| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H K Strüder, H Weicke. Physiology and pathophysiology of the serotonergic system and its implications on mental and physical performance. Part I. International journal of sports medicine. vol 22. issue 7. 2001-12-11. PMID:11590474. |
serotonergic neurotransmission improves the clinical course due to compensatory 5-ht impulse correction. |
2001-12-11 |
2023-08-12 |
human |
| I R Whittle, P A Kell. Mechanisms of peritumoural brain dysfunction: metabolic and neuroreceptor findings in striatal C6 glioma. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 8. issue 5. 2001-12-07. PMID:11535011. |
acetylcholinesterase (ache) histochemistry and a range of ligand binding studies for dopamine type 1 and 2, and serotonergic 5-ht(2)receptors were negative in the tumour and normal in peritumoural brain. |
2001-12-07 |
2023-08-12 |
Not clear |
| K Kishimoto, S Koyama, N Akaik. Synergistic mu-opioid and 5-HT1A presynaptic inhibition of GABA release in rat periaqueductal gray neurons. Neuropharmacology. vol 41. issue 5. 2001-12-07. PMID:11587707. |
the presynaptic serotonergic effect was mimicked by a specific 5-ht(1a) receptor agonist, 8-oh-dpat, and blocked by the specific antagonist, nan-190. |
2001-12-07 |
2023-08-12 |
rat |
| S Kalsner, S A Abdal. Rate-independent inhibition by norepinephrine of 5-HT release from the somadendritic region of serotonergic neurons. Brain research bulletin. vol 55. issue 6. 2001-12-07. PMID:11595360. |
rate-independent inhibition by norepinephrine of 5-ht release from the somadendritic region of serotonergic neurons. |
2001-12-07 |
2023-08-12 |
Not clear |
| J E Kello. Treatment goals in irritable bowel syndrome. International journal of clinical practice. vol 55. issue 8. 2001-12-07. PMID:11695076. |
a new understanding of the role of serotonin (5-ht) and specific receptors (5-ht3 and 5-ht4) found in the gastrointestinal (gi) tract has led to the development of serotonergic agents which have potential clinical benefits. |
2001-12-07 |
2023-08-12 |
Not clear |
| H Lu, H Ozawa, M Nishi, T Ito, M Kawat. Serotonergic neurones in the dorsal raphe nucleus that project into the medial preoptic area contain oestrogen receptor beta. Journal of neuroendocrinology. vol 13. issue 10. 2001-12-05. PMID:11679052. |
since previous findings showed that the density of serotonin-immunoreactive fibres and the concentration of serotonin within the mpa was significantly lower in the e2-group than the ovx-group, our present observations suggested that the regulatory effects of e2 on the serotonergic neurone system in the mpa may be via erbeta within the serotonin-containing cells in the drn of female rats. |
2001-12-05 |
2023-08-12 |
rat |
| O Rilke, K Will, M Jähkel, J Oehle. Behavioral and neurochemical effects of anpirtoline and citalopram in isolated and group housed mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 5. 2001-12-04. PMID:11444681. |
acute effects of serotonergic drugs acting via different mechanisms were investigated by a social interaction test and subsequent determination of serotonin and dopamine metabolisms in mice housed in groups or isolated for 6 weeks. |
2001-12-04 |
2023-08-12 |
mouse |
| O Rilke, K Will, M Jähkel, J Oehle. Behavioral and neurochemical effects of anpirtoline and citalopram in isolated and group housed mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 5. 2001-12-04. PMID:11444681. |
these results indicate that anpirtoline might induce antiaggressive effects via postsynaptic receptor- and structure-specific activation of serotonergic but also dopaminergic processes, whereas structure independent increase of synaptic serotonin via citalopram was ineffective to reverse aggressivity in isolated mice. |
2001-12-04 |
2023-08-12 |
mouse |
| P J Goodnic. Use of antidepressants in treatment of comorbid diabetes mellitus and depression as well as in diabetic neuropathy. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. vol 13. issue 1. 2001-12-04. PMID:11465683. |
in diabetic neuropathy, perhaps due to the fact that catecholamines and serotonin may both be implicated in pain pathways, dual-action antidepressants appear more effective at lower doses than do specific serotonergic agents. |
2001-12-04 |
2023-08-12 |
human |
| D T Malone, D A Taylo. Involvement of somatodendritic 5-HT(1A) receptors in Delta(9)-tetrahydrocannabinol-induced hypothermia in the rat. Pharmacology, biochemistry, and behavior. vol 69. issue 3-4. 2001-12-04. PMID:11509221. |
previously, it has been reported that modulating serotonergic neurones by use of selective serotonin reuptake inhibitors (ssri) can alter the hypothermic response produced by delta(9)-tetrahydrocannabinol (delta(9)-thc). |
2001-12-04 |
2023-08-12 |
rat |
| S Kasper, E Resinge. Panic disorder: the place of benzodiazepines and selective serotonin reuptake inhibitors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 11. issue 4. 2001-12-04. PMID:11532386. |
