| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michal Shayit, Gal Yadid, David H Overstreet, Aron Welle. 5-HT(1A) receptor subsensitivity in infancy and supersensitivity in adulthood in an animal model of depression. Brain research. vol 980. issue 1. 2003-11-12. PMID:12865163. |
flinders sensitive line (fsl) rats, a genetic animal model of depression, exhibit 5-ht abnormalities including an increased sensitivity to serotonergic agonists. |
2003-11-12 |
2023-08-12 |
rat |
| Michal Shayit, Gal Yadid, David H Overstreet, Aron Welle. 5-HT(1A) receptor subsensitivity in infancy and supersensitivity in adulthood in an animal model of depression. Brain research. vol 980. issue 1. 2003-11-12. PMID:12865163. |
this may contribute to a better understanding of the involvement of the serotonergic system in depression, and lead to pharmacological interventions aiming to modulate 5-ht regulation. |
2003-11-12 |
2023-08-12 |
rat |
| K Glatz, R Mössner, A Heils, K P Lesc. Glucocorticoid-regulated human serotonin transporter (5-HTT) expression is modulated by the 5-HTT gene-promotor-linked polymorphic region. Journal of neurochemistry. vol 86. issue 5. 2003-11-12. PMID:12911615. |
mood, emotion and cognition are modulated by serotonergic neurotransmission, while the physiological function of serotonergic synapses depends on serotonin reuptake, which is mediated by the serotonin transporter (5-htt). |
2003-11-12 |
2023-08-12 |
human |
| N K Popova, A V Kulikov, D F Avgustinovich, N N Barykin. Involvement of striatum serotonergic system in the expression of genetically defined catalepsy. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 83. issue 5-6. 2003-11-07. PMID:13677667. |
these results indicate that serotonergic system of striatum is involved in the expression of hereditary catalepsy and suggest that hereditary catalepsy may result from genetic changes in the regulation of serotonin metabolism and reception in striatum. |
2003-11-07 |
2023-08-12 |
mouse |
| E C Pooley, K Houston, K Hawton, P J Harriso. Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other serotonergic genes. Psychological medicine. vol 33. issue 5. 2003-11-06. PMID:12877392. |
given the putative role of the 5-ht (5-hydroxytryptamine; serotonin) system in suicidal behaviour, serotonergic genes are leading candidates. |
2003-11-06 |
2023-08-12 |
Not clear |
| G Hapfelmeier, C Tredt, R Haseneder, W Zieglgänsberger, B Eisensamer, R Rupprecht, G Ramme. Co-expression of the 5-HT3B serotonin receptor subunit alters the biophysics of the 5-HT3 receptor. Biophysical journal. vol 84. issue 3. 2003-11-04. PMID:12609874. |
because receptor desensitization and resensitization massively affect amplitude, duration, and frequency of synaptic signaling, these findings are evidence in favor of a pivotal role of subunit composition of 5-ht(3) receptors in serotonergic transmission. |
2003-11-04 |
2023-08-12 |
human |
| Hans C Dringenberg, Kristopher E B Dennis, Summer Tomaszek, Jody Marti. Orienting and defensive behaviors elicited by superior colliculus stimulation in rats: effects of 5-HT depletion, uptake inhibition, and direct midbrain or frontal cortex application. Behavioural brain research. vol 144. issue 1-2. 2003-11-03. PMID:12946599. |
defensive behaviors are modulated by serotonin (5-hydroxytryptamine, 5-ht), and serotonergic fibers provide a dense innervation of the sc. |
2003-11-03 |
2023-08-12 |
rat |
| Y-Y Wang, S-X Wu, X-Y Liu, W Wang, Y-Q L. Effects of c-fos antisense oligodeoxynucleotide on 5-HT-induced upregulation of preprodynorphin, preproenkephalin, and glutamic acid decarboxylase mRNA expression in cultured rat spinal dorsal horn neurons. Biochemical and biophysical research communications. vol 309. issue 3. 2003-10-30. PMID:12963037. |
effects of c-fos antisense oligodeoxynucleotide (aso) on serotonin (5-ht)-induced upregulation of preprodynorphin (ppdyn), preproenkephalin (ppenk), and glutamic acid decarboxylase (gad), a special chemical marker for gamma-aminobutyric acid (gaba) neurons, mrnas in cultured spinal dorsal horn neurons were investigated in order to extend our understanding of expressions of opioid peptides and gaba in spinal cord regulated by the descending serotonergic efferents. |
2003-10-30 |
2023-08-12 |
rat |
| Xiaoyan Luo, Antonio M Persico, Jean M Laude. Serotonergic regulation of somatosensory cortical development: lessons from genetic mouse models. Developmental neuroscience. vol 25. issue 2-4. 2003-10-30. PMID:12966215. |
recent studies using monoamine oxidase-a (mao-a), 5-ht transporter, vesicular monoamine transporter-2 (vmat2) and 5-ht1b receptor single, double and triple knockout mice have provided evidence that the serotonergic system plays important roles in barrel field formation in the developing somatosensory cortex. |
2003-10-30 |
2023-08-12 |
mouse |
| Yu-Qiang Ding, Ulrika Marklund, Wenlin Yuan, Jun Yin, Lauren Wegman, Johan Ericson, Evan Deneris, Randy L Johnson, Zhou-Feng Che. Lmx1b is essential for the development of serotonergic neurons. Nature neuroscience. vol 6. issue 9. 2003-10-28. PMID:12897786. |
