| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Chen, Z Li, H Pan, D L Murphy, H Tamir, H Koepsell, M D Gersho. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487658. |
the enteric serotonin reuptake transporter (sert) has been proposed to play a critical role in serotonergic neurotransmission and in the initiation of peristaltic and secretory reflexes. |
2001-08-30 |
2023-08-12 |
mouse |
| J J Chen, Z Li, H Pan, D L Murphy, H Tamir, H Koepsell, M D Gersho. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487658. |
the watery diarrhea is probably attributable to the potentiation of serotonergic signaling in sert -/- mice, whereas the transient constipation may be caused by episodes of enhanced 5-ht release leading to 5-ht receptor desensitization. |
2001-08-30 |
2023-08-12 |
mouse |
| C M Smart, S M Biell. WAY-100635, a specific 5-HT1A antagonist, can increase the responsiveness of the mammalian circadian pacemaker to photic stimuli. Neuroscience letters. vol 305. issue 1. 2001-08-23. PMID:11356301. |
daily entrainment is believed to be influenced by inputs to the scn, one of these being the dense serotonergic (5-ht) projection from the raphe nuclei. |
2001-08-23 |
2023-08-12 |
Not clear |
| B Di Cara, N Dusticier, C Forni, J C Lievens, A Daszut. Serotonin depletion produces long lasting increase in striatal glutamatergic transmission. Journal of neurochemistry. vol 78. issue 2. 2001-08-23. PMID:11461959. |
the ability of serotonin (5-ht) to influence striatal glutamatergic transmission was examined by determining changes over time in glutamate extracellular levels, transporter expression and synaptosomal uptake in rats with lesion of serotonergic neurones. |
2001-08-23 |
2023-08-12 |
rat |
| A Newman-Tancredi, C Chaput, M Touzard, M J Milla. Pindolol antagonises G-protein activation at both pre- and postsynaptic serotonin 5-HT1A receptors: a. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 4. 2001-08-16. PMID:11330332. |
both 8-oh-dpat (1 microm) and 5-ht (10 microm) elicited a pronounced increase in [35s]gtpys binding in the dorsal raphe nucleus, which contains serotonergic cell bodies bearing 5-ht1a autoreceptors. |
2001-08-16 |
2023-08-12 |
Not clear |
| P F Sullivan, Y Jiang, M C Neale, K S Kendler, R E Strau. Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependence. American journal of medical genetics. vol 105. issue 5. 2001-08-16. PMID:11449402. |
if these results replicate in other samples, the serotonergic system may be involved in the etiology of smoking initiation given the rate-limiting role of tph in the biosynthesis of serotonin. |
2001-08-16 |
2023-08-12 |
human |
| E M Mitsis, J M Halperin, J H Newcor. Serotonin and aggression in children. Current psychiatry reports. vol 2. issue 2. 2001-08-09. PMID:11122940. |
research consistently indicates that in animals and adults, reduced central serotonergic (5-ht) function is associated with increased aggression. |
2001-08-09 |
2023-08-12 |
Not clear |
| A Frisch, B Finkel, E Michaelovsky, M Sigal, N Laor, R Weizma. A rare short allele of the serotonin transporter promoter region (5-HTTLPR) found in an aggressive schizophrenic patient of Jewish Libyan origin. Psychiatric genetics. vol 10. issue 4. 2001-08-09. PMID:11324943. |
the serotonin transporter gene (slc6a4), which plays a key role in the serotonergic pathway in the brain, is a candidate for mediating genetic susceptibility to various psychiatric disorders. |
2001-08-09 |
2023-08-12 |
human |
| S B Turkel, J G Nadala, M Z Winco. Possible serotonin syndrome in association with 5-HT(3) antagonist agents. Psychosomatics. vol 42. issue 3. 2001-08-09. PMID:11351116. |
the serotonin syndrome results when serotonergic activity increases to abnormally high levels. |
2001-08-09 |
2023-08-12 |
Not clear |
| S B Turkel, J G Nadala, M Z Winco. Possible serotonin syndrome in association with 5-HT(3) antagonist agents. Psychosomatics. vol 42. issue 3. 2001-08-09. PMID:11351116. |
it occurs with selective serotonin reuptake inhibitors (ssris), opioids, and other serotonergic agents when the serotonin system has been modulated by another serotonergic agent or compromised by illness. |
2001-08-09 |
2023-08-12 |
Not clear |
| J Sprouse, J Braselton, L Reynolds, T Clarke, H Rollem. Activation of postsynaptic 5-HT(1A) receptors by fluoxetine despite the loss of firing-dependent serotonergic input: electrophysiological and neurochemical studies. Synapse (New York, N.Y.). vol 41. issue 1. 2001-08-09. PMID:11354013. |
activation of postsynaptic 5-ht(1a) receptors by fluoxetine despite the loss of firing-dependent serotonergic input: electrophysiological and neurochemical studies. |
2001-08-09 |
2023-08-12 |
Not clear |
| C G Nebigil, N Etienne, B Schaerlinger, P Hickel, J M Launay, L Maroteau. Developmentally regulated serotonin 5-HT2B receptors. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 19. issue 4. 2001-08-09. PMID:11378296. |
