| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oliver Pogarell, Klaus Tatsch, Georg Juckel, Christine Hamann, Christoph Mulert, Gabriele Pöpperl, Malte Folkerts, Martina Choukèr, Michael Riedel, Michael Zaudig, Hans-Jürgen Möller, Ulrich Heger. Serotonin and dopamine transporter availabilities correlate with the loudness dependence of auditory evoked potentials in patients with obsessive-compulsive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15292904. |
the loudness dependence (ld) of the n1/p2 component of auditory evoked potentials has been proposed as a noninvasive indicator of central serotonergic function, whereas single photon emission computed tomography (spect) and [123i]beta-cit can be used to visualize both serotonin (sert) and dopamine transporters (dat). |
2004-11-22 |
2023-08-12 |
human |
| J R Homberg, B Arends, G Wardeh, H S Raasø, A N M Schoffelmeer, T J de Vrie. Individual differences in the effects of serotonergic anxiolytic drugs on the motivation to self-administer cocaine. Neuroscience. vol 128. issue 1. 2004-11-16. PMID:15450359. |
in support of the differential effects of the serotonergic drugs on pr responding in hg and lg rats, we found that the in vitro electrically evoked release of [3h]serotonin from mesocorticolimbic brain slices was reduced in the medial prefrontal cortex, substantia nigra and nucleus accumbens core, and increased in the nucleus accumbens shell of hg rats relative to lg rats. |
2004-11-16 |
2023-08-12 |
rat |
| Ingeborg Goethals, Myriam Vervaet, Kurt Audenaert, Christophe Van de Wiele, Hamphrey Ham, Marleen Vandecapelle, Guido Slegers, Rudi Dierckx, Cees van Heeringe. Comparison of cortical 5-HT2A receptor binding in bulimia nervosa patients and healthy volunteers. The American journal of psychiatry. vol 161. issue 10. 2004-11-16. PMID:15465993. |
bulimia nervosa has been associated with alterations in central serotonergic (5-ht) function. |
2004-11-16 |
2023-08-12 |
human |
| Eugene E Nattie, Aihua Li, George B Richerson, George Richerson, Douglas A Lapp. Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo. The Journal of physiology. vol 556. issue Pt 1. 2004-11-09. PMID:14724193. |
we injected (2 x 100 nl) (a) substance p-saporin (sp-sap; 1 microm) to kill nk1r-expressing neurones, (b) a novel conjugate of a monoclonal antibody to the serotonin transporter (sert) and saporin (anti-sert-sap; 1 microm) to kill serotonergic neurones, or (c) sp-sap and anti-sert-sap together to kill both types. |
2004-11-09 |
2023-08-12 |
Not clear |
| Julien Mendlewicz, Isabelle Massat, Daniel Souery, Jurgen Del-Favero, Lilijana Oruc, Markus M Nöthen, Douglas Blackwood, Walter Muir, Sharon Battersby, Beny Lerer, Ronen H Segman, Radka Kaneva, Alessandro Serretti, Roberta Lilli, Christian Lorenzi, Miro Jakovljevic, Sladana Ivezic, Marcella Rietschel, Vihra Milanova, Christine Van Broeckhove. Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study. European journal of human genetics : EJHG. vol 12. issue 5. 2004-11-02. PMID:14735161. |
the available data from preclinical and pharmacological studies on the role of the serotonin transporter (5-htt) support the hypothesis that a dysfunction in brain serotonergic system activity contributes to the vulnerability to affective disorders (ad). |
2004-11-02 |
2023-08-12 |
Not clear |
| Haiping Lu, Mayumi Nishi, Ken-Ichi Matsuda, Mitsuhiro Kawat. Estrogen reduces the neurite growth of serotonergic cells expressing estrogen receptors. Neuroscience research. vol 50. issue 1. 2004-11-01. PMID:15288495. |
the serotonin level in the hypothalamus was modulated by estrogen, and the formation of sexual dimorphism of serotonergic fiber innervation in the hypothalamus has been shown by the effect of sexual hormone during the critical perinatal period. |
2004-11-01 |
2023-08-12 |
rat |
| Isaac Schweitzer, Philip Morris, Malcolm Hopwood, Kay Maguire, Trevor Norma. Prolactin response to d-fenfluramine in combat-related post-traumatic stress disorder. The international journal of neuropsychopharmacology. vol 7. issue 3. 2004-10-27. PMID:15122972. |
central serotonergic function can be investigated by measuring the prolactin response to the serotonin releasing/uptake agent, d-fenfluramine. |
2004-10-27 |
2023-08-12 |
human |
| H Sunny Sun, Hui-Chung Wang, Te-Jen Lai, Tso-Jen Wang, Chih-Ming L. Sequence variants and haplotype analysis of serotonin transporter gene and association with bipolar affective disorder in Taiwan. Pharmacogenetics. vol 14. issue 3. 2004-10-25. PMID:15167705. |
serotonin transporter (slc6a4) is responsible for serotonin re-uptake into presynaptic terminals, thus fine-tuning brain serotonergic neurotransmission. |
2004-10-25 |
2023-08-12 |
Not clear |
| Mark A Oatway, Yuhua Chen, Lynne C Weave. The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury. Pain. vol 110. issue 1-2. 2004-10-25. PMID:15275776. |
we propose that an observed threefold increase in serotonergic fibre immunoreactivity within spinal segments corresponding to these allodynic dermatomes facilitates the maintenance of chronic neuropathic pain via activation of the 5-ht(3) receptor (5-ht(3)-r). |
2004-10-25 |
2023-08-12 |
rat |
