| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Zhou, D J Rademacher, R E Steinpreis, J S Wei. Neurotransmitter levels in two populations of larval Fundulus heteroclitus after methylmercury exposure. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. vol 124. issue 3. 2000-03-14. PMID:10661721. |
for the two populations, the level of 5-ht and serotonergic activity, as well as dopac and hva levels, were correlated with previously noted spontaneous activity. |
2000-03-14 |
2023-08-12 |
Not clear |
| K Miyata, H Shimokawa, T Higo, T Yamawaki, N Katsumata, T Kandabashi, E Tanaka, Y Takamura, K Yogo, K Egashira, A Takeshit. Sarpogrelate, a selective 5-HT2A serotonergic receptor antagonist, inhibits serotonin-induced coronary artery spasm in a porcine model. Journal of cardiovascular pharmacology. vol 35. issue 2. 2000-03-13. PMID:10672864. |
however, it remains to be examined which serotonergic (5-ht) receptor subtype mediates coronary spasm and whether alterations in serotonergic receptors are involved in the abnormality. |
2000-03-13 |
2023-08-12 |
Not clear |
| J Croonenberghs, L Delmeire, R Verkerk, A H Lin, A Meskal, H Neels, M Van der Planken, S Scharpe, D Deboutte, G Pison, M Mae. Peripheral markers of serotonergic and noradrenergic function in post-pubertal, caucasian males with autistic disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 3. 2000-03-13. PMID:10693155. |
the results suggest that: 1) serotonergic disturbances, such as defects in the 5-ht transporter system and lowered plasma tryptophan, may play a role in the pathophysiology of autism; 2) autism is not associated with alterations in the noradrenergic system; and 3) the metabolism of serotonin in humans undergoes significant changes between the ages of 12 and 18 years. |
2000-03-13 |
2023-08-12 |
human |
| T Hori, S Abe, A Baba, T Suzuki, H Shiraish. Effects of repeated phencyclidine treatment on serotonin transporter in rat brain. Neuroscience letters. vol 280. issue 1. 2000-03-13. PMID:10696810. |
phencyclidine (pcp) is known to be an inhibitor of serotonin (5-ht) uptake and to increase serotonergic activity. |
2000-03-13 |
2023-08-12 |
rat |
| T Hori, S Abe, A Baba, T Suzuki, H Shiraish. Effects of repeated phencyclidine treatment on serotonin transporter in rat brain. Neuroscience letters. vol 280. issue 1. 2000-03-13. PMID:10696810. |
the development of tolerance to serotonergic stereotyped behaviors induced by repeated pcp treatment and changes of 5-ht transporters were examined. |
2000-03-13 |
2023-08-12 |
rat |
| T Hori, S Abe, A Baba, T Suzuki, H Shiraish. Effects of repeated phencyclidine treatment on serotonin transporter in rat brain. Neuroscience letters. vol 280. issue 1. 2000-03-13. PMID:10696810. |
these results indicate that repeated pcp treatment causes tolerance in serotonergic stereotyped behavior and increases affinity of 5-ht transporters for [3h]paroxetine binding. |
2000-03-13 |
2023-08-12 |
rat |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
in an effort to assess the role of 5-ht in drug-mediated reward, this study analyzed the serotonergic innervation of nac using immunocytochemistry for 5-ht and the 5-ht transporter (sert). |
2000-03-09 |
2023-08-12 |
rat |
| J M Gorman, G Sulliva. Noradrenergic approaches to antidepressant therapy. The Journal of clinical psychiatry. vol 61 Suppl 1. 2000-03-09. PMID:10703758. |
preclinical and clinical studies have shown that stimulation of the serotonergic system leads to noradrenergic effects and vice versa, confirming that the serotonin and norepinephrine systems are intimately connected in the central nervous system. |
2000-03-09 |
2023-08-12 |
Not clear |
| R Ramasubbu, A Flint, G Brown, G Awad, S Kenned. Neurohormonal responses to D-fenfluramine in healthy elderly subjects. A placebo-controlled study. Psychoneuroendocrinology. vol 25. issue 2. 2000-03-08. PMID:10674278. |
d-fen is a safe serotonergic probe and prl responsivity to d-fen is a reliable index of central 5ht function in the elderly. |
2000-03-08 |
2023-08-12 |
human |
| R Sandy. Serotonergic neuronal sprouting as a potential mechanism of recovery in multiple sclerosis. The International journal of neuroscience. vol 97. issue 1-2. 2000-03-08. PMID:10681122. |
damage to the bulbospinal serotonergic (5-ht) neurons occurs in the early paralytic stages of eae in rats with the severity of neurologic signs corresponding to spinal serotonergic depletion. |
2000-03-08 |
2023-08-12 |
rat |
| R Sandy. Serotonergic neuronal sprouting as a potential mechanism of recovery in multiple sclerosis. The International journal of neuroscience. vol 97. issue 1-2. 2000-03-08. PMID:10681122. |
