| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V M Pickel, J Cha. Ultrastructural localization of the serotonin transporter in limbic and motor compartments of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 17. 1999-09-23. PMID:10460242. |
our results suggest that in the nac (1) reuptake into serotonergic axons is most efficient after exocytotic release from dcvs, and (2) increased 5-ht release without concomitant increase in sert expression in individual axons may contribute to higher extracellular levels of serotonin in the shell versus the core. |
1999-09-23 |
2023-08-12 |
rat |
| M L Cohen, K Schenc. 5-Hydroxytryptamine(1F) receptors do not participate in vasoconstriction: lack of vasoconstriction to LY344864, a selective serotonin(1F) receptor agonist in rabbit saphenous vein. The Journal of pharmacology and experimental therapeutics. vol 290. issue 3. 1999-09-21. PMID:10454462. |
use of these serotonergic agonists revealed a significant correlation between the contractile potency in the rabbit saphenous vein and the affinities of these agonists at 5-ht(1b) and 5-ht(1d) receptors, although contractile agonist potencies were not quantitatively similar to 5-ht(1b) or 5-ht(1d) receptor affinities. |
1999-09-21 |
2023-08-12 |
rabbit |
| M L Cohen, K Schenc. 5-Hydroxytryptamine(1F) receptors do not participate in vasoconstriction: lack of vasoconstriction to LY344864, a selective serotonin(1F) receptor agonist in rabbit saphenous vein. The Journal of pharmacology and experimental therapeutics. vol 290. issue 3. 1999-09-21. PMID:10454462. |
in contrast, no significant correlation existed between the contractile potencies of these serotonergic agonists in the rabbit saphenous vein and their affinity at 5-ht(1f) receptors. |
1999-09-21 |
2023-08-12 |
rabbit |
| M L Cohen, K W Schenck, S H Hemrick-Lueck. 5-Hydroxytryptamine(1A) receptor activation enhances norepinephrine release from nerves in the rabbit saphenous vein. The Journal of pharmacology and experimental therapeutics. vol 290. issue 3. 1999-09-21. PMID:10454495. |
although serotonergic receptor agonists are known to modulate release of central serotonin, less is known about the ability of serotonin to alter neurotransmission in peripheral adrenergic nerves. |
1999-09-21 |
2023-08-12 |
rabbit |
| M L Cohen, K W Schenck, S H Hemrick-Lueck. 5-Hydroxytryptamine(1A) receptor activation enhances norepinephrine release from nerves in the rabbit saphenous vein. The Journal of pharmacology and experimental therapeutics. vol 290. issue 3. 1999-09-21. PMID:10454495. |
these observations suggested that serotonergic nerves or other cell types in the saphenous vein are activated by field stimulation to release serotonin, which in turn activates presynaptic 5-ht(1a) receptors on adrenergic neurons to effect norepinephrine release. |
1999-09-21 |
2023-08-12 |
rabbit |
| S Araneda, K Gysling, A Cala. Raphe serotonergic neurons projecting to the olfactory bulb contain galanin or somatostatin but not neurotensin. Brain research bulletin. vol 49. issue 3. 1999-09-20. PMID:10435785. |
retrograde axonal transport with [3h]5-ht has been developed as a specific tracing technique to identify serotonergic projections. |
1999-09-20 |
2023-08-12 |
rat |
| L Imeri, M Mancia, M R Op. Blockade of 5-hydroxytryptamine (serotonin)-2 receptors alters interleukin-1-induced changes in rat sleep. Neuroscience. vol 92. issue 2. 1999-09-17. PMID:10408622. |
to determine if sleep changes induced by interleukin-1 are mediated by a specific serotonergic receptor subtype, we evaluated interleukin-1 effects on sleep in rats pretreated with the 5-hydroxytryptamine (serotonin)-2 receptor antagonist ritanserin. |
1999-09-17 |
2023-08-12 |
rat |
| J S Morris, K A Smith, P J Cowen, K J Friston, R J Dola. Covariation of activity in habenula and dorsal raphé nuclei following tryptophan depletion. NeuroImage. vol 10. issue 2. 1999-09-17. PMID:10417248. |
these data support a model of the serotonergic system in which the habenula projection to the raphé represents a convergent feedback pathway that controls the release of 5-ht throughout the brain. |
1999-09-17 |
2023-08-12 |
human |
| F Chaouloff, O Berton, P Mormèd. Serotonin and stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432486. |
at the presynaptic level, numerous stressors increase nerve firing and extracellular 5-ht at the level of serotonergic cell bodies or nerve terminals. |
1999-09-17 |
2023-08-12 |
human |
| F Chaouloff, O Berton, P Mormèd. Serotonin and stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432486. |
different studies have reported stressor- and region-specific changes in extracellular 5-ht, a view challenged by electrophysiological and neurochemical evidence for a nonspecific response of serotonergic neurones to stressors when activity/arousal is taken into account. |
1999-09-17 |
2023-08-12 |
human |
