| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen M Stah. Does depression hurt? The Journal of clinical psychiatry. vol 63. issue 4. 2002-05-31. PMID:12000200. |
ascending serotonergic and noradrenergic pathways may mediate the emotional and vegetative symptoms of depression and can potentially be targets of serotonin and norepinephrine reuptake inhibitors to obtain relief of these symptoms. |
2002-05-31 |
2023-08-12 |
Not clear |
| Stephen M Stah. Does depression hurt? The Journal of clinical psychiatry. vol 63. issue 4. 2002-05-31. PMID:12000200. |
descending serotonergic and noradrenergic pathways may regulate the painful physical symptoms of depression, and when targeted by serotonin and norepinephrine reuptake inhibitors, relieve these symptoms as well. |
2002-05-31 |
2023-08-12 |
Not clear |
| Melissa S Gerald, J Dee Higle. Evolutionary underpinnings of excessive alcohol consumption. Addiction (Abingdon, England). vol 97. issue 4. 2002-05-30. PMID:11964058. |
indeed, many studies in both humans and rhesus macaques show relationships between excessive alcohol consumption, aggression and serotonergic function, as measured by concentrations of the principal metabolite of serotonin, 5-hydroxyindoleacetic acid (5-hiaa) in the cerebrospinal fluid (csf). |
2002-05-30 |
2023-08-12 |
monkey |
| Tomoyuki Kawamata, Keiichi Omote, Masaki Toriyabe, Mikito Kawamata, Akiyoshi Namik. Intracerebroventricular morphine produces antinociception by evoking gamma-aminobutyric acid release through activation of 5-hydroxytryptamine 3 receptors in the spinal cord. Anesthesiology. vol 96. issue 5. 2002-05-29. PMID:11981159. |
it has been generally considered that supraspinal morphine activates the serotonergic descending inhibitory system and releases serotonin (5-hydroxytryptamine [5-ht]) in the spinal cord, producing antinociception through activation of 5-ht receptors. |
2002-05-29 |
2023-08-12 |
Not clear |
| William C de Groa. Influence of central serotonergic mechanisms on lower urinary tract function. Urology. vol 59. issue 5 Suppl 1. 2002-05-29. PMID:12007520. |
studies in animals of the distribution of serotonergic nerves and receptors and the changes in voiding function induced by serotonin (5-hydroxytryptamine [5-ht]) receptor agonists and antagonists, as well as 5-ht reuptake inhibitors, form a basis for the development of such treatments. |
2002-05-29 |
2023-08-12 |
rat |
| William C de Groa. Influence of central serotonergic mechanisms on lower urinary tract function. Urology. vol 59. issue 5 Suppl 1. 2002-05-29. PMID:12007520. |
in rats and cats, spinal reflex circuits involved in voiding function exhibit a dense serotonergic innervation, multiple 5-ht receptors, and sensitivity to various drugs that affect serotonergic transmission. |
2002-05-29 |
2023-08-12 |
rat |
| William C de Groa. Influence of central serotonergic mechanisms on lower urinary tract function. Urology. vol 59. issue 5 Suppl 1. 2002-05-29. PMID:12007520. |
although there is some evidence in the rat for serotonergic facilitation of voiding, most experiments in rats and cats indicate that activation of the central serotonergic system by 5-ht reuptake inhibitors, as well as by 5-ht1a and 5-ht2 receptor agonists, depresses reflex bladder contractions and increases the bladder volume threshold for inducing micturition. |
2002-05-29 |
2023-08-12 |
rat |
| Maxim L Filipenko, Alexandra G Beilina, Olga V Alekseyenko, Vadim V Dolgov, Natalia N Kudryavtsev. Repeated experience of social defeats increases serotonin transporter and monoamine oxidase A mRNA levels in raphe nuclei of male mice. Neuroscience letters. vol 321. issue 1-2. 2002-05-23. PMID:11872248. |
it has been supposed that sert and maoa genes are involved in enhancement of serotonin inactivation in response to the increase of serotonergic activity shown earlier in the losers. |
2002-05-23 |
2023-08-12 |
mouse |
| L Matuszewich, M E Filon, D A Finn, B K Yamamot. Altered forebrain neurotransmitter responses to immobilization stress following 3,4-methylenedioxymethamphetamine. Neuroscience. vol 110. issue 1. 2002-05-23. PMID:11882371. |
from these studies we suggest that depletion of serotonin stores in terminal regions with the neurotoxin mdma compromises the ability of the serotonergic neurons to activate central systems that respond to stressful stimuli. |
2002-05-23 |
2023-08-12 |
rat |
| Serge Gobaille, Carmen Schleef, Viviane Hechler, Sandrine Viry, Dominique Aunis, Michel Maitr. Gamma-hydroxybutyrate increases tryptophan availability and potentiates serotonin turnover in rat brain. Life sciences. vol 70. issue 18. 2002-05-23. PMID:12002803. |
