| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Lerer, F Macciardi, R H Segman, R Adolfsson, D Blackwood, S Blairy, J Del Favero, D G Dikeos, R Kaneva, R Lilli, I Massat, V Milanova, W Muir, M Noethen, L Oruc, T Petrova, G N Papadimitriou, M Rietschel, A Serretti, D Souery, S Van Gestel, C Van Broeckhoven, J Mendlewic. Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder. Molecular psychiatry. vol 6. issue 5. 2001-10-18. PMID:11526472. |
substantial evidence supports a role for dysfunction of brain serotonergic (5-ht) systems in the pathogenesis of major affective disorder, both unipolar (recurrent major depression) and bipolar. |
2001-10-18 |
2023-08-12 |
human |
| E D O'Loinsigh, G Boland, J P Kelly, K M O'Boyl. Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 3. 2001-10-11. PMID:11371001. |
this study shows that large n-alkyl substitution decreases the ability of mdma analogues to evoke presynaptic 5-ht and da release, induce acute hyperthermia, hyperlocomotion and behavioural changes, and cause long-term serotonergic neurotoxicity. |
2001-10-11 |
2023-08-12 |
rat |
| R Buchert, J Obrocki, R Thomasius, O Väterlein, K Petersen, L Jenicke, K H Bohuslavizki, M Clause. Long-term effects of 'ecstasy' abuse on the human brain studied by FDG PET. Nuclear medicine communications. vol 22. issue 8. 2001-10-11. PMID:11473208. |
mdma is suspected of causing neurotoxic lesions to the serotonergic system as demonstrated by animal studies, examinations of human cerebrospinal fluid, and the first positron emission tomography (pet) studies using the serotonin transporter ligand [11c]-mcn5652. |
2001-10-11 |
2023-08-12 |
human |
| G M Asnis, F A Hameedi, A W Goddard, S G Potkin, D Black, M Jameel, K Desagani, S W Wood. Fluvoxamine in the treatment of panic disorder: a multi-center, double-blind, placebo-controlled study in outpatients. Psychiatry research. vol 103. issue 1. 2001-10-04. PMID:11472786. |
serotonergic mechanisms have been implicated in panic disorder, and several preliminary studies suggest that fluvoxamine, a selective serotonin reuptake inhibitor (ssri), is helpful in its treatment. |
2001-10-04 |
2023-08-12 |
Not clear |
| T Harkany, S O'Mahony, J Keijser, J P Kelly, C Kónya, Z A Borostyánkoi, T J Görcs, M Zarándi, B Penke, B E Leonard, P G Luite. Beta-amyloid(1-42)-induced cholinergic lesions in rat nucleus basalis bidirectionally modulate serotonergic innervation of the basal forebrain and cerebral cortex. Neurobiology of disease. vol 8. issue 4. 2001-09-27. PMID:11493031. |
in contrast, the loss of serotonin-positive fiber projections, decreased concentrations of both serotonin and 5-hydroxyindoleacetic acid, and decline of cortical 5-ht(1a) receptor binding sites indicated reduced serotonergic activity in the somatosensory cortex. |
2001-09-27 |
2023-08-12 |
rat |
| T Harkany, S O'Mahony, J Keijser, J P Kelly, C Kónya, Z A Borostyánkoi, T J Görcs, M Zarándi, B Penke, B E Leonard, P G Luite. Beta-amyloid(1-42)-induced cholinergic lesions in rat nucleus basalis bidirectionally modulate serotonergic innervation of the basal forebrain and cerebral cortex. Neurobiology of disease. vol 8. issue 4. 2001-09-27. PMID:11493031. |
we assume that enhanced serotonin immunoreactivity in the damaged mbn indicates intrinsic processes facilitating neuronal recovery and cellular repair mechanisms, while diminished cortical serotonergic activity correlates with the loss of the subcortical cholinergic input, thereby maintaining the balance of neurotransmitter concentrations in the cerebral cortex. |
2001-09-27 |
2023-08-12 |
rat |