| F Chaouloff, O Berton, P Mormèd. Serotonin and stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432486. |
in addition, early studies indicate that stress-induced elevation in 5-ht synthesis, a key counter-regulatory process allowing serotonergic homeostasis, is mediated by specific neuroendocrine mechanisms. |
1999-09-17 |
2023-08-12 |
human |
| E C Azmiti. Serotonin neurons, neuroplasticity, and homeostasis of neural tissue. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432487. |
a pivotal role for serotonin in the homeostasis of neural tissue is consistent with the function of serotonin throughout evolution and explains the large number of biological systems, behavioral activities, and clinical diseases associated with serotonergic neurons. |
1999-09-17 |
2023-08-12 |
Not clear |
| X Zhuang, C Gross, L Santarelli, V Compan, A C Trillat, R He. Altered emotional states in knockout mice lacking 5-HT1A or 5-HT1B receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432489. |
as a result, the 5-ht1a and 5-ht1b receptors control the tone of the serotonergic system and mediate some of the postsynaptic effects of serotonin. |
1999-09-17 |
2023-08-12 |
mouse |
| M J Millan, A Gobert, V Audinot, A Dekeyne, A Newman-Tancred. Inverse agonists and serotonergic transmission: from recombinant, human serotonin (5-HT)1B receptors to G-protein coupling and function in corticolimbic structures in vivo. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432490. |
inverse agonists and serotonergic transmission: from recombinant, human serotonin (5-ht)1b receptors to g-protein coupling and function in corticolimbic structures in vivo. |
1999-09-17 |
2023-08-12 |
human |
| A Gobert, M J Milla. Modulation of dialysate levels of dopamine, noradrenaline, and serotonin (5-HT) in the frontal cortex of freely-moving rats by (-)-pindolol alone and in association with 5-HT reuptake inhibitors: comparative roles of beta-adrenergic, 5-HT1A, and 5-HT1B receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2. 1999-09-14. PMID:10432475. |
in conclusion, (-)-pindolol modulates, both alone and together with 5-ht reuptake inhibitors, dopaminergic, adrenergic, and serotonergic transmission in the fcx via a complex pattern of actions at beta 1/2-ars, 5-ht1a, and 5-ht1b receptors. |
1999-09-14 |
2023-08-12 |
rat |
| V Contesse, S Lenglet, L Grumolato, Y Anouar, I Lihrmann, H Lefebvre, C Delarue, H Vaudr. Pharmacological and molecular characterization of 5-hydroxytryptamine(7) receptors in the rat adrenal gland. Molecular pharmacology. vol 56. issue 3. 1999-09-14. PMID:10462543. |
a series of 10 serotonergic receptor agonists and 12 receptor antagonists was used to characterize the receptor mediating the effect of 5-ht on aldosterone secretion from perifused rat adrenocortical slices. |
1999-09-14 |
2023-08-12 |
rat |
| A Onal, I Tuğlula. The relationship between pupil diameter and pain by the administration of morphine and antidepressant drugs in mice. General pharmacology. vol 33. issue 1. 1999-09-10. PMID:10428020. |
we studied the relation between the pupil diameter and analgesia responses to morphine and antidepressants by using the selective micro-receptor agonist morphine (2 and 4 mg/kg), the noradrenaline reuptake inhibitor desipramine (7.5 and 10 mg/kg), the mixed serotonergic and noradrenergic uptake inhibitor and cholinergic receptor antagonist amitriptyline (2.5 and 5 mg/kg), and the selective serotonin reuptake inhibitor sertraline (2.5 and 5 mg/kg) in mice. |
1999-09-10 |
2023-08-12 |
mouse |
| C P Stephenson, G E Hunt, A N Topple, I S McGrego. The distribution of 3,4-methylenedioxymethamphetamine "Ecstasy"-induced c-fos expression in rat brain. Neuroscience. vol 92. issue 3. 1999-09-09. PMID:10426541. |
double-labelling of fos-positive neurons with 5-hydroxytryptamine showed that only a small number of serotonergic neurons in the raphe expressed c-fos following 3,4-methylenedioxymethamphetamine. |
1999-09-09 |
2023-08-12 |
human |
| D O Lee, C D Le. Serotonin syndrome in a child associated with erythromycin and sertraline. Pharmacotherapy. vol 19. issue 7. 1999-09-03. PMID:10417041. |
serotonin syndrome is an uncommon, serious adverse reaction that is usually associated with the interaction of two or more serotonergic agents. |
1999-09-03 |
2023-08-12 |
Not clear |
| C Scorza, R Silveira, D E Nichols, M Reyes-Parad. Effects of 5-HT-releasing agents on the extracellullar hippocampal 5-HT of rats. Implications for the development of novel antidepressants with a short onset of action. Neuropharmacology. vol 38. issue 7. 1999-09-03. PMID:10428424. |
based on evidence showing that an acute enhancement of 5-ht neurotransmission might result in the rapid appearance of therapeutic effects of serotonergic antidepressants, we suggest that mta and mmai might serve as leads for a novel family of compounds with a short onset of action useful for treating depression. |
1999-09-03 |
2023-08-12 |
rat |