| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T E Robinson, E Castañeda, I Q Whisha. Effects of cortical serotonin depletion induced by 3,4-methylenedioxymethamphetamine (MDMA) on behavior, before and after additional cholinergic blockade. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 8. issue 1. 1993-02-26. PMID:8093836. |
it is concluded that the extent of serotonergic denervation produced by mdma is not sufficient to produce marked and lasting behavioral deficits, possibly because of neurocompensatory changes in the remaining serotonin terminals. |
1993-02-26 |
2023-08-12 |
human |
| Z Cohen, G Bovento, P Lacombe, J Seylaz, E T MacKenzie, E Hame. Cerebrovascular nerve fibers immunoreactive for tryptophan-5-hydroxylase in the rat: distribution, putative origin and comparison with sympathetic noradrenergic nerves. Brain research. vol 598. issue 1-2. 1993-02-25. PMID:1486481. |
the distribution of serotonergic nerves in major basal and isolated small pial arteries (diameter > or = 50 microns) was investigated immunohistochemically using an antibody directed against tryptophan-5-hydroxylase (tpoh), the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine (5-ht or serotonin), and compared to that of the noradrenergic system labeled for the selective noradrenaline (na) synthesizing enzyme, dopamine-beta-hydroxylase (dbh). |
1993-02-25 |
2023-08-11 |
rat |
| W J de Ridder, J A Schuurke. Cisapride and 5-hydroxytryptamine enhance motility in the canine antrum via separate pathways, not involving 5-hydroxytryptamine1,2,3,4 receptors. The Journal of pharmacology and experimental therapeutics. vol 264. issue 1. 1993-02-23. PMID:8093733. |
in vitro studies on the guinea pig ileum suggest that their effect is mediated via serotonergic 5-hydroxytryptamine (5-ht4) receptors, resulting in a facilitation of cholinergic neurotransmission. |
1993-02-23 |
2023-08-12 |
rat |
| S W Watts, M L Cohe. Further evidence that the guinea pig tracheal contractile serotonergic receptor is a 5-hydroxytryptamine2 receptor: use of 5-methyltryptamine and dipropyl-5-carboxamidotryptamine. The Journal of pharmacology and experimental therapeutics. vol 264. issue 1. 1993-02-23. PMID:8423530. |
as antagonists, both 5-mt and dp-5-ct inhibited tracheal contraction to 5-ht, indicating interaction with the same receptor as 5-ht and confirming partial serotonergic agonist activity. |
1993-02-23 |
2023-08-12 |
Not clear |
| M Orosco, S Nicolaidi. Spontaneous feeding-related monoaminergic changes in the rostromedial hypothalamus revealed by microdialysis. Physiology & behavior. vol 52. issue 5. 1993-02-18. PMID:1484832. |
concerning serotonergic changes, the sharp 5-ht release during the meal would be a signal of satiation (transient preabsorptive fullness) while the longer-lasting increase in 5-hiaa, reflecting 5-ht synthesis, would be associated with satiety (more persistent postabsorptive state substituting satiation). |
1993-02-18 |
2023-08-11 |
Not clear |
| N Adham, H T Kao, L E Schecter, J Bard, M Olsen, D Urquhart, M Durkin, P R Hartig, R L Weinshank, T A Branche. Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 2. 1993-02-18. PMID:8380639. |
competition studies revealed the following rank order of potencies for serotonergic ligands: 5-ht > sumatriptan >> 5-carboxyamidotryptamine > 8-hydroxy-2(di-1-propylamino)tetralin > spiperone. |
1993-02-18 |
2023-08-12 |
human |
| P Jäkälä, J Sirviö, J Jolkkonen, P Riekkinen, L Acsady, P Riekkine. The effects of p-chlorophenylalanine-induced serotonin synthesis inhibition and muscarinic blockade on the performance of rats in a 5-choice serial reaction time task. Behavioural brain research. vol 51. issue 1. 1993-02-17. PMID:1282817. |
