| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olivier Belzile, Roumiana Gulemetova, Richard Kinkea. Role of 5-HT2A/C receptors in serotonergic modulation of respiratory motor output during tadpole development. Respiratory physiology & neurobiology. vol 133. issue 3. 2003-01-29. PMID:12425975. |
our results show no apparent contribution of the 5-ht(2a/c) receptor subtypes to the serotonergic modulation of either gill- or lung-related neural activity in either group. |
2003-01-29 |
2023-08-12 |
Not clear |
| Lisandra Oliveira Margatho, Silas Pereira Barbosa, Laurival Antonio De Luca, José Vanderlei Menan. Central serotonergic and adrenergic/imidazoline inhibitory mechanisms on sodium and water intake. Brain research. vol 956. issue 1. 2003-01-29. PMID:12426052. |
similar effects were produced by bilateral injections of the 5ht(2a/2c) serotonergic agonist 2,5-dimetoxy-4-iodoamphetamine (doi, 5 microg/0.2 microl each site) into the lpbn on water (3.6+/-0.9 ml/2 h) and 0.3 m nacl intake (0.4+/-0.2 ml/2 h). |
2003-01-29 |
2023-08-12 |
rat |
| Tomio Inoue, Satsuki Itoh, Satoshi Wakisaka, Satoshi Ogawa, Mitsuru Saito, Toshifumi Morimot. Involvement of 5-HT7 receptors in serotonergic effects on spike afterpotentials in presumed jaw-closing motoneurons of rats. Brain research. vol 954. issue 2. 2003-01-28. PMID:12414103. |
intracellular recordings were obtained from rat presumed jaw-closing motoneurons in slice preparations to investigate the involvement of the serotonin(7) (5-ht(7)) receptors in serotonergic inhibition of the postspike medium-duration afterhyperpolarization (mahp) and enhancement of the afterdepolarization (adp). |
2003-01-28 |
2023-08-12 |
rat |
| Isabelle Malagié, Denis J David, Pascale Jolliet, René Hen, Michel Bourin, Alain M Gardie. Improved efficacy of fluoxetine in increasing hippocampal 5-hydroxytryptamine outflow in 5-HT(1B) receptor knock-out mice. European journal of pharmacology. vol 443. issue 1-3. 2003-01-27. PMID:12044798. |
these data suggest that 5-ht(1b) autoreceptors limit the effects of selective serotonin reuptake inhibitors on dialysate 5-ht levels at serotonergic nerve terminals located mainly in the ventral hippocampus. |
2003-01-27 |
2023-08-12 |
mouse |
| Dorotea Mück-Seler, Nela Pivac, Marina Sagud, Miro Jakovljević, Alma Mihaljević-Pele. The effects of paroxetine and tianeptine on peripheral biochemical markers in major depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 7-8. 2003-01-27. PMID:12502009. |
depression is related to the alterations of the central serotonergic system and some antidepressants achieve their therapeutic effects through alteration of serotonin (5-ht) (re)uptake. |
2003-01-27 |
2023-08-12 |
Not clear |
| E Calama, M M Fernández, A Morán, M L Martín, L San Romá. Vasodilator and vasoconstrictor responses induced by 5-hydroxytryptamine in the in situ blood autoperfused hindquarters of the anaesthetized rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 366. issue 2. 2003-01-24. PMID:12122496. |
the vasodilator effect was inhibited by methiothepin (a non-specific 5-ht(1,2,5,6,7) receptor antagonist) and by a 5-ht(1d/1b) receptor antagonist, i.e., 3-[4-(4-chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanolol (brl 15572), but not by ritanserin (a selective 5-ht(2) receptor antagonist), 5-methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f] indole (sb 206553, a selective 5-ht(2b/2c) receptor antagonist) or mesulergine (a non-specific serotonergic antagonist that shows affinity to the 5-ht(7) receptor). |
2003-01-24 |
2023-08-12 |
rat |
| Michael A Taffe, Sophia A Davis, Jie Yuan, Richard Schroeder, George Hatzidimitriou, Loren H Parsons, George A Ricaurte, Lisa H Gol. Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 6. 2003-01-24. PMID:12464456. |
these observations suggest that large depletions of brain 5-ht produced by mdma can persistently alter behavioral sensitivity to the disrupting effects of serotonergic agents. |
2003-01-24 |
2023-08-12 |
rat |
| Ilona Gurevich, Michael T Englander, Mella Adlersberg, Nathan B Siegal, Claudia Schmaus. Modulation of serotonin 2C receptor editing by sustained changes in serotonergic neurotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486144. |
modulation of serotonin 2c receptor editing by sustained changes in serotonergic neurotransmission. |
2003-01-23 |
2023-08-12 |
mouse |
| Albert Adell, Pau Celada, M Teresa Abellán, Francesc Artiga. Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei. Brain research. Brain research reviews. vol 39. issue 2-3. 2003-01-21. PMID:12423765. |
there is considerable interest in the regulation of the extracellular compartment of the transmitter serotonin (5-hydroxytryptamine, 5-ht) in the midbrain raphe nuclei because it can control the activity of ascending serotonergic systems and the release of 5-ht in terminal areas of the forebrain. |
2003-01-21 |
2023-08-12 |
Not clear |
| Albert Adell, Pau Celada, M Teresa Abellán, Francesc Artiga. Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei. Brain research. Brain research reviews. vol 39. issue 2-3. 2003-01-21. PMID:12423765. |
