| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Weizman, R Weizma. Serotonin transporter polymorphism and response to SSRIs in major depression and relevance to anxiety disorders and substance abuse. Pharmacogenomics. vol 1. issue 3. 2001-04-26. PMID:11256582. |
the selective serotonin re-uptake inhibitors (ssris) which modulate serotonergic activity are effective in the treatment of serotonin-related mental disorders, such as depression and anxiety. |
2001-04-26 |
2023-08-12 |
Not clear |
| L Santarelli, G Gobbi, P C Debs, E T Sibille, P Blier, R Hen, M J Heat. Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172050. |
these behavioral changes are paralleled by an increase in the firing rate of 5-ht neurons in the dorsal raphe nucleus, a major source of serotonergic input to the forebrain. |
2001-04-19 |
2023-08-12 |
mouse |
| G Fillio. Potential of 5-HT-moduline as a drug target for affective disorders. Current opinion in investigational drugs (London, England : 2000). vol 1. issue 1. 2001-04-19. PMID:11249585. |
the regulatory activity of the serotonergic system itself is modulated by an endogenous mechanism based on an allosteric interaction involving a newly discovered peptide, 5-ht-moduline, and the 5-ht1b receptor which, as an autoreceptor, controls the release of 5-ht from serotonergic neuron terminals. |
2001-04-19 |
2023-08-12 |
mouse |
| S Chiavegatto, V L Dawson, L A Mamounas, V E Koliatsos, T M Dawson, R J Nelso. Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 3. 2001-04-12. PMID:11158630. |
recent studies suggest that central serotonergic neuronal circuits and particularly 5-ht(1a) and 5-ht(1b) receptors play a prominent role in the regulation of aggression. |
2001-04-12 |
2023-08-12 |
mouse |
| R Mössner, A Schmitt, Y Syagailo, M Gerlach, P Riederer, K P Lesc. The serotonin transporter in Alzheimer's and Parkinson's disease. Journal of neural transmission. Supplementum. issue 60. 2001-04-12. PMID:11205152. |
in both disorders there is an extensive degeneration of serotonergic neurons, with corresponding losses of the serotonin (5ht) transporter (5htt), which is responsible for the reuptake of 5ht from the synaptic cleft. |
2001-04-12 |
2023-08-12 |
human |
| V K Bhargava, L Sah. Serotonergic mechanism in imipramine induced antinociception in rat tail flick test. Indian journal of physiology and pharmacology. vol 45. issue 1. 2001-04-12. PMID:11211562. |
therefore, we explored the effect of serotonergic system on imipramine induced antinociception by using 5-hydroxytryptamine-3 (5ht3) receptor antagonist ondansetron and 5-hydroxytryptamine-2 (5ht2) receptor antagonist mianserine, and depletion of brain 5-hydroxytryptamine (5ht) with p-chlorophenyl alanine (pcpa). |
2001-04-12 |
2023-08-12 |
human |
| P D Finn, M J Cunningham, D G Rickard, D K Clifton, R A Steine. Serotonergic neurons are targets for leptin in the monkey. The Journal of clinical endocrinology and metabolism. vol 86. issue 1. 2001-04-12. PMID:11232034. |
we observed that many cells in the raphe nuclei express serotonin transporter mrna, a marker of serotonergic cells, and ob-r mrna. |
2001-04-12 |
2023-08-12 |
rat |
| S Lenglet, C Delarue, H Lefebvre, H Vaudry, V Contess. Rat glomerulosa cells express functional 5-HT7 receptors. Endocrine research. vol 26. issue 4. 2001-03-22. PMID:11196435. |
the aim of the present study was to characterize the type of serotonergic receptor involved in the action of 5-ht on rat glomerulosa cells. |
2001-03-22 |
2023-08-12 |
rat |
| I Malagié, A C Trillat, M Bourin, C Jacquot, R Hen, A M Gardie. 5-HT1B Autoreceptors limit the effects of selective serotonin re-uptake inhibitors in mouse hippocampus and frontal cortex. Journal of neurochemistry. vol 76. issue 3. 2001-03-15. PMID:11158258. |
these data suggest that 5-ht1b autoreceptors limit the effects of ssris on dialysate 5-ht levels at serotonergic nerve terminals. |
2001-03-15 |
2023-08-12 |
mouse |
| M Matsumoto, H Togashi, K Mori, K Ueno, S Ohashi, T Kojima, M Yoshiok. Evidence for involvement of central 5-HT(4) receptors in cholinergic function associated with cognitive processes: behavioral, electrophysiological, and neurochemical studies. The Journal of pharmacology and experimental therapeutics. vol 296. issue 3. 2001-03-15. PMID:11181892. |
these findings suggest that the functional interaction between the serotonergic system mediated via 5-ht(4) receptors and the cholinergic system associated with cognitive processes exists in vivo. |