spinal serotonergic neuronal sprouting with regeneration of 5-ht nerve terminals may also occur in the early stages of ms and may be associated with spontaneous remission of ms symptoms following an acute relapse. |
2000-03-08 |
2023-08-12 |
rat |
| R Mössner, S Daniel, D Albert, A Heils, O Okladnova, A Schmitt, K P Lesc. Serotonin transporter function is modulated by brain-derived neurotrophic factor (BDNF) but not nerve growth factor (NGF). Neurochemistry international. vol 36. issue 3. 2000-03-02. PMID:10676853. |
the serotonin transporter (5-htt) regulates serotonergic neurotransmission by determining the magnitude and duration of serotonergic responses. |
2000-03-02 |
2023-08-12 |
Not clear |
| J Hardcastle, P T Hardcastl. Effects of 5-hydroxytryptamine on the transintestinal electrical activity and cardiovascular function of fawn-hooded rats in-vivo. The Journal of pharmacy and pharmacology. vol 51. issue 12. 2000-03-02. PMID:10678497. |
fawn-hooded rats, which have abnormal serotonergic function, were used to investigate the receptors involved in 5-hydroxytryptamine (5-ht)-induced intestinal secretion. |
2000-03-02 |
2023-08-12 |
rat |
| T A Lovick, D M Parry, V V Stezhka, B M Lum. Serotonergic transmission in the periaqueductal gray matter in relation to aversive behaviour: morphological evidence for direct modulatory effects on identified output neurons. Neuroscience. vol 95. issue 3. 2000-03-01. PMID:10670443. |
the data indicate that serotonergic transmission on to output neurons in the dorsolateral periaqueductal gray matter is largely mediated by non-junctional contacts, suggesting that the actions of 5-hydroxytryptamine on these cells are mediated predominantly by volume rather than wiring transmission. |
2000-03-01 |
2023-08-12 |
Not clear |
| L Imeri, M Mancia, S Bianchi, M R Op. 5-Hydroxytryptophan, but not L-tryptophan, alters sleep and brain temperature in rats. Neuroscience. vol 95. issue 2. 2000-02-29. PMID:10658624. |
the initial non-rapid eye movement sleep inhibition observed following low doses of l-5-hydroxytryptophan may be attributable to increased serotonergic activity since 5-hydroxytryptamine may promote wakefulness per se, whereas the delayed non-rapid eye movement sleep enhancement after higher doses may be due to the induction by 5-hydroxytryptamine of sleep-inducing factor(s), as previously hypothesized. |
2000-02-29 |
2023-08-12 |
rat |
| L Imeri, M Mancia, S Bianchi, M R Op. 5-Hydroxytryptophan, but not L-tryptophan, alters sleep and brain temperature in rats. Neuroscience. vol 95. issue 2. 2000-02-29. PMID:10658624. |
the results of the present study suggest that the complex effects of 5-ht on sleep depend on the degree and time course of activation of the serotonergic system such that 5-ht may directly inhibit sleep, yet induce a cascade of physiological processes that enhance subsequent sleep. |
2000-02-29 |
2023-08-12 |
rat |
| D J Fickbohm, P S Kat. Paradoxical actions of the serotonin precursor 5-hydroxytryptophan on the activity of identified serotonergic neurons in a simple motor circuit. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 4. 2000-02-25. PMID:10662852. |
paradoxical actions of the serotonin precursor 5-hydroxytryptophan on the activity of identified serotonergic neurons in a simple motor circuit. |
2000-02-25 |
2023-08-12 |
Not clear |
| D J Fickbohm, P S Kat. Paradoxical actions of the serotonin precursor 5-hydroxytryptophan on the activity of identified serotonergic neurons in a simple motor circuit. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 4. 2000-02-25. PMID:10662852. |
we used electrophysiological, electrochemical, and immunohistochemical techniques to investigate the effects of augmenting the serotonin (5-ht) content of identified serotonergic neurons embedded in a simple motor circuit. |
2000-02-25 |
2023-08-12 |
Not clear |
| S E Marshall, T G Bird, K Hart, K I Wels. Unified approach to the analysis of genetic variation in serotonergic pathways. American journal of medical genetics. vol 88. issue 6. 2000-02-24. PMID:10581480. |
serotonin is a key neurotransmitter in the central nervous system, and dysregulation of serotonergic pathways has been implicated in the pathogenesis of many complex psychiatric diseases. |
2000-02-24 |
2023-08-12 |
Not clear |
| E Hollander, S Novotny, A Allen, B Aronowitz, C Cartwright, C DeCari. The relationship between repetitive behaviors and growth hormone response to sumatriptan challenge in adult autistic disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 2. 2000-02-14. PMID:10649829. |
specifically, we assessed growth hormone response to the 5-ht 1d agonist, sumatriptan, and linked this measure of serotonergic function to the severity of repetitive behaviors in adult autistic patients. |
2000-02-14 |
2023-08-12 |
Not clear |