| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Ahleniu. Brain monoaminergic neurotransmission in the mediation of lordosis behavior in the female rat. Neuroscience and biobehavioral reviews. vol 17. issue 1. 1993-04-20. PMID:8384349. |
following the initial observations by meyerson and his colleagues in the early 1960s, demonstrating an inhibitory serotonergic mechanism, continued studies have identified 5-hydroxytryptamine (5-ht) 5-ht1a receptors to be of particular importance. |
1993-04-20 |
2023-08-12 |
rat |
| D S Kreiss, S Wieland, I Luck. The presence of a serotonin uptake inhibitor alters pharmacological manipulations of serotonin release. Neuroscience. vol 52. issue 2. 1993-04-15. PMID:7680787. |
the blockade of fenfluramine's effects by citalopram supports the hypothesis that transport of fenfluramine into serotonergic neurons is necessary to increase serotonin release. |
1993-04-15 |
2023-08-12 |
Not clear |
| P Mathiau, D Riche, G Behzadi, V Dimitriadou, P Aubinea. Absence of serotonergic innervation from raphe nuclei in rat cerebral blood vessels--I. Histological evidence. Neuroscience. vol 52. issue 3. 1993-04-15. PMID:7680791. |
anterograde tracing from dorsal raphe neurons by phaseolus vulgaris leucoagglutinin and serotonin immunocytochemistry revealed no serotonergic projections from raphe nuclei to cerebral pial vessels in the rat. |
1993-04-15 |
2023-08-12 |
rat |
| I D Hentall, M J Andresen, K Taguch. Serotonergic, cholinergic and nociceptive inhibition or excitation of raphe magnus neurons in barbiturate-anesthetized rats. Neuroscience. vol 52. issue 2. 1993-04-15. PMID:8450948. |
they were then subjected to iontophoresis of serotonin, some serotonergic agonists and antagonists, acetylcholine, and gamma-amino-n-butyric acid. |
1993-04-15 |
2023-08-12 |
rat |
| M C Ritz, F R Georg. Cocaine-induced seizures and lethality appear to be associated with distinct central nervous system binding sites. The Journal of pharmacology and experimental therapeutics. vol 264. issue 3. 1993-04-14. PMID:8450469. |
these findings suggest that, although seizure initiation may depend primarily on affinity of cocaine and related compounds for binding sites associated with the serotonin transporter, the seizure-inducing properties of cocaine may ultimately depend on a final summation of its effects not only on serotonergic systems, but on muscarinic and sigma neuronal systems as well. |
1993-04-14 |
2023-08-12 |
Not clear |
| C J Helke, C H McDonald, E T Phillip. Hypotensive effects of 5-HT1A receptor activation: ventral medullary sites and mechanisms of action in the rat. Journal of the autonomic nervous system. vol 42. issue 2. 1993-04-13. PMID:8450176. |
the role of serotonergic terminals in mediating the responses of 8-oh-dpat was evaluated in animals pretreated with the serotonin nerve toxin, 5,7-dihydroxytryptamine (5,7-dht). |
1993-04-13 |
2023-08-12 |
rat |
| N F Tajuddin, M J Drus. Treatment of pregnant alcohol-consuming rats with buspirone: effects on serotonin and 5-hydroxyindoleacetic acid content in offspring. Alcoholism, clinical and experimental research. vol 17. issue 1. 1993-04-12. PMID:7680841. |
because of the importance of fetal serotonin (5-ht) and 5-ht1a receptors for the normal development of 5-ht containing neurons, we initiated studies to determine whether administration of a 5-ht1a agonist, buspirone, to pregnant rats could overcome the adverse effects of in utero ethanol exposure on the developing serotonergic system in offspring. |
1993-04-12 |
2023-08-12 |
rat |
| N F Tajuddin, M J Drus. Treatment of pregnant alcohol-consuming rats with buspirone: effects on serotonin and 5-hydroxyindoleacetic acid content in offspring. Alcoholism, clinical and experimental research. vol 17. issue 1. 1993-04-12. PMID:7680841. |
these results suggest that the abnormal development of cortical projections of serotonergic neurons may be due in part to the low fetal 5-ht content in ethanol-exposed rats and may potentially be overcome by in utero treatment with a 5-ht1a agonist. |
1993-04-12 |
2023-08-12 |
rat |
| R A Stone, Y M Worsdell, R W Fuller, P J Barne. Effects of 5-hydroxytryptamine and 5-hydroxytryptophan infusion on the human cough reflex. Journal of applied physiology (Bethesda, Md. : 1985). vol 74. issue 1. 1993-04-06. PMID:8444719. |
to investigate whether serotonergic mechanisms influence the control of the human cough reflex, we have induced cough responses before and during infusions of 5-ht; its precursor 5-hydroxytryptophan (5-htp), which, in contrast to 5-ht, crosses the blood-brain barrier; and saline control. |
1993-04-06 |
2023-08-12 |
human |
| U Hegerl, H Wulff, B Müller-Oerlinghause. Intensity dependence of auditory evoked potentials and clinical response to prophylactic lithium medication: a replication study. Psychiatry research. vol 44. issue 3. 1993-03-25. PMID:1289916. |
since a steep asf slope seems to indicate low central serotonergic function, it is speculated that a steep asf slope characterizes those patients with a serotonin deficit who respond to serotonin agonists like lithium. |
