| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Ivgy-May, H Tamir, M D Gersho. Synaptic properties of serotonergic growth cones in developing rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 3 Pt 1. 1994-04-07. PMID:7509861. |
radioautography with 3h-imipramine or 3h-paroxetine (another marker for the transporter) confirmed that the 5-ht transporter is present in the cerebral cortex when it contains serotonergic growth cones, but not serotonergic synapses. |
1994-04-07 |
2023-08-12 |
rat |
| L H Rolf, B Voge. Effect of vigabatrin (GVG) on serotonin (5-HT) uptake and release of human platelets in vitro. Epilepsy research. vol 16. issue 3. 1994-04-07. PMID:8119274. |
if platelets represent a model for 5-ht transport processes in presynaptic serotonergic neurons it is concluded that gvg has no effect on serotonergic activity. |
1994-04-07 |
2023-08-12 |
human |
| J H Prehn, M Welsch, C Backhauss, J Nuglisch, F Ausmeier, C Karkoutly, J Krieglstei. Effects of serotonergic drugs in experimental brain ischemia: evidence for a protective role of serotonin in cerebral ischemia. Brain research. vol 630. issue 1-2. 1994-04-05. PMID:8118677. |
effects of serotonergic drugs in experimental brain ischemia: evidence for a protective role of serotonin in cerebral ischemia. |
1994-04-05 |
2023-08-12 |
mouse |
| J H Prehn, M Welsch, C Backhauss, J Nuglisch, F Ausmeier, C Karkoutly, J Krieglstei. Effects of serotonergic drugs in experimental brain ischemia: evidence for a protective role of serotonin in cerebral ischemia. Brain research. vol 630. issue 1-2. 1994-04-05. PMID:8118677. |
roxindole, a 5-ht1a agonist and 5-ht uptake inhibitor, was the most potent serotonergic compound tested. |
1994-04-05 |
2023-08-12 |
mouse |
| M Fujita, S Shimada, H Maeno, T Nishimura, M Tohyam. Cellular localization of serotonin transporter mRNA in the rat brain. Neuroscience letters. vol 162. issue 1-2. 1994-04-04. PMID:8121638. |
the localization pattern of the 5-ht transporter mrna-positive neurons coincides fairly well with that of 5-ht-immunoreactive neurons, indicating that 5-ht transporter is primarily located in serotonergic neurons. |
1994-04-04 |
2023-08-12 |
rat |
| J Akiyoshi, K Tsuchiyama, Y Mizobe, M Nakamura, H Kuranaga, H Nagayam. Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model. Progress in neuro-psychopharmacology & biological psychiatry. vol 18. issue 1. 1994-03-31. PMID:7509496. |
to further investigate a previous postulate that increased serotonergic activity may cause depression, the effects of chronic mianserin administration on 5-ht, its metabolites, and the subtypes of 5-ht receptors were studied. |
1994-03-31 |
2023-08-12 |
Not clear |
| A C Rovescalli, N Brunello, J Perez, S Vitali, L Steardo, G Racagn. Heterologous sensitization of adenylate cyclase activity by serotonin in the rat cerebral cortex. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 3. issue 4. 1994-03-31. PMID:7906577. |
serotonergic 5ht2 receptors are involved in the sensitization of adenylate cyclase to gppnhp, since the selective 5ht2 antagonist ketanserin inhibits the effect of 5ht, whereas the 5ht2 agonist doi mimics 5ht. |
1994-03-31 |
2023-08-12 |
rat |
| J H McLean, A Darby-King, R M Sullivan, S R Kin. Serotonergic influence on olfactory learning in the neonate rat. Behavioral and neural biology. vol 60. issue 2. 1994-03-31. PMID:7906939. |
one hundred fifty nanoliters of the neurotoxin 5,7-dihydroxytryptamine (5,7-dht, 10 micrograms/microliters) was injected into each anterior olfactory nucleus of postnatal day 2 (pnd 2) pups in order to selectively deplete the serotonergic (5-ht) innervation of the olfactory bulb. |
1994-03-31 |
2023-08-12 |
rat |
| H Shimamoto, Y Shimamoto, C Y Kwan, E E Danie. Amplification of 5-hydroxytryptamine-induced contractile responses via 5-hydroxytryptamine receptors and alpha-adrenoceptors in dog mesenteric artery and vein. The Journal of pharmacology and experimental therapeutics. vol 268. issue 2. 1994-03-28. PMID:8113990. |
the interactions between 5-hydroxytryptamine (5-ht) and both serotonergic and alpha adrenoceptors were investigated by using isolated dog mesenteric vascular rings mounted in tissue baths for the measurement of isometric contraction. |
1994-03-28 |
2023-08-12 |
dog |
| A M Andrews, D L Murph. Fluoxetine and desipramine selectively attenuate 2'-NH2-MPTP-induced depletions in serotonin and norepinephrine. European journal of pharmacology. vol 250. issue 2. 1994-03-25. PMID:8112382. |
these data suggest that 2'-nh2-mptp acts in a dose-dependent manner and that the serotonergic and noradrenergic uptake systems are involved in the mechanism by which 2'-nh2-mptp causes selective deficits in cortical and hippocampal 5-ht and norepinephrine. |
1994-03-25 |
2023-08-12 |
mouse |
| M J Owens, C B Nemerof. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clinical chemistry. vol 40. issue 2. 1994-03-24. PMID:7508830. |
