| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L C Daws, G G Gould, S D Teicher, G A Gerhardt, A Fraze. 5-HT(1B) receptor-mediated regulation of serotonin clearance in rat hippocampus in vivo. Journal of neurochemistry. vol 75. issue 5. 2000-11-09. PMID:11032901. |
the 5-hydroxytryptamine (5-ht; serotonin) transporter (5-htt) is important in terminating serotonergic neurotransmission and is a primary target for many psychotherapeutic drugs. |
2000-11-09 |
2023-08-12 |
rat |
| Y Masuda, T Sugiyam. The effect of globopentaosylceramide on a depression model, mouse forced swimming. The Tohoku journal of experimental medicine. vol 191. issue 1. 2000-11-07. PMID:10896039. |
we investigated the late effects of serotonergic drugs on mouse forced swimming and found that serotonin 1a antagonist nan-190 hydrobromide (nan-190) and serotonin 2 agonist r(-)-do1 hydrochloride (do1) increase the typical anti-depressive behavior climbing 6 hours after the intraperitoneal injection. |
2000-11-07 |
2023-08-12 |
mouse |
| Y Saito, S Takashim. Neurotransmitter changes in the pathophysiology of Lesch-Nyhan syndrome. Brain & development. vol 22 Suppl 1. 2000-11-07. PMID:10984673. |
an increased serotonergic action in the striatum may be crucial for the appearance of self-injurious behavior, and pharmacological evidence suggests the efficacy of serotonin agonists/antagonists for the treatment of the self-mutilation in lns. |
2000-11-07 |
2023-08-12 |
Not clear |
| M Lautenschlager, M Höltje, B von Jagow, R W Veh, C Harms, A Bergk, U Dirnagl, G Ahnert-Hilger, H Hörtnag. Serotonin uptake and release mechanisms in developing cultures of rat embryonic raphe neurons: age- and region-specific differences. Neuroscience. vol 99. issue 3. 2000-11-07. PMID:11029543. |
specific uptake as well as regulated serotonin release, however, was clearly discernible in these cultures after nine days in vitro, indicating developmental differentiation of the initially immature serotonergic neurons in culture. |
2000-11-07 |
2023-08-12 |
rat |
| M Lautenschlager, M Höltje, B von Jagow, R W Veh, C Harms, A Bergk, U Dirnagl, G Ahnert-Hilger, H Hörtnag. Serotonin uptake and release mechanisms in developing cultures of rat embryonic raphe neurons: age- and region-specific differences. Neuroscience. vol 99. issue 3. 2000-11-07. PMID:11029543. |
in contrast, serotonergic neurons obtained from the three raphe sub-groups at embryonic day 14 took up and released [3h]serotonin, as early as after two days in culture. |
2000-11-07 |
2023-08-12 |
rat |
| A Plenevaux, C Lemaire, J Aerts, G Lacan, D Rubins, W P Melega, C Brihaye, C Degueldre, S Fuchs, E Salmon, P Maquet, S Laureys, P Damhaut, D Weissmann, D Le Bars, J F Pujol, A Luxe. [(18)F]p-MPPF: aA radiolabeled antagonist for the study of 5-HT(1A) receptors with PET. Nuclear medicine and biology. vol 27. issue 5. 2000-11-03. PMID:10962252. |
this paper summarizes the present status of the researches conducted with [(18)f]4-(2'-methoxyphenyl)-1-[2'-[n-(2"-pyridinyl)-p-fluorobenzamido ]ethyl]-piperazine known as [(18)f]p-mppf, a new 5-ht(1a) antagonist for the study of the serotonergic neurotransmission with positron emission tomography (pet). |
2000-11-03 |
2023-08-12 |
human |
| L Steardo, P Monteleone, L Trabace, C Cannizzaro, M Maj, V Cuom. Serotonergic modulation of rat pineal gland activity: in vivo evidence for a 5-Hydroxytryptamine(2C) receptor involvement. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991989. |
serotonergic modulation of rat pineal gland activity: in vivo evidence for a 5-hydroxytryptamine(2c) receptor involvement. |
2000-11-03 |
2023-08-12 |
rat |
| L Steardo, P Monteleone, L Trabace, C Cannizzaro, M Maj, V Cuom. Serotonergic modulation of rat pineal gland activity: in vivo evidence for a 5-Hydroxytryptamine(2C) receptor involvement. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991989. |
these results suggest that 5-ht(2c) receptors are likely involved in the mediation of the serotonergic modulation of pineal biosynthetic activity in rats. |
2000-11-03 |
2023-08-12 |
rat |
| G Neec. Neuroendocrine and hormonal perturbations and relations to the serotonergic system in fibromyalgia patients. Scandinavian journal of rheumatology. Supplement. vol 113. 2000-11-03. PMID:11028824. |
serotonin (5ht), precursors like tryptophan (5htp), drugs which release 5ht or act directly on 5ht receptors stimulate hpa axis, indicating a stimulatory serotonergic influence on hpa axis function. |
2000-11-03 |
2023-08-12 |
Not clear |
| A Sarihi, F Motamedi, N Naghdi, A Rashidy-Pou. Lidocaine reversible inactivation of the median raphe nucleus has no effect on reference memory but enhances working memory versions of the Morris water maze task. Behavioural brain research. vol 114. issue 1-2. 2000-10-19. PMID:10996040. |
