| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V S Basile, V Ozdemir, M Masellis, H Y Meltzer, J A Lieberman, S G Potkin, F M Macciardi, A Petronis, J L Kenned. Lack of association between serotonin-2A receptor gene (HTR2A) polymorphisms and tardive dyskinesia in schizophrenia. Molecular psychiatry. vol 6. issue 2. 2001-06-28. PMID:11317228. |
theoretically, central serotonergic function can be subject to genetic control at various other mechanistic levels including the rate of serotonin synthesis (tryptophane hydroxylase gene), release, reuptake (serotonin transporter gene) and degradation (monoamine oxidase gene). |
2001-06-28 |
2023-08-12 |
human |
| G Seeger, P Schloss, M H Schmid. Functional polymorphism within the promotor of the serotonin transporter gene is associated with severe hyperkinetic disorders. Molecular psychiatry. vol 6. issue 2. 2001-06-28. PMID:11317229. |
the efficiency of serotonergic signalling relates to the concentration of the neurotransmitter in the synaptic cleft and is controlled by the serotonin transporter (5-htt), which selectively removes serotonin out of the synaptic cleft. |
2001-06-28 |
2023-08-12 |
Not clear |
| G Seeger, P Schloss, M H Schmid. Functional polymorphism within the promotor of the serotonin transporter gene is associated with severe hyperkinetic disorders. Molecular psychiatry. vol 6. issue 2. 2001-06-28. PMID:11317229. |
as a consequence, for a successful treatment of these patients one should now also consider drugs which specifically modulate serotonergic signalling such as selective serotonin reuptake inhibitors. |
2001-06-28 |
2023-08-12 |
Not clear |
| R Martín-Ruiz, L Ugedo, M A Honrubia, G Mengod, F Artiga. Control of serotonergic neurons in rat brain by dopaminergic receptors outside the dorsal raphe nucleus. Journal of neurochemistry. vol 77. issue 3. 2001-06-28. PMID:11331405. |
thus, the discrepancy between local and systemic effects of dopaminergic agonists and the absence of da d(2) receptor transcript in 5-ht neurons suggest that da d(2) receptors outside the dr control serotonergic activity. |
2001-06-28 |
2023-08-12 |
rat |
| R Legutko, R L Ganno. Serotonin transporter localization in the hamster suprachiasmatic nucleus. Brain research. vol 893. issue 1-2. 2001-06-21. PMID:11222995. |
consequently, serotonergic agonists and antagonists or agents that alter levels of serotonin in the synapse following transmission can modulate many aspects of circadian rhythmicity. |
2001-06-21 |
2023-08-12 |
Not clear |
| R Legutko, R L Ganno. Serotonin transporter localization in the hamster suprachiasmatic nucleus. Brain research. vol 893. issue 1-2. 2001-06-21. PMID:11222995. |
our results demonstrate a dense labeling of the serotonin transporter throughout the ventral and medial regions of the suprachiasmatic nucleus, a pattern that overlaps the distribution of serotonergic afferents in this nucleus. |
2001-06-21 |
2023-08-12 |
Not clear |
| G Lee, A Villella, B J Taylor, J C Hal. New reproductive anomalies in fruitless-mutant Drosophila males: extreme lengthening of mating durations and infertility correlated with defective serotonergic innervation of reproductive organs. Journal of neurobiology. vol 47. issue 2. 2001-06-21. PMID:11291102. |
such abnormalities may be associated with certain serotonergic neurons in the abdominal ganglion in which production of 5ht is regulated by fru. |
2001-06-21 |
2023-08-12 |
drosophila_melanogaster |
| I Murak. [Behavioral and neurochemical study on the mechanism of the anxiolytic effect of a selective serotonin reuptake inhibitor, a selective serotonin1A agonist and lithium carbonate]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 76. issue 2. 2001-06-21. PMID:11344903. |
these results suggest that subchronic lithium treatment enhanced the anxiolytic-like effects of these serotonergic drugs by facilitating central 5-ht neurotransmission at clinically therapeutic plasma lithium levels. |
2001-06-21 |
2023-08-12 |
Not clear |
| K P Lesc. Serotonergic gene expression and depression: implications for developing novel antidepressants. Journal of affective disorders. vol 62. issue 1-2. 2001-06-14. PMID:11172874. |
several lines of evidence indicate that genetically determined variability in serotonergic gene expression, as it has been documented for the 5-ht transporter, influences temperamental traits and may lead to psychopathological conditions with increased anxiety, depression, and aggression. |
2001-06-14 |
2023-08-12 |
Not clear |
| U Hegerl, J Gallinat, G Jucke. Event-related potentials. Do they reflect central serotonergic neurotransmission and do they predict clinical response to serotonin agonists? Journal of affective disorders. vol 62. issue 1-2. 2001-06-14. PMID:11172876. |
do they reflect central serotonergic neurotransmission and do they predict clinical response to serotonin agonists? |
2001-06-14 |
2023-08-12 |
Not clear |
