| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Endo, K Morita, Y Uchiyama, K Takada, A Tsujimoto, T Doh. Involvement of brain serotonergic function in lidocaine-induced convulsions in mice. Japanese journal of pharmacology. vol 62. issue 3. 1993-11-22. PMID:8411779. |
agents that suppressed serotonergic transmission increased, whereas drugs that facilitated serotonin (5-ht) function decreased the incidence of lidocaine-induced convulsions. |
1993-11-22 |
2023-08-12 |
mouse |
| S P Bailey, J M Davis, E N Ahlbor. Serotonergic agonists and antagonists affect endurance performance in the rat. International journal of sports medicine. vol 14. issue 6. 1993-11-18. PMID:8407063. |
the purpose of this experiment was to examine the effects of administration of serotonergic (5-ht) agonist and antagonist drugs on run-time to exhaustion (run-exh) in male and female rats. |
1993-11-18 |
2023-08-12 |
rat |
| P T Francis, C Holmes, M T Webster, G C Stratmann, A W Procter, D M Bowe. Preliminary neurochemical findings in non-Alzheimer dementia due to lobar atrophy. Dementia (Basel, Switzerland). vol 4. issue 3-4. 1993-11-16. PMID:8401788. |
serotonin receptors were markedly reduced (based on pick cases) whereas measures that reflected presynaptic serotonergic activity were either not affected or increased. |
1993-11-16 |
2023-08-12 |
Not clear |
| S Puig, J P Rivot, J M Besso. Effect of RU 24969 on 5-HT metabolism in the medullary dorsal horn as studied by in vivo voltammetry. Brain research. vol 618. issue 1. 1993-11-15. PMID:8402172. |
with reference to similar in vivo studies demonstrating the responsiveness of ascending serotonergic systems to ru 24969, it is concluded that the 5-ht metabolism in the serotonergic nmr-dorsal horn system is affected by this 5-ht1b agonist. |
1993-11-15 |
2023-08-12 |
rat |
| B Arranz, A Eriksson, E Mellerup, P Plenge, J Marcusso. Effect of aging in human cortical pre- and postsynaptic serotonin binding sites. Brain research. vol 620. issue 1. 1993-11-09. PMID:8402192. |
furthermore, aging does not seem to be associated with a reduced cortical serotonergic innervation, as indicated by the stability of the [3h]paroxetine-labeled 5-ht uptake sites. |
1993-11-09 |
2023-08-12 |
human |
| R I Westphalen, P R Dod. The regeneration of d,l-fenfluramine-destroyed serotonergic nerve terminals. European journal of pharmacology. vol 238. issue 2-3. 1993-11-09. PMID:8405109. |
treating rats with fenfluramine (80 mg/kg over 2 days) destroyed 80% of serotonergic nerve terminals, indicated by reduced maximal [3h]paroxetine binding to 5-hydroxytryptamine (5-ht) uptake sites on synaptic membranes (bmax) and maximal [14c]5-ht uptake rate into synaptosomes (vmax). |
1993-11-09 |
2023-08-12 |
rat |
| R I Westphalen, P R Dod. The regeneration of d,l-fenfluramine-destroyed serotonergic nerve terminals. European journal of pharmacology. vol 238. issue 2-3. 1993-11-09. PMID:8405109. |
maximal synaptosomal loading (alpha) with [14c]5-ht also recovered (to 79% of control), reflecting an increased number of serotonergic synaptosomes. |
1993-11-09 |
2023-08-12 |
rat |
| S C Cheetham, J A Viggers, N A Slater, D J Heal, W R Bucket. [3H]paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments. Neuropharmacology. vol 32. issue 8. 1993-11-09. PMID:8413837. |
paroxetine is a selective and potent inhibitor of 5-hydroxytryptamine (5-ht) uptake into serotonergic neurones. |
1993-11-09 |
2023-08-12 |
rat |
| B D Sloley, S Orikasa, A A Boulto. Catabolism of intracerebroventricularly injected 5-hydroxytryptamine in mouse: effect of coinjection of tryptamine and several pretreatments. Canadian journal of physiology and pharmacology. vol 71. issue 3-4. 1993-11-04. PMID:8402383. |
this catabolism is not affected by inhibition of presynaptic uptake, 5-hydroxytryptamine receptor type 1 or type 2 blockade, or destruction of serotonergic nerve terminals. |
1993-11-04 |
2023-08-12 |
mouse |
| H Sommermeyer, R Schreiber, J M Greuel, J De Vry, T Glase. Anxiolytic effects of the 5-HT1A receptor agonist ipsapirone in the rat: neurobiological correlates. European journal of pharmacology. vol 240. issue 1. 1993-11-02. PMID:7691626. |
in the hippocampus, one of the projection areas of the serotonergic dorsal raphe neurons, systemic application of ipsapirone resulted in a dose- and time-dependent reduction in serotonergic neurotransmission, measured as a reduced serotonin output in microdialysis experiments with freely moving rats. |
1993-11-02 |
