| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Candiani, A Augello, D Oliveri, M Passalacqua, R Pennati, F De Bernardi, M Pestarin. Immunocytochemical localization of serotonin in embryos, larvae and adults of the lancelet, Branchiostoma floridae. The Histochemical journal. vol 33. issue 7. 2002-08-07. PMID:11858461. |
in vertebrates, serotonin regulates the morphogenesis of the central nervous system and the specification of serotonergic as well as dopaminergic neurons. |
2002-08-07 |
2023-08-12 |
Not clear |
| Françoise Lejeune, Alain Gobert, Mark J Milla. The selective neurokinin (NK)(1) antagonist, GR205,171, stereospecifically enhances mesocortical dopaminergic transmission in the rat: a combined dialysis and electrophysiological study. Brain research. vol 935. issue 1-2. 2002-08-07. PMID:12062484. |
further, they were selective for dopaminergic pathways inasmuch as the firing rate of dorsal raphe serotonergic neurones and dialysate levels of serotonin were unaffected by gr205,171. |
2002-08-07 |
2023-08-12 |
rat |
| Lucienne Léger, Nadine Gay, Raymond Cespugli. Neurokinin NK1- and NK3-immunoreactive neurons in serotonergic cell groups in the rat brain. Neuroscience letters. vol 323. issue 2. 2002-08-05. PMID:11950514. |
to investigate whether sp can directly influence serotonergic neurons, double immunohistochemical labelings were performed on rat brain sections with nk1 or nk3 affinity-purified antibodies and a 5-ht monoclonal antibody. |
2002-08-05 |
2023-08-12 |
rat |
| Jerrold S Meyer, Syed F Al. Serotonergic neurotoxicity of MDMA (ecstasy) in the developing rat brain. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105113. |
pups subsequently remained undisturbed until sacrifice at pd 25 and pd 60 for assessment of serotonergic damage by measuring 5-ht transporter (sert) binding in the hippocampus and neocortex as well as 5-ht and 5-hiaa concentrations (pd 25 only). |
2002-08-02 |
2023-08-12 |
rat |
| Thomas L Schwartz, Prakash S Masan. The role of atypical antipsychotics in the treatment of delirium. Psychosomatics. vol 43. issue 3. 2002-08-01. PMID:12075031. |
their mechanism of action, preferential serotonergic (5ht(2a)) blockade, results in a markedly lower rate of extrapyramidal side effects, an advantage over the typical, older antipsychotic medications. |
2002-08-01 |
2023-08-12 |
Not clear |
| Humberto Corrêa, Fabrice Duval, Marie-Claude Mokrani, Paul Bailey, Fabien Trémeau, Luc Staner, Than-Son Diep, Marc-Antoine Crocq, Jean-Paul Mache. Serotonergic function and suicidal behavior in schizophrenia. Schizophrenia research. vol 56. issue 1-2. 2002-07-31. PMID:12084422. |
recent studies suggest that altered serotonergic (5-ht) function, as assessed by lower prolactin (prl) response to fenfluramine (fen), a specific 5-ht releaser and uptake inhibitor, is associated with suicidal behavior in either depressed and personality disordered patients. |
2002-07-31 |
2023-08-12 |
Not clear |
| Diego J Walther, Jens-Uwe Peter, Michael Bade. 7-Hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumors. Cancer. vol 94. issue 12. 2002-07-31. PMID:12115345. |
carcinoids and small cell lung carcinomas stimulate their growth in an autocrine manner by releasing serotonin, an effect that is blocked by selective serotonergic receptor antagonists that, unfortunately, exert undesirable side effects on serotonergic central nervous function. |
2002-07-31 |
2023-08-12 |
Not clear |
| Edoardo Spina, Maria Gabriella Scord. Clinically significant drug interactions with antidepressants in the elderly. Drugs & aging. vol 19. issue 4. 2002-07-23. PMID:12038880. |
however, the possibility of the serotonin syndrome should be taken into account when drugs affecting serotonergic transmission, such as ssris, venlafaxine or nefazodone, are coadministered with other serotonergic agents. |
2002-07-23 |
2023-08-12 |
Not clear |
| Andrew Holmes, Dennis L Murphy, Jacqueline N Crawle. Reduced aggression in mice lacking the serotonin transporter. Psychopharmacology. vol 161. issue 2. 2002-07-16. PMID:11981596. |
as a key regulator of central serotonergic activity, dysfunction of the serotonin transporter (5-htt) represents a potential mechanism mediating pathological aggression. |
2002-07-16 |
2023-08-12 |
mouse |
| Antonio Orlacchio, Toshitaka Kawarai, Eleonora Paciotti, Alessandro Stefani, Aldo Orlacchio, Sandro Sorbi, Peter H St George-Hyslop, Giorgio Bernard. Association study of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease. Neuroscience letters. vol 325. issue 1. 2002-07-10. PMID:12023056. |
serotonergic (5-hydroxytryptamine; 5-ht) transmission has been implicated in the pathogenesis of alzheimer's disease (ad). |
2002-07-10 |
2023-08-12 |
Not clear |
| Nicolas Costes, Isabelle Merlet, Luc Zimmer, Franck Lavenne, Luc Cinotti, Jacques Delforge, André Luxen, Jean-François Pujol, Didier Le Bar. Modeling [18 F]MPPF positron emission tomography kinetics for the determination of 5-hydroxytryptamine(1A) receptor concentration with multiinjection. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 22. issue 6. 2002-07-10. PMID:12045674. |