the specification and differentiation of serotonergic (5-ht) neurons require both extrinsic signaling molecules and intrinsic transcription factors to work in concert or in cascade. |
2003-10-28 |
2023-08-12 |
mouse |
| Ai-Ming Yu, Jeffrey R Idle, Linda G Byrd, Kristopher W Krausz, Adrian Küpfer, Frank J Gonzale. Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6. Pharmacogenetics. vol 13. issue 3. 2003-10-23. PMID:12618595. |
this potent serotonergic neuromodulator in numerous physiological systems binds tightly to recombinant cyp2d6 enzyme with an equilibrium dissociation constant (k(s)) of 23.4 micromol/l, and is o-demethylated to serotonin (5-hydroxytryptamine, 5-ht) with a high turnover of 51.7 min(-1) and low michaelis-menten constant of 19.5 micromol/l. |
2003-10-23 |
2023-08-12 |
mouse |
| Eliyahu Dremencov, Eitan Gur, Bernard Lerer, Michael E Newma. Effects of chronic antidepressants and electroconvulsive shock on serotonergic neurotransmission in the rat hippocampus. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 5. 2003-10-23. PMID:12921903. |
there are two main lines of evidence for this: firstly, many of its functions correspond to those altered in depression, and secondly, many hippocampal functions are regulated by the serotonergic (5-ht) system, which is a common target of antidepressant treatments. |
2003-10-23 |
2023-08-12 |
rat |
| Alfredo Manfridi, Dario Brambilla, Susanna Bianchi, Maurizio Mariotti, Mark R Opp, Luca Imer. Interleukin-1beta enhances non-rapid eye movement sleep when microinjected into the dorsal raphe nucleus and inhibits serotonergic neurons in vitro. The European journal of neuroscience. vol 18. issue 5. 2003-10-23. PMID:12956704. |
serotonin enhances wakefulness and these novel data also suggest that il-1beta-induced enhancement of nrem sleep could be due in part to the inhibition of drn serotonergic neurons. |
2003-10-23 |
2023-08-12 |
rat |
| Francesco Benedetti, Cristina Colombo, Alessandro Serretti, Cristina Lorenzi, Adriana Pontiggia, Barbara Barbini, Enrico Smerald. Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene. Biological psychiatry. vol 54. issue 7. 2003-10-23. PMID:14512208. |
a functional polymorphism within the promoter of the serotonin transporter has been shown to influence the antidepressant response to serotonergic drug treatments and to total sleep deprivation (tsd). |
2003-10-23 |
2023-08-12 |
Not clear |
| Lotte de Groote, André A Klompmakers, Berend Olivier, Herman G M Westenber. Role of extracellular serotonin levels in the effect of 5-HT1B receptor blockade. Psychopharmacology. vol 167. issue 2. 2003-10-14. PMID:12644890. |
the release of serotonin (5-ht) at serotonergic nerve terminals is regulated by 5-ht(1b) autoreceptors. |
2003-10-14 |
2023-08-12 |
rat |
| A L Halberstadt, C D Balaba. Organization of projections from the raphe nuclei to the vestibular nuclei in rats. Neuroscience. vol 120. issue 2. 2003-10-14. PMID:12890525. |
the distribution of serotonergic axons in the vestibular nuclei was visualized immunohistochemically in rat brain slices using antisera directed against the serotonin transporter. |
2003-10-14 |
2023-08-12 |
rat |
| A L Halberstadt, C D Balaba. Organization of projections from the raphe nuclei to the vestibular nuclei in rats. Neuroscience. vol 120. issue 2. 2003-10-14. PMID:12890525. |
the combination of retrograde tracing with serotonin immunohistofluorescence in additional experiments revealed that the vestibular nuclei receive both serotonergic and non-serotonergic projections from raphe nuclei. |
2003-10-14 |
2023-08-12 |
rat |
| George I Papakostas, Timothy Petersen, David Mischoulon, Megan E Hughes, Jonathan E Alpert, Andrew A Nierenberg, Jerrold F Rosenbaum, Maurizio Fav. Serum cholesterol and serotonergic function in major depressive disorder. Psychiatry research. vol 118. issue 2. 2003-10-10. PMID:12798978. |
studies have revealed a relationship between serum cholesterol levels and serotonergic (5ht) function in healthy young adults. |
2003-10-10 |
2023-08-12 |
Not clear |
| Giovanni Cucchiaro, Kathryn G Common. Alpha 4 nicotinic acetylcholine receptor subunit links cholinergic to brainstem monoaminergic neurotransmission. Synapse (New York, N.Y.). vol 49. issue 3. 2003-10-07. PMID:12774304. |
the alpha4-subunit immunoreactivity was enriched in serotonergic (nucleus raphe magnus, pallidus, obscurus, and dorsalis) and noradrenergic (a5, locus coeruleus (lc), a7) areas associated with antinociception, where it was commonly colocalized with serotonin (5-ht) or tyrosine hydroxylase (th) immunoreactivity. |
2003-10-07 |
2023-08-12 |
Not clear |
| Sondra T Bland, Carin Twining, Linda R Watkins, Steven F Maie. Stressor controllability modulates stress-induced serotonin but not dopamine efflux in the nucleus accumbens shell. Synapse (New York, N.Y.). vol 49. issue 3. 2003-10-07. PMID:12774305. |
previous research indicates that uncontrollable stress (inescapable shock, is) activates serotonergic (5-ht) neurons of the dorsal raphe nucleus (drn) to a greater degree than controllable stress (escapable shock, es), potentiating 5-ht efflux in the drn and in target regions. |
2003-10-07 |
2023-08-12 |
rat |