2001-03-15 |
2023-08-12 |
rat |
| G Gobbi, D L Murphy, K Lesch, P Blie. Modifications of the serotonergic system in mice lacking serotonin transporters: an in vivo electrophysiological study. The Journal of pharmacology and experimental therapeutics. vol 296. issue 3. 2001-03-15. PMID:11181933. |
modifications of the serotonergic system in mice lacking serotonin transporters: an in vivo electrophysiological study. |
2001-03-15 |
2023-08-12 |
mouse |
| R S El-Mallakh, C Peters, C Waltri. Antidepressant treatment and neural plasticity. Journal of child and adolescent psychopharmacology. vol 10. issue 4. 2001-03-15. PMID:11191689. |
for example, the effects of serotonin on neuronal plasticity suggest that agents that can alter serotonergic function may alter neuronal wiring. |
2001-03-15 |
2023-08-12 |
Not clear |
| S Hashimot. [Anxiolytic effects of serotonin reuptake inhibitors and their mechanism of action]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 75. issue 6. 2001-03-15. PMID:11193934. |
the purpose of this study was to examine the anxiolytic effects of serotonin (5-ht) reuptake inhibitors and to clarify their action mechanisms and roles in the brain serotonergic system in the psychopathology of anxiety. |
2001-03-15 |
2023-08-12 |
rat |
| B Bjorvatn, C A Fornal, F J Martín, C W Metzler, B L Jacob. Venlafaxine and its interaction with WAY 100635: effects on serotonergic unit activity and behavior in cats. European journal of pharmacology. vol 404. issue 1-2. 2001-02-22. PMID:10980270. |
the therapeutic efficacy of antidepressant drugs that inhibit the reuptake of serotonin (5-hydroxytryptamine, 5-ht) may be enhanced by blocking their indirect activation of 5-ht(1a) autoreceptors, which mediate feedback inhibition of serotonergic neuronal activity. |
2001-02-22 |
2023-08-12 |
Not clear |
| B Bjorvatn, C A Fornal, F J Martín, C W Metzler, B L Jacob. Venlafaxine and its interaction with WAY 100635: effects on serotonergic unit activity and behavior in cats. European journal of pharmacology. vol 404. issue 1-2. 2001-02-22. PMID:10980270. |
in this study, we examined the effects of venlafaxine, a dual 5-ht/noradrenaline reuptake inhibitor, alone and in combination with the selective 5-ht(1a) receptor antagonist n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexanecarboxamide (way 100635), on the single-unit activity of serotonergic dorsal raphe neurons and concurrent behavior in freely moving cats. |
2001-02-22 |
2023-08-12 |
Not clear |
| J Veenstra-VanderWeele, G M Anderson, E H Coo. Pharmacogenetics and the serotonin system: initial studies and future directions. European journal of pharmacology. vol 410. issue 2-3. 2001-02-22. PMID:11134668. |
serotonin (5-hydroxytryptamine, 5-ht) appears to play a role in the pathophysiology of a range of neuropsychiatric disorders, and serotonergic agents are of central importance in neuropharmacology. |
2001-02-22 |
2023-08-12 |
Not clear |
| R Mössner, S Daniel, A Schmitt, D Albert, K P Lesc. Modulation of serotonin transporter function by interleukin-4. Life sciences. vol 68. issue 8. 2001-02-22. PMID:11213357. |
5-ht signaling is regulated by the 5-ht transporter (5-htt), which determines the magnitude and duration of serotonergic responses. |
2001-02-22 |
2023-08-12 |
Not clear |
| G Neeck, L J Croffor. Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome. Rheumatic diseases clinics of North America. vol 26. issue 4. 2001-02-15. PMID:11084955. |
serotonin (5-ht) precursors such as tryptophan (5-htp), drugs that release 5-ht, or drugs that act directly on 5-ht receptors stimulate the hpa axis, indicating a stimulatory effect of serotonergic input on hpa axis function. |
2001-02-15 |
2023-08-12 |
Not clear |
| Z Sarnyai, E L Sibille, C Pavlides, R J Fenster, B S McEwen, M Tot. Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 26. 2001-02-15. PMID:11121072. |
the hippocampus is a major limbic target of the brainstem serotonergic neurons that modulate fear, anxiety, and learning through postsynaptic serotonin(1a) receptors (5-ht(1a) receptors). |
2001-02-15 |
2023-08-12 |
mouse |
| Z G Chu, F M Zhou, J J Hablit. Nicotinic acetylcholine receptor-mediated synaptic potentials in rat neocortex. Brain research. vol 887. issue 2. 2001-02-15. PMID:11134630. |
eaa-antagonist resistant epscs were observed in the presence of antagonists of metabotropic glutamate, serotonergic (5-ht(3)) and purinergic (p2) receptors. |
2001-02-15 |
2023-08-12 |
rat |