| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weidong Yang, Qingde Wang, Stephen J Kanes, John M Murray, Kazuko Nishikur. Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine therapy. Brain research. Molecular brain research. vol 124. issue 1. 2004-06-28. PMID:15093687. |
it has been speculated that rna editing may play a role in several pharmacological and behavioral processes where the serotonergic plasticity is mediated through 5-ht(2c)r. interferon-alpha (ifn-alpha) often causes severe depression in patients treated for chronic viral hepatitis and certain malignancies. |
2004-06-28 |
2023-08-12 |
human |
| María A Sosa, Nadja Spitzer, Donald H Edwards, Deborah J Bar. A crustacean serotonin receptor: cloning and distribution in the thoracic ganglia of crayfish and freshwater prawn. The Journal of comparative neurology. vol 473. issue 4. 2004-06-24. PMID:15116388. |
we found examples of colocalization of 5-ht(1crust) with 5-ht, consistent with the short-term modulatory role of 5-ht, as well as cases of serotonergic staining in the absence of a 5-ht(1crust) signal, which might imply that other 5-ht receptors are found at these locations. |
2004-06-24 |
2023-08-12 |
lobster |
| Shenyuan Zhang, Irina Sokolchik, Gabriela Blanco, Ji Ying Sz. Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons. Development (Cambridge, England). vol 131. issue 7. 2004-06-22. PMID:14998926. |
mutations in the trpv genes osm-9 or ocr-2 dramatically downregulate the expression of the gene encoding the 5ht synthesis enzyme tryptophan hydroxylase (tph-1) in the serotonergic chemosensory neurons adf, but neither the mutation nor the double mutation of both channel genes affects other types of serotonergic neurons. |
2004-06-22 |
2023-08-12 |
caenorhabditis_elegans |
| Barry D Waterhouse, David Devilbiss, Scott Seiple, Ronald Markowit. Sensorimotor-related discharge of simultaneously recorded, single neurons in the dorsal raphe nucleus of the awake, unrestrained rat. Brain research. vol 1000. issue 1-2. 2004-06-22. PMID:15053966. |
as a group, presumed serotonergic neurons exhibited low tonic discharge rates, depressed firing after serotonin (5ht)-1a agonist administration, and, except for the transition from sleep to waking, a general insensitivity to specific sensory or motor events. |
2004-06-22 |
2023-08-12 |
rat |
| Kanji Yoshimoto, Setsuo Komura, Hiroyuki Hattori, Yukio Yamori, Ayako Miura, Toshihide Yoshida, Chizuko Hioki, Baku Kato, Fuimihiko Fukuda, Shiho Tanaka, Ayako Hirai, Akira Nishimura, Yasuko Sawai, Masahiro Yasuhar. Pharmacological studies of alcohol susceptibility and brain monoamine function in stroke-prone spontaneously hypertensive rats (SHRSP) and stroke-resistant spontaneously hypertensive rats (SHRSR). The Tohoku journal of experimental medicine. vol 201. issue 1. 2004-06-21. PMID:14609256. |
increased basal extracellular 5-ht releases showing low levels of 5-ht in the c/p of shrsp mean an abnormality of serotonergic neuronal functions in a normal physiological condition. |
2004-06-21 |
2023-08-12 |
rat |
| Stephen B Manuck, Janine D Flory, Robert E Ferrell, Matthew F Muldoo. Socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic region. Psychoneuroendocrinology. vol 29. issue 5. 2004-06-18. PMID:15041087. |
socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic region. |
2004-06-18 |
2023-08-12 |
human |
| Stephen B Manuck, Janine D Flory, Robert E Ferrell, Matthew F Muldoo. Socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic region. Psychoneuroendocrinology. vol 29. issue 5. 2004-06-18. PMID:15041087. |
it was reported recently that exposure to an adverse rearing environment lowers central nervous system (cns) serotonergic activity in a nonhuman primate (rhesus monkeys), but only among animals having the shorter variant of a functional, biallelic repeat polymorphism in the regulatory region of the serotonin transporter (5-htt) gene. |
2004-06-18 |
2023-08-12 |
human |
| Stephen B Manuck, Janine D Flory, Robert E Ferrell, Matthew F Muldoo. Socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic region. Psychoneuroendocrinology. vol 29. issue 5. 2004-06-18. PMID:15041087. |
the 5-httlpr was genotyped in 139 adult men and women (n = 75 and 64) who were administered a standard neuroendocrine challenge to assess central serotonergic responsivity (plasma prolactin (prl) response to the serotonin releasing agent, fenfluramine). |
2004-06-18 |
2023-08-12 |
human |
| David J Brunswick, David B P Goodman, John P O'Reardon, Mohit Chopra, Jay D Amsterda. Pindolol does not augment cortisol and prolactin responses to paroxetine in healthy subjects. Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 3. 2004-06-17. PMID:15093954. |
since the release of cortisol and prolactin is under serotonergic control, we hypothesized that pindolol augmentation of synaptic 5-ht concentrations produced by an ssri in humans should lead to enhanced ssri-induced cortisol and prolactin responses. |
2004-06-17 |
2023-08-12 |
human |
| Albert Adel. Antidepressant properties of substance P antagonists: relationship to monoaminergic mechanisms? Current drug targets. CNS and neurological disorders. vol 3. issue 2. 2004-06-10. PMID:15078186. |
this effect on serotonergic cells is seen consistently only after long-term treatment and has been associated with a functional desensitisation of somatodendritic 5-ht(1a) autoreceptors. |
