| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Janna L Morrison, K Wayne Riggs, Caly Chien, Nancy Gruber, I Caroline McMillen, Dan W Rura. Chronic maternal fluoxetine infusion in pregnant sheep: effects on the maternal and fetal hypothalamic-pituitary-adrenal axes. Pediatric research. vol 56. issue 1. 2004-12-22. PMID:15128928. |
fx increases serotonergic neurotransmission and serotonin plays a role in the regulation of the hypothalamic-pituitary-adrenal (hpa) axis. |
2004-12-22 |
2023-08-12 |
Not clear |
| Samina S Riaz, Spyridon Theofilopoulos, Eric Jauniaux, Gerald M Stern, Henry F Bradfor. The differentiation potential of human foetal neuronal progenitor cells in vitro. Brain research. Developmental brain research. vol 153. issue 1. 2004-12-21. PMID:15464216. |
it was found that, with the right cocktails of agents, serotonin (ser) (75 microm), acidic fibroblast growth factor (afgf) (10 ng/ml), bdnf (50 ng/ml) and forskolin (10 microm), these same cells could be directed down the serotonergic cell lineage pathway (as judged by the appearance of tryptophan hydroxylase (tph) positive immunoreactivity, and synthesis of 5-ht and its metabolites, secreted into the culture medium). |
2004-12-21 |
2023-08-12 |
human |
| Janine D Flory, Stephen B Manuck, James M Perel, Matthew F Muldoo. A comparison of d, l-fenfluramine and citalopram challenges in healthy adults. Psychopharmacology. vol 174. issue 3. 2004-12-20. PMID:14997271. |
plasma prolactin (prl)] responses to the serotonin agonist, fenfluramine, have been used widely to index cns serotonergic responsivity, safety concerns constrain continued use of fenfluramine. |
2004-12-20 |
2023-08-12 |
Not clear |
| Gerald Holtmann, Tobias Liebregts, Winfried Siffer. Molecular basis of functional gastrointestinal disorders. Best practice & research. Clinical gastroenterology. vol 18. issue 4. 2004-12-16. PMID:15324704. |
considering these disorders of function and the psychiatric comorbidity, polymorphisms of adrenergic, opioidergic or serotonergic receptors as well as g-protein beta3 (gnb3) subunit gene polymorphisms (c825t) and polymorphisms of 5-ht transporter genes are suitable causes. |
2004-12-16 |
2023-08-12 |
Not clear |
| Katsutoshi Shioda, Koichi Nisijima, Shingo Nishida, Satoshi Kat. Possible serotonin syndrome arising from an interaction between caffeine and serotonergic antidepressants. Human psychopharmacology. vol 19. issue 5. 2004-12-15. PMID:15252829. |
possible serotonin syndrome arising from an interaction between caffeine and serotonergic antidepressants. |
2004-12-15 |
2023-08-12 |
Not clear |
| Xin-Xian Ye, Jyh-Cheng Chen, Ren-Shen Liu, Shiaw-Pyng Wey, Jin-Shin Lee, Chia-Chieh Chen, Ying-Kai Fu, Gann Ting, Jeng-Jong Hwan. Microautoradiography of [123I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors. Nuclear medicine and biology. vol 31. issue 5. 2004-12-14. PMID:15219272. |
fluoxetine and desipramine, both are psychotropics and specific sert ligands and decreased the affinity of [(123)i]adam, while p-chloroamphetamine (pca), a narcotic, destroyed most of serotonergic neurons, as well as reducing the concentration of serotonin and the number of sert in the brain as shown by the biodistribution of [(123)i]adam. |
2004-12-14 |
2023-08-12 |
mouse |
| E J Peters, S L Slager, P J McGrath, J A Knowles, S P Hamilto. Investigation of serotonin-related genes in antidepressant response. Molecular psychiatry. vol 9. issue 9. 2004-12-08. PMID:15052272. |
the investigation focused on seven candidate genes in the serotonergic pathway involved in the synthesis, transport, recognition, and degradation of serotonin. |
2004-12-08 |
2023-08-12 |
human |
| Philippe Courtet, Fabrice Jollant, Didier Castelnau, Bernard Astruc, Catherine Buresi, Alain Malafoss. [Implication of genes of the serotonergic system on vulnerability to suicidal behavior]. Journal of psychiatry & neuroscience : JPN. vol 29. issue 5. 2004-12-07. PMID:15534946. |
there is compelling evidence from research in biological psychiatry that abnormalities in the functioning of the central serotonergic system are involved in the pathogenesis of suicidal behavior, and the results of association studies suggest that the gene coding for tryptophan hydroxylase, which is the serotonin synthesis enzyme, and the serotonin transporter gene are involved in susceptibility to suicidal behavior. |
2004-12-07 |
2023-08-12 |
Not clear |
| N Bhasin, A-S LaMantia, J M Laude. Opposing regulation of cell proliferation by retinoic acid and the serotonin2B receptor in the mouse frontonasal mass. Anatomy and embryology. vol 208. issue 2. 2004-12-02. PMID:14991402. |
teratogenesis by retinoic acid (ra) or blockade of serotonergic (5-ht) signaling by the pan-5-ht(2) receptor antagonist, ritanserin, perturbs development of these embryonic structures. |
2004-12-02 |
2023-08-12 |
mouse |
| Jerrold S Meyer, Mark Grande, Kenneth Johnson, Syed F Al. Neurotoxic effects of MDMA ("ecstasy") administration to neonatal rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 5-6. 2004-12-02. PMID:15380826. |
changes in forebrain serotonergic innervation were assessed at postnatal day 25 (serotonin transporter binding and serotonin levels), postnatal day 60 (serotonin transporter binding), and 9 months of age (serotonin transporter immunohistochemistry). |
