| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hideki Horiuchi, Tadanori Ogata, Tadao Morino, Jun Takeba, Haruyasu Yamamot. Serotonergic signaling inhibits hyperalgesia induced by spinal cord damage. Brain research. vol 963. issue 1-2. 2003-04-28. PMID:12560138. |
these results suggest that the change in the descending serotonergic signal plays an important role in hyperalgesia after the spinal cord injury, and that the application of selective serotonin reuptake inhibitors will be one of the candidates for new therapeutic methods against post-spinal cord injury dysesthesia. |
2003-04-28 |
2023-08-12 |
rat |
| Gabor G Kovacs, Stefan Klöppel, Ingeborg Fischer, Suzanne Dorner, Elisabeth Lindeck-Pozza, Peter Birner, Ingolf C Bötefür, Peter Pilz, Benedikt Volk, Herbert Budk. Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders. Neuroreport. vol 14. issue 1. 2003-04-25. PMID:12544834. |
to evaluate the involvement of serotonergic raphe nuclei, we compared the percentage of neurons synthesizing serotonin in the nucleus centralis superior (ncs), raphe obscurus and pallidus (nrop) in alzheimer's disease (ad), progressive supranuclear palsy (psp), parkinson's disease (pd), multiple system atrophy (msa), and control brains. |
2003-04-25 |
2023-08-12 |
human |
| A Schmitt, R Mössner, A Gossmann, I G Fischer, V Gorboulev, D L Murphy, H Koepsell, K P Lesc. Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice. Journal of neuroscience research. vol 71. issue 5. 2003-04-24. PMID:12584728. |
the serotonin (5ht) transporter (5htt) regulates serotonergic neurotransmission by mediating the reuptake of 5ht from the synaptic cleft. |
2003-04-24 |
2023-08-12 |
mouse |
| D N D'Souza, Y Zhang, F Garcia, G Battaglia, L D Van De Ka. Destruction of serotonergic nerve terminals prevents fluoxetine-induced desensitization of hypothalamic 5-HT(1A) receptors. Psychopharmacology. vol 164. issue 4. 2003-04-23. PMID:12457269. |
destruction of serotonergic nerve terminals prevents fluoxetine-induced desensitization of hypothalamic 5-ht(1a) receptors. |
2003-04-23 |
2023-08-12 |
Not clear |
| Jon E Sprague, Matthew L Banks, Valerie J Cook, Edward M Mill. Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy). The Journal of pharmacology and experimental therapeutics. vol 305. issue 1. 2003-04-22. PMID:12649364. |
the hypo and tx animals were also resistant to the serotonergic neurotoxic effects of mdma assessed by serotonin measurements 4 to 7 days later in the striatum and hippocampus. |
2003-04-22 |
2023-08-12 |
rat |
| Heike Franke, Jens Grosche, Peter Illes, Clemens Allgaie. 5,7-Dihydroxytryptamine--a selective marker of dopaminergic or serotonergic neurons? Naunyn-Schmiedeberg's archives of pharmacology. vol 366. issue 4. 2003-04-21. PMID:12237744. |
the aim of the present study was to investigate whether 5,7-dihydroxytryptamine (5,7-dht), an autofluorescent serotonin derivative, can be used as a specific marker for serotonergic or dopaminergic neurons in rat mesencephalic cultures. |
2003-04-21 |
2023-08-12 |
rat |
| Kathryn G Commons, K Ryan Connolley, Rita J Valentin. A neurochemically distinct dorsal raphe-limbic circuit with a potential role in affective disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 2. 2003-04-21. PMID:12589373. |
dual-labeling immunohistochemistry revealed that almost all crf-containing neurons were serotonergic, implicating crf as a cotransmitter with serotonin in this subpopulation of dr neurons. |
2003-04-21 |
2023-08-12 |
rat |
| Hans C Dringenberg, C H Vanderwolf, Peter A Noseworth. Superior colliculus stimulation enhances neocortical serotonin release and electrocorticographic activation in the urethane-anesthetized rat. Brain research. vol 964. issue 1. 2003-04-18. PMID:12573510. |
these data suggest that efferents from the sc, possibly by an excitatory action on serotonergic dorsal raphe cells, produce an enhanced release of serotonin and ecog activation in the neocortex. |
2003-04-18 |
2023-08-12 |
rat |
| Xiang-Rong Jiang, Glenn Dryhurs. Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione. Chemical research in toxicology. vol 15. issue 10. 2003-04-17. PMID:12387620. |
a transient energy impairment with resultant release and subsequent reuptake of 5-hydroxytryptamine (5-ht) and nmda receptor activation with consequent cytoplasmic superoxide (o(2)(-)(*)), nitric oxide (no(*)), and peroxynitrite (onoo(-)) generation have all been implicated in a neurotoxic cascade which ultimately leads to the degeneration of serotonergic neurons evoked by methamphetamine (ma) and 3,4-methylenedioxymethamphetamine (mdma). |
2003-04-17 |
2023-08-12 |
rat |
| Xiang-Rong Jiang, Glenn Dryhurs. Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione. Chemical research in toxicology. vol 15. issue 10. 2003-04-17. PMID:12387620. |
such observations raise the possibility that the o(2)(-)(*)/no(*)/onoo(-)-mediated oxidation of 5-ht, as it returns via the plasma membrane transporter to the cytoplasm of serotonergic neurons when the ma/mdma-induced energy impairment begins to subside, may generate an endogenous neurotoxin. |
