| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Oishi, Y Itoh, N Adachi, K Saek. Effect of a new psychoactive compound, MCI-225, on brain monoamine metabolism in rats. Japanese journal of pharmacology. vol 63. issue 2. 1994-02-16. PMID:8283838. |
these results suggest that mci-225 enhances both noradrenergic and serotonergic function by inhibiting na uptake and accelerating 5-ht turnover, respectively. |
1994-02-16 |
2023-08-12 |
rat |
| T M Cabrera, A D Levy, Q Li, L D van de Kar, G Battagli. Prenatal methamphetamine attenuates serotonin mediated renin secretion in male and female rat progeny: evidence for selective long-term dysfunction of serotonin pathways in brain. Synapse (New York, N.Y.). vol 15. issue 3. 1994-02-09. PMID:8278897. |
functional alterations in serotonergic systems were determined in postnatal day (pd) 70 male progeny and in pd 30 female progeny by measuring changes in 5-ht mediated increases in plasma hormones following a single injection of the 5-ht releaser p-chloroamphetamine (pca; 8 mg/kg). |
1994-02-09 |
2023-08-12 |
rat |
| L Castilla-Serna, M G Barragán-Mejía, R A Rodríguez-Pérez, A García Rillo, C Reyes-Vázque. Effects of acute and chronic toluene inhalation on behavior, monoamine metabolism and specific binding (3H-serotonin and 3H-norepinephrine) of rat brain. Archives of medical research. vol 24. issue 2. 1994-02-08. PMID:8274844. |
these results indicate that serotonin syndrome may be a consequence of changes of serotonergic mechanism, specifically a reduced affinity in specific (3h)-5ht binding sites. |
1994-02-08 |
2023-08-12 |
rat |
| P Jäkälä, M Mazurkiewicz, J Sirviö, P Riekkinen, P Riekkine. The behavioral effects of serotonin synthesis inhibition and quisqualic acid induced lesions of the nucleus basalis magnocellularis in rats. General pharmacology. vol 24. issue 5. 1994-02-01. PMID:8270173. |
to investigate the role of the cholinergic and serotonergic systems in the regulation of cognitive functions, the effects of concurrent lesioning of nucleus basalis magnocellularis (nb) with quisqualic acid (quis) and inhibition of brain serotonin synthesis by systemic p-chlorophenylalanine (pcpa) treatment on passive avoidance (pa) retention and water maze (wm) spatial navigation performance were studied in rats. |
1994-02-01 |
2023-08-12 |
rat |
| A M Andrews, D L Murph. 2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neurotransmission. The Journal of pharmacology and experimental therapeutics. vol 267. issue 3. 1994-01-27. PMID:8263805. |
lastly, 2'-nh2-mptp administered 3 weeks earlier, abolished hypothermia caused by the serotonin agonist, m-chlorophenylpiperazine, which provided preliminary evidence for an associated functional change in the central serotonergic system. |
1994-01-27 |
2023-08-12 |
mouse |
| T J Lauterio, T S Rieg, I Ahmed, P F Aravic. Fluoxetine induced insulin-like growth factor II (IGF-II) changes in hypothalami of normal, exercised and food restricted rats. Regulatory peptides. vol 48. issue 1-2. 1994-01-27. PMID:8265809. |
these data suggest that a serotonergic influence on cns igf-ii exists and that igf-ii secretion may be altered by factors affecting serotonin metabolism or efficacy. |
1994-01-27 |
2023-08-12 |
rat |
| T M Cabrera, J M Yracheta, Q Li, A D Levy, L D Van de Kar, G Battagli. Prenatal cocaine produces deficits in serotonin mediated neuroendocrine responses in adult rat progeny: evidence for long-term functional alterations in brain serotonin pathways. Synapse (New York, N.Y.). vol 15. issue 2. 1994-01-19. PMID:8259525. |
functional alterations in serotonergic systems were determined in postnatal day (pd) 70 male progeny by measuring changes in 5-ht mediated plasma hormones following a single 8 mg/kg injection of the 5-ht releaser p-chloroamphetamine (pca). |
1994-01-19 |
2023-08-12 |
rat |
| S Ching, S Catarsi, P Drapea. Selection of transmitter responses at sites of neurite contact during synapse formation between identified leech neurons. The Journal of physiology. vol 468. 1994-01-12. PMID:7504730. |
serotonergic retzius (r) neurons in culture reform inhibitory, cl(-)-dependent synapses with p neurons but fail to elicit the extrasynaptic, depolarizing response to 5-ht. |
1994-01-12 |
2023-08-12 |
Not clear |
| A D Levy, P A Rittenhouse, A M Bonadonna, M C Alvarez Sanz, C L Bethea, L D Van de Ka. Repeated exposure to cocaine produces long-lasting deficits in the serotonergic stimulation of prolactin and renin, but not adrenocorticotropin secretion. European journal of pharmacology. vol 241. issue 2-3. 1994-01-06. PMID:8243563. |
to determine whether cocaine-induced deficits in serotonergic function are long-lasting, the neuroendocrine responses to the serotonin (5-hydroxytryptamine, 5-ht) releaser, p-chloroamphetamine were evaluated 1-8 weeks subsequent to 7 days of cocaine exposure (15 mg/kg b.i.d.). |
1994-01-06 |
2023-08-12 |
rat |
| A J Bouckoms, W H Sweet, C Poletti, P Lavori, D Carr, W Matson, P Gamache, N Aroni. Monoamines in the brain cerebrospinal fluid of facial pain patients. Anesthesia progress. vol 39. issue 6. 1993-12-30. PMID:7504420. |