2023-08-12 |
rat |
| J H McLean, M T Shipley, D I Bernstein, D Corbet. Selective lesions of neural pathways following viral inoculation of the olfactory bulb. Experimental neurology. vol 122. issue 2. 1993-10-26. PMID:8104818. |
short-term (2-5 days postinjection) studies using immunocytochemical colocalization of virus and transmitter markers showed that cholinergic (ach) neurons in the horizontal nucleus of the diagonal band, serotonergic (5-ht) neurons in the dorsal and median raphe nuclei, and noradrenergic (ne) neurons in the lc became infected with virus. |
1993-10-26 |
2023-08-12 |
rat |
| R D Porsol. Serotonin: neurotransmitter "a la mode". Report on the Third International I.T.E.M.-LABO symposium on strategies in psychopharmacology: serotonin: animal models and clinical targets. Pharmacopsychiatry. vol 26. issue 1. 1993-10-21. PMID:8378408. |
the recently held symposium "serotonin: animal models and clinical targets" (paris, 26-28th february 1992) reviewed the present status of new serotonergic drugs. |
1993-10-21 |
2023-08-12 |
Not clear |
| J A Harvey, S E McMaster, A G Roman. Methylenedioxyamphetamine: neurotoxic effects on serotonergic projections to brainstem nuclei in the rat. Brain research. vol 619. issue 1-2. 1993-10-20. PMID:7690669. |
the neurotoxic effects of mda on serotonergic projections to forebrain and brainstem were completely blocked by the prior administration of the 5-ht reuptake inhibitor, fluoxetine. |
1993-10-20 |
2023-08-12 |
rat |
| A S Linden, D J Desmecht, H Amory, F A Rollin, P M Lekeu. Comparison of three metrenperone dosage regimens inhibiting the 5-hydroxytryptamine-induced pulmonary dysfunction in cattle. Research in veterinary science. vol 55. issue 1. 1993-10-19. PMID:8378609. |
the effects of a 5-hydroxytryptamine (5-ht) challenge infusion on pulmonary function values were studied in healthy calves, pretreated with varying doses of metrenperone, a selective type 2 serotonergic (5-ht2) antagonist. |
1993-10-19 |
2023-08-12 |
cattle |
| R I Westphalen, P R Dod. New evidence for a loss of serotonergic nerve terminals in rats treated with d,l-fenfluramine. Pharmacology & toxicology. vol 72. issue 4-5. 1993-10-12. PMID:8372042. |
fenfluramine has been classified as a neurotoxin because animals treated with this anorectic lose 5-ht uptake sites located on serotonergic nerve terminals. |
1993-10-12 |
2023-08-12 |
rat |
| R I Westphalen, P R Dod. New evidence for a loss of serotonergic nerve terminals in rats treated with d,l-fenfluramine. Pharmacology & toxicology. vol 72. issue 4-5. 1993-10-12. PMID:8372042. |
since their 5-ht sites were inhibited (blocked) non-competitively, by this agent, such animals had effectively lost 5-ht uptake sites from intact serotonergic terminals. |
1993-10-12 |
2023-08-12 |
rat |
| S P Bailey, J M Davis, E N Ahlbor. Neuroendocrine and substrate responses to altered brain 5-HT activity during prolonged exercise to fatigue. Journal of applied physiology (Bethesda, Md. : 1985). vol 74. issue 6. 1993-10-01. PMID:8366000. |
pharmacological manipulation of brain serotonergic [5-hydroxytryptamine (5-ht)] activity affects run time to exhaustion in the rat. |
1993-10-01 |
2023-08-12 |
rat |
| A Abi-Dargham, M Laruelle, B Lipska, G E Jaskiw, D T Wong, D W Robertson, D R Weinberger, J E Kleinma. Serotonin 5-HT3 receptors in schizophrenia: a postmortem study of the amygdala. Brain research. vol 616. issue 1-2. 1993-09-30. PMID:8358629. |
alterations in density of some serotonin receptor sites (5-ht1a receptors, 5-ht2 receptors and 5-ht uptake sites) have been reported in postmortem studies of brain obtained from subjects with schizophrenia, suggesting a disturbance in serotonergic transmission in schizophrenia. |
1993-09-30 |
2023-08-12 |
human |
| J Pascua. [Migraine, serotonin and serotonergic receptors]. Neurologia (Barcelona, Spain). vol 8. issue 6. 1993-09-23. PMID:8394726. |
[migraine, serotonin and serotonergic receptors]. |
1993-09-23 |
2023-08-12 |
Not clear |
| S Le Corre, P Cheminea. Serotonergic 5HT2 receptors mediate the inhibitory action of serotonin on luteinizing hormone secretion in ovariectomized, estradiol-treated ewes that are refractory to short days. Biology of reproduction. vol 49. issue 1. 1993-09-22. PMID:8353180. |
serotonergic 5ht2 receptors mediate the inhibitory action of serotonin on luteinizing hormone secretion in ovariectomized, estradiol-treated ewes that are refractory to short days. |
1993-09-22 |
2023-08-12 |
Not clear |