| R J Lamb, T U Järb. Effects of fluvoxamine on ethanol-reinforced behavior in the rat. The Journal of pharmacology and experimental therapeutics. vol 297. issue 3. 2001-06-14. PMID:11356922. |
serotonergic deficiencies have been associated with alcoholism, and increasing serotonin function has been reported to decrease ethanol consumption. |
2001-06-14 |
2023-08-12 |
rat |
| J Benton, B Belt. Effects of serotonin depletion on local interneurons in the developing olfactory pathway of lobsters. Journal of neurobiology. vol 46. issue 3. 2001-06-07. PMID:11169505. |
this study documents proliferation and survival in the local interneuron cell clusters, and examines the differentiation of a prominent local interneuron, the serotonergic dorsal giant neuron (dgn), following serotonin depletion. |
2001-06-07 |
2023-08-12 |
lobster |
| M T Hsieh, C R Wu, W H Wang, L W Li. The ameliorating effect of the water layer of Fructus Schisandrae on cycloheximide-induced amnesia in rats: interaction with drugs acting at neurotransmitter receptors. Pharmacological research. vol 43. issue 1. 2001-06-07. PMID:11207061. |
these results suggest that the beneficial effect of fs(w)on cxm-induced amnesia is amplified by treatment with serotonergic 5-ht(2)receptor antagonists, but reduced by serotonergic 5-ht(1a)receptor agonists as well as gaba(a)and cholinergic receptor antagonists. |
2001-06-07 |
2023-08-12 |
rat |
| K P Schulz, J H Newcorn, K E McKay, J Himelstein, V H Koda, L J Siever, V Sharma, J M Halperi. Relationship between central serotonergic function and aggression in prepubertal boys: effect of age and attention-deficit/hyperactivity disorder. Psychiatry research. vol 101. issue 1. 2001-06-07. PMID:11223114. |
data indicate that diminished central serotonergic (5-ht) function is related to aggression in adults, but discrepant findings in children suggest that age or the presence of attention-deficit/hyperactivity disorder (adhd) may influence this relationship. |
2001-06-07 |
2023-08-12 |
Not clear |
| L Ferraro, S Tanganelli, K Fuxe, B W Bebe, M C Tomasini, F A Rambert, T Antonell. Modafinil does not affect serotonin efflux from rat frontal cortex synaptosomes: comparison with known serotonergic drugs. Brain research. vol 894. issue 2. 2001-06-07. PMID:11251206. |
modafinil does not affect serotonin efflux from rat frontal cortex synaptosomes: comparison with known serotonergic drugs. |
2001-06-07 |
2023-08-12 |
rat |
| A Mehta, K Eberle-Wang, M F Chessele. Increased m-CPP-induced oral dyskinesia after lesion of serotonergic neurons. Pharmacology, biochemistry, and behavior. vol 68. issue 2. 2001-06-07. PMID:11267640. |
the data indicate that lesion of serotonergic neurons in adult rats induces a transient increase in motor responses mediated by subthalamic 5-ht(2c) receptors. |
2001-06-07 |
2023-08-12 |
rat |
| N Ramírez, B Arranz, R M Dueñas, L Sa. [Electroconvulsive therapy and serotonergic system]. Actas espanolas de psiquiatria. vol 28. issue 5. 2001-06-07. PMID:11269912. |
with regard to the serotonergic system, several levels of alteration can be targeted, that concerning serotonin and its metabolite concentrations, that concerning changes in the density of presynaptic and postsynaptic receptors located both in brain tissue or in platelets, and finally, alterations at the intracellular signalling system or second messenger level. |
2001-06-07 |
2023-08-12 |
Not clear |
| J M Meythaler, L Depalma, M J Devivo, S Guin-Renfroe, T A Novac. Sertraline to improve arousal and alertness in severe traumatic brain injury secondary to motor vehicle crashes. Brain injury. vol 15. issue 4. 2001-06-07. PMID:11299133. |
serotonin is a major inhibitory as well an excitatory neurotransmitter, and serotonergic neurons modulate the activity of brain regions responsible for motor control, arousal, attention, and emotional regulation. |
2001-06-07 |
2023-08-12 |
Not clear |
| H Nakano, U J Magalang, S D Lee, J A Krasney, G A Farka. Serotonergic modulation of ventilation and upper airway stability in obese Zucker rats. American journal of respiratory and critical care medicine. vol 163. issue 5. 2001-06-07. PMID:11316658. |
we suggest that the 5-ht(2a/2c) receptor subtype plays an important role in the maintenance of ua stability and normal breathing in obesity, and we speculate that older obese z rats may have augmented serotonergic control of ua dilator muscles as a mechanism to prevent pharyngeal collapse. |
2001-06-07 |
2023-08-12 |
rat |
| H Hasegawa, T Yazawa, M Yasumatsu, M Otokawa, Y Aihar. Alteration in dopamine metabolism in the thermoregulatory center of exercising rats. Neuroscience letters. vol 289. issue 3. 2001-05-31. PMID:10961654. |
however, exercise did not induce an increase in the level of either serotonergic substances (5-hydroxytryptamine and 5-hydroxyindoleacetic acid) or amino acids (aspartate and glutamate). |
2001-05-31 |
2023-08-12 |
rat |