| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Edelman, D R Gandara, F J Meyers, R Ishii, M O'Mahony, M Uhrich, I Lauder, J Houston, D W Gietze. Serotonergic blockade in the treatment of the cancer anorexia-cachexia syndrome. Cancer. vol 86. issue 4. 1999-09-03. PMID:10440697. |
blockade of type 3 serotonergic receptors (5ht(3)) can ameliorate anorexia in this animal model. |
1999-09-03 |
2023-08-12 |
human |
| A Velayudhan, T A Sunitha, S Balachander, J Y Reddy, S Khann. A study of platelet serotonin receptor in mania. Biological psychiatry. vol 45. issue 8. 1999-09-02. PMID:10386192. |
serotonergic (5-ht) dysfunction has been hypothesized in mania; however platelet studies on the 5-ht uptake rate and the 5-ht transporter have revealed inconsistent results. |
1999-09-02 |
2023-08-12 |
Not clear |
| S Dryden, M Brown, P King, G William. Decreased plasma leptin levels in lean and obese Zucker rats after treatment with the serotonin reuptake inhibitor fluoxetine. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 31. issue 6. 1999-09-02. PMID:10437624. |
we therefore investigated the effects of the serotonergic drug fluoxetine, which inhibits serotonin reuptake, on food intake and plasma leptin levels in lean and obese zucker rats. |
1999-09-02 |
2023-08-12 |
rat |
| D A Clemett, D A Kendall, M I Cockett, C A Marsden, K C Fon. Pindolol-insensitive [3H]-5-hydroxytryptamine binding in the rat hypothalamus; identity with 5-hydroxytryptamine7 receptors. British journal of pharmacology. vol 127. issue 1. 1999-09-01. PMID:10369478. |
intracerebroventricular pretreatment with the serotonergic neurotoxin 5,7-dihydroxytryptamine, 5,7-dht, elevated the [3h]-5-ht bmax 2 fold, indicating that the hypothalamic 5-ht7 receptor is post-synaptic to 5-ht nerve terminals and regulated by synaptic 5-ht levels. |
1999-09-01 |
2023-08-12 |
rat |
| I A Ferguson, C D Hardman, L R Marotte, A Salardini, P Halasz, D Vu, P M Wait. Serotonergic neurons in the brainstem of the wallaby, Macropus eugenii. The Journal of comparative neurology. vol 411. issue 4. 1999-08-31. PMID:10421866. |
the organisation and cytoarchitecture of the serotonergic neurons in a diprotodont marsupial were examined by using serial sections of the brainstem processed for serotonin immunohistochemistry and routine histology. |
1999-08-31 |
2023-08-12 |
rabbit |
| P J Schwartz, E H Turner, D Garcia-Borreguero, J Sedway, R G Vetticad, T A Wehr, D L Murphy, N E Rosentha. Serotonin hypothesis of winter depression: behavioral and neuroendocrine effects of the 5-HT(1A) receptor partial agonist ipsapirone in patients with seasonal affective disorder and healthy control subjects. Psychiatry research. vol 86. issue 1. 1999-08-30. PMID:10359479. |
winter depressions in seasonal affective disorder (sad) are associated with central serotonergic (5-ht) dysfunction. |
1999-08-30 |
2023-08-12 |
human |
| J M Gorma. Mirtazapine: clinical overview. The Journal of clinical psychiatry. vol 60 Suppl 17. 1999-08-17. PMID:10446735. |
there is currently available evidence that suggests that drugs combining 2 synergistic mechanisms of action (e.g., enhancement of both noradrenergic and serotonergic neurotransmission) may yield superior therapeutic efficacy compared with a single therapeutic mechanism of highly selective agents such as selective serotonin reuptake inhibitors (ssris). |
1999-08-17 |
2023-08-12 |
Not clear |
| L G Chia, D R Ni, F C Cheng, Y P Ho, J S Ku. Intrastriatal injection of 5,7-dihydroxytryptamine decreased 5-HT levels in the striatum and suppressed locomotor activity in C57BL/6 mice. Neurochemical research. vol 24. issue 6. 1999-08-12. PMID:10447454. |
however, injection of the serotonergic neurotoxin 5,7-dht in the striatum, either alone or following high doses of mptp, significantly decreased locomotor activity, and concomitantly decreased striatal levels of 5-ht and 5-hiaa. |
1999-08-12 |
2023-08-12 |
mouse |
| M D Gersho. Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel. Alimentary pharmacology & therapeutics. vol 13 Suppl 2. 1999-08-10. PMID:10429737. |
mucosal 5-ht is inactivated by uptake into epithelial cells mediated by the same 5-ht transporter utilized by serotonergic neurons. |
1999-08-10 |
2023-08-12 |
Not clear |
| A C Swann, B A Johnson, C R Cloninger, Y R Che. Relationships of plasma tryptophan availability to course of illness and clinical features of alcoholism: a preliminary study. Psychopharmacology. vol 143. issue 4. 1999-08-05. PMID:10367555. |
serotonergic (5-ht) mechanisms may be involved in impulse control (including antisocial behavior) across psychiatric syndromes. |
1999-08-05 |
2023-08-12 |
Not clear |
| T L Sills, A J Greenshaw, G B Baker, P J Fletche. The potentiating effect of sertraline and fluoxetine on amphetamine-induced locomotor activity is not mediated by serotonin. Psychopharmacology. vol 143. issue 4. 1999-08-05. PMID:10367561. |
both sertraline (5 mg/kg) and fluoxetine (5 mg/kg) produced an augmentation of amphetamine-induced hyperactivity that was unaltered by a serotonergic lesion of the median and dorsal raphe nuclei that resulted in a greater than 90% depletion of serotonin in hippocampus, striatum, and nucleus accumbens. |