the effects of serotonergic dysfunction induced by treatment with p-chlorophenylalanine (pcpa), an inhibitor of serotonin synthesis, and cholinergic dysfunction induced by scopolamine on the performance of adult rats in the 5-choice serial reaction time task measuring selective attention were studied. |
1993-02-17 |
2023-08-11 |
rat |
| P Celada, J Pérez, E Alvarez, F Artiga. Monoamine oxidase inhibitors phenelzine and brofaromine increase plasma serotonin and decrease 5-hydroxyindoleacetic acid in patients with major depression: relationship to clinical improvement. Journal of clinical psychopharmacology. vol 12. issue 5. 1993-02-10. PMID:1282522. |
we have examined the effects of two monoamine oxidase (mao) inhibitors with different mechanisms of action--phenelzine and brofaromine--on peripheral serotonergic (5-hydroxytryptamine [5-ht]) measures, sensitive to the inhibition of mao-a (intra- and extracellular 5-ht and related metabolites in blood). |
1993-02-10 |
2023-08-11 |
Not clear |
| H Tamir, S C Hsiung, P Y Yu, K P Liu, M Adlersberg, E A Nunez, M D Gersho. Serotonergic signalling between thyroid cells: protein kinase C and 5-HT2 receptors in the secretion and action of serotonin. Synapse (New York, N.Y.). vol 12. issue 2. 1993-02-08. PMID:1336223. |
serotonergic signalling between thyroid cells: protein kinase c and 5-ht2 receptors in the secretion and action of serotonin. |
1993-02-08 |
2023-08-11 |
Not clear |
| K T Sillar, J F Wedderburn, A J Simmer. Modulation of swimming rhythmicity by 5-hydroxytryptamine during post-embryonic development in Xenopus laevis. Proceedings. Biological sciences. vol 250. issue 1328. 1993-02-02. PMID:1361984. |
to begin to examine whether serotonergic neurons of brainstem raphe nuclei might have a role in this swimming development, we have studied the effects of 5-hydroxytryptamine (5ht) on fictive swimming in embryonic and larval animals. |
1993-02-02 |
2023-08-11 |
xenopus_laevis |
| N Bel, F Artiga. Fluvoxamine preferentially increases extracellular 5-hydroxytryptamine in the raphe nuclei: an in vivo microdialysis study. European journal of pharmacology. vol 229. issue 1. 1993-02-01. PMID:1282104. |
these results confirm that 5-ht uptake inhibitors preferentially increase extracellular concentrations of 5-ht in the vicinity of cell bodies and dendrites of serotonergic neurones. |
1993-02-01 |
2023-08-11 |
rat |
| M C Fisher, R J Bodna. 2-Deoxy-D-glucose antinociception and serotonin receptor subtype antagonists: test-specific effects in rats. Pharmacology, biochemistry, and behavior. vol 43. issue 4. 1993-02-01. PMID:1475308. |
although 2-dg antinociception was not affected by tryptophan hydroxylase inhibition, a possible serotonergic role in 2-dg antinociception was investigated because of the existence of serotonin [5-hydroxytryptamine (5-ht)] receptor subtypes. |
1993-02-01 |
2023-08-11 |
rat |
| G Muñoz-Acedo, S López-Sañudo, E Arill. Reduction of somatostatin receptors in rat hippocampus by treatment with 5,7-dihydroxytryptamine. Neuroscience letters. vol 146. issue 1. 1993-01-29. PMID:1361978. |
to assess whether ss acts presynaptically on serotonin (5-hydroxytryptamine, (5-ht)) neurons, ss receptors were measured in membranes from the hippocampus, a brain region that receives dense serotonergic innervation and has a high number of ss receptors in control and 5,7-dihydroxytryptamine (5,7-dht)-treated rats, at 1 and 3 weeks after injection. |
1993-01-29 |
2023-08-11 |
rat |
