| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Strobel, S Debener, D Schmidt, R Hünnerkopf, K-P Lesch, B Brock. Allelic variation in serotonin transporter function associated with the intensity dependence of the auditory evoked potential. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 118B. issue 1. 2003-07-14. PMID:12627465. |
as individual differences in serotonergic neurotransmission can be accounted for in part by genetic variation in genes of the serotonergic pathway, we investigated whether a functional polymorphism in the promoter region of the serotonin transporter gene (5-httlpr) is associated with the aep intensity dependence. |
2003-07-14 |
2023-08-12 |
Not clear |
| Carey D Balaba. Neural substrates linking balance control and anxiety. Physiology & behavior. vol 77. issue 4-5. 2003-07-11. PMID:12526985. |
both serotonergic and nonserotonergic pathways from the dorsal raphe nucleus and the nucleus raphe obscurus also project differentially to the vestibular nuclei, and 5-ht(2a) receptors are expressed in amygdaloid and cortical targets of the pbn. |
2003-07-11 |
2023-08-12 |
Not clear |
| Omar A Gharbawie, Ian Q Whisha. Cholinergic and serotonergic neocortical projection lesions given singly or in combination cause only mild impairments on tests of skilled movement in rats: evaluation of a model of dementia. Brain research. vol 970. issue 1-2. 2003-07-08. PMID:12706251. |
the cholinergic (ach) projections of the nucleus basalis and the serotonergic (5-ht) projections of the raphe nuclei to the neocortex are required for the normal function of the neocortex. |
2003-07-08 |
2023-08-12 |
rat |
| Twum-Ampofo Ansah, Sammanda Ramamoorthy, Sylvia Montañez, Lynette C Daws, Randy D Blakel. Calcium-dependent inhibition of synaptosomal serotonin transport by the alpha 2-adrenoceptor agonist 5-bromo-N-[4,5-dihydro-1H-imidazol-2-yl]-6-quinoxalinamine (UK14304). The Journal of pharmacology and experimental therapeutics. vol 305. issue 3. 2003-07-07. PMID:12626658. |
termination of serotonergic transmission is the function of the plasma membrane 5-hydroxytryptamine (serotonin, 5-ht) transporter (sert), which is also a high-affinity target in vivo for antidepressants, amphetamines, and cocaine. |
2003-07-07 |
2023-08-12 |
mouse |
| E J Bull, P H Hutson, K C F Fon. Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity. Neuropharmacology. vol 44. issue 4. 2003-07-03. PMID:12646281. |
this study examined the long-term change in serotonergic (5-hydroxytryptamine, 5-ht) neuronal function and 5-ht(2c) receptor agonist-induced behaviour following treatment of young rats with 3,4-methylenedioxymethamphetamine (mdma). |
2003-07-03 |
2023-08-12 |
rat |
| Chantal Moret, Brigitt Grimaldi, Olivier Massot, Gille Fillio. The role and therapeutic potential of 5-HT-moduline in psychiatry. Seminars in clinical neuropsychiatry. vol 8. issue 2. 2003-07-01. PMID:12728412. |
these conformational changes ultimately lead to the prevention of 5-ht binding resulting in desensitization of these receptors and reduction of the serotonergic function. |
2003-07-01 |
2023-08-12 |
mouse |
| Maria D Zhelyazkova-Savova, Delcho K Zhelyazko. Behavioural evidence of agonist-like effect of isoteoline at 5-HT1B serotonergic receptors in mice. The Journal of pharmacy and pharmacology. vol 55. issue 1. 2003-06-24. PMID:12625876. |
previous studies with isoteoline have shown antagonistic activity at 5-ht(2c) serotonergic receptors. |
2003-06-24 |
2023-08-12 |
mouse |
| C P Müller, R J Carey, J B Salloum, J P Husto. Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668045. |
both structures receive a serotonergic (5-ht) innervation. |
2003-06-23 |
2023-08-12 |
rat |
| A Harkin, T J Connor, M Walsh, N St John, J P Kell. Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668047. |
this behavioural profile parallels the one previously shown with selective serotonin re-uptake inhibitors and serotonergic agonists. |
2003-06-23 |
2023-08-12 |
rat |
| O Gandolfi, R Gaggi, M Voltattorni, R Dall'Oli. The activation of serotonin receptors prevents glutamate-induced neurotoxicity and NMDA-stimulated cGMP accumulation in primary cortical cell cultures. Pharmacological research. vol 46. issue 5. 2003-06-18. PMID:12419645. |
in the present study, we performed experiments on primary cell cultures from rat neocortex to assess the effects of the selective serotonergic 5ht(1a), 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) or 5ht(2), (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) agonists on neuronal death induced by 15min exposure to (-)glutamate (300 microm) as measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (mtt). |
2003-06-18 |
2023-08-12 |
rat |
| O Gandolfi, R Gaggi, M Voltattorni, R Dall'Oli. The activation of serotonin receptors prevents glutamate-induced neurotoxicity and NMDA-stimulated cGMP accumulation in primary cortical cell cultures. Pharmacological research. vol 46. issue 5. 2003-06-18. PMID:12419645. |