1999-08-05 |
2023-08-12 |
rat |
| P S Padayatti, C S Paulos. Alpha2 adrenergic and high affinity serotonergic receptor changes in the brain stem of streptozotocin-induced diabetic rats. Life sciences. vol 65. issue 4. 1999-08-05. PMID:10421426. |
this showed that in serotonergic nerves there is a disturbance in both synthetic and breakdown pathways which lead to an increased 5-ht. |
1999-08-05 |
2023-08-12 |
rat |
| Y B Shmukler, G A Buznikov, M J Whitake. Action of serotonin antagonists on cytoplasmic calcium levels in early embryos of sea urchin Lytechinus pictus. The International journal of developmental biology. vol 43. issue 2. 1999-08-02. PMID:10235395. |
some serotonin antagonists specifically increase free intracellular ca2+ and evoke transient regression of the first cleavage furrow, suggesting possible linkage of serotonergic and calcium mechanisms in the regulation of cellular events during cleavage divisions. |
1999-08-02 |
2023-08-12 |
Not clear |
| V Wegerer, G H Moll, M Bagli, A Rothenberger, E Rüther, G Huethe. Persistently increased density of serotonin transporters in the frontal cortex of rats treated with fluoxetine during early juvenile life. Journal of child and adolescent psychopharmacology. vol 9. issue 1. 1999-08-02. PMID:10357514. |
this experimental animal study was performed in order to assess possible long-term effects of the administration of the selective serotonin reuptake inhibitor fluoxetine (prozac) during early periods of juvenile life on the developing central serotonergic and noradrenergic systems. |
1999-08-02 |
2023-08-12 |
rat |
| V Wegerer, G H Moll, M Bagli, A Rothenberger, E Rüther, G Huethe. Persistently increased density of serotonin transporters in the frontal cortex of rats treated with fluoxetine during early juvenile life. Journal of child and adolescent psychopharmacology. vol 9. issue 1. 1999-08-02. PMID:10357514. |
this is the first empirical demonstration of long-lasting effects of the administration of a selective serotonin reuptake inhibitor during juvenile life on the maturation of the central serotonergic system. |
1999-08-02 |
2023-08-12 |
rat |
| C Pornnoppadol, D S Friesen, T S Haussler, P E Glaser, R D Tod. No difference between platelet serotonin--5-HT(2A) receptors from children with and without ADHD. Journal of child and adolescent psychopharmacology. vol 9. issue 1. 1999-08-02. PMID:10357515. |
to further investigate the possible function of the serotonergic system in the pathophysiology of attention deficit hyperactivity disorder (adhd), platelet serotonin 5-ht2a receptors were characterized for 19 adhd children and 17 age-matched control subjects. |
1999-08-02 |
2023-08-12 |
human |
| D Kim, V Adipudi, M Shibayama, S Giszter, A Tessler, M Murray, K J Simansk. Direct agonists for serotonin receptors enhance locomotor function in rats that received neural transplants after neonatal spinal transection. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 14. 1999-08-02. PMID:10407057. |
systemic administration of two directly acting agonists for serotonergic 5-ht(2) receptor subtypes, quipazine and (+/-)-1-[2, 5]-dimethoxy-4-iodophenyl-2-aminopropane), further increased weight-supported stepping in transplant rats. |
1999-08-02 |
2023-08-12 |
rat |
| D Kim, V Adipudi, M Shibayama, S Giszter, A Tessler, M Murray, K J Simansk. Direct agonists for serotonin receptors enhance locomotor function in rats that received neural transplants after neonatal spinal transection. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 14. 1999-08-02. PMID:10407057. |
in contrast, indirectly acting serotonergic agonists, which block reuptake of 5-ht (sertraline) or release 5-ht and block its reuptake (d-fenfluramine), failed to enhance motor function. |
1999-08-02 |
2023-08-12 |
rat |
| G P Moloney, G R Martin, N Mathews, A Milne, H Hobbs, S Dodsworth, P Y Sang, C Knight, M Williams, M Maxwell, R C Gle. Synthesis and serotonergic activity of substituted 2, N-benzylcarboxamido-5-(2-ethyl-1-dioxoimidazolidinyl)-N, N-dimethyltryptamine derivatives: novel antagonists for the vascular 5-HT(1B)-like receptor. Journal of medicinal chemistry. vol 42. issue 14. 1999-08-02. PMID:10411472. |
synthesis and serotonergic activity of substituted 2, n-benzylcarboxamido-5-(2-ethyl-1-dioxoimidazolidinyl)-n, n-dimethyltryptamine derivatives: novel antagonists for the vascular 5-ht(1b)-like receptor. |
1999-08-02 |
2023-08-12 |
dog |
| D Galter, M Böttner, K Krieglstein, E Schömig, K Unsicke. Differential regulation of distinct phenotypic features of serotonergic neurons by bone morphogenetic proteins. The European journal of neuroscience. vol 11. issue 7. 1999-07-30. PMID:10383634. |
to start to define roles for bmps in the regulation of serotonergic (5-ht) neuron development, we have generated serum-free cultures of 5-ht neurons isolated from the embryonic (e14) rat raphe. |
1999-07-30 |
2023-08-12 |
rat |