the selectivity of [18f]mppf (fluorine-18-labeled 4-(2;-methoxyphenyl)-1-[2;-(n-2"-pirydynyl)-p-fluorobenzamido]ethylpiperazine) for serotonergic 5-hydroxytryptamine(1a) (5-ht1a) receptors has been established in animals and humans. |
2002-07-10 |
2023-08-12 |
Not clear |
| E Sibille, R He. Combining genetic and genomic approaches to study mood disorders. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 11. issue 6. 2002-07-03. PMID:11704418. |
the serotonin system, and the serotonin(1a) (5-ht(1a)) receptor in particular, have been under intense investigation, mostly due to the fact that serotonergic drugs that directly or indirectly affect the 5-ht(1a) receptor, are effective therapeutic agents in treating patients with various neuropsychiatric disorders, including anxiety and depression. |
2002-07-03 |
2023-08-12 |
mouse |
| Michelle Day, Patricia A Olson, Josef Platzer, Joerg Striessnig, D James Surmeie. Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade. Journal of neurophysiology. vol 87. issue 5. 2002-06-28. PMID:11976386. |
prefrontal pyramidal neurons are richly innervated by serotonergic fibers and express high levels of serotonergic 5-ht(2)-class receptors. |
2002-06-28 |
2023-08-12 |
mouse |
| Pau Celada, Josep M Casanovas, Ximena Paez, Francesc Artiga. Control of serotonergic neurons in the dorsal raphe nucleus by the lateral hypothalamus. Brain research. vol 932. issue 1-2. 2002-06-25. PMID:11911864. |
anatomical evidence indicates the presence of projections from the lateral hypothalamus to serotonergic (5-hydroxytryptamine, 5-ht) neurons of the dorsal raphe nucleus (dr). |
2002-06-25 |
2023-08-12 |
Not clear |
| Roberto Arcioni, Marco della Rocca, Sarah Romanò, Rocco Romano, Paolo Pietropaoli, Alessandro Gasparett. Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT(3) spinal receptor involvement in acute pain in humans. Anesthesia and analgesia. vol 94. issue 6. 2002-06-19. PMID:12032025. |
to investigate a possible antinociceptive role of serotonin receptor subtype 3 (5-ht(3)), we evaluated the effects of a coadministration of ondansetron, a 5-ht(3) selective antagonist, and tramadol, a central analgesic dependent on enhanced serotonergic transmission. |
2002-06-19 |
2023-08-12 |
Not clear |
| Mariko Yamano, Hiroo Ogura, Shigeru Okuyama, Hiroko Ohki-Hamazak. Modulation of 5-HT system in mice with a targeted disruption of neuromedin B receptor. Journal of neuroscience research. vol 68. issue 1. 2002-06-18. PMID:11933049. |
to assess the role of neuromedin b receptor (nmb-r) on the modulation of serotonergic (5-ht) system, the function of the 5-ht system was examined in mice lacking the nmb-r gene. |
2002-06-18 |
2023-08-12 |
mouse |
| Philippe Manivet, Benoit Schneider, Jeremy Christopher Smith, Doo-Sup Choi, Luc Maroteaux, Odile Kellermann, Jean-Marie Launa. The serotonin binding site of human and murine 5-HT2B receptors: molecular modeling and site-directed mutagenesis. The Journal of biological chemistry. vol 277. issue 19. 2002-06-13. PMID:11859080. |
taken together, the computed models and the site-directed mutagenesis experiments give a structural explanation to (i) the different 5-ht pk(d) values measured with the human and mouse 5-ht(2b)rs (7.9 and 5.8, respectively) and (ii) the specificity of 5-ht binding to 5-ht(2b)rs as compared with other serotonergic g-protein coupled receptors. |
2002-06-13 |
2023-08-12 |
mouse |
| C Roberts, J Watson, G W Price, D N Middlemis. SB-236057-A: a selective 5-HT1B receptor inverse agonist. CNS drug reviews. vol 7. issue 4. 2002-06-10. PMID:11830759. |
5-ht1b autoreceptors are involved in the control of extracellular 5-ht levels from both the terminal and cell body regions of serotonergic neurons. |
2002-06-10 |
2023-08-12 |
human |
| Ulf Berggren, Matts Eriksson, Claudia Fahlke, Jan Balldi. Is long-term heavy alcohol consumption toxic for brain serotonergic neurons? Relationship between years of excessive alcohol consumption and serotonergic neurotransmission. Drug and alcohol dependence. vol 65. issue 2. 2002-06-07. PMID:11772477. |
it is therefore suggested that long duration of excessive alcohol consumption in alcohol-dependent subjects causes a reduction in central serotonergic neurotransmission, possibly by a toxic effect of alcohol on serotonin neurons. |
2002-06-07 |
2023-08-12 |
human |
| Bruce McEwe. Estrogen actions throughout the brain. Recent progress in hormone research. vol 57. 2002-06-04. PMID:12017552. |
first, regulation of the serotonergic system appears to be linked to the presence of estrogen- and progestin-sensitive neurons in the midbrain raphe as well as possibly nongenomic actions in brain areas to which serotonin neurons project their axons. |
2002-06-04 |
2023-08-12 |
rat |