the results show that both drugs attenuated (-)glutamate-induced neurotoxicity and this effect was fully antagonized by the selective antagonists of 5ht(1) (nan-190) or 5ht(2) (ketanserin) receptors.the effects of the selective serotonergic agonists on the production of cyclic gmp (cgmp) accumulation induced by n-methyl-d-aspartate (nmda) in the same neuronal preparation were also evaluated. |
2003-06-18 |
2023-08-12 |
rat |
| Claudia von Meyenburg, Wolfgang Langhans, Brian J Hrupk. Evidence that the anorexia induced by lipopolysaccharide is mediated by the 5-HT2C receptor. Pharmacology, biochemistry, and behavior. vol 74. issue 2. 2003-06-18. PMID:12479973. |
because inhibition of serotonergic (5-ht) activity by 8-oh-dpat (5-ht(1a) activation) attenuates lps-induced anorexia, we conducted a series of studies to examine whether other 5-ht-receptors are involved in the mediation of peripheral lps-induced anorexia. |
2003-06-18 |
2023-08-12 |
rat |
| Hans-Peter Landolt, John R Kelsoe, Marc H Rapaport, J Christian Gilli. Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep. Journal of sleep research. vol 12. issue 1. 2003-06-17. PMID:12603782. |
hypothesizing that increased serotonergic neurotransmission eliminated rem sleep, we administered a tryptophan-free amino acid drink (tfd) known to reduce plasma tryptophan and brain levels of serotonin. |
2003-06-17 |
2023-08-12 |
human |
| Y P Yip, L Rinaman, C Capriotti, J W Yi. Ectopic sympathetic preganglionic neurons maintain proper connectivity in the reeler mutant mouse. Neuroscience. vol 118. issue 2. 2003-06-16. PMID:12699780. |
using antibodies against tyrosine hydroxylase, serotonin, neuropeptide y, substance p and calcitonin gene-related peptide as markers for adrenergic, serotonergic and peptidergic terminals, we found that axons which normally innervate spn follow these neurons to their ectopic spinal location in the reeler. |
2003-06-16 |
2023-08-12 |
mouse |
| Christelle Monaca, Benjamin Boutrel, René Hen, Michel Hamon, Joëlle Adrie. 5-HT 1A/1B receptor-mediated effects of the selective serotonin reuptake inhibitor, citalopram, on sleep: studies in 5-HT 1A and 5-HT 1B knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 5. 2003-06-11. PMID:12637954. |
such an effect can be accounted for by the action of serotonin at various types of serotonergic receptors involved in ps regulation, among which the 5-ht(1a) and 5-ht(1b) types are the best candidates. |
2003-06-11 |
2023-08-12 |
mouse |
| Olivier Lepage, Olof Tottmar, Svante Winber. Elevated dietary intake of L-tryptophan counteracts the stress-induced elevation of plasma cortisol in rainbow trout (Oncorhynchus mykiss). The Journal of experimental biology. vol 205. issue Pt 23. 2003-06-06. PMID:12409494. |
the central serotonergic system is involved in the control of the hypothalamic-pituitary-interrenal axis, the action of serotonin being to stimulate or inhibit this neuroendocrine axis through different projections. |
2003-06-06 |
2023-08-12 |
Not clear |
| Alina Borkowska, Ewa Pilaczyńska, Aleksander Araszkiewicz, Janusz Rybakowsk. [The effect of sertraline on cognitive functions in patients with obsessive-compulsive disorder]. Psychiatria polska. vol 36. issue 6 Suppl. 2003-06-05. PMID:12647451. |
the effect of sertraline on ocd symptoms, similarly like other drugs inhibiting serotonin transporter (clomipramine, other ssri) is associated with its influence on serotonergic system. |
2003-06-05 |
2023-08-12 |
Not clear |
| Bryan C Hains, William D Willis, Claire E Hulsebosc. Serotonin receptors 5-HT1A and 5-HT3 reduce hyperexcitability of dorsal horn neurons after chronic spinal cord hemisection injury in rat. Experimental brain research. vol 149. issue 2. 2003-06-02. PMID:12610685. |
in a rodent model of sci, t13 spinal hemisection results in allodynia and hyperalgesia due in part to interruption of descending pathways, including serotonergic (5-ht) systems, that leads to hyperexcitability of dorsal horn neurons. |
2003-06-02 |
2023-08-12 |
rat |
| Naotoshi Tamura, Yoshihiko Nakazato, Toshimasa Yamamoto, Shin-ichi Iwasaki, Kunio Shimaz. [Serotonin syndrome caused by tandospirone citrate alone]. Rinsho shinkeigaku = Clinical neurology. vol 42. issue 9. 2003-06-02. PMID:12710093. |
we describe a case of serotonin syndrome provoked by tandospirone citrate alone, a serotonergic antianxiety agent. |
2003-06-02 |
2023-08-12 |
Not clear |
| David C Purselle, Charles B Nemerof. Serotonin transporter: a potential substrate in the biology of suicide. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 4. 2003-05-29. PMID:12655305. |
these findings, taken together, suggest that alterations in the serotonergic system might contribute to suicidal behavior, serving as an impetus for researchers to scrutinize the serotonin transporter (sert) as a potential substrate for the pathophysiology of suicide. |
2003-05-29 |
2023-08-12 |
Not clear |