| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C M Portas, B Bjorvatn, R Ursi. Serotonin and the sleep/wake cycle: special emphasis on microdialysis studies. Progress in neurobiology. vol 60. issue 1. 2000-01-20. PMID:10622375. |
in this view the level of extracellular serotonin would be consistent with the pattern of discharge of the drn serotonergic neurons which show the highest firing rate during w, followed by a decrease in slow wave sleep and by virtual electrical silence during rem sleep. |
2000-01-20 |
2023-08-12 |
Not clear |
| D E McBean, I M Ritchie, H J Olverman, P A Kell. Effects of the specific serotonin reuptake inhibitor, citalopram, upon local cerebral blood flow and glucose utilisation in the rat. Brain research. vol 847. issue 1. 2000-01-19. PMID:10564738. |
while decreases in blood flow were observed, it cannot be concluded that these were in fact the result of a direct action of 5-ht upon serotonergic receptors in cerebrovascular smooth muscle, since the dynamic relationship between flow and metabolism remains largely intact. |
2000-01-19 |
2023-08-12 |
rat |
| M Matsumoto, H Togashi, K Mori, K Ueno, A Miyamoto, M Yoshiok. Characterization of endogenous serotonin-mediated regulation of dopamine release in the rat prefrontal cortex. European journal of pharmacology. vol 383. issue 1. 2000-01-13. PMID:10556679. |
in other words, 5-ht(6) receptors may play, in part, a significant role in the functional interaction between the dopaminergic and serotonergic neuronal system in the rat prefrontal cortex. |
2000-01-13 |
2023-08-12 |
rat |
| P J Currie, N Saxena, A Y T. 5-HT(2A/2C) receptor antagonists in the paraventricular nucleus attenuate the action of DOI on NPY-stimulated eating. Neuroreport. vol 10. issue 14. 2000-01-04. PMID:10549818. |
the present study examined the ability of two serotonergic antagonists, spiperone (spip), a 5-ht2a antagonist, and mianserin (mian), a 5-ht(2a/2c) antagonist, to block the inhibitory action of the 5-ht(2a/2c) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) on npy-stimulated eating. |
2000-01-04 |
2023-08-12 |
Not clear |
| B G Condro. Serotonergic neurons transiently require a midline-derived FGF signal. Neuron. vol 24. issue 3. 2000-01-04. PMID:10595507. |
in the grasshopper cns, serotonergic growth cones cross the midline early in development and initiate expression of serotonin uptake activity, or sert. |
2000-01-04 |
2023-08-12 |
Not clear |
| T J Sexton, C McEvoy, J F Neumaie. (+) 3,4-methylenedioxymethamphetamine ('ecstasy') transiently increases striatal 5-HT1B binding sites without altering 5-HT1B mRNA in rat brain. Molecular psychiatry. vol 4. issue 6. 2000-01-03. PMID:10578240. |
[3h]-citalopram binding to serotonin transporters in hippocampus was reduced in the high dose protocol, indicating degeneration of forebrain serotonergic fibers. |
2000-01-03 |
2023-08-12 |
rat |
| T R Saito, M Saito, T Arai, S Aokikomori, K Taniguchi, K W Takahash. p-Chloroamphetamine (PCA) suppresses ingestive behavior in male rats. Experimental animals. vol 48. issue 4. 1999-12-27. PMID:10591006. |
intraperitoneal injection of p-chloroamphetamine (pca), releasing central 5-hydroxytryptamine (5-ht) from serotonergic nerve terminals, inhibited ingestion of the sucrose solution. |
1999-12-27 |
2023-08-12 |
rat |
| G P Leung, S L Dun, N J Dun, P Y Won. Serotonin via 5-HT1B and 5-HT2B receptors stimulates anion secretion in the rat epididymal epithelium. The Journal of physiology. vol 519 Pt 3. 1999-12-21. PMID:10457081. |
it is suggested that the 5-ht released from serotonergic nerve endings and/or from mast cells regulates electrolyte and fluid secretion in the epididymis. |
1999-12-21 |
2023-08-12 |
rat |
| L Arborelius, C Wallsten, S Ahlenius, T H Svensso. The 5-HT(1A) receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing. European journal of pharmacology. vol 382. issue 2. 1999-12-17. PMID:10528148. |
the 5-ht(1a) receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing. |
1999-12-17 |
2023-08-12 |
rat |
| J H Atkinson, M A Slater, D R Wahlgren, R A Williams, S Zisook, S D Pruitt, J E Epping-Jordan, T L Patterson, I Grant, I Abramson, S R Garfi. Effects of noradrenergic and serotonergic antidepressants on chronic low back pain intensity. Pain. vol 83. issue 2. 1999-12-17. PMID:10534584. |