since panic may be mediated by a dysfunction of serotonin neuronal pathways, there is a rationale for treatment with antidepressants that modulate serotonergic systems. |
2001-12-04 |
2023-08-12 |
Not clear |
| M Z Wrona, G Dryhurs. A putative metabolite of serotonin, tryptamine-4,5-dione, is an irreversible inhibitor of tryptophan hydroxylase: possible relevance to the serotonergic neurotoxicity of methamphetamine. Chemical research in toxicology. vol 14. issue 9. 2001-12-04. PMID:11559032. |
a putative metabolite of serotonin, tryptamine-4,5-dione, is an irreversible inhibitor of tryptophan hydroxylase: possible relevance to the serotonergic neurotoxicity of methamphetamine. |
2001-12-04 |
2023-08-12 |
rat |
| M Diksi. Labelled alpha-methyl-L-tryptophan as a tracer for the study of the brain serotonergic system. Journal of psychiatry & neuroscience : JPN. vol 26. issue 4. 2001-12-04. PMID:11590969. |
the alpha-methyl-l-trypotophan (alpha-mtrp) method for the study of the brain serotonergic system is based on the fact that labelled alpha-mtrp is taken up by and, in part, retained in the brain, and this retention (trapping) is proportional to brain serotonin (5-ht) synthesis. |
2001-12-04 |
2023-08-12 |
Not clear |
| B Camarena, G Rinetti, C Cruz, S Hernández, J R de la Fuente, H Nicolin. Association study of the serotonin transporter gene polymorphism in obsessive-compulsive disorder. The international journal of neuropsychopharmacology. vol 4. issue 3. 2001-12-04. PMID:11602033. |
the hypothesis implicating the serotonergic system in the pathophysiology of obsessive-compulsive disorder (ocd) is supported by the therapeutic efficacy of selective serotonin reuptake inhibitors (ssris). |
2001-12-04 |
2023-08-12 |
Not clear |
| B S Beltz, J L Benton, J M Sulliva. Transient uptake of serotonin by newborn olfactory projection neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 22. 2001-12-04. PMID:11675504. |
this paper presents evidence that serotonin also regulates the proliferation and survival of projection neurons in lobsters, and that the serotonergic effects are associated with a transient uptake of serotonin into newborn neurons. |
2001-12-04 |
2023-08-12 |
Not clear |
| b' S Dieudonn\\xc3\\xa. Serotonergic neuromodulation in the cerebellar cortex: cellular, synaptic, and molecular basis. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 7. issue 3. 2001-11-01. PMID:11499400.' |
understanding the mechanisms of the serotonergic modulation of the cerebellar cortex is of clinical relevance, as abnormal serotonin metabolism has been observed in animal models and pathological cases of motor disorders involving the cerebellum, and as chronic intravenous administration of l-5-hydroxytryptophan (5-htp), a precursor of serotonin, was the first treatment shown to improve significantly cerebellar symptoms. |
2001-11-01 |
2023-08-12 |
Not clear |
| R E Strecker, M M Thakkar, T Porkka-Heiskanen, L J Dauphin, A A Bjørkum, R W McCarle. Behavioral state-related changes of extracellular serotonin concentration in the pedunculopontine tegmental nucleus: a microdialysis study in freely moving animals. Sleep research online : SRO. vol 2. issue 2. 2001-10-25. PMID:11421239. |
the data support the hypothesis that, during slow wave sleep and rem sleep, the declining levels of serotonin release the ppt rem-promoting neurons from serotonergic inhibition, which, in turn, leads to increases in acetylcholine release in terminal areas, facilitating the emergence of rem sleep. |
2001-10-25 |
2023-08-12 |
Not clear |
| A Python, T Steimer, Z de Saint Hilaire, R Mikolajewski, S Nicolaidi. Extracellular serotonin variations during vigilance states in the preoptic area of rats: a microdialysis study. Brain research. vol 910. issue 1-2. 2001-10-25. PMID:11489253. |
numerous studies have shown that serotonergic transmission decreases from waking (w) to slow wave sleep (sws) to paradoxical sleep (ps), suggesting an active role of serotonin (5-ht) in w but not in sleep. |
2001-10-25 |
2023-08-12 |
rat |
| G G Kinney, M T Taber, V K Gribkof. The augmentation hypothesis for improvement of antidepressant therapy: is pindolol a suitable candidate for testing the ability of 5HT1A receptor antagonists to enhance SSRI efficacy and onset latency? Molecular neurobiology. vol 21. issue 3. 2001-10-18. PMID:11379796. |
one hypothesis suggests that this delay in efficacy is due to a paradoxical decrease in serotonergic (5-ht) neuronal impulse flow and release, following activation of inhibitory presynaptic 5-ht1a autoreceptors, following acute administration of ssris. |
2001-10-18 |
2023-08-12 |
Not clear |
| M C Dulchin, M A Oquendo, K M Malone, S P Ellis, S Li, J J Man. Prolactin response to dl-fenfluramine challenge before and after treatment with paroxetine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 3. 2001-10-18. PMID:11522467. |
the prolactin response to dl-fenfluramine (an indirect central serotonin agonist) challenge has been used to assess serotonergic function and appears to be blunted in depressed patients. |
2001-10-18 |
2023-08-12 |
Not clear |