numerous studies in the past have dealt with the role of serotonergic system lesions in tasks aimed at measurement of cognitive behavior, but the literature concerning the role of serotonin in cognition remains controversial. |
2000-10-19 |
2023-08-12 |
rat |
| E Sørensen, B Bjorvatn, R Ursi. Sleep-wake effects following the selective 5-HT(1A) receptor antagonist p-MPPI in the freely moving rat. Behavioural brain research. vol 114. issue 1-2. 2000-10-19. PMID:10996044. |
the 5-ht(1a) receptors appear to play an important role in the serotonergic modulation of sleep and waking. |
2000-10-19 |
2023-08-12 |
rat |
| E Sørensen, B Bjorvatn, R Ursi. Sleep-wake effects following the selective 5-HT(1A) receptor antagonist p-MPPI in the freely moving rat. Behavioural brain research. vol 114. issue 1-2. 2000-10-19. PMID:10996044. |
however, the rem sleep reduction probably reflects p-mppis ability to block the presynaptic 5-ht(1a) autoreceptors, increasing the firing activity in the serotonergic neurones and possibly inhibiting serotonin sensitive rem sleep active neurones. |
2000-10-19 |
2023-08-12 |
rat |
| S Schreiber, M M Backer, I Herman, D Shamir, T Boniel, C G Pic. The antinociceptive effect of trazodone in mice is mediated through both mu-opioid and serotonergic mechanisms. Behavioural brain research. vol 114. issue 1-2. 2000-10-19. PMID:10996046. |
when adrenergic and serotonergic antagonists were used, metergoline (p<0.05) but not phentolamine or yohimbine, decreased antinociception elicited by trazodone, implying a clear 5-ht mechanism of antinociception. |
2000-10-19 |
2023-08-12 |
mouse |
| S Feldman, M E Newman, J Weidenfel. Effects of adrenergic and serotonergic agonists in the amygdala on the hypothalamo-pituitary-adrenocortical axis. Brain research bulletin. vol 52. issue 6. 2000-10-16. PMID:10974493. |
the effect of direct administration of adrenergic and serotonergic (5-ht) agonists into the central nucleus of the amygdala (amg) on the hypothalamo-pituitary-adrenal (hpa) axis have been studied in intact male rats and in animals with 6-hydroxydopamine (6-ohda) or 5, 7-dihydroxytryptamine (5,7-dht) neurotoxic lesions in the paraventricular nucleus of the hypothalamus (pvn). |
2000-10-16 |
2023-08-12 |
rat |
| K G Harikumar, A Chattopadhya. Effect of alcohols on G-protein coupling of serotonin(1A) receptors from bovine hippocampus. Brain research bulletin. vol 52. issue 6. 2000-10-16. PMID:10974502. |
g-protein coupling of the 5-ht(1a) receptor serves as an important determinant for serotonergic signalling. |
2000-10-16 |
2023-08-12 |
cattle |
| J Stefulj, B Jernej, L Cicin-Sain, I Rinner, K Schauenstei. mRNA expression of serotonin receptors in cells of the immune tissues of the rat. Brain, behavior, and immunity. vol 14. issue 3. 2000-10-13. PMID:10970681. |
these results may be useful as a starting point for future functional studies on immunomodulatory effects of 5-ht and may help to understand conflicting serotonergic effects on immune functions as found in the literature. |
2000-10-13 |
2023-08-12 |
rat |
| R Liu, T Jolas, G Aghajania. Serotonin 5-HT(2) receptors activate local GABA inhibitory inputs to serotonergic neurons of the dorsal raphe nucleus. Brain research. vol 873. issue 1. 2000-10-12. PMID:10915808. |
serotonin 5-ht(2) receptors activate local gaba inhibitory inputs to serotonergic neurons of the dorsal raphe nucleus. |
2000-10-12 |
2023-08-12 |
rat |
| M M Fernández, A Morán, M L Martín, L San Romá. Mesenteric vasoconstrictor response to 5-hydroxytryptamine in the in situ blood autoperfused rat mesentery: involvement of 5-HT(2B) and/or 5-HT(2C) receptor activation. European journal of pharmacology. vol 401. issue 2. 2000-10-12. PMID:10924930. |
our data suggest that the vasoconstrictor serotonergic response induced in the in situ autoperfused rat mesenteric vascular bed is mainly mediated by activation of 5-ht(2b) and/or 5-ht(2c) receptors. |
2000-10-12 |
2023-08-12 |
rat |
| D J Castle, D Morkel. Imagined ugliness: a symptom which can become a disorder. The Medical journal of Australia. vol 173. issue 4. 2000-10-06. PMID:11008595. |
bdd is treatable, with serotonergic antidepressants (e.g., selective serotonin reuptake inhibitors) and cognitive-behavioural treatments being the most effective. |
2000-10-06 |
2023-08-12 |
Not clear |
| F Bellivier, A Szöke, C Henry, J Lacoste, C Bottos, M Nosten-Bertrand, P Hardy, F Rouillon, J M Launay, J L Laplanche, M Leboye. Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders. Biological psychiatry. vol 48. issue 4. 2000-10-04. PMID:10960164. |
in this case-control study we investigated whether the serotonin transporter (5-htt) gene encoding the protein responsible for the reuptake of serotonin from the synapse after its release from serotonergic neurons is a susceptibility factor for suicidal behavior. |
2000-10-04 |
2023-08-12 |
Not clear |