| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Tao, Z Ma, S B Auerbac. Differential effect of local infusion of serotonin reuptake inhibitors in the raphe versus forebrain and the role of depolarization-induced release in increased extracellular serotonin. The Journal of pharmacology and experimental therapeutics. vol 294. issue 2. 2000-08-24. PMID:10900234. |
because serotonergic neuronal activity is suppressed, the mechanism underlying ssri-induced increases in extracellular 5-ht is unclear. |
2000-08-24 |
2023-08-12 |
rat |
| R Tao, Z Ma, S B Auerbac. Differential effect of local infusion of serotonin reuptake inhibitors in the raphe versus forebrain and the role of depolarization-induced release in increased extracellular serotonin. The Journal of pharmacology and experimental therapeutics. vol 294. issue 2. 2000-08-24. PMID:10900234. |
this study determined whether local infusion of ssris also elicited regionally selective increases in extracellular 5-ht, and whether changes depended on serotonergic neuronal depolarization. |
2000-08-24 |
2023-08-12 |
rat |
| R Tao, Z Ma, S B Auerbac. Differential effect of local infusion of serotonin reuptake inhibitors in the raphe versus forebrain and the role of depolarization-induced release in increased extracellular serotonin. The Journal of pharmacology and experimental therapeutics. vol 294. issue 2. 2000-08-24. PMID:10900234. |
consistent with evidence that autoreceptor activation inhibits serotonergic neuronal discharge, ssri infusion into drn produced a moderate decrease in 5-ht in nacc. |
2000-08-24 |
2023-08-12 |
rat |
| A C Parrott, E Sisk, J J Turne. Psychobiological problems in heavy 'ecstasy' (MDMA) polydrug users. Drug and alcohol dependence. vol 60. issue 1. 2000-08-17. PMID:10821995. |
however, since repeated mdma can cause serotonergic neurotoxicity in laboratory animals and man, these problems may reflect reduced serotonin activity induced by regular ecstasy use. |
2000-08-17 |
2023-08-12 |
Not clear |
| W H Frishman, P Grewal. Serotonin and the heart. Annals of medicine. vol 32. issue 3. 2000-08-15. PMID:10821327. |
the vasoconstrictive actions of serotonin are mediated by 5-ht2 serotonergic receptors, and serotonin also amplifies the release and activities of other vasoconstrictors, such as angiotensin and norepinephrine. |
2000-08-15 |
2023-08-12 |
Not clear |
| L Sundin, G E Nilsso. Branchial and circulatory responses to serotonin and rapid ambient water acidification in rainbow trout. The Journal of experimental zoology. vol 287. issue 2. 2000-08-10. PMID:10900430. |
in conclusion, acidic water and injected serotonin elevate the branchial resistance, but the involvement of a serotonergic component in the acidic response appears negligible. |
2000-08-10 |
2023-08-12 |
Not clear |
| J J Simpson, W E Davie. A review of evidence in support of a role for 5-HT in the perception of tinnitus. Hearing research. vol 145. issue 1-2. 2000-08-09. PMID:10867271. |
from neuroanatomical considerations and analogies with other clinical conditions, we postulate the involvement of serotonin (5-ht) in these plastic changes and consider the evidence available from the use of serotonergic drugs in different conditions. |
2000-08-09 |
2023-08-12 |
Not clear |
| M Hachisu, Y Ichimar. [Pharmacological and clinical aspects of fluvoxamine (Depromel), the first selective serotonin reuptake inhibitor approved for clinical use employed in Japan]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 115. issue 5. 2000-08-07. PMID:10872178. |
the antidepressant and the anti-ocd action are considered the result of the serotonin reuptake inhibition at the serotonergic neurons. |
2000-08-07 |
2023-08-12 |
mouse |
| K R Oliver, A M Kinsey, A Wainwright, D J Sirinathsinghj. Localization of 5-ht(5A) receptor-like immunoreactivity in the rat brain. Brain research. vol 867. issue 1-2. 2000-08-04. PMID:10837806. |
5-ht(5a)-like immunoreactivity was detected in areas known to have significant serotonergic input, such as hypothalamic and amygdaloid nuclei. |
2000-08-04 |
2023-08-12 |
rat |
| G Gerra, A Zaimovic, M Timpano, U Zambelli, R Delsignore, F Brambill. Neuroendocrine correlates of temperamental traits in humans. Psychoneuroendocrinology. vol 25. issue 5. 2000-08-03. PMID:10818282. |
in the present study, we have investigated the dopaminergic (da), serotonergic (5-ht), and noradrenergic (ne) functions in healthy volunteers by challenging the monoamine systems with the da agonist bromocriptine, the 5-ht agonist d-fenfluramine, and the ne agonist clonidine, respectively. |
2000-08-03 |
2023-08-12 |
human |
| B Bondy, A Erfurth, S de Jonge, M Krüger, H Meye. Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5-HTTLPR) with violent suicide. Molecular psychiatry. vol 5. issue 2. 2000-08-03. PMID:10822348. |