to understand the relative efficacy of noradrenergic and serotonergic antidepressants as analgesics in chronic back pain without depression, we conducted a randomized, double-blind, placebo-control head-to-head comparison of maprotiline (a norepinephrine reuptake blocker) and paroxetine (a serotonin reuptake blocker) in 103 patients with chronic low back pain. |
1999-12-17 |
2023-08-12 |
Not clear |
| T Hendricks, N Francis, D Fyodorov, E S Deneri. The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575032. |
the ets domain factor pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. |
1999-12-17 |
2023-08-12 |
mouse |
| T Hendricks, N Francis, D Fyodorov, E S Deneri. The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575032. |
serotonin (5-ht) plays a crucial neuromodulatory role in numerous physiological and behavioral functions, and dysfunction of the serotonergic system has been implicated in several psychiatric disorders. |
1999-12-17 |
2023-08-12 |
mouse |
| T Hendricks, N Francis, D Fyodorov, E S Deneri. The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575032. |
despite the widespread importance of the central serotonergic neurotransmitter system, little is known about the molecular mechanisms controlling the development of 5-ht neurons. |
1999-12-17 |
2023-08-12 |
mouse |
| M Behan, M S Brownfiel. Age-related changes in serotonin in the hypoglossal nucleus of rat: implications for sleep-disordered breathing. Neuroscience letters. vol 267. issue 2. 1999-12-15. PMID:10400230. |
serotonin has a facilitatory effect on hypoglossal motoneurons that innervate the tongue, and manipulations of the serotonergic system alter airway patency. |
1999-12-15 |
2023-08-12 |
rat |
| J García-Colunga, R Miled. Blockage of mouse muscle nicotinic receptors by serotonergic compounds. Experimental physiology. vol 84. issue 5. 1999-12-15. PMID:10502654. |
xenopus laevis oocytes were used to analyse the effects of serotonin (5-hydroxytryptamine, 5-ht) and serotonergic agents on ionic currents elicited by the activation of mammalian muscle nicotinic acetylcholine receptors (achrs). |
1999-12-15 |
2023-08-12 |
mouse |
| J García-Colunga, R Miled. Blockage of mouse muscle nicotinic receptors by serotonergic compounds. Experimental physiology. vol 84. issue 5. 1999-12-15. PMID:10502654. |
5-ht as well as other serotonergic agents, such as ketanserin, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), methysergide, spiperone, or fluoxetine alone (up to 1 mm), did not elicit membrane currents in xenopus oocytes expressing achrs, but they reversibly reduced the current elicited by acetylcholine (ach-current). |
1999-12-15 |
2023-08-12 |
mouse |
| J García-Colunga, R Miled. Blockage of mouse muscle nicotinic receptors by serotonergic compounds. Experimental physiology. vol 84. issue 5. 1999-12-15. PMID:10502654. |
the electrical distance of the binding site for 5-ht was 0.75, whereas for the other serotonergic agents tested it was 0.22, suggesting that ketanserin, 8-oh-dpat, methysergide, spiperone and fluoxetine act within the ion channel, but at a site more external than that for 5-ht. |
1999-12-15 |
2023-08-12 |
mouse |
| J García-Colunga, R Miled. Blockage of mouse muscle nicotinic receptors by serotonergic compounds. Experimental physiology. vol 84. issue 5. 1999-12-15. PMID:10502654. |
we conclude that 5-ht and serotonergic agents inhibit, in a non-competitive manner, the ach-current in muscle achrs by blocking the open receptor-channel complex. |
1999-12-15 |
2023-08-12 |
mouse |
| M Poyurovsky, A Weizma. Lack of efficacy of the 5-HT3 receptor antagonist granisetron in the treatment of acute neuroleptic-induced akathisia. International clinical psychopharmacology. vol 14. issue 6. 1999-12-15. PMID:10565803. |
the specific mechanism underlying the apparent involvement of the serotonergic (5-ht) system in the pathophysiology of extrapyramidal side-effects, particularly neuroleptic-induced akathisia (nia), remains unknown. |
1999-12-15 |
2023-08-12 |
Not clear |
| S M Southwick, S Paige, C A Morgan, J D Bremner, J H Krystal, D S Charne. Neurotransmitter alterations in PTSD: catecholamines and serotonin. Seminars in clinical neuropsychiatry. vol 4. issue 4. 1999-12-13. PMID:10553029. |
evidence of serotonergic dysregulation in ptsd includes frequent symptoms of aggression, impulsivity, depression and suicidality, decreased platelet paroxetine binding, blunted prolactin response to fenfluramine, exaggerated reactivity to m-chloro-phenyl-piperazine, and clinical efficacy of serotonin reuptake inhibitors. |
1999-12-13 |
2023-08-12 |
Not clear |