2003-04-17 |
2023-08-12 |
rat |
| Xiang-Rong Jiang, Glenn Dryhurs. Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione. Chemical research in toxicology. vol 15. issue 10. 2003-04-17. PMID:12387620. |
these and other properties of t-4,5-d raise the possibility that it may be an endogenously formed intraneuronal metabolite of 5-ht that contributes to the serotonergic neurotoxicity of ma and mdma. |
2003-04-17 |
2023-08-12 |
rat |
| H Jørgensen, M Riis, U Knigge, A Kjaer, J Warber. Serotonin receptors involved in vasopressin and oxytocin secretion. Journal of neuroendocrinology. vol 15. issue 3. 2003-04-17. PMID:12588512. |
we investigated the involvement of 5-ht receptors in the serotonergic regulation of vasopressin and oxytocin secretion. |
2003-04-17 |
2023-08-12 |
Not clear |
| Hugh Jones, Vivienne A Curtis, Padraig Wright, Lyn S Pilowsky, James V Luce. D-fenfluramine-evoked serotonergic responses in olanzapine-treated schizophrenic patients. Psychiatry research. vol 113. issue 1-2. 2003-04-15. PMID:12467944. |
this neuroendocrine study examined the in vivo functional serotonergic (5-ht) activity of the atypical antipsychotic olanzapine. |
2003-04-15 |
2023-08-12 |
Not clear |
| Yajin Ni, D Goldman, B Hoffman, P J Brook. Overexpression of an epitope-tagged serotonin transporter in serotonin neurons of the dorsal raphe nucleus using a defective HSV-1 vector. Behavioural brain research. vol 138. issue 2. 2003-04-15. PMID:12527444. |
we were also able to overexpress an epitope tagged 5htt in serotonergic neurons in the dorsal raphe nucleus (drn) using this approach. |
2003-04-15 |
2023-08-12 |
rat |
| Gianfranco Bellipanni, Elke Rink, Laure Bally-Cui. Cloning of two tryptophan hydroxylase genes expressed in the diencephalon of the developing zebrafish brain. Gene expression patterns : GEP. vol 2. issue 3-4. 2003-04-11. PMID:12617810. |
the monoamine serotonin (5-ht) exerts key neuromodulatory activities in all animal phyla, but the development and function of the serotonergic system is still incompletely understood. |
2003-04-11 |
2023-08-12 |
zebrafish |
| Gianfranco Bellipanni, Elke Rink, Laure Bally-Cui. Cloning of two tryptophan hydroxylase genes expressed in the diencephalon of the developing zebrafish brain. Gene expression patterns : GEP. vol 2. issue 3-4. 2003-04-11. PMID:12617810. |
in order to characterize the organization of serotonergic neurons in the zebrafish we cloned two cdnas encoding distinct forms of tryptophan hydroxylase (tph), the rate-limiting enzyme in serotonin synthesis. |
2003-04-11 |
2023-08-12 |
zebrafish |
| Daisuke Mochizuki, Tadami Hokonohara, Koh Kawasaki, Naomasa Mik. Repeated administration of milnacipran induces rapid desensitization of somatodendritic 5-HT1A autoreceptors but not postsynaptic 5-HT1A receptors. Journal of psychopharmacology (Oxford, England). vol 16. issue 3. 2003-04-07. PMID:12236634. |
in-vitro electrophysiological recordings in the dorsal raphe nucleus showed that 5-ht inhibited the firing of serotonergic neurones, and the selective 5-ht1a receptor antagonist, n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexane carboxamide (way 100635), reversed the inhibitory effect of 5-ht. |
2003-04-07 |
2023-08-12 |
rat |
| Daisuke Mochizuki, Tadami Hokonohara, Koh Kawasaki, Naomasa Mik. Repeated administration of milnacipran induces rapid desensitization of somatodendritic 5-HT1A autoreceptors but not postsynaptic 5-HT1A receptors. Journal of psychopharmacology (Oxford, England). vol 16. issue 3. 2003-04-07. PMID:12236634. |
the potency of 5-ht to inhibit the firing of serotonergic neurones was slightly attenuated after 3 days of treatment with milnacipran (30 mg/kg, p.o., twice daily), and significantly attenuated after 7 or 14 days treatment at the same dose. |
2003-04-07 |
2023-08-12 |
rat |
| Daisuke Mochizuki, Tadami Hokonohara, Koh Kawasaki, Naomasa Mik. Repeated administration of milnacipran induces rapid desensitization of somatodendritic 5-HT1A autoreceptors but not postsynaptic 5-HT1A receptors. Journal of psychopharmacology (Oxford, England). vol 16. issue 3. 2003-04-07. PMID:12236634. |
after 7 days treatment at 30 mg/kg, p.o., once daily, milnacipran reduced the potency of 5-ht to inhibit the firing of serotonergic neurones, whereas the selective serotonin reuptake inhibitors, fluvoxamine and fluoxetine (60 and 30 mg/kg, p.o., once daily, respectively), did not modify it under these conditions. |
2003-04-07 |
2023-08-12 |
rat |
| Timothy J Hendricks, Dmitry V Fyodorov, Lauren J Wegman, Nadia B Lelutiu, Elizabeth A Pehek, Bryan Yamamoto, Jerry Silver, Edwin J Weeber, J David Sweatt, Evan S Deneri. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron. vol 37. issue 2. 2003-04-04. PMID:12546819. |
these findings indicate that pet-1 is a critical determinant of 5-ht neuron identity and implicate a pet-1-dependent program in serotonergic modulation of behavior. |
2003-04-04 |
2023-08-12 |
mouse |