| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Meerlo, K M Horvath, P G Luiten, L Angelucci, A Catalani, J M Koolhaa. Increased maternal corticosterone levels in rats: effects on brain 5-HT1A receptors and behavioral coping with stress in adult offspring. Behavioral neuroscience. vol 115. issue 5. 2002-02-04. PMID:11584924. |
this study examined the consequences of elevated corticosterone levels in lactating rats on their offspring's serotonergic 5-hydroxytryptamine (5-ht)1a receptor system and behavioral coping with stress. |
2002-02-04 |
2023-08-12 |
rat |
| K A Berg, W P Clark. Regulation of 5-HT(1A) and 5-HT(1B) receptor systems by phospholipid signaling cascades. Brain research bulletin. vol 56. issue 5. 2002-02-01. PMID:11750792. |
the 5-ht(1a) and 5-ht(1b) receptor systems play central roles in the control of serotonergic neurotransmission and feature prominently in many behaviors and physiological functions. |
2002-02-01 |
2023-08-12 |
Not clear |
| P M Whitaker-Azmiti. Serotonin and brain development: role in human developmental diseases. Brain research bulletin. vol 56. issue 5. 2002-02-01. PMID:11750793. |
serotonin regulates both the development of serotonergic neurons (termed autoregulation of development) and the development of target tissues. |
2002-02-01 |
2023-08-12 |
human |
| M A Geyer, K Krebs-Thomson, D L Braff, N R Swerdlo. Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology. vol 156. issue 2-3. 2002-01-28. PMID:11549216. |
in rodents, disruptions in ppi of startle are produced by: stimulation of d2 dopamine (da) receptors, produced by amphetamine or apomorphine; activation of serotonergic systems, produced by serotonin (5-ht) releasers or direct agonists at multiple serotonin receptors; and blockade of n-methyl-d-aspartate (nmda) receptors, produced by drugs such as phencyclidine (pcp). |
2002-01-28 |
2023-08-12 |
rat |
| C A Fornal, C W Metzler, C Mirescu, S K Stein, B L Jacob. Effects of standardized extracts of St. John's wort on the single-unit activity of serotonergic dorsal Raphe neurons in awake cats: comparisons with fluoxetine and sertraline. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 6. 2002-01-28. PMID:11750179. |
did not alter the responsiveness of serotonergic neurons to the 5-ht(1a) agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) (10 microg/kg, i.v.). |
2002-01-28 |
2023-08-12 |
Not clear |
| C A Fornal, C W Metzler, C Mirescu, S K Stein, B L Jacob. Effects of standardized extracts of St. John's wort on the single-unit activity of serotonergic dorsal Raphe neurons in awake cats: comparisons with fluoxetine and sertraline. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 6. 2002-01-28. PMID:11750179. |
overall, these findings indicate that the mode of action of st. john's wort is different from that of conventional antidepressant drugs, which elevate brain serotonin and evoke negative feedback control of serotonergic neurons. |
2002-01-28 |
2023-08-12 |
Not clear |
| R Martín-Ruiz, M V Puig, P Celada, D A Shapiro, B L Roth, G Mengod, F Artiga. Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 24. 2002-01-23. PMID:11739593. |
doi suppressed the firing rate of 7 of 12 dorsal raphe (dr) serotonergic (5-ht) neurons and partially inhibited the rest (ed(50) = 20 microg/kg, i.v. |
2002-01-23 |
2023-08-12 |
Not clear |
| R Martín-Ruiz, M V Puig, P Celada, D A Shapiro, B L Roth, G Mengod, F Artiga. Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 24. 2002-01-23. PMID:11739593. |
thus, doi reduces the activity of ascending 5-ht neurons through a dr-based action and enhances serotonergic and glutamatergic transmission in mpfc through 5-ht(2a) and ampa receptors. |
2002-01-23 |
2023-08-12 |
Not clear |
| P Celada, M V Puig, J M Casanovas, G Guillazo, F Artiga. Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: Involvement of serotonin-1A, GABA(A), and glutamate receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 24. 2002-01-23. PMID:11739599. |
ascending serotonergic pathways may control the activity of this descending pathway by acting on postsynaptic 5-ht(1a) receptors. |
2002-01-23 |
2023-08-12 |
rat |
| P Balaban, O Maksimov. Decrease of effectivity of "competing" synaptic input requires protein synthesis. Brain research. vol 919. issue 2. 2002-01-15. PMID:11701144. |
the decrease of responses also did not occur in experiments when tetanization was substituted by short-term serotonin applications or extracellular stimulation of serotonergic cells known to potentiate investigated synaptic inputs. |
2002-01-15 |
2023-08-12 |
Not clear |
| Y Sugimoto, M Ohkura, K Inoue, J Yamad. Involvement of serotonergic and dopaminergic mechanisms in hyperthermia induced by a serotonin-releasing drug, p-chloroamphetamine in mice. European journal of pharmacology. vol 430. issue 2-3. 2002-01-14. PMID:11711040. |
