| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Bengel, B D Greenberg, G Corá-Locatelli, M Altemus, A Heils, Q Li, D L Murph. Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder. Molecular psychiatry. vol 4. issue 5. 1999-12-10. PMID:10523819. |
the serotonin (5-ht) transporter (5-htt), which is the key modulator of serotonergic neurotransmission, is the target for serotonin reuptake inhibiting drugs (sris) that are uniquely effective in the treatment of ocd. |
1999-12-10 |
2023-08-12 |
Not clear |
| M J Ormazábal, C Goicoechea, M J Alfaro, E Sánchez, M I Martí. Study of mechanisms of calcitonin analgesia in mice. Involvement of 5-HT3 receptors. Brain research. vol 845. issue 2. 1999-12-10. PMID:10536192. |
the effect of 2-methyl-5-ht on calcitonin analgesia was also reversed by tropisetron, this result suggests that the 5-ht(3) receptor may play an important role in the relationship between calcitonin and the serotonergic system. |
1999-12-10 |
2023-08-12 |
mouse |
| B Grimaldi, A Bonnin, M P Fillion, N Prudhomme, G Fillio. 5-Hydroxytryptamine-moduline: a novel endogenous peptide involved in the control of anxiety. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501445. |
at least 14 different types of serotonin receptors mediate serotonergic activity and among them, serotonin-1b receptors play an important role in the control of the serotonergic function. |
1999-12-09 |
2023-08-12 |
mouse |
| E Hame. The biology of serotonin receptors: focus on migraine pathophysiology and treatment. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 26 Suppl 3. 1999-12-07. PMID:10563226. |
5-ht receptors have been implicated in the regulation of several psychiatric and neurological disorders related to serotonergic neurotransmission, and specific receptor subtypes have recently been associated with either the pathogenesis or the treatment of migraine headache. |
1999-12-07 |
2023-08-12 |
Not clear |
| J Brunner, T Bronisc. [Neurobiological correlates of suicidal behavior]. Fortschritte der Neurologie-Psychiatrie. vol 67. issue 9. 1999-12-03. PMID:10548997. |
neuroendocrine challenge tests, platelet studies and a polymorphism in the gene for tryptophan hydroxylase, the rate-limiting enzyme in the biosynthesis of serotonin, suggest that serotonergic activity may be reduced. |
1999-12-03 |
2023-08-12 |
monkey |
| R J Porter, R H McAllister-Williams, A H Youn. Acute effects of venlafaxine and paroxetine on serotonergic transmission in human volunteers. Psychopharmacology. vol 146. issue 2. 1999-12-02. PMID:10525755. |
antidepressant drugs are thought to enhance serotonergic neurotransmission through postsynaptic 5-ht(1a) receptors. |
1999-12-02 |
2023-08-12 |
human |
| J Wingrove, A J Bond, A J Cleare, R Sherwoo. Plasma tryptophan and trait aggression. Journal of psychopharmacology (Oxford, England). vol 13. issue 3. 1999-11-19. PMID:10512077. |
many studies have reported correlations between measures of aggression and indices of serotonergic function, but most have studied patient or offender populations and relatively few have investigated plasma concentrations of the serotonin precursor tryptophan. |
1999-11-19 |
2023-08-12 |
human |
| J F Cryan, P Kelliher, J P Kelly, B E Leonar. Comparative effects of serotonergic agonists with varying efficacy at the 5-HT(1A) receptor on core body temperature: modification by the selective 5-HT(1A) receptor antagonist WAY 100635. Journal of psychopharmacology (Oxford, England). vol 13. issue 3. 1999-11-19. PMID:10512084. |
comparative effects of serotonergic agonists with varying efficacy at the 5-ht(1a) receptor on core body temperature: modification by the selective 5-ht(1a) receptor antagonist way 100635. |
1999-11-19 |
2023-08-12 |
Not clear |
| N Ohtani, T Sugano, M Oht. Alterations in monoamines and GABA in the ventromedial and paraventricular nuclei of the hypothalamus following cold exposure: a reduction in noradrenaline induces hyperphagia. Brain research. vol 842. issue 1. 1999-11-19. PMID:10526090. |
extracellular 5-ht in the pvn was significantly increased, along with a significant decrease in 5-hydroxyindoleacetic acid, in cold-exposed rats, suggesting that serotonergic fibers terminating in the pvm are more closely related to the increases in adrenocortical and thyroid hormone secretion than to food intake. |
1999-11-19 |
2023-08-12 |
rat |
| R Suhr, E Balse, A Haaf, C Kelche, J C Cassel, R Jackisc. Modulation of acetylcholine and 5-hydroxytryptamine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts containing cholinergic and/or serotonergic neurons. Brain research bulletin. vol 50. issue 1. 1999-11-10. PMID:10507467. |
modulation of acetylcholine and 5-hydroxytryptamine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts containing cholinergic and/or serotonergic neurons. |
1999-11-10 |
2023-08-12 |
rat |
| J Flett, C S Colwel. Serotonin modulation of calcium transients in cells in the suprachiasmatic nucleus. Journal of biological rhythms. vol 14. issue 5. 1999-11-02. PMID:10511003. |