2004-12-02 |
2023-08-12 |
rat |
| Bassem F El-Khodor, Miriam Hernandez Dimmler, Djamel Ait Amara, Myron Hofer, Rene Hen, Dani Brunne. Juvenile 5HT(1B) receptor knockout mice exhibit reduced pharmacological sensitivity to 5HT(1A) receptor activation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 5-6. 2004-12-02. PMID:15380839. |
our results show that important adaptations to a disturbance of serotonin homeostasis occur during the first week of life within the serotonergic system. |
2004-12-02 |
2023-08-12 |
mouse |
| Bassem F El-Khodor, Miriam Hernandez Dimmler, Djamel Ait Amara, Myron Hofer, Rene Hen, Dani Brunne. Juvenile 5HT(1B) receptor knockout mice exhibit reduced pharmacological sensitivity to 5HT(1A) receptor activation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 5-6. 2004-12-02. PMID:15380839. |
the observed decreased in sensitivity of 5ht(1b) knockout mice to 5ht(1a) and increased to gaba(a) manipulations are discussed within the context of serotonergic plasticity during development and the implication for clinical treatment of anxiety in genetically predisposed individuals. |
2004-12-02 |
2023-08-12 |
mouse |
| Wen-Sheng Huang, Kuo-Hsing Ma, Cheng-Yi Cheng, Cheng-Yu Chen, Ying-Kai Fu, Yuan-Hwa Chou, Shiaw-Pyng Wey, Jian-Chuan Li. Imaging serotonin transporters with 123I-ADAM brain SPECT in healthy non-human primates. Nuclear medicine communications. vol 25. issue 5. 2004-11-30. PMID:15100512. |
serotonin transporters (serts) play a major role in modulating serotonergic neuronal function and are the target of many antidepressant drugs used in neuro-psychiatric disorders. |
2004-11-30 |
2023-08-12 |
Not clear |
| Marco Giorgetti, Laurence H Tecot. Contributions of 5-HT(2C) receptors to multiple actions of central serotonin systems. European journal of pharmacology. vol 488. issue 1-3. 2004-11-29. PMID:15044029. |
both pharmacological and genetic approaches to the analysis of 5-ht(2c) receptor function reveal that it contributes substantially to the serotonergic regulation of a wide variety of behavioral and physiological processes. |
2004-11-29 |
2023-08-12 |
Not clear |
| Marco Giorgetti, Laurence H Tecot. Contributions of 5-HT(2C) receptors to multiple actions of central serotonin systems. European journal of pharmacology. vol 488. issue 1-3. 2004-11-29. PMID:15044029. |
finally, we will review a growing body of evidence indicating a role of 5-ht(2c) receptors in the serotonergic regulation of energy balance. |
2004-11-29 |
2023-08-12 |
Not clear |
| Nissar A Darmani, Jane C Johnso. Central and peripheral mechanisms contribute to the antiemetic actions of delta-9-tetrahydrocannabinol against 5-hydroxytryptophan-induced emesis. European journal of pharmacology. vol 488. issue 1-3. 2004-11-29. PMID:15044052. |
relatively, a large dose of delta-9-thc (20 mg/kg) was required to significantly reduce the number of vomits produced by direct acting serotonergic 5-ht(3) receptor agonists, serotonin and 2-methylserotonin. |
2004-11-29 |
2023-08-12 |
Not clear |
| Sandra L Hrometz, Andrew W Brown, David E Nichols, Jon E Spragu. 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated production of hydrogen peroxide in an in vitro model: the role of dopamine, the serotonin-reuptake transporter, and monoamine oxidase-B. Neuroscience letters. vol 367. issue 1. 2004-11-24. PMID:15308297. |
several studies have suggested that dopamine (da) uptake into serotonin (5-ht) terminals by the 5-ht reuptake transporter (sert) and subsequent deamination by monoamine oxidase-b (mao-b) leads to the formation of hydrogen peroxide and may be major contributors to this serotonergic toxicity. |
2004-11-24 |
2023-08-12 |
human |
| Stéphane Marinesco, Kristine E Kolkman, Thomas J Care. Serotonergic modulation in aplysia. I. Distributed serotonergic network persistently activated by sensitizing stimuli. Journal of neurophysiology. vol 92. issue 4. 2004-11-22. PMID:15140903. |
most serotonergic neurons in the pedal and abdominal ganglion were also excited by 5-ht and by intracellular activation of the two serotonergic neurons cb1/cc3. |
2004-11-22 |
2023-08-12 |
aplysia |
| Stéphane Marinesco, Kristine E Kolkman, Thomas J Care. Serotonergic modulation in aplysia. I. Distributed serotonergic network persistently activated by sensitizing stimuli. Journal of neurophysiology. vol 92. issue 4. 2004-11-22. PMID:15140903. |
it is also possible that serotonergic neurons could be activated by 5-ht present in the hemolymph via a neuro-humoral positive feedback mechanism. |
2004-11-22 |
2023-08-12 |
aplysia |
| Stéphane Marinesco, Nimalee Wickremasinghe, Kristine E Kolkman, Thomas J Care. Serotonergic modulation in aplysia. II. Cellular and behavioral consequences of increased serotonergic tone. Journal of neurophysiology. vol 92. issue 4. 2004-11-22. PMID:15140904. |
increased tonic 5-ht release after 5-htp treatment was manifested by facilitation of sensorimotor (sn-mn) synapses, increased firing rate of serotonergic neurons in the pedal and abdominal ganglia, and enhanced 5-ht release evoked by tail-nerve shock. |
2004-11-22 |
2023-08-12 |
aplysia |