| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Norio Saka. [Functional regulation of serotonin transporter, a molecule involved in the pathogenesis of anxiety disorder]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 3. 2004-08-16. PMID:15291238. |
the serotonin transporter (set) is a member of the na+/cl(-)-dependent neurotransmitter transporter family and functions as a membrane protein which terminates the serotonergic neuronal transmission by re-uptaking serotonin into the pre-synaptic terminal. |
2004-08-16 |
2023-08-12 |
Not clear |
| Ugur Salli, Arubala P Reddy, Nurgul Salli, Nick Z Lu, Hung-Chih Kuo, Francis K-Y Pau, Don P Wolf, Cynthia L Bethe. Serotonin neurons derived from rhesus monkey embryonic stem cells: similarities to CNS serotonin neurons. Experimental neurology. vol 188. issue 2. 2004-08-10. PMID:15246835. |
in summary, a remarkably high percentage of cells derived from monkey es cells exhibited neuronal plus serotonergic markers as well as nuclear steroid receptors similar to primate cns serotonin neurons, suggesting that these cells may serve as a useful primate model for serotonergic neurons. |
2004-08-10 |
2023-08-12 |
human |
| Michael Levi. A novel immunohistochemical method for evaluation of antibody specificity and detection of labile targets in biological tissue. Journal of biochemical and biophysical methods. vol 58. issue 1. 2004-08-05. PMID:14597192. |
using our method, we identify antibodies that are specific for serotonin and show that some commercial 5ht antibodies often used to identify serotonergic cells in published papers are not 5ht-specific. |
2004-08-05 |
2023-08-12 |
Not clear |
| G Juckel, P Mavrogiorgou, S Bredemeier, J Gallinat, T Frodl, C Schulz, H-J Möller, U Heger. Loudness dependence of primary auditory-cortex-evoked activity as predictor of therapeutic outcome to prophylactic lithium treatment in affective disorders--a retrospective study. Pharmacopsychiatry. vol 37. issue 2. 2004-08-02. PMID:15048610. |
since lithium acts as a serotonin agonist in prophylactic treatment, a predictor of being able to identify patients with low serotonergic activity, who may be responders to lithium, is promising. |
2004-08-02 |
2023-08-12 |
Not clear |
| Catharine A Winstanley, Jeffrey W Dalley, David E H Theobald, Trevor W Robbin. Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 7. 2004-08-02. PMID:15054475. |
rats received intracerebroventricular (icv) infusions of vehicle (n=10) or the serotonergic neurotoxin 5,7-dihydroxytryptamine (n=12) which depleted forebrain 5-ht levels by about 90%. |
2004-08-02 |
2023-08-12 |
rat |
| Atsunobu Murata, Osamu Nakagawasai, Fumihiro Yamadera, Akira Oba, Kenji Wakui, Yuichiro Arai, Takeshi Tadan. [Dysfunction of serotonergic systems in thiamine-deficient diet fed mice: effects of SSRI on abnormality induced by thiamine deficiency]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 2. 2004-07-30. PMID:15164618. |
with those results of ours, the possible mechanisms between the abnormal behaviors derived from the dysfunction of serotonergic neurons and the role of serotonin in td and wks are reviewed here. |
2004-07-30 |
2023-08-12 |
mouse |
| Matthew J Will, Andre Der-Avakian, Sondra T Bland, Ruth E Grahn, Sayamwong E Hammack, Peter D Sparks, Julie L Pepin, Linda R Watkins, Steven F Maie. Electrolytic lesions and pharmacological inhibition of the dorsal raphe nucleus prevent stressor potentiation of morphine conditioned place preference in rats. Psychopharmacology. vol 171. issue 2. 2004-07-27. PMID:13680080. |
many other behavioral outcomes of stressors that depend on the uncontrollability of the stressor are mediated by alterations in serotonergic (5-ht) neurons within the dorsal raphe nucleus (drn). |
2004-07-27 |
2023-08-12 |
rat |
| Klaus Peter Lesch, Yong Zeng, Andreas Reif, Lise Gutknech. Anxiety-related traits in mice with modified genes of the serotonergic pathway. European journal of pharmacology. vol 480. issue 1-3. 2004-07-22. PMID:14623362. |
in this review, we discuss the pertinent literature regarding phenotypic changes in mice bearing inactivation mutations of 5-ht receptors, 5-ht transporter, monoamine oxidase a and other components of the serotonergic pathway. |
2004-07-22 |
2023-08-12 |
mouse |
| Alexandre Pattyn, Nicolas Simplicio, J Hikke van Doorninck, Christo Goridis, François Guillemot, Jean-François Brune. Ascl1/Mash1 is required for the development of central serotonergic neurons. Nature neuroscience. vol 7. issue 6. 2004-07-20. PMID:15133515. |
the transcriptional control of the differentiation of central serotonergic (5-ht) neurons in vertebrates has recently come under scrutiny and has been shown to involve the homeobox genes nkx2-2 and lmx1b, the ets-domain gene pet1 (also known as fev) and the zinc-finger gene gata3. |
2004-07-20 |
2023-08-12 |
mouse |
| Alexandre Pattyn, Nicolas Simplicio, J Hikke van Doorninck, Christo Goridis, François Guillemot, Jean-François Brune. Ascl1/Mash1 is required for the development of central serotonergic neurons. Nature neuroscience. vol 7. issue 6. 2004-07-20. PMID:15133515. |
here we show in the mouse that ascl1 is essential for the birth of 5-ht neurons, both as a proneural gene for the production of postmitotic neuronal precursors and as a determinant of the serotonergic phenotype for the parallel activation of gata3, lmx1b and pet1. |