these results indicate that (1) the electrochemical detection method provides a unique way of accurately measuring nanogram concentrations of multiple monoamines in a little as 0.25 ml of csf; (2) trigeminal cistern and posterior fossa brain csf monoamine metabolites reflect a different profile of dopaminergic and serotonergic functioning in these facial pain patients from that previously reported with lumbar csf measurements of other patients; and (3) trigeminal sensory ganglion or brain dopamine and serotonin systems may be concomitantly dysfunctional in intractable facial pain. |
1993-12-30 |
2023-08-12 |
Not clear |
| M Briley, C More. Neurobiological mechanisms involved in antidepressant therapies. Clinical neuropharmacology. vol 16. issue 5. 1993-12-22. PMID:8221701. |
the firing rate of dorsal raphe serotonergic neurons is under the control of somatodendritic 5-hydroxytryptamine 1a (5-ht1a) autoreceptors, the release of serotonin from nerve terminals is under the control of 5-ht autoreceptors (5-ht1b subtype in rodents, 5-ht1d in other species), whereas the control of the activity of tryptophan hydroxylase, the rate-limiting enzyme of serotonin synthesis, is complex, involving 5-ht1a but possibly other 5-ht receptors including the 5-ht1b/d subtype. |
1993-12-22 |
2023-08-12 |
Not clear |
| S Endo, M Itoh, O Serizaw. Serotonergic regulation of the spinal cord content of thyrotropin releasing hormone in the cerebellar ataxia mutant mouse. Journal of the neurological sciences. vol 118. issue 2. 1993-12-16. PMID:8229069. |
these results suggest that trh turnover is abnormally regulated by serotonergic neurons in the rmn and that the dysfunction of the serotonergic nerves is attributable to the serotonin autoreceptor. |
1993-12-16 |
2023-08-12 |
mouse |
| K S Wong, R N Goyal, M Z Wrona, C L Blank, G Dryhurs. 7-S-glutathionyl-tryptamine-4,5-dione: a possible aberrant metabolite of serotonin. Biochemical pharmacology. vol 46. issue 9. 1993-12-16. PMID:8240421. |
in the event that compound 1 is formed as a result of oxidation of 5-ht within serotonergic nerve terminals or axons, it would be expected to be rapidly conjugated by intraneuronal glutathione (gsh) to give 7-s-glutathionyl-tryptamine-4,5-dione (compound 2). |
1993-12-16 |
2023-08-12 |
mouse |
| M W Baker, M M Vohra, R P Crol. Serotonin depletors, 5,7-dihydroxytryptamine and p-chlorophenylalanine, cause sprouting in the CNS of the adult snail. Brain research. vol 623. issue 2. 1993-12-13. PMID:7693304. |
these results support the role suggested for 5-ht as a neuritogenic modulator and additionally advise caution in the use of pharmacological depletors in studies examining serotonergic function. |
1993-12-13 |
2023-08-12 |
Not clear |
| G Richter-Levin, M Sega. Age-related cognitive deficits in rats are associated with a combined loss of cholinergic and serotonergic functions. Annals of the New York Academy of Sciences. vol 695. 1993-12-10. PMID:8239292. |
we found that restoration of the serotonergic innervation in the hippocampus of serotonin depleted rats, using tissue transplants, can restore impaired behavior. |
1993-12-10 |
2023-08-12 |
rat |
| M M Heitkemper, E F Bond, M K Gruver, A Horit. A possible 5-HT3 component of thyrotropin-releasing hormone-induced increases in gastric motility in developing rats. Developmental pharmacology and therapeutics. vol 19. issue 2-3. 1993-12-03. PMID:1340437. |
however, a serotonergic (5-ht) component may also exist. |
1993-12-03 |
2023-08-11 |
rat |
| M G Cattaneo, A Codignola, L M Vicentini, F Clementi, E She. Nicotine stimulates a serotonergic autocrine loop in human small-cell lung carcinoma. Cancer research. vol 53. issue 22. 1993-12-01. PMID:8221698. |
serotonin itself stimulates cell proliferation in a dose-dependent manner, an effect blocked by the selective serotonergic receptor antagonists methiotepine and metergoline. |
1993-12-01 |
2023-08-12 |
human |
| M G Cattaneo, A Codignola, L M Vicentini, F Clementi, E She. Nicotine stimulates a serotonergic autocrine loop in human small-cell lung carcinoma. Cancer research. vol 53. issue 22. 1993-12-01. PMID:8221698. |
these data suggest that nicotine might affect proliferation of small-cell lung carcinoma cells by inducing the release of hormones (such as serotonin) with autocrine capabilities and place both the nicotinic and the serotonergic receptors at key positions in the biological and, possibly, pharmacological approach to this human lung cancer. |
1993-12-01 |
2023-08-12 |
human |
| J A Bard, J Zgombick, N Adham, P Vaysse, T A Branchek, R L Weinshan. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. The Journal of biological chemistry. vol 268. issue 31. 1993-11-29. PMID:8226867. |
the rank order of potencies for serotonergic ligands to displace specific [3h]5-ht binding was: 5-carboxamido-tryptamine > methiothepin > metergoline > 5-ht > 8-hydroxy-2-(di-n-propylamino)tetralin > sumatriptan > ketanserin > zacopride. |
1993-11-29 |
2023-08-12 |
human |
| H Ichinose, T Nagats. [Molecular genetics of aromatic L-amino acid decarboxylase]. Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology. vol 13. issue 4. 1993-11-26. PMID:8237142. |
aromatic l-amino acid decarboxylase (aadc) decarboxylates both l-5-hydroxytryptophan to serotonin in serotonergic neurons and pineal cells, and l-dopa to dopamine in catecholaminergic neurons and adrenal medullary cells. |
1993-11-26 |
2023-08-12 |
human |