| Mark A Oatway, Yuhua Chen, Lynne C Weave. The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury. Pain. vol 110. issue 1-2. 2004-10-25. PMID:15275776. |
however, the more long-lasting effects of this enhanced serotonergic input may facilitate chronic, at-level allodynia via the 5-ht(3)-r. |
2004-10-25 |
2023-08-12 |
rat |
| Carina Stenfors, Teresa Hallerbäck, Lars-Gunnar Larsson, Carin Wallsten, Svante B Ros. Pharmacology of a novel selective 5-hydroxytryptamine1B receptor antagonist, AR-A000002. Naunyn-Schmiedeberg's archives of pharmacology. vol 369. issue 3. 2004-10-22. PMID:14758468. |
the terminal 5-ht(1b) autoreceptors have attracted great pharmacological interest since they are potential targets for compounds modifying serotonergic neurotransmission. |
2004-10-22 |
2023-08-12 |
Not clear |
| Carina Stenfors, Teresa Hallerbäck, Lars-Gunnar Larsson, Carin Wallsten, Svante B Ros. Pharmacology of a novel selective 5-hydroxytryptamine1B receptor antagonist, AR-A000002. Naunyn-Schmiedeberg's archives of pharmacology. vol 369. issue 3. 2004-10-22. PMID:14758468. |
it is concluded that ar-a000002 is a 5-ht(1b) receptor antagonist that enhances the serotonergic neurotransmission in guinea pig brain. |
2004-10-22 |
2023-08-12 |
Not clear |
| Takayuki Ishiwata, Takehito Saito, Hiroshi Hasegawa, Toru Yazawa, Minoru Otokawa, Yasutsugu Aihar. Changes of body temperature and extracellular serotonin level in the preoptic area and anterior hypothalamus after thermal or serotonergic pharmacological stimulation of freely moving rats. Life sciences. vol 75. issue 22. 2004-10-21. PMID:15369702. |
changes of body temperature and extracellular serotonin level in the preoptic area and anterior hypothalamus after thermal or serotonergic pharmacological stimulation of freely moving rats. |
2004-10-21 |
2023-08-12 |
rat |
| Katsuhito Hikiji, Koki Inoue, Shinichi Iwasaki, Kyuichiro Ichihara, Nobuo Kiriik. Local perfusion of mCPP into ventromedial hypothalamic nucleus, but not into lateral hypothalamic area and frontal cortex, inhibits food intake in rats. Psychopharmacology. vol 174. issue 2. 2004-10-19. PMID:14997269. |
the serotonergic (5-hydroxytryptamine, 5-ht) system is extensively implicated in feeding behavior. |
2004-10-19 |
2023-08-12 |
rat |
| Katsutoshi Shioda, Koichi Nisijima, Tatsuki Yoshino, Satoshi Kat. Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine. Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 4. 2004-10-18. PMID:15276688. |
serotonin (5-ht) syndrome is a potentially fatal condition associated with various combinations of serotonergic drugs. |
2004-10-18 |
2023-08-12 |
Not clear |
| Tom H Johnston, Jonathan M Brotchi. Drugs in development for Parkinson's disease. Current opinion in investigational drugs (London, England : 2000). vol 5. issue 7. 2004-10-18. PMID:15298067. |
these include alpha2 adrenergic receptor antagonists (eg, fipamezole), adenosine a2a receptor antagonists (eg, istradefylline), ampa receptor antagonists (eg, talampanel), neuronal synchronization modulators (eg, levetiracetam) and agents that interact with serotonergic systems such as 5-hydroxytryptamine (5-ht)1a agonists (eg, sarizotan) and 5-ht2a antagonists (eg, quetiapine). |
2004-10-18 |
2023-08-12 |
Not clear |
| Michael D Crowell, Michael P Jones, Lucinda A Harris, Tisha N Dineen, V Ann Schettler, Kevin W Olde. Antidepressants in the treatment of irritable bowel syndrome and visceral pain syndromes. Current opinion in investigational drugs (London, England : 2000). vol 5. issue 7. 2004-10-18. PMID:15298070. |
recognition of the importance of serotonin in digestive motility and sensation has sparked interest in the use of agents that modify serotonergic transmission in visceral pain syndromes. |
2004-10-18 |
2023-08-12 |
Not clear |
| E Rink, S Gu. The too few mutant selectively affects subgroups of monoaminergic neurons in the zebrafish forebrain. Neuroscience. vol 127. issue 1. 2004-10-14. PMID:15219677. |
in this study, we examined the states of forebrain dopaminergic (da) and serotonergic (5ht) neurons in larval and adult zebrafish of wild type and the too few mutant. |
2004-10-14 |
2023-08-12 |
zebrafish |
| H Teraoka, C Russell, J Regan, A Chandrasekhar, M L Concha, R Yokoyama, K Higashi, M Take-Uchi, W Dong, T Hiraga, N Holder, S W Wilso. Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos. Journal of neurobiology. vol 60. issue 3. 2004-10-07. PMID:15281067. |
serotonin (5ht) plays major roles in the physiological regulation of many behavioral processes, including sleep, feeding, and mood, but the genetic mechanisms by which serotonergic neurons arise during development are poorly understood. |
2004-10-07 |
2023-08-12 |
zebrafish |
| Timo Heinrich, Henning Böttcher, Gerd D Bartoszyk, Hartmut E Greiner, Christoph A Seyfried, Christoph Van Amsterda. Indolebutylamines as selective 5-HT(1A) agonists. Journal of medicinal chemistry. vol 47. issue 19. 2004-10-07. PMID:15341483. |
in particular, the introduction of the methyl ether or the unsubstituted carboxamide as substituents in position 5 of the indole (r) guaranteed serotonergic 5-ht(1a) affinity compared to the unsubstituted analogue. |
2004-10-07 |
2023-08-12 |
Not clear |