| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P S Naidu, S K Kulkarn. Effect of 5-HT1A and 5-HT2A/2C receptor modulation on neuroleptic-induced vacuous chewing movements. European journal of pharmacology. vol 428. issue 1. 2002-04-02. PMID:11779040. |
these findings indicate that the serotonergic system, and particularly 5-ht1a and 5-ht2a/2c receptors, may be involved in haloperidol-induced orofacial dyskinesia, and that 5-ht receptors may provide novel targets for the development of drugs that can be used to reverse or prevent the extrapyramidal side effects associated with long-term antipsychotic treatment. |
2002-04-02 |
2023-08-12 |
rat |
| S Winberg, Ø Øverli, O Lepag. Suppression of aggression in rainbow trout (Oncorhynchus mykiss) by dietary L-tryptophan. The Journal of experimental biology. vol 204. issue Pt 22. 2002-04-01. PMID:11807104. |
central serotonin is believed to have an inhibitory effect on aggressive behaviour, and it is suggested that the suppressive effect of dietary l-tryptophan on aggressive behaviour is mediated by an elevation of brain serotonergic activity. |
2002-04-01 |
2023-08-12 |
Not clear |
| M Yamamot. Depression in Parkinson's disease: its prevalence, diagnosis, and neurochemical background. Journal of neurology. vol 248 Suppl 3. 2002-03-27. PMID:11697689. |
with regard to the neurochemical background, the level of 5-hydroxyindoleacetic acid (a major metabolite of serotonin) is reduced in the cerebrospinal fluid suggesting that serotonergic dysfunction exists in the brain of pd patients. |
2002-03-27 |
2023-08-12 |
human |
| Paul W Ament, Namirah Jamshed, John P Horn. Linezolid: its role in the treatment of gram-positive, drug-resistant bacterial infections. American family physician. vol 65. issue 4. 2002-03-26. PMID:11871684. |
as a nonselective inhibitor of monoamine oxidase, caution is recommended when used with adrenergic or serotonergic agents (e.g., tyramine, dopamine, pseudoephedrine, and selective serotonin reuptake inhibitors). |
2002-03-26 |
2023-08-12 |
Not clear |
| Stefania Bonaccorso, Valentina Marino, Antonella Puzella, Massimo Pasquini, Massimo Biondi, Marco Artini, Cristiana Almerighi, Robert Verkerk, Herbert Meltzer, Michael Mae. Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system. Journal of clinical psychopharmacology. vol 22. issue 1. 2002-03-25. PMID:11799348. |
the latter is related to changes in the serotonergic system, such as depletion of serum 5-ht and induction of the catabolism of tryptophan to kynurenine. |
2002-03-25 |
2023-08-12 |
Not clear |
| Karl C Corley, Tam-Hao Phan, Wilson P Daugherty, Margaret C Boadle-Bibe. Stress-induced activation of median raphe serotonergic neurons in rats is potentiated by the neurotensin antagonist, SR 48692. Neuroscience letters. vol 319. issue 1. 2002-03-25. PMID:11814639. |
the activation of rostrally projecting serotonergic (5-ht) neurons by acute sound stress is blocked by exogenous administration of the tridecapeptide neurotensin (nt). |
2002-03-25 |
2023-08-12 |
rat |
| C Bendotti, S E Cole, M Gobbi, C Hohmann, R H Reeve. Overexpression of S100beta in transgenic mice does not protect from serotonergic denervation induced by 5,7-dihydroxytryptamine. Journal of neuroscience research. vol 67. issue 4. 2002-03-20. PMID:11835317. |
quantitative analysis of the density of 5-ht transporter sites using [(3)h]citalopram binding, a marker of serotonergic terminals, showed a marked decrease in different brain regions at both 5 and 60 days after 5,7-dht injections. |
2002-03-20 |
2023-08-12 |
mouse |
| C Bendotti, S E Cole, M Gobbi, C Hohmann, R H Reeve. Overexpression of S100beta in transgenic mice does not protect from serotonergic denervation induced by 5,7-dihydroxytryptamine. Journal of neuroscience research. vol 67. issue 4. 2002-03-20. PMID:11835317. |
in conclusion, this study demonstrates that constitutive overexpression of s100beta in transgenic mice does not modify serotonin levels during development, nor does it protect the serotonergic neurons from selective neurotoxicity or modify the serotonergic sprouting induced by partial lesion. |
2002-03-20 |
2023-08-12 |
mouse |
| Dierk Endemann, Frank Schweda, Mike Stubanus, Karl-Peter Ittner, Michael Fischereder, Martin C Kammerl, Bernhard K Kräme. Naftidrofuryl exerts antiserotonergic but no endothelin-receptor blocking effects in AS4.1 cells, juxtaglomerular cells and isolated perfused rat kidneys. Journal of cardiovascular pharmacology. vol 39. issue 1. 2002-03-18. PMID:11743222. |
naftidrofuryl, a 5-hydroxytryptamine 2 (5-ht 2 ) serotonergic receptor antagonist with vasodilator effects, has successfully been used for intermittent claudication, some forms of dementia, and glaucoma. |
2002-03-18 |
2023-08-12 |
mouse |
| S Horschitz, R Hummerich, P Schlos. Structure, function and regulation of the 5-hydroxytryptamine (serotonin) transporter. Biochemical Society transactions. vol 29. issue Pt 6. 2002-03-12. PMID:11709064. |
the serotonin transporter (sert), which terminates serotonergic neurotransmission by rapid re-uptake of 5-hydroxytryptamine (5-ht) back into the nerve terminal was the subject of two studies. |
2002-03-12 |
2023-08-12 |
human |
