| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L A Mamounas, C A Altar, M E Blue, D R Kaplan, L Tessarollo, W E Lyon. BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 2. 2000-02-09. PMID:10632606. |
brain-derived neurotrophic factor (bdnf) has trophic effects on serotonergic (5-ht) neurons in the adult brain and can prevent the severe loss of cortical 5-ht axons caused by the neurotoxin p-chloroamphetamine (pca). |
2000-02-09 |
2023-08-12 |
rat |
| M Markianos, J Hatzimanolis, L Lykoura. Switch from neuroleptics to clozapine does not influence pituitary-gonadal axis hormone levels in male schizophrenic patients. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 6. 2000-02-08. PMID:10625122. |
hypothalamic dopaminergic and serotonergic inputs participate in the regulation of pituitary hormones, and drugs that block central dopamine and serotonin receptors are expected to influence the hypothalamus-pituitary-gonadal (hpg) and -adrenal (hpa) axes. |
2000-02-08 |
2023-08-12 |
Not clear |
| F Maekawa, S Tsukahara, H Tsukamura, K I Maeda, K Yamanouch. Prevention of inhibitory effect of dorsal raphe nucleus lesions on ovulation and LH surge by 5-HT 2A/2C receptor agonists in female rats. Neuroscience research. vol 35. issue 4. 2000-02-07. PMID:10617320. |
in order to investigate the role of the dorsal raphe nucleus and the serotonergic system in the regulation of ovulation, the number of ova and plasma luteinizing hormone (lh) concentrations were measured in female rats after making lesions in this nucleus (drl) and/or treatment with 5-hydroxytryptamine (5-ht) receptor agonists or antagonists. |
2000-02-07 |
2023-08-12 |
rat |
| Y H Chang, M T Hiseh, C R W. Effects of acupuncture at pai-hui on the deficit of memory storage in rats. The American journal of Chinese medicine. vol 27. issue 3-4. 2000-02-03. PMID:10592837. |
the preventive effect of acupuncture at pai-hui on cxm-induced impairment is significantly reduced by serotonergic 5-ht releaser, and slightly by cholinergic manipulations. |
2000-02-03 |
2023-08-12 |
rat |
| F M Zhou, J J Hablit. Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex. Journal of neurophysiology. vol 82. issue 6. 2000-02-03. PMID:10601434. |
the cerebral cortex receives an extensive serotonergic (5-hydroxytryptamine, 5-ht) input. |
2000-02-03 |
2023-08-12 |
rat |
| A Brambilla, A Baschirotto, N Grippa, F Borsin. Effect of flibanserin (BIMT 17), fluoxetine, 8-OH-DPAT and buspirone on serotonin synthesis in rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 1. 2000-02-02. PMID:10647099. |
in male rats, the effects of the administration of the novel serotonergic agent flibanserin on the synthesis of 5-ht were evaluated in the frontal cortex (fc), hippocampus (hip) and brainstem (br). |
2000-02-02 |
2023-08-12 |
rat |
| Y Sugimoto, K Inoue, J Yamad. Involvement of serotonin in zimelidine-induced hyperglycemia in mice. Biological & pharmaceutical bulletin. vol 22. issue 11. 2000-01-31. PMID:10598036. |
to determine the involvement of the serotonergic system in zimelidine-induced hyperglycemia, effects of the 5-ht depleter p-chlorophenylalanine(pcpa) were examined. |
2000-01-31 |
2023-08-12 |
mouse |
| Y Sugimoto, K Inoue, J Yamad. Involvement of serotonin in zimelidine-induced hyperglycemia in mice. Biological & pharmaceutical bulletin. vol 22. issue 11. 2000-01-31. PMID:10598036. |
this suggests that zimelidine-induced hyperglycemia is mediated by the serotonergic system through its 5-ht reuptake inhibition. |
2000-01-31 |
2023-08-12 |
mouse |
| M Minami, Y Kohno, T Endo, M Nemoto, T Ogawa, E Ihira, N Hamaue, M Hirafuj. Differential effects of talipexole and bromocriptine on serotonin release from rat intestinal tissues--an in vitro study of the emetic response of antiparkinsonian dopamine agonists. Research communications in molecular pathology and pharmacology. vol 104. issue 1. 2000-01-31. PMID:10604273. |
these results showed the involvement of both dopaminergic and serotonergic mechanisms in the 5-ht release from ec cells following the administration of dopamine receptor agonists. |
2000-01-31 |
2023-08-12 |
rat |
| L Thibault, E Mok, K Nagai, C Y Won. Serotonin infusion in the SCN reduces casein ingestion in rats. Physiology & behavior. vol 68. issue 1-2. 2000-01-31. PMID:10627060. |
the present results reinforce the hypothesis of a serotonergic control of water intake and provide evidence for scn 5-ht involvement in casein-specific dietary selection. |
2000-01-31 |
2023-08-12 |
rat |
| S Schuhler, B Pitrosky, M Saboureau, N Lakhdar-Ghazal, P Péve. Role of the thalamic intergeniculate leaflet and its 5-HT afferences in the chronobiological properties of 8-OH-DPAT and triazolam in syrian hamster. Brain research. vol 849. issue 1-2. 2000-01-28. PMID:10592283. |
the 5-ht(1a/7) receptor agonist 8-hydroxy-2-[di-n-propylamino]-tetralin (8-oh-dpat) has chronobiological effects on the circadian system and, in the syrian hamster, it is known that serotonergic (5-ht) projections connecting the median raphe nucleus to the suprachiasmatic nuclei (scn) of the hypothalamus are a prerequisite for the expression of 8-oh-dpat-induced phase advance of locomotor activity rhythm. |