2004-06-10 |
2023-08-12 |
mouse |
| Maria Graziella De Montis, Silvia Grappi, Carla Gambarana, Benedetta Leggio, Giulio Nanni, Simona Scheggi, Alessandro Tagliamont. Sardinian alcohol-preferring rats show low 5-HT extraneuronal levels in the mPFC and no habituation in monoaminergic response to repeated ethanol consumption in the NAcS. Brain research. vol 1006. issue 1. 2004-06-07. PMID:15047020. |
in the mpfc, wistar and snp rats showed similar serotonin increases after two vanilla sugar meals, while sp rats, which had low serotonin basal levels, did not show a serotonergic response. |
2004-06-07 |
2023-08-12 |
rat |
| S Aznar, Z-X Qian, G M Knudse. Non-serotonergic dorsal and median raphe projection onto parvalbumin- and calbindin-containing neurons in hippocampus and septum. Neuroscience. vol 124. issue 3. 2004-06-03. PMID:14980728. |
parallel immunohistochemistry studies showing serotonin fibers contacting calbindin- and parvalbumin-positive neurons have led to the assumption that raphe fibers projecting on these types of neurons are mainly serotonergic. |
2004-06-03 |
2023-08-12 |
Not clear |
| Gregory H Grossman, Laure Farnbauch, J David Glas. Regulation of serotonin release in the Syrian hamster intergeniculate leaflet region. Neuroreport. vol 15. issue 1. 2004-05-27. PMID:15106840. |
in addition, electrical stimulation of the dorsal raphe nucleus acutely increases serotonin release the igl region, confirming a functional serotonergic projection from this nucleus to the igl. |
2004-05-27 |
2023-08-12 |
Not clear |
| H F Clarke, J W Dalley, H S Crofts, T W Robbins, A C Robert. Cognitive inflexibility after prefrontal serotonin depletion. Science (New York, N.Y.). vol 304. issue 5672. 2004-05-27. PMID:15131308. |
serotonergic dysregulation within the prefrontal cortex (pfc) is implicated in many neuropsychiatric disorders, but the precise role of serotonin within the pfc is poorly understood. |
2004-05-27 |
2023-08-12 |
marmoset |
| Boris B Quednow, Kai-Uwe Kühn, Klaus Hoenig, Wolfgang Maier, Michael Wagne. Prepulse inhibition and habituation of acoustic startle response in male MDMA ('ecstasy') users, cannabis users, and healthy controls. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 5. 2004-05-25. PMID:14970829. |
despite the broad database concerning the selective serotonergic neurotoxicity of recreational mdma consumption by humans, controversy still exists with respect to the question of whether the well-known functional consequences of these neurotoxic effects, such as memory impairment, were caused by chronic 5-ht deficiency. |
2004-05-25 |
2023-08-12 |
human |
| Sylvie Chalon, Cécile Bronquard, Johnny Vercouillie, Ercem Kodas, Lucette Garreau, Sylvie Bodard, Patrick Emond, Jean-Claude Besnard, Denis Guillotea. ADAM is an effective tool for in vivo study of serotonergic function: validation in rat models. Synapse (New York, N.Y.). vol 52. issue 2. 2004-05-21. PMID:15034919. |
we evaluated its potential to detect abnormalities in serotonergic function in the rat using 1) a model of serotonergic neuron lesion induced with 5,7-dihydroxytryptamine (5,7-dht), and 2) experimental induction of acute decrease in endogenous brain serotonin levels. |
2004-05-21 |
2023-08-12 |
human |
| Sylvie Chalon, Cécile Bronquard, Johnny Vercouillie, Ercem Kodas, Lucette Garreau, Sylvie Bodard, Patrick Emond, Jean-Claude Besnard, Denis Guillotea. ADAM is an effective tool for in vivo study of serotonergic function: validation in rat models. Synapse (New York, N.Y.). vol 52. issue 2. 2004-05-21. PMID:15034919. |
the present findings thus demonstrate that adam is a specific sert radioligand which can be used for in vivo study of central serotonin systems, and supports its use as a tracer for spect studies in human disorders involving dysfunction of serotonergic neurotransmission. |
2004-05-21 |
2023-08-12 |
human |
| Heidi A N Perreault, Katharine Semsar, John Godwi. Fluoxetine treatment decreases territorial aggression in a coral reef fish. Physiology & behavior. vol 79. issue 4-5. 2004-05-19. PMID:12954414. |
we used fluoxetine, a selective serotonin reuptake inhibitor, to experimentally enhance serotonergic neurotransmission in a territorial coral reef fish and test the role of this neurotransmitter in mediating aggressive behavior and dominance interactions. |
2004-05-19 |
2023-08-12 |
Not clear |
| A E Massey, V R Marsh, R H McAllister-William. Lack of effect of tryptophan depletion on the loudness dependency of auditory event related potentials in healthy volunteers. Biological psychology. vol 65. issue 2. 2004-05-19. PMID:14706436. |
it has previously been suggested that auditory event related potentials (aeps) are a potential marker of central serotonergic (5-ht) activity in man, with the slope of the aep amplitude stimulus intensity function (asf-slope) inversely correlating with 5-ht activity. |
2004-05-19 |
2023-08-12 |
human |
| L Linnér, C Wiker, L Arborelius, M Schalling, T H Svensso. Selective noradrenaline reuptake inhibition enhances serotonergic neuronal activity and transmitter release in the rat forebrain. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 2. 2004-05-19. PMID:14767716. |
however, experimental studies have shown that noradrenaline may regulate serotonergic neurotransmission both at the serotonin cell body and nerve-terminal level. |
2004-05-19 |
2023-08-12 |
rat |