| S D Ugarte, G E Homanics, D L Hammon. Effect of embryonic knock-down of GABAA receptors on the levels of monoamines and their metabolites in the CNS of the mouse. Brain research. vol 904. issue 2. 2002-03-11. PMID:11406127. |
in contrast, the levels of serotonin, dopamine or their metabolites were unaffected, suggesting that the development of serotonergic and dopaminergic neurons may require activation of only a small fraction of gaba(a) receptors or may not be dependent on beta3 subunit-containing gaba(a) receptors. |
2002-03-11 |
2023-08-12 |
mouse |
| J A Bouwknecht, J van der Gugten, T H Hijzen, R A Maes, R Hen, B Olivie. Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes. Physiology & behavior. vol 74. issue 4-5. 2002-03-07. PMID:11790410. |
5-ht(1b) receptors have a regulatory role in serotonergic activity and influence feeding behavior and body weight. |
2002-03-07 |
2023-08-12 |
mouse |
| W P Daugherty, K C Corley, T H Phan, M C Boadle-Bibe. Further studies on the activation of rat median raphe serotonergic neurons by inescapable sound stress. Brain research. vol 923. issue 1-2. 2002-03-05. PMID:11743977. |
two approaches are used in sprague-dawley rat to measure the activation of serotonergic neurons: (1) determination ex vivo of accumulation of 5-hydroxytryptophan (5-htp) in tissue from the dorsal and median raphe nuclei, hippocampus, cortex, caudate nucleus, and nucleus accumbens following in vivo inhibition of aromatic amino acid decarboxylase; and (2) measurement of extracellular serotonin levels in hippocampus, caudate nucleus, and nucleus accumbens. |
2002-03-05 |
2023-08-12 |
rat |
| Karla P Zeitz, Nicolas Guy, Annika B Malmberg, Sahera Dirajlal, William J Martin, Linda Sun, Douglas W Bonhaus, Cheryl L Stucky, David Julius, Allan I Basbau. The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 3. 2002-02-27. PMID:11826129. |
this result is explained by the localization of 5-ht(3) receptor transcripts to a previously uncharacterized subset of myelinated and unmyelinated afferents, few of which express the proinflammatory neuropeptide substance p. finally, we provide evidence that central serotonergic circuits modulate nociceptive transmission via a facilitatory action at spinal 5-ht(3) receptors. |
2002-02-27 |
2023-08-12 |
mouse |
| A El Khoury, L Johnson, A Aberg-Wistedt, R Stain-Malmgre. Effects of long-term lithium treatment on monoaminergic functions in major depression. Psychiatry research. vol 105. issue 1-2. 2002-02-26. PMID:11740973. |
they also postulate that the effect of lithium may be attained by a dual influence on postsynaptic serotonergic structures, as it increases both the density and the sensitivity of 5-ht(2) receptors. |
2002-02-26 |
2023-08-12 |
human |
| Christopher P Washburn, Jay E Sirois, Edmund M Talley, Patrice G Guyenet, Douglas A Baylis. Serotonergic raphe neurons express TASK channel transcripts and a TASK-like pH- and halothane-sensitive K+ conductance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 4. 2002-02-26. PMID:11850453. |
whole-cell voltage-clamp recordings were obtained from raphe cells that responded to 5-ht in a manner characteristic of serotonergic neurons (i.e., with activation of an inwardly rectifying k+ current). |
2002-02-26 |
2023-08-12 |
Not clear |
| b' Juan F L\\xc3\\xb3pez-Gim\\xc3\\xa9nez, Laurence H Tecott, Jos\\xc3\\xa9 M Palacios, Guadalupe Mengod, M Teresa Vilar\\xc3\\xb. Serotonin 5- HT (2C) receptor knockout mice: autoradiographic analysis of multiple serotonin receptors. Journal of neuroscience research. vol 67. issue 1. 2002-02-21. PMID:11754082.' |
the present results indicate that the mouse serotonergic system does not exhibit compensatory up- or down-regulation of the majority of its components (serotonin transporter and most 5-ht receptor subtypes) in response to the absence of 5-ht(2c) receptors. |
2002-02-21 |
2023-08-12 |
mouse |
| A Siniscalchi, D Rodi, S Cavallini, S Marino, L Beani, C Bianch. Effects of cholecystokinin tetrapeptide (CCK(4)) and anxiolytic drugs on the electrically evoked [(3)H]5-hydroxytryptamine outflow from rat cortical slices. Brain research. vol 922. issue 1. 2002-02-19. PMID:11730707. |
thus, anxiolytic drugs with different receptor targets can reduce 5-ht outflow by dampening the glutamatergic signal, and in turn, the secretory process of the serotonergic nerve ending. |
2002-02-19 |
2023-08-12 |
rat |
| J Amat, P D Sparks, P Matus-Amat, J Griggs, L R Watkins, S F Maie. The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress. Brain research. vol 917. issue 1. 2002-02-12. PMID:11602236. |
previous research indicates that the serotonergic neurons of the caudal dorsal raphe nucleus (drn) are activated to a greater degree by inescapable shock (is) as compared to escapable shock (es), causing a greater release of serotonin (5-ht) in the drn and in target regions. |
2002-02-12 |
2023-08-12 |
rat |
| M W Bridge, G Marvin, C E Thompson, A Sharma, D A Jones, M J Kendal. Quantifying the 5-HT1A agonist action of buspirone in man. Psychopharmacology. vol 158. issue 3. 2002-02-12. PMID:11713611. |
buspirone is used as a neuroendocrine challenge in which the increase of circulating prolactin is taken as a measure of the sensitivity of central serotonergic (5-ht(1a)) pathways. |
2002-02-12 |
2023-08-12 |
Not clear |