| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S F de Boer, M Lesourd, E Mocaër, J M Koolhaa. Somatodendritic 5-HT(1A) autoreceptors mediate the anti-aggressive actions of 5-HT(1A) receptor agonists in rats: an ethopharmacological study with S-15535, alnespirone, and WAY-100635. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 1. 2000-07-17. PMID:10869883. |
these data provide extensive evidence that the anti-aggressive effects of 5-ht(1a) receptor agonists are expressed via their action on somatodendritic 5-ht(1a) autoreceptors, thereby most likely attenuating intruder-activated serotonergic neurotransmission. |
2000-07-17 |
2023-08-12 |
rat |
| M Kubera, G Kenis, E Bosmans, S Scharpé, M Mae. Effects of serotonin and serotonergic agonists and antagonists on the production of interferon-gamma and interleukin-10. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 1. 2000-07-17. PMID:10869889. |
effects of serotonin and serotonergic agonists and antagonists on the production of interferon-gamma and interleukin-10. |
2000-07-17 |
2023-08-12 |
Not clear |
| J Sprouse, J Braselton, L Reynold. 5-HT(1A) agonist potential of pindolol: electrophysiologic studies in the dorsal raphe nucleus and hippocampus. Biological psychiatry. vol 47. issue 12. 2000-07-12. PMID:10862804. |
previous investigators have probed the effects of pindolol on serotonergic dorsal raphe cell firing in animal species; here we confirm their findings and extend them to include observations on postsynaptic 5-ht(1a) receptors in the hippocampus. |
2000-07-12 |
2023-08-12 |
Not clear |
| M T Abellán, A Adell, M A Honrubia, G Mengod, F Artiga. GABAB-RI receptors in serotonergic neurons: effects of baclofen on 5-HT output in rat brain. Neuroreport. vol 11. issue 5. 2000-07-10. PMID:10790860. |
gabab-ri receptors in serotonergic neurons: effects of baclofen on 5-ht output in rat brain. |
2000-07-10 |
2023-08-12 |
rat |
| K E Goeringer, L Raymon, G D Christian, B K Loga. Postmortem forensic toxicology of selective serotonin reuptake inhibitors: a review of pharmacology and report of 168 cases. Journal of forensic sciences. vol 45. issue 3. 2000-07-07. PMID:10855970. |
the four selective serotonin reuptake inhibitors (ssris) considered--fluoxetine, fluvoxamine, sertraline and paroxetine--can result in toxicity and death through contributing to serotonergic excess resulting in serotonin syndrome, inhibiting the metabolism of other centrally acting drugs, leading to accumulation of toxic concentrations, and exerting complex vasoactive effects on the vascular smooth muscle. |
2000-07-07 |
2023-08-12 |
Not clear |
| R C van der Mast, D Fekke. Serotonin and amino acids: partners in delirium pathophysiology? Seminars in clinical neuropsychiatry. vol 5. issue 2. 2000-07-06. PMID:10837101. |
the plasma ratio of trp/lnaa, plasma level of trp, and serotonin in plasma and platelets have been used as indirect peripheral measures for central serotonergic functioning. |
2000-07-06 |
2023-08-12 |
human |
| R C van der Mast, D Fekke. Serotonin and amino acids: partners in delirium pathophysiology? Seminars in clinical neuropsychiatry. vol 5. issue 2. 2000-07-06. PMID:10837101. |
serotonin agonists can induce psychosis, both elevated trp availability and increased cerebral serotonin have been associated with hepatic encephalopathy, and excess serotonergic brain activity has been related to the development of the serotonin syndrome of which delirium is a main symptom. |
2000-07-06 |
2023-08-12 |
human |
| S E File, P J Kenny, S Cheet. The role of the dorsal hippocampal serotonergic and cholinergic systems in the modulation of anxiety. Pharmacology, biochemistry, and behavior. vol 66. issue 1. 2000-07-06. PMID:10837844. |
a review of the literature suggests that the dorsal hippocampal serotonergic system, and, in particular, the postsynaptic 5-ht(1a) receptor, mediates an anxiogenic response, whereas endogenous dorsal hippocampal cholinergic tone mediates an anxiolytic response. |
2000-07-06 |
2023-08-12 |
rat |
| S E File, P J Kenny, S Cheet. The role of the dorsal hippocampal serotonergic and cholinergic systems in the modulation of anxiety. Pharmacology, biochemistry, and behavior. vol 66. issue 1. 2000-07-06. PMID:10837844. |
however, the anxiogenic effects of mecamylamine and nicotine in the dorsal hippocampus are blocked by coadministration of the 5-ht(1a) receptor antagonist, way 100635, suggesting that both of these compounds act by enhancing hippocampal serotonergic transmission, thereby stimulating postsynaptic 5-ht(1a) receptors. |
2000-07-06 |
2023-08-12 |
rat |
| S E File, P J Kenny, S Cheet. The role of the dorsal hippocampal serotonergic and cholinergic systems in the modulation of anxiety. Pharmacology, biochemistry, and behavior. vol 66. issue 1. 2000-07-06. PMID:10837844. |
a possible mechanism by which nicotinic receptor ligands modulate hippocampal 5-ht release is discussed, and it is proposed that the dorsal hippocampal serotonergic and cholinergic systems are tightly coupled and function antagonistically in the modulation of anxiety, as measured in the social interaction test. |
2000-07-06 |
2023-08-12 |
rat |
| L Bardin, J Lavarenne, A Eschalie. Serotonin receptor subtypes involved in the spinal antinociceptive effect of 5-HT in rats. Pain. vol 86. issue 1-2. 2000-06-30. PMID:10779655. |
