| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Linnér, C Wiker, L Arborelius, M Schalling, T H Svensso. Selective noradrenaline reuptake inhibition enhances serotonergic neuronal activity and transmitter release in the rat forebrain. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 2. 2004-05-19. PMID:14767716. |
hence, nris may cause a secondary enhancement of central serotonergic activity by a mechanism separate from 5-ht reuptake inhibition; an effect that may contribute to their clinical antidepressant efficacy. |
2004-05-19 |
2023-08-12 |
rat |
| Pierre A Guerti. Synergistic activation of the central pattern generator for locomotion by l-beta-3,4-dihydroxyphenylalanine and quipazine in adult paraplegic mice. Neuroscience letters. vol 358. issue 2. 2004-05-19. PMID:15026151. |
l-beta-3,4-dihydroxyphenylalanine (l-dopa) and quipazine, respectively dopamine/noradrenaline precursor and serotonergic (5-ht(2)) receptor agonist, were injected intraperitoneally in low-thoracic spinal mice at 7 days post-spinalization. |
2004-05-19 |
2023-08-12 |
mouse |
| Michael D Gersho. Plasticity in serotonin control mechanisms in the gut. Current opinion in pharmacology. vol 3. issue 6. 2004-05-13. PMID:14644011. |
in the central and enteric nervous systems, sert is located in serotonergic neurons; however, these neurons are not present in the gastrointestinal mucosa, where 5-ht initiates peristaltic and secretory reflexes. |
2004-05-13 |
2023-08-12 |
Not clear |
| G M Sparks, S Dasari, R L Coope. Actions of MDMA at glutamatergic neuromuscular junctions. Neuroscience research. vol 48. issue 4. 2004-05-12. PMID:15041196. |
3,4-methylenedioxymethamphetamine (mdma, "ecstasy") compels mammalian serotonergic neurons to release serotonin (5-ht). |
2004-05-12 |
2023-08-12 |
drosophila_melanogaster |
| O Fajardo, J Galeno, M Urbina, I Carreira, L Lim. Serotonin, serotonin 5-HT(1A) receptors and dopamine in blood peripheral lymphocytes of major depression patients. International immunopharmacology. vol 3. issue 9. 2004-05-10. PMID:12890432. |
thus, there is a serotonergic dysfunction in immune circulating cells of major depression patients, without changes in the number of 5-ht(1a) receptors, although the coupling of these receptors to transduction mechanisms could be affected and may be related to the alteration of 5-ht turnover rate. |
2004-05-10 |
2023-08-12 |
human |
| Jordi Serrats, Francesc Artigas, Guadalupe Mengod, Roser Corté. An autoradiographic study of the influence of pindolol upon [35S]GTPgammaS binding in rat, guinea pig and human brain. The international journal of neuropsychopharmacology. vol 7. issue 1. 2004-05-07. PMID:14720318. |
the accelerating effect of (+/-)pindolol is thought to derive from its blockade of the ssri-induced, 5-ht1a autoreceptor-mediated inhibition of serotonergic cell firing and 5-ht release. |
2004-05-07 |
2023-08-12 |
human |
| Justin E Aldridge, Frederic J Seidler, Theodore A Slotki. Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environmental health perspectives. vol 112. issue 2. 2004-05-06. PMID:14754568. |
developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. |
2004-05-06 |
2023-08-12 |
Not clear |
| Laguzzi Rau. Serotonin2 receptors in the nucleus tractus solitarius: characterization and role in the baroreceptor reflex arc. Cellular and molecular neurobiology. vol 23. issue 4-5. 2004-04-30. PMID:14514026. |
in this context, the present review focuses on serotonin, and the possible facilitatory influence of nts serotonergic afferents and receptors on the baroreceptor reflex arc. |
2004-04-30 |
2023-08-12 |
rat |
| Sarah E Craven, Kim-Chew Lim, Weilan Ye, James Douglas Engel, Frederic de Sauvage, Arnon Rosentha. Gata2 specifies serotonergic neurons downstream of sonic hedgehog. Development (Cambridge, England). vol 131. issue 5. 2004-04-28. PMID:14973276. |
distinct classes of serotonergic (5-ht) neurons develop along the ventral midline of the vertebrate hindbrain. |
2004-04-28 |
2023-08-12 |
Not clear |
| Michael J Owen. Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond. The Journal of clinical psychiatry. vol 65 Suppl 4. 2004-04-27. PMID:15046536. |
for the majority of antidepressants, these long-term changes in serotonergic and/or noradrenergic function result from direct antagonism of serotonin and/ or norepinephrine transporters (also termed "uptake sites"). |
2004-04-27 |
2023-08-12 |
Not clear |
| Analía Bortolozzi, Mercè Amargós-Bosch, Miklos Toth, Francesc Artigas, Albert Adel. In vivo efflux of serotonin in the dorsal raphe nucleus of 5-HT1A receptor knockout mice. Journal of neurochemistry. vol 88. issue 6. 2004-04-15. PMID:15009637. |