serotonergic and dopaminergic involvement in hyperthermia induced by a serotonin (5-hydroxytryptamine, 5-ht)-releasing drug, p-chloroamphetamine, was investigated in mice. |
2002-01-14 |
2023-08-12 |
mouse |
| H Z Hu, N Gao, Z Lin, C Gao, S Liu, J Ren, Y Xia, J D Woo. P2X(7) receptors in the enteric nervous system of guinea-pig small intestine. The Journal of comparative neurology. vol 440. issue 3. 2002-01-11. PMID:11745625. |
rapidly activating depolarizing responses evoked by application of nicotinic, serotonergic 5-ht(3), or gamma-aminobutyric acid a (gaba(a)) receptor agonists were unaffected by brilliant blue g. immunoreactivity for the p2x(7) receptor was widely distributed surrounding ganglion cell bodies and associated with nerve fibers in both myenteric and submucous plexuses. |
2002-01-11 |
2023-08-12 |
Not clear |
| B B Gorzalka, L A Hanson, J J Hon. Ketanserin attenuates the behavioural effects of corticosterone: implications for 5-HT(2A) receptor regulation. European journal of pharmacology. vol 428. issue 2. 2002-01-07. PMID:11675041. |
the serotonergic type 2a (5-ht(2a)) receptor antagonist ketanserin was administered to test the hypothesis that the behavioural effects of corticosterone were mediated by increased 5-ht(2a) receptor activity. |
2002-01-07 |
2023-08-12 |
rat |
| F Yamane, H Okazawa, P Blier, M Diksi. Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan(2). Biochemical pharmacology. vol 62. issue 11. 2002-01-02. PMID:11728384. |
in the first series of experiments, an acute intraperitoneal injection of paroxetine (10 mg/kg) produced a significant reduction in 5-ht synthesis in brain structures containing serotonergic cell bodies (the dorsal, median, and pallidum raphe nuclei), as well as in most projection areas: the ventral tegmental area, median forebrain bundle, hippocampus ca3 region, and nigrostriatal structures (substantia nigra, lateral and medial caudate nuclei). |
2002-01-02 |
2023-08-12 |
rat |
| L Du, G Faludi, M Palkovits, D Bakish, P D Hrdin. Serotonergic genes and suicidality. Crisis. vol 22. issue 2. 2001-12-21. PMID:11727894. |
genes that code for proteins, such as tryptophan hydroxylase, 5-ht transporter, and 5-ht2a receptor, involved in regulating serotonergic neurotransmission, have thus been major candidate genes for association studies of suicide and suicidal behavior. |
2001-12-21 |
2023-08-12 |
Not clear |
| S B Sonawalla, M Fav. Severe depression: is there a best approach? CNS drugs. vol 15. issue 10. 2001-12-19. PMID:11602003. |
these include tricyclic antidepressants (tcas), selective serotonin reuptake inhibitors (ssris), serotonin-noradrenaline (norepinephrine) reuptake inhibitors, noradrenergic and specific serotonergic antidepressants, serotonin 5-ht(2) receptor antagonists, monoamine oxidase inhibitors, and amfebutamone (bupropion). |
2001-12-19 |
2023-08-12 |
Not clear |
| F Fernandez, V Coomans, P Mormede, F Chaoulof. Effects of corticosterone ingestion on hippocampal [(3)H]serotonin reuptake in inbred rat strains. Endocrine regulations. vol 35. issue 3. 2001-12-17. PMID:11674840. |
there is evidence for a regulatory impact of corticoids on hippocampal serotonergic systems, including serotonin (5-ht) synthesis and 5-ht(1a) receptor expression and/or activity. |
2001-12-17 |
2023-08-12 |
rat |
| R C Shelton, A J Tomarke. Can recovery from depression be achieved? Psychiatric services (Washington, D.C.). vol 52. issue 11. 2001-12-14. PMID:11684742. |
general distress and somatic anxiety appear to be significantly modulated by serotonin, and serotonergic drugs may exert their effects most significantly on these symptoms. |
2001-12-14 |
2023-08-12 |
Not clear |
| B C Hains, S D Fullwood, M J Eaton, C E Hulsebosc. Subdural engraftment of serotonergic neurons following spinal hemisection restores spinal serotonin, downregulates serotonin transporter, and increases BDNF tissue content in rat. Brain research. vol 913. issue 1. 2001-12-12. PMID:11532245. |
subdural engraftment of serotonergic neurons following spinal hemisection restores spinal serotonin, downregulates serotonin transporter, and increases bdnf tissue content in rat. |
2001-12-12 |
2023-08-12 |
rat |
| Y C Xu, K W Johnson, L A Phebus, M Cohen, D L Nelson, K Schenck, C D Walker, J E Fritz, S W Kaldor, M E LeTourneau, R E Murff, J M Zgombick, D O Calligaro, J E Audia, J M Schau. N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy. Journal of medicinal chemistry. vol 44. issue 24. 2001-12-12. PMID:11708905. |
this communication describes the synthesis and discovery of a novel compound, n-[3-(2-(dimethylamino)ethyl)-2-methyl-1h-indol-5-yl]-4-fluorobenzamide (4), which possesses high binding affinity and selectivity at the 5-ht(1f) receptor relative to more than 40 other serotonergic and nonserotonergic receptors examined. |
2001-12-12 |
2023-08-12 |
Not clear |