| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Regina B Guimarães, Mônica M Telles, Vivian B O Coelho, Rosana C T Mori, Cláudia M O Nascimento, Eliane Beraldi Ribeir. Adrenalectomy abolishes the food-induced hypothalamic serotonin release in both normal and monosodium glutamate-obese rats. Brain research bulletin. vol 58. issue 4. 2002-11-15. PMID:12183012. |
this observation demonstrates that glucocorticoids are necessary for food intake to acutely stimulate 5-ht release and indicates that serotonergic activity in the lh is not likely to participate in the adrenalectomy-induced attenuation of the msg-obesity. |
2002-11-15 |
2023-08-12 |
rat |
| James C Dodge, Lori L Badur. 5HT and 5HIAA dialysate levels within the arcuate nucleus of the hypothalamus: relationship with photoperiod-driven differences in serum prolactin and luteinizing hormone in the Siberian hamster. Brain research. vol 946. issue 2. 2002-11-12. PMID:12137919. |
in experiment 2, the profile of 5ht and 5hiaa dialysate levels within the arc on the afternoon of proestrous was investigated to determine if changes in serotonergic neurotransmission are correlated with preovulatory surges in lh and prl. |
2002-11-12 |
2023-08-12 |
Not clear |
| Shaul Schreiber, Avi Bleich, Chaim G Pic. Venlafaxine and mirtazapine: different mechanisms of antidepressant action, common opioid-mediated antinociceptive effects--a possible opioid involvement in severe depression? Journal of molecular neuroscience : MN. vol 18. issue 1-2. 2002-11-08. PMID:11931344. |
among the antidepressants of the newer generations, that involvement occurs only with venlafaxine (a presynaptic drug which blocks the synaptosomal uptake of noradrenaline and serotonin and, to a lesser degree, of dopamine) and with mirtazapine (a postsynaptic drug which enhances noradrenergic and 5-ht1a-mediated serotonergic neurotransmission via antagonism of central alpha-auto- and hetero-adrenoreceptors). |
2002-11-08 |
2023-08-12 |
mouse |
| Stanley Kalsner, Syed Amir Abdal. Rate-independent inhibition of 5-HT release by 5-HT in the somadendritic regions of raphe neurons. Brain research bulletin. vol 58. issue 3. 2002-11-06. PMID:12128155. |
it is concluded that serotonergic somadendritic sites contain inhibitory receptors for 5-ht release that operate independently of rate regulation and feedback. |
2002-11-06 |
2023-08-12 |
rabbit |
| Stanley Kalsner, Syed Amir Abdal. Rate-independent inhibition of 5-HT release by 5-HT in the somadendritic regions of raphe neurons. Brain research bulletin. vol 58. issue 3. 2002-11-06. PMID:12128155. |
these findings could explain how other transmitters, and 5-ht itself (through dendritic release of transmitter), could exert synaptic effects on serotonergic and other neurons without being promptly countermanded by a somadendritic feedback-induced rate correction. |
2002-11-06 |
2023-08-12 |
rabbit |
| T Tanimoto, M Takeda, S Matsumot. Suppressive effect of vagal afferents on cervical dorsal horn neurons responding to tooth pulp electrical stimulation in the rat. Experimental brain research. vol 145. issue 4. 2002-11-06. PMID:12172658. |
these results suggest that va stimulation inhibits nociceptive transmission in the c1 spinal neuron activity via the activation of both noradrenergic and serotonergic (5-ht(3)) descending inhibitory systems. |
2002-11-06 |
2023-08-12 |
rat |
| S Z East, P W J Burnet, R W Kerwin, P J Harriso. An RT-PCR study of 5-HT(6) and 5-HT(7) receptor mRNAs in the hippocampal formation and prefrontal cortex in schizophrenia. Schizophrenia research. vol 57. issue 1. 2002-10-30. PMID:12165372. |
regional decreases in 5-ht(6)r and 5-ht(7)r expression in schizophrenia may contribute to the overall serotonergic alterations which occur in the disorder, in part through their interactions with other neurotransmitter systems including glutamate and acetylcholine. |
2002-10-30 |
2023-08-12 |
human |
| Abdelmalik Slass. Recent advances in 5-HT1B/1D receptor antagonists and agonists and their potential therapeutic applications. Current topics in medicinal chemistry. vol 2. issue 6. 2002-10-24. PMID:12052194. |
emphasis is given to recent advances in the potential therapeutic applications of 5-ht(1b/1d) serotonergic agents. |
2002-10-24 |
2023-08-12 |
human |
| Lisa Won, Nancy Bubula, Alfred Helle. Fetal exposure to (+/-)-methylenedioxymethamphetamine in utero enhances the development and metabolism of serotonergic neurons in three-dimensional reaggregate tissue culture. Brain research. Developmental brain research. vol 137. issue 1. 2002-10-16. PMID:12128255. |
there was a long-term enhancement of serotonergic development and metabolism by fetal exposure to mdma as evidenced by increased reaggregate serotonin levels as well as the elevated production and release of 5-hydroxyindoleacetic acid in cultures prepared from mdma-exposed embryos which persisted for up to 36 days of culture. |
2002-10-16 |
2023-08-12 |
mouse |
| Bérangère Ballion, Pascal Branchereau, Jacqueline Chapron, Denise Vial. Ontogeny of descending serotonergic innervation and evidence for intraspinal 5-HT neurons in the mouse spinal cord. Brain research. Developmental brain research. vol 137. issue 1. 2002-10-16. PMID:12128257. |
ontogeny of descending serotonergic innervation and evidence for intraspinal 5-ht neurons in the mouse spinal cord. |
2002-10-16 |
2023-08-12 |
mouse |