there is abundant evidence that the serotonin (5-ht) system is modulating mood and several behavioural traits and that disturbances in the regulation of this system can be associated with severe behavioural malfunctions, as aggressive implusive and suicidal behaviour.1 recently a functional polymorphism in the promoter region of the serotonin transporter gene (5-httlpr) was identified2 and the presence of one or two short alleles was associated with anxiety-related personality traits3 and several psychiatric disturbances, such as affective disorder4 or severe alcohol dependence.5 with respect to the importance of the 5-ht transporter in serotonergic transmission, we have genotyped the dna of 58 caucasian suicide victims (with unknown psychiatric diagnoses) and 110 healthy controls for the biallelic functional polymorphism in the 5-httlpr. |
2000-08-03 |
2023-08-12 |
Not clear |
| D Galter, K Unsicke. Sequential activation of the 5-HT1(A) serotonin receptor and TrkB induces the serotonergic neuronal phenotype. Molecular and cellular neurosciences. vol 15. issue 5. 2000-07-27. PMID:10833301. |
serotonin (5-ht) is an important factor controlling survival, differentiation, and plasticity of neurons in serotonergic target regions of the brain and has been implicated in major psychiatric and autonomic disorders. |
2000-07-27 |
2023-08-12 |
rat |
| D Galter, K Unsicke. Sequential activation of the 5-HT1(A) serotonin receptor and TrkB induces the serotonergic neuronal phenotype. Molecular and cellular neurosciences. vol 15. issue 5. 2000-07-27. PMID:10833301. |
we show now that 5-ht, the 5-ht1(a) receptor, brain-derived neurotrophic factor (bdnf), and its receptor, trkb, form an auto/paracrine loop for the regulation of the serotonergic phenotype. |
2000-07-27 |
2023-08-12 |
rat |
| D Galter, K Unsicke. Sequential activation of the 5-HT1(A) serotonin receptor and TrkB induces the serotonergic neuronal phenotype. Molecular and cellular neurosciences. vol 15. issue 5. 2000-07-27. PMID:10833301. |
serotonin applied to cultures from e14 rat raphe increased numbers of neurons expressing serotonergic markers in a dose-dependent manner. |
2000-07-27 |
2023-08-12 |
rat |
| D Galter, K Unsicke. Sequential activation of the 5-HT1(A) serotonin receptor and TrkB induces the serotonergic neuronal phenotype. Molecular and cellular neurosciences. vol 15. issue 5. 2000-07-27. PMID:10833301. |
induction of serotonergic markers by serotonin was suppressed by a trkb-igg fusion protein but not by trkc-igg. |
2000-07-27 |
2023-08-12 |
rat |
| D Galter, K Unsicke. Sequential activation of the 5-HT1(A) serotonin receptor and TrkB induces the serotonergic neuronal phenotype. Molecular and cellular neurosciences. vol 15. issue 5. 2000-07-27. PMID:10833301. |
taken together, our data indicate that serotonin acts on 5-ht1(a) autoreceptors, causing up-regulation of bdnf, which activates trkb to promote serotonergic phenotype-specific markers. |
2000-07-27 |
2023-08-12 |
rat |
| V Fabre, B Boutrel, N Hanoun, L Lanfumey, C M Fattaccini, B Demeneix, J Adrien, M Hamon, M P Martre. Homeostatic regulation of serotonergic function by the serotonin transporter as revealed by nonviral gene transfer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 13. 2000-07-26. PMID:10864964. |
homeostatic regulation of serotonergic function by the serotonin transporter as revealed by nonviral gene transfer. |
2000-07-26 |
2023-08-12 |
rat |
| P De Deurwaèrdere, M F Chessele. Nigrostriatal lesions alter oral dyskinesia and c-Fos expression induced by the serotonin agonist 1-(m-chlorophenyl)piperazine in adult rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 13. 2000-07-26. PMID:10864974. |
in the present study, we sought to determine the effects of chronic dopamine (da) depletion on responses mediated by stimulation of serotonergic 2c (5-ht(2c)) receptors, a serotonergic receptor subtype present in discrete regions of the basal ganglia. |
2000-07-26 |
2023-08-12 |
rat |
| Y Kodama, R Nonaka, Y Hagino, M Watanab. The distribution of serotonergic nerves in microencephalic rats treated prenatally with methylazoxymethanol. Neurochemical research. vol 25. issue 4. 2000-07-18. PMID:10823582. |
the results imply serotonergic hyperinnervation in the cerebral hemispheres of mam rats, while a target-dependent secondary degeneration of 5-ht neurons might be induced in the dorsal raphe nuclei of mam rats. |
2000-07-18 |
2023-08-12 |
rat |
| S Novotny, E Hollander, A Allen, S Mosovich, B Aronowitz, C Cartwright, C DeCaria, R Dolgoff-Kaspa. Increased growth hormone response to sumatriptan challenge in adult autistic disorders. Psychiatry research. vol 94. issue 2. 2000-07-17. PMID:10808042. |
serotonergic (5-ht) abnormalities have been documented in autism. |
2000-07-17 |
2023-08-12 |
human |