1993-03-25 |
2023-08-11 |
Not clear |
| S Puig, J P Rivot, J M Besso. Effects of tianeptine on 5-hydroxyindoles and on the morphine-induced increase in 5-HT metabolism at the medullary dorsal horn level as measured by in vivo voltammetry in freely moving rats. Brain research. vol 600. issue 2. 1993-03-23. PMID:7679603. |
the present study, by the use of in vivo electrochemical detection of 5-hydroxyindole (peak '3') in the bulbo spinal serotonergic system at the medullary dorsal horn (mdh) level, investigated the effects of the new tricyclic antidepressant (tca) tianeptine, which has been shown to be a specific serotonin (5-ht) uptake enhancer. |
1993-03-23 |
2023-08-12 |
rat |
| E Monferini, P Gaetani, R Rodriguez y Baena, E Giraldo, M Parenti, A Zocchetti, C A Rizz. Pharmacological characterization of the 5-hydroxytryptamine receptor coupled to adenylyl cyclase stimulation in human brain. Life sciences. vol 52. issue 9. 1993-03-22. PMID:8437506. |
recently, a 5-hydroxytryptamine (5-ht) receptor has been described, whose pharmacology was distinct from that of the already known serotonergic receptors, so that it has been called 5-ht4. |
1993-03-22 |
2023-08-12 |
mouse |
| G Muñoz-Acedo, S López-Sañudo, E Arill. Effect of serotonin axon injury on the somatostatinergic system in rat frontoparietal cortex. Life sciences. vol 52. issue 9. 1993-03-22. PMID:8437509. |
in order to investigate the possibility that, in the rat, some cerebral cortex somatostatin (ss) receptors may be localized presynaptically on the terminals of serotonergic neurons, serotonin [5-hydroxytryptamine, (5-ht)] neurons in the central nervous system were damaged with a local intracerebral injection of the serotonergic neurotoxin, 5,7-dihydroxytryptamine(5,7-dht). |
1993-03-22 |
2023-08-12 |
rat |
| S K Bhattacharya, A P Se. Effects of muscarinic receptor agonists and antagonists on rat brain serotonergic activity. Journal of neural transmission. General section. vol 90. issue 3. 1993-03-18. PMID:1283683. |
the effects of some muscarinic m1 and m2 receptor agonists and antagonists on rat brain serotonergic activity was assessed by noting their effects on the levels of 5-hydroxytryptamine (5-ht) and its major metabolite, 5-hydroxyindole acetic acid (5-hiaa), estimated by a high pressure-liquid chromatographic (hplc) technique. |
1993-03-18 |
2023-08-11 |
rat |
| M Frankfurt, S D Mendelson, C R McKittrick, B S McEwe. Alterations of serotonin receptor binding in the hypothalamus following acute denervation. Brain research. vol 601. issue 1-2. 1993-03-17. PMID:8431786. |
quantitative autoradiography was used to determine the effect of acute serotonergic denervation with 5,7-dihydroxytryptamine (5,7-dht) or serotonin 5ht1a and 5-ht1b receptors in male rats. |
1993-03-17 |
2023-08-12 |
rat |
| E B Erdtsieck-Ernste, M G Feenstra, M Botterblom, G J Boe. Postnatal exposure to the beta-adrenoceptor agonist clenbuterol has regionally selective direct and long-term effects on rat brain beta-adrenoceptors and monoamine metabolism. Brain research. Developmental brain research. vol 71. issue 1. 1993-03-15. PMID:7679335. |
the serotonergic (5-ht) and dopaminergic (da) system were not altered. |
1993-03-15 |
2023-08-12 |
rat |
| D L Shuey, T W Sadler, H Tamir, J M Laude. Serotonin and morphogenesis. Transient expression of serotonin uptake and binding protein during craniofacial morphogenesis in the mouse. Anatomy and embryology. vol 187. issue 1. 1993-03-11. PMID:8430902. |
whole mouse embryos were incubated in the presence of various serotonergic compounds followed by immunocytochemical localization of serotonin (5-ht) and its binding protein. |
1993-03-11 |
2023-08-12 |
mouse |
| P C Waldmeie. Newer aspects of the reversible inhibitor of MAO-A and serotonin reuptake, brofaromine. Progress in neuro-psychopharmacology & biological psychiatry. vol 17. issue 2. 1993-03-10. PMID:8430214. |
the evidence is discussed that 5-ht uptake inhibition by brofaromine is relevant in its therapeutic effect in humans and may synergize with mao-a inhibition, thus enhancing the impact of the latter on serotonergic transmission. |
1993-03-10 |
2023-08-12 |
human |
| B Poeschla, J Gibbs, K J Simansky, D Greenberg, G P Smit. Cholecystokinin-induced satiety depends on activation of 5-HT1C receptors. The American journal of physiology. vol 264. issue 1 Pt 2. 1993-03-05. PMID:8430887. |
to investigate the dependence of the satiating action of cholecystokinin on serotonergic function in rats, we examined the effects of systemic pretreatment with serotonin (5-ht) antagonists of varying selectivity for 5-ht receptor subtypes on suppression of food intake induced by systemic administration of cholecystokinin octapeptide (cck-8). |
1993-03-05 |
2023-08-12 |
rat |
| S L Rauch, M A Jenik. Neurobiological models of obsessive-compulsive disorder. Psychosomatics. vol 34. issue 1. 1993-03-02. PMID:8426888. |
a review of neuropharmacological concepts related to the serotonergic (5-ht) hypothesis of ocd is also presented. |
1993-03-02 |
2023-08-12 |
Not clear |