in the dorsal raphe nucleus (dr), extracellular serotonin (5-ht) regulates serotonergic transmission through 5-ht1a autoreceptors. |
2004-04-15 |
2023-08-12 |
mouse |
| Karl J Kaiyala, Evelyn S Vincow, Timothy J Sexton, John F Neumaie. 5-HT1B receptor mRNA levels in dorsal raphe nucleus: inverse association with anxiety behavior in the elevated plus maze. Pharmacology, biochemistry, and behavior. vol 75. issue 4. 2004-04-13. PMID:12957218. |
serotonergic neurons in the dorsal raphe nucleus, the major source of forebrain serotonin projections, synthesize a terminal autoreceptor that inhibits serotonin release-the 5-ht(1b) autoreceptor. |
2004-04-13 |
2023-08-12 |
rat |
| Ghanshyam N Pandey, Subhash C Pandey, Xinguo Ren, Yogesh Dwivedi, Philip G Janica. Serotonin receptors in platelets of bipolar and schizoaffective patients: effect of lithium treatment. Psychopharmacology. vol 170. issue 2. 2004-04-12. PMID:12845409. |
abnormalities of serotonin (5ht) function have been implicated in mood disorders, and lithium treatment may produce its beneficial effects by modifying serotonergic mechanisms. |
2004-04-12 |
2023-08-12 |
Not clear |
| Taizo Kita, George C Wagner, Toshikatsu Nakashim. Current research on methamphetamine-induced neurotoxicity: animal models of monoamine disruption. Journal of pharmacological sciences. vol 92. issue 3. 2004-04-08. PMID:12890883. |
methamphetamine (meth)-induced neurotoxicity is characterized by a long-lasting depletion of striatal dopamine (da) and serotonin as well as damage to striatal dopaminergic and serotonergic nerve terminals. |
2004-04-08 |
2023-08-12 |
mouse |
| Andria L Del Tredici, Hans H Schiffer, Ethan S Burstein, Jelveh Lameh, Nina Mohell, Uli Hacksell, Mark R Brann, David M Weine. Pharmacology of polymorphic variants of the human 5-HT1A receptor. Biochemical pharmacology. vol 67. issue 3. 2004-04-05. PMID:15037200. |
the 5-ht1a receptor is a critical mediator of serotonergic (5-ht) function. |
2004-04-05 |
2023-08-12 |
human |
| Jean-Pierre Hornun. The human raphe nuclei and the serotonergic system. Journal of chemical neuroanatomy. vol 26. issue 4. 2004-04-02. PMID:14729135. |
finally, recent experimental data support the role of serotonin in modulating brain development, such that a dysfunction in serotonergic transmission during early life could lead to long lasting structural and functional alterations. |
2004-04-02 |
2023-08-12 |
human |
| Georg Juckel, Jürgen Gallinat, Michael Riedel, Safet Sokullu, Carl Schulz, Hans-Jürgen Möller, Norbert Müller, Ulrich Heger. Serotonergic dysfunction in schizophrenia assessed by the loudness dependence measure of primary auditory cortex evoked activity. Schizophrenia research. vol 64. issue 2-3. 2004-04-01. PMID:14613676. |
after treatment with the 5-ht(2) antagonists, the ldaep (of the right hemisphere) tended to be increased, indicating normalization of serotonergic function in the patients with schizophrenia. |
2004-04-01 |
2023-08-12 |
human |
| M Strittmatter, M Grauer, E Isenberg, G Hamann, C Fischer, K H Hoffmann, F Blaes, K Schimrig. [Substance P, somatostatin and monoaminergic transmitters in the cerebrospinal fluid of patients with chronic idiopathic trigeminal neuralgia]. Schmerz (Berlin, Germany). vol 10. issue 5. 2004-03-24. PMID:12799848. |
as a marker for the serotonergic system, we measured csf levels of serotonin metabolite 5-hydroxyindoleacetic acid (5-hiaa). |
2004-03-24 |
2023-08-12 |
Not clear |
| Monika Z Wrona, Xiang-Rong Jiang, Yashige Kotake, Glenn Dryhurs. Stability of the putative neurotoxin tryptamine-4,5-dione. Chemical research in toxicology. vol 16. issue 4. 2004-03-23. PMID:12703966. |
tryptamine-4,5-dione (1) is formed by oxidation of the neurotransmitter 5-hydroxytryptamine by reactive oxygen and reactive nitrogen species, and on the basis of in vitro and in vivo studies, it has been proposed to be a neurotoxin that may contribute to the selective neurodegeneration in alzheimer's disease and the serotonergic neurotoxicity of methamphetamine. |
2004-03-23 |
2023-08-12 |
Not clear |
| J E Belforte, J H Paz. Turning behaviour induced by stimulation of the 5-HT receptors in the subthalamic nucleus. The European journal of neuroscience. vol 19. issue 2. 2004-03-18. PMID:14725629. |
to address the role of subthalamic serotonergic innervation in its motor function, turning behaviour was studied in rats with stimulation of the subthalamic serotonin (5-ht) receptors by intracerebral microinjections. |
2004-03-18 |
2023-08-12 |
rat |