furthermore, 5-ht, through the 5-ht2b receptors, has the ability to control serotonergic differentiation of committed neuron-like cells. |
2001-08-09 |
2023-08-12 |
drosophila_melanogaster |
| O Spreux-Varoquaux, J C Alvarez, I Berlin, G Batista, P G Despierre, A Gilton, D Cremnite. Differential abnormalities in plasma 5-HIAA and platelet serotonin concentrations in violent suicide attempters: relationships with impulsivity and depression. Life sciences. vol 69. issue 6. 2001-08-09. PMID:11476186. |
because some monoaminergic mechanisms seem to be similar in the central nervous system and peripheral tissues, we tested whether serotonergic or dopaminergic biochemical parameters in peripheral venous blood are related or not to violent suicide behavior.we simultaneously studied plasma serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), homovanillic acid (hva) and platelet 5-ht content in patients within 3 days following a violent suicide attempt and in matched healthy controls. |
2001-08-09 |
2023-08-12 |
Not clear |
| S Klöppel, G G Kovacs, T Voigtländer, J Wanschitz, H Flicker, J A Hainfellner, M Guentchev, H Budk. Serotonergic nuclei of the raphe are not affected in human ageing. Neuroreport. vol 12. issue 4. 2001-08-02. PMID:11277560. |
using immunohistochemistry for the serotonin synthesizing enzyme, tryptophan hydroxylase, we investigated the serotonergic median raphe nuclei (dorsal raphe nucleus, superior central nucleus, and raphe obscurus nucleus) in brains of an older (n = 12; age range 62-84 years) and a younger group (n = 10; age range 5-29 years). |
2001-08-02 |
2023-08-12 |
human |
| K Audenaert, K Van Laere, F Dumont, G Slegers, J Mertens, C van Heeringen, R A Dierck. Decreased frontal serotonin 5-HT 2a receptor binding index in deliberate self-harm patients. European journal of nuclear medicine. vol 28. issue 2. 2001-08-02. PMID:11303887. |
studies of serotonin metabolites in body fluids in attempted suicide patients and of post-mortem brain tissue of suicide victims have demonstrated the involvement of the serotonergic neurotransmission system in the pathogenesis of suicidal behaviour. |
2001-08-02 |
2023-08-12 |
Not clear |
| T A van Amelsvoort, K M Abel, D M Robertson, E Daly, H Critchley, M Whitehead, D G Murph. Prolactin response to d-fenfluramine in postmenopausal women on and off ERT: comparison with young women. Psychoneuroendocrinology. vol 26. issue 5. 2001-08-02. PMID:11337133. |
the biological basis to this is not fully understood, but may involve estrogen's interactions with central serotonergic (5-ht) systems. |
2001-08-02 |
2023-08-12 |
Not clear |
| F Duval, M C Mokrani, H Correa, P Bailey, M Valdebenito, J Monreal, M A Crocq, J P Mache. Lack of effect of HPA axis hyperactivity on hormonal responses to d-fenfluramine in major depressed patients: implications for pathogenesis of suicidal behaviour. Psychoneuroendocrinology. vol 26. issue 5. 2001-08-02. PMID:11337135. |
there is evidence for inhibitory effects of adrenocorticosteroids on serotonergic (5-ht) activity. |
2001-08-02 |
2023-08-12 |
human |
| M Funada, C Har. Differential effects of psychological stress on activation of the 5-hydroxytryptamine- and dopamine-containing neurons in the brain of freely moving rats. Brain research. vol 901. issue 1-2. 2001-08-02. PMID:11368973. |
psychological stress-induced 5-ht release in the bla was significantly greater than those in the drn, indicating that modifications of the serotonergic neurons in the bla are more sensitive to psychological stress than are those of the drn. |
2001-08-02 |
2023-08-12 |
rat |
| A A Harrison, Y T Liem, A Marko. Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 1. 2001-08-02. PMID:11377919. |
the reversal of the affective aspects of drug withdrawal by a treatment that enhances serotonin neurotransmission indicates that decreased serotonergic function may mediate the reward decrements characterizing nicotine and amphetamine withdrawal, and that these symptoms may be homologous to a core symptom of non-drug-induced depressions. |
2001-08-02 |
2023-08-12 |
rat |
| A J Rush, M H Trivedi, T J Carmody, R M Donahue, T L Houser, C Bolden-Watson, S R Batey, J A Ascher, A Met. Response in relation to baseline anxiety levels in major depressive disorder treated with bupropion sustained release or sertraline. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 1. 2001-08-02. PMID:11377926. |
these results contradict the commonly held, but unsubstantiated, belief that in clinically depressed anxious patients, serotonergic antidepressants are especially anxiolytic and that such patients preferentially benefit from the antidepressant or anxiolytic effects of selective serotonin reuptake inhibitors. |
2001-08-02 |
2023-08-12 |
Not clear |