the demonstration that 5ht can have a dramatic modulatory action on synaptic-evoked ca2+ transients measured in scn neurons adds support to the notion that the serotonergic innervation of the scn may function to regulate environmental input to the circadian system. |
1999-11-02 |
2023-08-12 |
Not clear |
| E W Freeman, K Rickels, S J Sondheimer, M Polansk. Differential response to antidepressants in women with premenstrual syndrome/premenstrual dysphoric disorder: a randomized controlled trial. Archives of general psychiatry. vol 56. issue 10. 1999-10-29. PMID:10530636. |
this study compares the efficacy of a selective serotonin reuptake inhibitor with that of a tricyclic antidepressant to determine whether efficacy for premenstrual syndrome/premenstrual dysphoric disorder is a general or more serotonergic effect of antidepressants. |
1999-10-29 |
2023-08-12 |
Not clear |
| C A Fornal, F J Martín, A Mendlin, C W Metzler, B Bjorvatn, B L Jacob. Pindolol increases extracellular 5-HT while inhibiting serotonergic neuronal activity. European journal of pharmacology. vol 377. issue 2-3. 1999-10-27. PMID:10456429. |
pindolol increases extracellular 5-ht while inhibiting serotonergic neuronal activity. |
1999-10-27 |
2023-08-12 |
Not clear |
| C A Fornal, F J Martín, A Mendlin, C W Metzler, B Bjorvatn, B L Jacob. Pindolol increases extracellular 5-HT while inhibiting serotonergic neuronal activity. European journal of pharmacology. vol 377. issue 2-3. 1999-10-27. PMID:10456429. |
the effects of pindolol, a beta-adrenoceptor blocker/putative 5-hydroxytryptamine (5-ht)1a/1b antagonist, on both the single-unit activity of serotonergic neurons in the dorsal raphe nucleus (drn) and extracellular 5-ht levels in the caudate nucleus, were examined in freely moving cats. |
1999-10-27 |
2023-08-12 |
Not clear |
| R Sandy. Impairment of depth perception in multiple sclerosis is improved by treatment with AC pulsed electromagnetic fields. The International journal of neuroscience. vol 98. issue 1-2. 1999-10-26. PMID:10395363. |
cerebral serotonin concentrations are diminished in ms patients and at least some aspects of deficient depth perception in ms may be related to dysfunction of serotonergic transmission in the primary visual cortex. |
1999-10-26 |
2023-08-12 |
Not clear |
| L L Murphy, B A Adrian, M Kohl. Inhibition of luteinizing hormone secretion by delta9-tetrahydrocannabinol in the ovariectomized rat: effect of pretreatment with neurotransmitter or neuropeptide receptor antagonists. Steroids. vol 64. issue 9. 1999-10-26. PMID:10503726. |
furthermore, the ability of a relatively nonspecific serotonin 5-ht(1a/1b) receptor antagonist pindolol (4 mg/kg, s.c.) or the specific 5-ht1a receptor antagonist way-100635 (1 mg/kg, s.c.) to significantly attenuate thc-induced lh suppression indicates that activation of serotonergic 5-ht1a receptors may be an important mode by which thc causes inhibition of lh release in the ovariectomized rat. |
1999-10-26 |
2023-08-12 |
rat |
| V J Knott, A L Howson, M Perugini, A V Ravindran, S N Youn. The effect of acute tryptophan depletion and fenfluramine on quantitative EEG and mood in healthy male subjects. Biological psychiatry. vol 46. issue 2. 1999-10-25. PMID:10418698. |
efforts to model putative serotonergic deficits associated with affective disorders have frequently involved acute tryptophan depletion (atd) as a manipulation strategy aimed at lowering brain serotonin synthesis. |
1999-10-25 |
2023-08-12 |
human |
| S Hashimoto, T Inoue, T Koyam. Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats. European journal of pharmacology. vol 378. issue 1. 1999-10-21. PMID:10478561. |
in an attempt to clarify the role of the brain serotonergic system in the psychopathology of anxiety, we examined the effect of a psychological stress, conditioned fear stress, on extracellular serotonin (5-hydroxytryptamine, 5-ht) concentrations in the rat medial prefrontal cortex using the method of in vivo microdialysis, while simultaneously observing conditioned fear stress-induced freezing behavior, an index of anxiety. |
1999-10-21 |
2023-08-12 |
rat |
| J Mendlewic. Predicting response: serotonin reuptake inhibition. International clinical psychopharmacology. vol 14 Suppl 1. 1999-10-19. PMID:10468324. |
the serotonergic network of the central and peripheral nervous systems comprises many different pathways and at least 14 distinct serotonin receptors. |
1999-10-19 |
2023-08-12 |
Not clear |
| I S Geerts, K E Matthys, A G Herman, H Bul. Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. British journal of pharmacology. vol 127. issue 6. 1999-10-18. PMID:10455282. |
taken together, this study demonstrates that the serotonergic receptor involved in the hypersensitivity to 5-ht of rabbit collared carotid artery is a 5-ht1b receptor subtype. |
1999-10-18 |
2023-08-12 |
rabbit |