2004-07-20 |
2023-08-12 |
mouse |
| Yvonne M van Hierden, Sietse F de Boer, Jaap M Koolhaas, S Mechiel Kort. The control of feather pecking by serotonin. Behavioral neuroscience. vol 118. issue 3. 2004-07-19. PMID:15174935. |
scientific knowledge on the causation of such disorders strongly suggests involvement of the serotonergic (5-hydroxytryptamine; 5-ht) system in feather pecking. |
2004-07-19 |
2023-08-12 |
human |
| Christina P Lynn-Bullock, Kristy Welshhans, Sarah L Pallas, Paul S Kat. The effect of oral 5-HTP administration on 5-HTP and 5-HT immunoreactivity in monoaminergic brain regions of rats. Journal of chemical neuroanatomy. vol 27. issue 2. 2004-07-16. PMID:15121217. |
these results suggest that a single oral dose of 5-htp increases the 5-htp and serotonin content of serotonergic neurons and causes the transient ectopic appearance of serotonin in some normally non-serotonergic neurons. |
2004-07-16 |
2023-08-12 |
rat |
| B Eisensamer, G Rammes, G Gimpl, M Shapa, U Ferrari, G Hapfelmeier, B Bondy, C Parsons, K Gilling, W Zieglgänsberger, F Holsboer, R Rupprech. Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor. Molecular psychiatry. vol 8. issue 12. 2004-07-13. PMID:14647397. |
the tricyclic antidepressants desipramine, imipramine, and trimipramine, the serotonin reuptake inhibitor fluoxetine, the norepinephrine reuptake inhibitor reboxetine, and the noradrenergic and specific serotonergic antidepressant mirtazapine effectively reduced the serotonin-induced na(+)- and ca(2)(+)-currents in a dose-dependent fashion. |
2004-07-13 |
2023-08-12 |
human |
| Zijing Sheng, June Kawano, Akie Yanai, Ryutaro Fujinaga, Mayumi Tanaka, Yoshifumi Watanabe, Koh Shinod. Expression of estrogen receptors (alpha, beta) and androgen receptor in serotonin neurons of the rat and mouse dorsal raphe nuclei; sex and species differences. Neuroscience research. vol 49. issue 2. 2004-07-12. PMID:15140561. |
sex steroids have been inferred to be involved in the regulation of affective status at least partly through the serotonergic (5-ht) system, particularly in the dorsal raphe nucleus (drn), which innervates enormous projections to the cerebral cortex and limbic system. |
2004-07-12 |
2023-08-12 |
mouse |
| Zijing Sheng, June Kawano, Akie Yanai, Ryutaro Fujinaga, Mayumi Tanaka, Yoshifumi Watanabe, Koh Shinod. Expression of estrogen receptors (alpha, beta) and androgen receptor in serotonin neurons of the rat and mouse dorsal raphe nuclei; sex and species differences. Neuroscience research. vol 49. issue 2. 2004-07-12. PMID:15140561. |
the current results strongly suggest that sex steroids can modulate the affective regulation of the serotonergic system through eralpha and/or erbeta in 5-ht neurons of the mouse rostral drn (but not so much through ar), and that such effects might be different depending on the sex and species, as shown by the prominent sex differences in ar expression and prominent species differences in eralpha and erbeta expression. |
2004-07-12 |
2023-08-12 |
mouse |
| M Angeles Vicente-Torres, David Dávila, M Visitación Bartolomé, Francisco Carricondo, Pablo Gil-Loyzag. Biochemical evidence for the presence of serotonin transporters in the rat cochlea. Hearing research. vol 182. issue 1-2. 2004-07-08. PMID:12948600. |
previous detection of serotonin (5-ht) metabolites and 5-ht receptor mrnas suggests the existence of serotonergic synaptic activity in the cochlea. |
2004-07-08 |
2023-08-12 |
rat |
| M Angeles Vicente-Torres, David Dávila, M Visitación Bartolomé, Francisco Carricondo, Pablo Gil-Loyzag. Biochemical evidence for the presence of serotonin transporters in the rat cochlea. Hearing research. vol 182. issue 1-2. 2004-07-08. PMID:12948600. |
these findings could indicate that 6-nq induced the blockade of the 5-ht selective reuptake to the cochlear serotonergic fibers. |
2004-07-08 |
2023-08-12 |
rat |
| M Angeles Vicente-Torres, David Dávila, M Visitación Bartolomé, Francisco Carricondo, Pablo Gil-Loyzag. Biochemical evidence for the presence of serotonin transporters in the rat cochlea. Hearing research. vol 182. issue 1-2. 2004-07-08. PMID:12948600. |
this suggests that plasma membrane 5-ht transporters are present in cochlear serotonergic fibers. |
2004-07-08 |
2023-08-12 |
rat |
| Undine E Lang, Malek Bajbouj, Catrin Wernicke, Hans Rommelspacher, Heidi Danker-Hopfe, Jürgen Gallina. No association of a functional polymorphism in the serotonin transporter gene promoter and anxiety-related personality traits. Neuropsychobiology. vol 49. issue 4. 2004-07-06. PMID:15118354. |
serotonergic neurotransmission, which is involved in many psychiatric disorders, is mediated by the serotonin transporter protein. |
2004-07-06 |
2023-08-12 |
human |
| David E Nichol. Hallucinogens. Pharmacology & therapeutics. vol 101. issue 2. 2004-06-28. PMID:14761703. |
in the 1950s, after the virtually contemporaneous discovery of both serotonin (5-ht) and lysergic acid diethylamide (lsd-25), early brain research focused intensely on the possibility that lsd or other hallucinogens had a serotonergic basis of action and reinforced the idea that 5-ht was an important neurotransmitter in brain. |
2004-06-28 |
2023-08-12 |
Not clear |