| D E Johnson, H Rollema, A W Schmidt, A D McHar. Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain. European journal of pharmacology. vol 425. issue 3. 2001-09-27. PMID:11513839. |
in vivo microdialysis was used to assess the central serotonergic effects and extracellular brain levels of the 5-ht(1b/1d) receptor agonists eletriptan, zolmitriptan and sumatriptan in rats after intravenous and intracerebral administration, while their binding affinities and functional potencies were determined at 5-ht(1b), 5-ht(1d) and 5-ht(1a) receptors. |
2001-09-27 |
2023-08-12 |
rat |
| D E Johnson, H Rollema, A W Schmidt, A D McHar. Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain. European journal of pharmacology. vol 425. issue 3. 2001-09-27. PMID:11513839. |
the observation that eletriptan and zolmitriptan produce almost identical central serotonergic effects, after intracerebral as well as after systemic administration, is in agreement with their comparable functional 5-ht(1b/1d) receptor agonist potencies and their free levels in cortical dialysates after 3.2 mg/kg i.v. |
2001-09-27 |
2023-08-12 |
rat |
| M Chennaoui, C Drogou, D Gomez-Merino, B Grimaldi, G Fillion, C Y Guezenne. Endurance training effects on 5-HT(1B) receptors mRNA expression in cerebellum, striatum, frontal cortex and hippocampus of rats. Neuroscience letters. vol 307. issue 1. 2001-09-27. PMID:11516568. |
the 5-ht(1b) receptors are the predominant auto- and heteroreceptors located on serotonergic and non-serotonergic terminals where they regulate the neuronal release of neurotransmitters. |
2001-09-27 |
2023-08-12 |
rat |
| J S Rubinsztein, R D Rogers, W J Riedel, M A Mehta, T W Robbins, B J Sahakia. Acute dietary tryptophan depletion impairs maintenance of "affective set" and delayed visual recognition in healthy volunteers. Psychopharmacology. vol 154. issue 3. 2001-09-20. PMID:11351939. |
altered serotonergic transmission in affective disorders and alzheimer's disease has prompted research aimed at defining the precise cognitive effects of depleting central serotonin in humans, using acute dietary tryptophan depletion. |
2001-09-20 |
2023-08-12 |
human |
| B Buwalda, W A Blom, J M Koolhaas, G van Dij. Behavioral and physiological responses to stress are affected by high-fat feeding in male rats. Physiology & behavior. vol 73. issue 3. 2001-09-20. PMID:11438364. |
the serotonergic 5-ht(1a) receptor hyposensitivity that was observed in hc-fed rats 2 weeks after stress was absent in the hf regimen. |
2001-09-20 |
2023-08-12 |
rat |
| J Feng, X Cai, J Zhao, Z Ya. Serotonin receptors modulate GABA(A) receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 17. 2001-09-20. PMID:11517239. |
although multiple 5-ht receptors were coexpressed in pfc pyramidal neurons, the serotonergic modulation of gaba-evoked currents was mimicked by the 5-ht(2)-class agonist (-)-2,5-dimethoxy-4-iodoamphetamine and blocked by 5-ht(2) antagonists risperidone and ketanserin, indicating the mediation by 5-ht(2) receptors. |
2001-09-20 |
2023-08-12 |
Not clear |
| J Feng, X Cai, J Zhao, Z Ya. Serotonin receptors modulate GABA(A) receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 17. 2001-09-20. PMID:11517239. |
disrupting the interaction of pkc with its anchoring protein rack1 (receptor for activated c kinase) eliminated the 5-ht(2) modulation of gaba(a) currents, suggesting that rack1-mediated targeting of pkc to the vicinity of gaba(a) receptors is required for the serotonergic signaling. |
2001-09-20 |
2023-08-12 |
Not clear |
| J A Mikkola, A Honkanen, T P Piepponen, K Kiianmaa, L Ahte. Effects of repeated morphine treatment on metabolism of cerebral dopamine and serotonin in alcohol-preferring AA and alcohol-avoiding ANA rats. Alcohol and alcoholism (Oxford, Oxfordshire). vol 36. issue 4. 2001-09-13. PMID:11468126. |