| P Navarra, M Martire, R del Carmine, G Pozzoli, P Prezios. A dual effect of some 5-HT3 receptor antagonists on cisplatin-induced emesis in the pigeon. Toxicology letters. vol 64-65 Spec No. 1993-01-25. PMID:1471230. |
a serotonergic mechanism appears to be involved in both cisplatin- and 5-ht3 receptor antagonist-induced emesis, since pretreatment with an inhibitor of 5-ht synthesis, para-chlorophenylalanine (300 mg/kg x 3 days), is able to hamper vomiting induced by either cisplatin or 5-ht3 receptor antagonists. |
1993-01-25 |
2023-08-11 |
pigeon |
| Y Watanabe, E Gould, D C Daniels, H Cameron, B S McEwe. Tianeptine attenuates stress-induced morphological changes in the hippocampus. European journal of pharmacology. vol 222. issue 1. 1993-01-22. PMID:1468492. |
because tianeptine is known to enhance neural uptake of serotonin, these results suggest that the serotonergic system may be involved in modulating stress and corticosterone effects on dendritic morphology. |
1993-01-22 |
2023-08-11 |
rat |
| R W Fulle. The involvement of serotonin in regulation of pituitary-adrenocortical function. Frontiers in neuroendocrinology. vol 13. issue 3. 1993-01-14. PMID:1334001. |
the physiological role of this stimulatory serotonergic influence on pituitary-adrenocortical function is still not well understood, but serotonin may play a role in circadian rhythmicity of adrenocortical secretion and in the activation of pituitary-adrenocortical function by certain types of stress. |
1993-01-14 |
2023-08-11 |
rat |
| R W Fulle. The involvement of serotonin in regulation of pituitary-adrenocortical function. Frontiers in neuroendocrinology. vol 13. issue 3. 1993-01-14. PMID:1334001. |
measurement of acth or cortisol levels in humans after administration of a direct- or indirect-acting serotonin agonist provides one means of probing the functional state of brain serotonergic systems in disease or after drug treatment. |
1993-01-14 |
2023-08-11 |
rat |
| K J Simansky, J Jakubow, F C Sisk, A H Vaidya, K Eberle-Wan. Peripheral serotonin is an incomplete signal for eliciting satiety in sham-feeding rats. Pharmacology, biochemistry, and behavior. vol 43. issue 3. 1992-12-30. PMID:1448479. |
the actions of 5-ht on feeding and resting were behaviorally selective because serotonergic treatment did not retard the beginning of feeding, alter sham drinking of water, or reduce investigation by food-deprived rats of a novel object in an open field. |
1992-12-30 |
2023-08-11 |
rat |
| J Butler, A O'Halloran, B E Leonar. The Galway Study of Panic Disorder. II: Changes in some peripheral markers of noradrenergic and serotonergic function in DSM III-R panic disorder. Journal of affective disorders. vol 26. issue 2. 1992-12-29. PMID:1447432. |
the results of this study suggest that, despite clinical improvement, the peripheral markers of both adrenergic (platelet aggregation to noradrenaline, platelet alpha 2 receptor density and lymphocyte beta receptor density) and serotonergic (platelet aggregation to serotonin, 3h-ketanserin binding to platelet 5ht2 receptors and 3h-5ht uptake into platelets) function largely remained abnormal. |
1992-12-29 |
2023-08-11 |
Not clear |
| J E Macor, J Blake, C B Fox, C Johnson, B K Koe, L A Lebel, J M Morrone, K Ryan, A W Schmidt, D W Schul. Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin. Journal of medicinal chemistry. vol 35. issue 23. 1992-12-28. PMID:1447752. |
synthesis and serotonergic pharmacology of the enantiomers of 3-[(n-methylpyrrolidin-2-yl)methyl]-5-methoxy-1h-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin. |
1992-12-28 |
2023-08-11 |
Not clear |