these findings include the following: (a) reduced cerebrospinal fluid (csf) concentrations of 5-hydroxyindoleacetic acid (5-hiaa), the major metabolite of serotonin (5-ht) in drug-free depressed patients; (b) reduced concentrations of 5-ht and 5-hiaa in postmortem brain tissue of depressed and (or) suicidal patients; (c) decreased plasma tryptophan concentrations in depressed patients and a profound relapse in remitted depressed patients who have responded to a serotonergic antidepressant when brain tryptophan availability is reduced; (d) in general, all clinically efficacious antidepressants augment 5-ht neurotransmission following chronic treatment; (e) clinically efficacious antidepressant action by all inhibitors of 5-ht uptake; (f) increases in the density of 5-ht2 binding sites in postmortem brain tissue of depressed patients and suicide victims, as well as in platelets of drug-free depressed patients; (g) decreased number of 5-ht transporter (determined with [3h]imipramine or [3h]paroxetine) binding sites in postmortem brain tissue of suicide victims and depressed patients and in platelets of drug-free depressed patients. |
1994-03-24 |
2023-08-12 |
Not clear |
| S W Ying, D X Zhang, B Rusa. Effects of serotonin agonists and melatonin on photic responses of hamster intergeniculate leaflet neurons. Brain research. vol 628. issue 1-2. 1994-03-23. PMID:8313174. |
the activating effects of light on firing rates of igl cells may be regulated by serotonin (5-ht), since the igl receives a dense serotonergic input from the midbrain raphe. |
1994-03-23 |
2023-08-12 |
Not clear |
| K Eberle-Wang, B T Braun, K J Simansk. Serotonin contracts the isolated rat pylorus via a 5-HT2-like receptor. The American journal of physiology. vol 266. issue 1 Pt 2. 1994-03-09. PMID:8304552. |
furthermore, the parallel between the overall pharmacological profile for serotonergic contraction of the pylorus and that observed previously for the anorectic action of peripheral 5-ht makes the pylorus a logical candidate for peripheral serotonergic control of feeding. |
1994-03-09 |
2023-08-12 |
rat |
| P Simon, J Bertrand, J Costenti. 5-HT1A receptor blockade increases penile erections induced by indirect serotonin agonists. Neuroreport. vol 5. issue 3. 1994-03-07. PMID:7905292. |
indirect serotonergic agonists, whether promoters of 5-ht release such as fenfluramine (5 mg kg-1) or inhibitors of 5-ht uptake such as fluoxetine (10 mg kg-1), elicited in rats penile erections at a modest but significant level. |
1994-03-07 |
2023-08-12 |
rat |
| P Simon, J Bertrand, J Costenti. 5-HT1A receptor blockade increases penile erections induced by indirect serotonin agonists. Neuroreport. vol 5. issue 3. 1994-03-07. PMID:7905292. |
thus, it appears that increasing serotonergic transmission increases only moderately penile erections because of the functional opposition exerted by 5-ht1a (inhibition) and 5-ht1c (activation) serotonin receptors on this response. |
1994-03-07 |
2023-08-12 |
rat |
| M S Ledoux, J F Lorden, J M Ervi. Inferior olive serotonin and norepinephrine levels during development in the genetically dystonic rat. Brain research bulletin. vol 33. issue 3. 1994-03-03. PMID:7507398. |
at the pharmacological level, the dt rats exhibit enhanced sensitivity to the behavioral effects of serotonergic (5ht) agonists, including quipazine, a drug that activates the neurons of the inferior olive (io). |
1994-03-03 |
2023-08-12 |
rat |
| J M Halperin, V Sharma, L J Siever, S T Schwartz, K Matier, G Wornell, J H Newcor. Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. The American journal of psychiatry. vol 151. issue 2. 1994-02-25. PMID:8296897. |
this study was designed to assess central serotonergic (5-ht) function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. |
1994-02-25 |
2023-08-12 |
Not clear |
| P Barone, S Millet, C Moret, N Prudhomme, G Fillio. Quantitative autoradiography of 5-HT1E binding sites in rodent brains: effect of lesion of serotonergic neurones. European journal of pharmacology. vol 249. issue 2. 1994-02-24. PMID:8287904. |
in rat brain, selective lesioning of serotonergic fibres by intracerebroventricular injection of 5,7-dihydroxytryptamine (5,7-dht), a specific 5-ht neurotoxin, did not affect the density of 5-ht1e binding, indicating that these receptors are mainly localized on non-serotonergic neurones. |
1994-02-24 |
2023-08-12 |
mouse |
| U D McCann, G A Ricaurt. Strategies for detecting subclinical monoamine depletions in humans. NIDA research monograph. vol 136. 1994-02-23. PMID:8289914. |
finally, detailed neuropsychiatric evaluation of individuals with confirmed subclinical serotonergic neurotoxicity may enhance knowledge regarding the functional role of brain serotonin neurons in health and disease. |
1994-02-23 |
2023-08-12 |
Not clear |
| V Aubin-Brune. [A scale for clinical evaluation of serotonergic deficit in elderly people]. L'Encephale. vol 19 Spec No 2. 1994-02-17. PMID:8281907. |
the aim of this study was to develop a scale for the clinical and transnosographic quantitation of serotonergic deficiency in elderly persons (5-ht scale). |
1994-02-17 |
2023-08-12 |
human |