| John P Welsh, Dimitris G Placantonakis, Sarah I Warsetsky, Rolando G Marquez, Lana Bernstein, Sue A Aiche. The serotonin hypothesis of myoclonus from the perspective of neuronal rhythmicity. Advances in neurology. vol 89. 2002-10-09. PMID:11968457. |
although some forms of myoclonic epilepsy may benefit from serotonin drugs because they are caused by a decrease in brain serotonin, our data indicate that posthypoxic myoclonus is not caused by a decrease in the serotonergic innervation of any region of the brain. |
2002-10-09 |
2023-08-12 |
human |
| Rosa M Tordera, Antonio Monge, Joaquín Del Río, Berta Lashera. Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors. European journal of pharmacology. vol 442. issue 1-2. 2002-10-08. PMID:12020683. |
consequently, vn2222 is a new compound with a dual effect on the serotonergic system, as 5-ht uptake blocker and 5-ht1a receptor partial agonist, and with a remarkable activity in an animal model of depression with high predictive validity. |
2002-10-08 |
2023-08-12 |
mouse |
| Frederik J Geurts, Erik De Schutter, Jean-Pierre Timmerman. Localization of 5-HT2A, 5-HT3, 5-HT5A and 5-HT7 receptor-like immunoreactivity in the rat cerebellum. Journal of chemical neuroanatomy. vol 24. issue 1. 2002-09-30. PMID:12084412. |
although serotonin (5-hydroxytryptamine, 5-ht) is known to exert a modulatory action on cerebellar function, our current knowledge of the nature of receptor subtypes mediating serotonergic activity in this part of the brain remains fragmentary. |
2002-09-30 |
2023-08-12 |
rat |
| Naoki Nishiguchi, Osamu Shirakawa, Hisae Ono, Akiyoshi Nishimura, Hideyuki Nushida, Yasuhiro Ueno, Kiyoshi Maed. Lack of an association between 5-HT1A receptor gene structural polymorphisms and suicide victims. American journal of medical genetics. vol 114. issue 4. 2002-09-27. PMID:11992564. |
serotonin 1a (5-ht1a) receptors are known to be located on serotonergic nerve terminals and to be involved in the presynaptic regulation of serotonin release. |
2002-09-27 |
2023-08-12 |
Not clear |
| Gurpreet Kaur, Shrinivas K Kulkarn. Evidence for serotonergic modulation of progesterone-induced hyperphagia, depression and algesia in female mice. Brain research. vol 943. issue 2. 2002-09-27. PMID:12101043. |
these data suggest that the modulation of progesterone-induced effects by these serotonergic agents possibly involve 5-ht(2) receptor mechanisms. |
2002-09-27 |
2023-08-12 |
mouse |
| B Bjorvatn, J Grønli, F Hamre, E Sørensen, E Fiske, A A Bjørkum, C M Portas, R Ursi. Effects of sleep deprivation on extracellular serotonin in hippocampus and frontal cortex of the rat. Neuroscience. vol 113. issue 2. 2002-09-26. PMID:12127089. |
however, since 5-ht levels are strongly behavioral state dependent, by eliminating sleep, there may be a net increase in serotonergic neurotransmission during the sleep deprivation period. |
2002-09-26 |
2023-08-12 |
rat |
| Gonzalo Viana Di Prisco, Zimbul Albo, Robert P Vertes, Bernat Kocsi. Discharge properties of neurons of the median raphe nucleus during hippocampal theta rhythm in the rat. Experimental brain research. vol 145. issue 3. 2002-09-26. PMID:12136388. |
an activation of local serotonergic and gabaergic theta-on cells would inhibit 5-ht slow- or moderate-firing theta-off projection cells to release or generate theta, whereas the suppression of serotonergic- or gabaergic theta-on cells would disinhibit 5-ht theta-off cells, resulting in a blockade of theta or a desynchronization of the hippocampal eeg. |
2002-09-26 |
2023-08-12 |
rat |
| Jolanta Neuger, Börje Wistedt, Anna Aberg-Wistedt, Rigmor Stain-Malmgre. Effect of citalopram treatment on relationship between platelet serotonin functions and the Karolinska scales of personality in panic patients. Journal of clinical psychopharmacology. vol 22. issue 4. 2002-09-18. PMID:12172340. |
using the karolinska scales of personality (ksp), we investigated the effect of the selective serotonin reuptake inhibitor citalopram on personality traits and the relationship between personality traits and peripheral indexes for central serotonergic function in patients with panic disorder at baseline and after 6 months of treatment. |
2002-09-18 |
2023-08-12 |
Not clear |
| T J Wright, H Huddar. The nature of the acetylcholine and 5-hydroxytryptamine receptors in buccal smooth muscle of the pest slug Deroceras reticulatum. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 172. issue 3. 2002-09-17. PMID:11919705. |
serotonergic agonist and antagonist experiments using 1-(3-chlorophenyl) piperazine, 1-(m-chlorophenyl) biguanide, methiothepin, methysergide and metoclopramide strongly suggested that the 5-ht receptor showed closest pharmacological affinity with the 5-ht(1) receptor class of mammals but with some 5-ht(2) activity. |
2002-09-17 |
2023-08-12 |
Not clear |
| M L Filipenko, A G Beilina, O V Alekseyenko, V V Dolgov, N N Kudryavtsev. Increase in expression of brain serotonin transporter and monoamine oxidase a genes induced by repeated experience of social defeats in male mice. Biochemistry. Biokhimiia. vol 67. issue 4. 2002-09-16. PMID:11996659. |
increased expression of mao a and serotonin transporter genes is suggested to reflect the accelerated serotonin degradation in response to activation of the serotonergic system functioning induced by social stress. |
2002-09-16 |
2023-08-12 |
mouse |