overall, it appears that the extracellular concentration of 5-ht in the dr and the mnr is tightly controlled by intrinsic serotonergic mechanisms as well as afferent connections. |
2003-01-21 |
2023-08-12 |
Not clear |
| Shannon D Sullivan, Laura C Howard, Anita H Clayton, Suzanne M Moente. Serotonergic activation rescues reproductive function in fasted mice: does serotonin mediate the metabolic effects of leptin on reproduction? Biology of reproduction. vol 66. issue 6. 2003-01-14. PMID:12021050. |
serotonergic activation rescues reproductive function in fasted mice: does serotonin mediate the metabolic effects of leptin on reproduction? |
2003-01-14 |
2023-08-12 |
mouse |
| Shannon D Sullivan, Laura C Howard, Anita H Clayton, Suzanne M Moente. Serotonergic activation rescues reproductive function in fasted mice: does serotonin mediate the metabolic effects of leptin on reproduction? Biology of reproduction. vol 66. issue 6. 2003-01-14. PMID:12021050. |
serotonin (5ht) has satiety effects similar to those of leptin and alters lh release, and serotonergic neurons, which have been shown to express leptin receptors, terminate on gnrh neurons. |
2003-01-14 |
2023-08-12 |
mouse |
| Maura Corsetti, Jan Tac. Tegaserod: a new 5-HT(4) agonist in the treatment of irritable bowel syndrome. Expert opinion on pharmacotherapy. vol 3. issue 8. 2003-01-14. PMID:12150698. |
tegaserod is a selective partial agonist acting on serotonergic type 4 receptors (5-ht(4)). |
2003-01-14 |
2023-08-12 |
Not clear |
| Frank I Tarazi, Kehong Zhang, Ross J Baldessarin. Long-term effects of olanzapine, risperidone, and quetiapine on serotonin 1A, 2A and 2C receptors in rat forebrain regions. Psychopharmacology. vol 161. issue 3. 2003-01-13. PMID:12021829. |
altered serotonergic neurotransmission and interactions between 5-ht and dopamine (da) systems may contribute to the pathophysiology of idiopathic psychotic or manic disorders. |
2003-01-13 |
2023-08-12 |
rat |
| Alan F Schatzber. Pharmacological principles of antidepressant efficacy. Human psychopharmacology. vol 17 Suppl 1. 2003-01-13. PMID:12404665. |
those that affect both monoamine systems, such as tricyclic antidepressants and the noradrenergic and specific serotonergic antidepressant mirtazapine, may have greater efficacy and a faster onset of action than drugs that act on a single monoamine system only, such as the selective serotonin reuptake inhibitors (ssris). |
2003-01-13 |
2023-08-12 |
Not clear |
| H J Stuerenburg, K Petersen, T Bäumer, M Rosenkranz, C Buhmann, R Thomasiu. Plasma concentrations of 5-HT, 5-HIAA, norepinephrine, epinephrine and dopamine in ecstasy users. Neuro endocrinology letters. vol 23. issue 3. 2003-01-10. PMID:12080289. |
although it is known that significant changes in 5-ht and 5-hiaa appear in the cerebrospinal fluid in ecstasy users, we could not detect alterations in serotonergic neurotransmitters in plasma in this large sample of subjects. |
2003-01-10 |
2023-08-12 |
human |
| H J Stuerenburg, K Petersen, T Bäumer, M Rosenkranz, C Buhmann, R Thomasiu. Plasma concentrations of 5-HT, 5-HIAA, norepinephrine, epinephrine and dopamine in ecstasy users. Neuro endocrinology letters. vol 23. issue 3. 2003-01-10. PMID:12080289. |
thus, in the drug-free interval, ecstasy users show lowered central serotonergic activity (lowered 5-ht and 5-hiaa concentrations in csf) along with unchanged central noradrenergic and dopaminergic activity (hva and mhpg unchanged in csf) and elevated peripheral noradrenergic, dopaminergic and adrenergic activity along with unchanged peripheral serotonergic activity (plasma levels). |
2003-01-10 |
2023-08-12 |
human |
| Jamie C Bruce, Mark A Oatway, Lynne C Weave. Chronic pain after clip-compression injury of the rat spinal cord. Experimental neurology. vol 178. issue 1. 2003-01-08. PMID:12460606. |
the decreased serotonin and presence of tactile allodynia and hyperalgesia caudal to the injury are consistent with disruption of descending antinociceptive serotonergic tracts that modulate pain transmission. |
2003-01-08 |
2023-08-12 |
rat |
| William Pitchot, Jacques Wauthy, Michel Hansenne, Emmanuel Pinto, Sonia Fuchs, Jean Reggers, Jean-Jacques Legros, Marc Anssea. Hormonal and temperature responses to the 5-HT1A receptor agonist flesinoxan in normal volunteers. Psychopharmacology. vol 164. issue 1. 2003-01-07. PMID:12373416. |
flesinoxan is a highly potent and selective 5-ht(1a) agonist and appears to be a potentially interesting neuroendocrine serotonergic probe. |
2003-01-07 |
2023-08-12 |
human |
| Patrizia Oliva, Caterina Aurilio, Francesco Massimo, Antonio Grella, Sabatino Maione, Elisa Grella, Mariantonietta Scafuro, Francesco Rossi, Liberato Berrin. The antinociceptive effect of tramadol in the formalin test is mediated by the serotonergic component. European journal of pharmacology. vol 445. issue 3. 2003-01-03. PMID:12079682. |
in conclusion, we demonstrate that the serotonergic pathway is responsible for the antinociceptive effect of tramadol in phase 2 of the formalin test, and that this effect is mediated by 5-ht(2) receptors. |
2003-01-03 |
2023-08-12 |
mouse |