to study the involvement of dopaminergic and serotonergic transmission in this behaviour, the effects of acute morphine (1 mg/kg) challenge on the concentrations of dopamine (da), 5-hydroxytryptamine (5-ht, serotonin) and their metabolites were estimated in three dopaminergic areas in aa and ana rats on the fourth day after a 3-day morphine or saline treatment. |
2001-09-13 |
2023-08-12 |
rat |
| D A Knobelman, R Hen, J A Blendy, I Luck. Regional patterns of compensation following genetic deletion of either 5-hydroxytryptamine(1A) or 5-hydroxytryptamine(1B) receptor in the mouse. The Journal of pharmacology and experimental therapeutics. vol 298. issue 3. 2001-09-13. PMID:11504806. |
plasticity in serotonergic transmission in serotonin or 5-hydroxytryptamine (5-ht) receptor mutants was examined by measuring the regulation of extracellular 5-ht levels in the striatum and ventral hippocampus of 5-ht(1a) and 5-ht(1b) receptor knockout mice using in vivo microdialysis. |
2001-09-13 |
2023-08-12 |
mouse |
| G R Twitchell, G L Hanna, E H Cook, S F Stoltenberg, H E Fitzgerald And, R A Zucke. Serotonin transporter promoter polymorphism genotype is associated with behavioral disinhibition and negative affect in children of alcoholics. Alcoholism, clinical and experimental research. vol 25. issue 7. 2001-09-13. PMID:11505018. |
serotonergic (5-ht) dysfunction has been implicated in the etiology of both behavioral disinhibition (bd) and negative affect (na). |
2001-09-13 |
2023-08-12 |
Not clear |
| E B Larson, L M Schrott, L Bordone, S B Sparbe. Embryonic cocaine exposure and corticosterone: serotonin(2) receptor mediation. Pharmacology, biochemistry, and behavior. vol 69. issue 1-2. 2001-09-06. PMID:11420070. |
although prenatal cocaine exposure is associated with altered responsiveness of the hpa axis to "stress" and serotonergic compounds postnatally, it is unknown whether cocaine directly activates the embryonic hpa axis or if 5-ht(2) receptors are involved. |
2001-09-06 |
2023-08-12 |
chicken |
| S Horschitz, R Hummerich, P Schlos. Down-regulation of the rat serotonin transporter upon exposure to a selective serotonin reuptake inhibitor. Neuroreport. vol 12. issue 10. 2001-09-06. PMID:11447330. |
the serotonin transporter (sert) terminates serotonergic neurotransmission by rapid reuptake of 5-hydroxytryptamine (5-ht) into the nerve terminal or axonal varicosities. |
2001-09-06 |
2023-08-12 |
rat |
| G Tang, D Ren, R Xin, Y Qian, D Wang, S Jian. Lack of association between the tryptophan hydroxylase gene A218C polymorphism and attention-deficit hyperactivity disorder in Chinese Han population. American journal of medical genetics. vol 105. issue 6. 2001-09-06. PMID:11496362. |
previous studies have suggested that the serotonergic (5-ht) system might be involved in the development of attention-deficit hyperactivity disorder (adhd). |
2001-09-06 |
2023-08-12 |
Not clear |
| V T Ramaekers, J Senderek, M Häusler, M Häring, N Abeling, K Zerres, C Bergmann, G Heimann, N Bla. A novel neurodevelopmental syndrome responsive to 5-hydroxytryptophan and carbidopa. Molecular genetics and metabolism. vol 73. issue 2. 2001-08-30. PMID:11386854. |
in conclusion, this new neurodevelopmental syndrome responsive to treatment with 5-hydroxytryptophan and carbidopa might result from an overall reduced capacity of serotonin production due to a tph gene regulatory defect, unknown factors inactivating the tph enzyme, or selective loss of serotonergic neurons. |
2001-08-30 |
2023-08-12 |
Not clear |