taken together, these results indicate that the ghb-induced stimulation of tissue serotonin turnover may be due to an increase in tryptophan transport to the brain and in its uptake by serotonergic cells. |
2002-05-23 |
2023-08-12 |
rat |
| C Dugovi. Role of serotonin in sleep mechanisms. Revue neurologique. vol 157. issue 11 Pt 2. 2002-05-22. PMID:11924032. |
while early studies indicate that serotonin (5-ht) was associated with the initiation and maintenance of sleep, later studies indicate that serotonergic neurons also play a role in inhibiting sleep. |
2002-05-22 |
2023-08-12 |
Not clear |
| Martin Metzger, Claudio Toledo, Katharina Brau. Serotonergic innervation of the telencephalon in the domestic chick. Brain research bulletin. vol 57. issue 3-4. 2002-05-20. PMID:11923026. |
the serotonergic system in the telencephalon of the domestic chick was investigated using an antibody specific to serotonin (5-ht). |
2002-05-20 |
2023-08-12 |
chicken |
| Stacy L Donovan, Laura A Mamounas, Anne M Andrews, Mary E Blue, James S McCaslan. GAP-43 is critical for normal development of the serotonergic innervation in forebrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 9. 2002-05-20. PMID:11978831. |
serotonergic (5-ht) axons from the raphe nuclei are among the earliest afferents to innervate the developing forebrain. |
2002-05-20 |
2023-08-12 |
mouse |
| Cornelius Gross, Xiaoxi Zhuang, Kimberly Stark, Sylvie Ramboz, Ronald Oosting, Lynn Kirby, Luca Santarelli, Sheryl Beck, René He. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature. vol 416. issue 6879. 2002-05-14. PMID:11919622. |
serotonin is implicated in mood regulation, and drugs acting via the serotonergic system are effective in treating anxiety and depression. |
2002-05-14 |
2023-08-12 |
mouse |
| Gerhard J Moldering. [Physiologic and therapeutic importance of serotonin and the serotonergic system]. Arzneimittel-Forschung. vol 52. issue 3. 2002-05-14. PMID:11963640. |
[physiologic and therapeutic importance of serotonin and the serotonergic system]. |
2002-05-14 |
2023-08-12 |
Not clear |
| Gerhard J Moldering. [Physiologic and therapeutic importance of serotonin and the serotonergic system]. Arzneimittel-Forschung. vol 52. issue 3. 2002-05-14. PMID:11963640. |
in the light of the current knowledge about the anatomy and physiology of the serotonergic system and the distribution of the various 5-ht receptors in the organs and tissues, the established and potential therapeutic applications of 5-ht receptor ligands in the treatment of several disorders are discussed. |
2002-05-14 |
2023-08-12 |
Not clear |
| Erick H Turner, Paul J Schwartz, Catherine H Lowe, Stefan S Nawab, Susana Feldman-Naim, Christopher L Drake, Frances S Myers, Ronald L Barnett, Norman E Rosentha. Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder. Journal of clinical psychopharmacology. vol 22. issue 2. 2002-05-13. PMID:11910270. |
a role for serotonin in season affective disorder (sad) has been explored with a variety of serotonergic pharmacologic agents. |
2002-05-13 |
2023-08-12 |
Not clear |
| M Bianchi, C Moser, C Lazzarini, E Vecchiato, F Cresp. Forced swimming test and fluoxetine treatment: in vivo evidence that peripheral 5-HT in rat platelet-rich plasma mirrors cerebral extracellular 5-HT levels, whilst 5-HT in isolated platelets mirrors neuronal 5-HT changes. Experimental brain research. vol 143. issue 2. 2002-05-10. PMID:11880895. |
the initial action of this ssri upon the 5-ht transporter in brain has also been confirmed by in vivo voltammetric data showing selective increase in the serotonergic signal following local injection of fluoxetine into the brain region studied. |
2002-05-10 |
2023-08-12 |
rat |
| F E Scheepers, C C Gespen de Wied, R S Kah. The effect of olanzapine treatment on m-chlorophenylpiperazine-induced hormone release in schizophrenia. Journal of clinical psychopharmacology. vol 21. issue 6. 2002-05-07. PMID:11763004. |
the clinical efficacy of the atypical antipsychotic clozapine is associated with the 5-ht antagonistic action of the drug and a high serotonergic tone before treatment. |
2002-05-07 |
2023-08-12 |
Not clear |
| Julie G Hensle. Differential regulation of 5-HT1A receptor-G protein interactions in brain following chronic antidepressant administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 5. 2002-05-07. PMID:11927181. |
we have examined the effect of chronic administration of the ssri fluoxetine or the tricyclic antidepressant amitriptyline on 5-ht(1a) receptor-stimulated [(35)s]gtpgammas binding in serotonergic cell body areas, and cortical and limbic structures using quantitative autoradiography. |
2002-05-07 |
2023-08-12 |
rat |