2000-01-28 |
2023-08-12 |
Not clear |
| I Muraki, T Inoue, S Hashimoto, T Izumi, K Ito, T Ohmori, T Koyam. Effect of subchronic lithium carbonate treatment on anxiolytic-like effect of citalopram and MKC-242 in conditioned fear stress in the rat. European journal of pharmacology. vol 383. issue 3. 2000-01-27. PMID:10594313. |
these results suggest that subchronic lico(3) treatment enhanced the anxiolytic-like effects of these serotonergic drugs by facilitating central 5-ht neurotransmission at clinically therapeutic plasma lithium levels. |
2000-01-27 |
2023-08-12 |
rat |
| M J Millan, A Gobert, A Newman-Tancredi, F Lejeune, D Cussac, J M Rivet, V Audinot, A Adhumeau, M Brocco, J P Nicolas, J A Boutin, N Despaux, J L Peglio. S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2)-adrenergic receptors: I. Receptorial, neurochemical, and electrophysiological profile. The Journal of pharmacology and experimental therapeutics. vol 292. issue 1. 2000-01-27. PMID:10604930. |
finally, s18327 reduced synthesis and dialysate levels of 5-ht in striatum and suppressed firing of dorsal raphe-localized serotonergic neurons, an action attenuated by the alpha(1)-ar agonist cirazoline. |
2000-01-27 |
2023-08-12 |
human |
| M S Cousins, G Vosmer, D H Overstreet, L S Seide. Rats selectively bred for responsiveness to 5-hydroxytryptamine(1A) receptor stimulation: differences in differential reinforcement of low rate 72-second performance and response to serotonergic drugs. The Journal of pharmacology and experimental therapeutics. vol 292. issue 1. 2000-01-27. PMID:10604936. |
rats selectively bred for responsiveness to 5-hydroxytryptamine(1a) receptor stimulation: differences in differential reinforcement of low rate 72-second performance and response to serotonergic drugs. |
2000-01-27 |
2023-08-12 |
rat |
| W E Lyons, L A Mamounas, G A Ricaurte, V Coppola, S W Reid, S H Bora, C Wihler, V E Koliatsos, L Tessaroll. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 26. 2000-01-27. PMID:10611369. |
brain-derived neurotrophic factor (bdnf) has trophic effects on serotonergic (5-ht) neurons in the central nervous system. |
2000-01-27 |
2023-08-12 |
mouse |
| U Scheffel, Z Szabo, W B Mathews, P A Finley, J Yuan, B Callahan, G Hatzidimitriou, R F Dannals, H T Ravert, G A Ricaurt. Fenfluramine-induced loss of serotonin transporters in baboon brain visualized with PET. Synapse (New York, N.Y.). vol 24. issue 4. 2000-01-27. PMID:10638827. |
findings with pet corresponded well with post-mortem neurochemical findings indicative of serotonergic neurotoxicity (lasting depletions of regional brain 5-ht, 5-hiaa, and 5-ht uptake sites). |
2000-01-27 |
2023-08-12 |
Not clear |
| C Drogou, M Chennaoui, L Forestier, B Grimaldi, G Fillion, Y Guezenne. Application of the polymerase chain reaction to the RNase protection assay for 5-HT(1B) receptor mRNA levels measurement in rat brain tissues. Brain research. Brain research protocols. vol 4. issue 3. 2000-01-24. PMID:10592341. |
since the 5-ht(1b) receptors are the predominant auto- and heteroreceptors located on serotonergic and non-serotonergic terminals where they regulate the neuronal release of neurotransmitters and the protocol described here permits the determination of 5-ht(1b) receptor mrna levels in the rat cerebellum, striatum, hippocampus and frontal cortex, this protocol is helpful in understanding the involvement of 5-ht(1b) receptors in various physiological phenomena. |
2000-01-24 |
2023-08-12 |
rat |
| M A Abou-Gharbia, W E Childers, H Fletcher, G McGaughey, U Patel, M B Webb, J Yardley, T Andree, C Boast, R J Kucharik, K Marquis, H Morris, R Scerni, J A Moye. Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents. Journal of medicinal chemistry. vol 42. issue 25. 2000-01-24. PMID:10602693. |
compound 1, 2-[4-(2-pyrimidinyl)-1-piperazinyl]ethyl adamantyl-1-carboxylate, demonstrated relatively high affinity for 5-ht(1a) receptors (k(i) = 8 nm) and acceptable selectivity versus d(2) receptors (k(i) = 708 mm); however, it lacked in vivo activity in serotonergic behavioral models. |
2000-01-24 |
2023-08-12 |
rat |
| D Marazziti, A Rossi, L Dell'Osso, L Palego, G P Placidi, G Giannaccini, A Lucacchini, G B Cassan. Decreased platelet 3H-paroxetine binding in untreated panic disorder patients. Life sciences. vol 65. issue 25. 2000-01-20. PMID:10622283. |
the presence of the 5-ht transporter in blood platelets similar to that in presynaptic serotonergic neurons, permits the investigation of this structure in periphery. |
2000-01-20 |
2023-08-12 |
Not clear |
| C M Portas, B Bjorvatn, R Ursi. Serotonin and the sleep/wake cycle: special emphasis on microdialysis studies. Progress in neurobiology. vol 60. issue 1. 2000-01-20. PMID:10622375. |
however, more recent microdialysis experiments provide evidence that the level of serotonin during w is higher in most cortical and subcortical areas receiving serotonergic projections. |
2000-01-20 |
2023-08-12 |
Not clear |