 137. issue 1. 1992-08-07. PMID:1385646. |
effect of local injection of 8-oh-dpat into the dorsal or median raphe nuclei on extracellular levels of serotonin in serotonergic projection areas in the rat brain. |
1992-08-07 |
2023-08-11 |
rat |
| E F Coccar. Impulsive aggression and central serotonergic system function in humans: an example of a dimensional brain-behavior relationship. International clinical psychopharmacology. vol 7. issue 1. 1992-08-07. PMID:1624755. |
a dimensional relationship between central serotonergic (5-ht) system function and indices of suicidal and impulsive aggressive behaviors has been suggested by more than a decade of research in patients with psychiatric disorders. |
1992-08-07 |
2023-08-11 |
Not clear |
| J V Lucey, G Butcher, A W Clare, T G Dina. Buspirone induced prolactin responses in obsessive-compulsive disorder (OCD): is OCD a 5-HT2 receptor disorder? International clinical psychopharmacology. vol 7. issue 1. 1992-08-07. PMID:1624756. |
buspirone (busp) is a serotonergic (5-ht) agonist with activity at the 5-ht1a receptor. |
1992-08-07 |
2023-08-11 |
Not clear |
| N Shimizu, S Take, T Hori, Y Oomur. In vivo measurement of hypothalamic serotonin release by intracerebral microdialysis: significant enhancement by immobilization stress in rats. Brain research bulletin. vol 28. issue 5. 1992-08-05. PMID:1377587. |
immobilization-stress caused an immediate increase in both the extracellular serotonin and 5-hiaa in the hypothalamus, suggesting that the hypothalamic serotonergic system is activated during immobilization stress. |
1992-08-05 |
2023-08-11 |
rat |
| R Bertorelli, D Amoroso, P Girotti, S Consol. Effect of tianeptine on the central cholinergic system: involvement of serotonin. Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 3. 1992-08-05. PMID:1620232. |
impairment of serotonergic (5-ht) neurotransmission by chemical lesion of the median raphe nucleus or by metergoline, a blocker of 5-ht receptors, antagonized the cholinergic effect of tianeptine. |
1992-08-05 |
2023-08-11 |
rat |
| R Gaggi, A M Gianni, L Chirivi, P Roncad. Effects of nimodipine on biogenic amines in discrete brain areas. Pharmacology. vol 44. issue 5. 1992-07-31. PMID:1377827. |
since the 5-hiaa/5-hydroxytryptamine (5-ht) ratio was increased, whereas the dopac/dopamine (da) and hva/da ratios were decreased, it was argued that nimodipine activated the serotonergic and inhibited the dopaminergic systems. |
1992-07-31 |
2023-08-11 |
rat |
| C M Meston, B B Gorzalk. Psychoactive drugs and human sexual behavior: the role of serotonergic activity. Journal of psychoactive drugs. vol 24. issue 1. 1992-07-31. PMID:1619520. |
in this review, a wide range of drugs that affect both brain serotonergic systems and human sexual behavior is examined in an effort to determine the possible role of serotonin in human sexual behavior. |
1992-07-31 |
2023-08-11 |
human |
| C H Schenck, M W Mahowald, S W Kim, K A O'Connor, T D Hurwit. Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder. Sleep. vol 15. issue 3. 1992-07-31. PMID:1621023. |
the effect of fluoxetine, a potent and specific serotonin reuptake inhibitor, on nrem eye movements is postulated to derive from potentiation of serotonergic neurons that inhibit brainstem "omnipause neurons", which, in turn, inhibit saccadic eye movements, thus resulting in disinhibited release of saccades. |
1992-07-31 |
2023-08-11 |
Not clear |
| P J Currie, L M Wilso. Central injection of 5-hydroxytryptamine reduces food intake in obese and lean mice. Neuroreport. vol 3. issue 1. 1992-07-29. PMID:1611036. |
although these results are consisted with a role for serotonin in the control of food intake in mice, the altered sensitivity of the ob/ob to serotonergic stimulation may result, in part, from an impaired satiety control mechanism in this mutant. |
1992-07-29 |
2023-08-11 |
mouse |
| A Takada, Y Takad. [Inhibition of serotonin-induced platelet aggregation by endothelins]. Nihon rinsho. Japanese journal of clinical medicine. vol 50. issue 2. 1992-07-28. PMID:1613985. |
in order to investigate the possible interaction between endothelins and human platelet serotonergic receptors, their effect on the platelet aggregation, induced by serotonin, was studied. |
1992-07-28 |
2023-08-11 |
human |