these results suggest that although the precise degree of the involvement of spinal serotonergic 5-ht(3) receptors remains to be elucidated due to some differences in the effect of agonists or antagonists, these receptors seem to play a role in the antinociceptive effect of 5-ht against a mechanical acute noxious stimulus. |
2000-06-30 |
2023-08-12 |
rat |
| K J Maloney, L Mainville, B E Jone. c-Fos expression in GABAergic, serotonergic, and other neurons of the pontomedullary reticular formation and raphe after paradoxical sleep deprivation and recovery. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 12. 2000-06-30. PMID:10844036. |
as a continuation, we examined in the present study c-fos expression in the pontomedullary reticular and raphe neurons, including importantly gabaergic neurons [immunostained for glutamic acid decarboxylase (gad)] and serotonergic neurons [immunostained for serotonin (ser)]. |
2000-06-30 |
2023-08-12 |
rat |
| M Preisig, F Bellivier, B T Fenton, P Baud, A Berney, P Courtet, P Hardy, J Golaz, M Leboyer, J Mallet, M L Matthey, D Mouthon, E Neidhart, M Nosten-Bertrand, E Stadelmann-Dubuis, J Guimon, F Ferrero, C Buresi, A Malafoss. Association between bipolar disorder and monoamine oxidase A gene polymorphisms: results of a multicenter study. The American journal of psychiatry. vol 157. issue 6. 2000-06-29. PMID:10831475. |
given the link between abnormalities in serotonergic neurotransmission and bipolar disorder, a candidate gene association approach was applied to study the involvement of the monoamine oxidase a (maoa) gene, which codes for a catabolic enzyme of serotonin, in the susceptibility to bipolar disorder. |
2000-06-29 |
2023-08-12 |
Not clear |
| L Cicin-Sain, N Mimica, D Hranilovic, M Balija, T Ljubin, G Makarić, V Folnegović-Smalc, B Jerne. Posttraumatic stress disorder and platelet serotonin measures. Journal of psychiatric research. vol 34. issue 2. 2000-06-27. PMID:10758258. |
in the present study, the blood platelet, which has been proposed as a peripheral model for the central serotonergic neurons, has been used to search for alterations in 5ht mechanisms in ptsd. |
2000-06-27 |
2023-08-12 |
human |
| W Z Zhan, C B Mantilla, P Zhan, A Bitton, Y S Prakash, A de Troyer, G C Siec. Regional differences in serotonergic input to canine parasternal intercostal motoneurons. Journal of applied physiology (Bethesda, Md. : 1985). vol 88. issue 5. 2000-06-23. PMID:10797116. |
in the present study, we tested the hypotheses that serotonergic [5-hydroxytryptamine (5-ht)] input from descending central drive and/or intrinsic size-related properties of pi motoneurons leads to the differential activation of pi muscles. |
2000-06-23 |
2023-08-12 |
Not clear |
| J M Monti, D Mont. Role of dorsal raphe nucleus serotonin 5-HT1A receptor in the regulation of REM sleep. Life sciences. vol 66. issue 21. 2000-06-23. PMID:10823340. |
all these neurons are inhibited by serotonergic (5-ht), noradrenergic, and presumably histaminergic (h2 receptor) and dopaminergic (d2 and d3 receptor) cells. |
2000-06-23 |
2023-08-12 |
Not clear |
| J Neuger, B Wistedt, B Sinner, A Aberg-Wistedt, R Stain-Malmgre. The effect of citalopram treatment on platelet serotonin function in panic disorders. International clinical psychopharmacology. vol 15. issue 2. 2000-06-16. PMID:10759339. |
we investigated the effect of the selective serotonin reuptake inhibitor (ssri) citalopram after 6-8 weeks and 6 months of treatment on clinical and peripheral indexes for central serotonergic function: platelet [14c]serotonin uptake and [3h]paroxetine- and [3h]lsd-binding to platelets membranes in 33 patients with panic disorder. |
2000-06-16 |
2023-08-12 |
human |
| M Sakai, M Matsunaga, A Kubota, Y Yamanishi, Y Nishizaw. Reduction in excessive muscle tone by selective depletion of serotonin in intercollicularly decerebrated rats. Brain research. vol 860. issue 1-2. 2000-06-15. PMID:10727628. |
descending serotonergic pathways are known to modulate, directly or indirectly, the excitability of spinal cord motoneurons and it is inferred that serotonin (5-ht) plays an important role in locomotion. |
2000-06-15 |
2023-08-12 |
rat |
| M Sakai, M Matsunaga, A Kubota, Y Yamanishi, Y Nishizaw. Reduction in excessive muscle tone by selective depletion of serotonin in intercollicularly decerebrated rats. Brain research. vol 860. issue 1-2. 2000-06-15. PMID:10727628. |
these findings suggest that the descending serotonergic pathways are essential to induce excessive muscle tone in the intercollicular decerebrated rats and that 5-ht antagonists might be candidates for centrally acting muscle relaxants. |
2000-06-15 |
2023-08-12 |
rat |
| A Gobert, J M Rivet, F Lejeune, A Newman-Tancredi, A Adhumeau-Auclair, J P Nicolas, L Cistarelli, C Melon, M J Milla. Serotonin(2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: a combined dialysis and electrophysiological analysis in the rat. Synapse (New York, N.Y.). vol 36. issue 3. 2000-06-06. PMID:10819900. |
serotonin(2c) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: a combined dialysis and electrophysiological analysis in the rat. |
2000-06-06 |
2023-08-12 |
rat |